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| 1 | Programmable time-domain digital-coding metasurface for non-linear harmonic manipulation and new wireless communication systems显示文摘Optical non-linear phenomena are typically observed in natural materials interacting with light at high intensities, and they benefit a diverse range of applications from communication to sensing. However,controlling harmonic conversion with high efficiency and flexibility remains a major issue in modern optical and radio-frequency systems. Here, we introduce a dynamic time-domain digital-coding metasurface that enables efficient manipulation of spectral harmonic distribution. By dynamically modulating the local phase of the surface reflectivity, we achieve accurate control of different harmonics in a highly programmable and dynamic fashion, enabling unusual responses, such as velocity illusion. As a relevant application, we propose and realize a novel architecture for wireless communication systems based on the time-domain digital-coding metasurface, which largely simplifies the architecture of modern communication systems, at the same time yielding excellent performance for real-time signal transmission. The presented work, from new concept to new system, opens new pathways in the application of metamaterials to practical technology. | Jie Zhao Xi Yang Jun Yan Dai Qiang Cheng Xiang Li Ning Hua Qi Jun Chen Ke Guo Dong Bai Shuo Liu Shi Jin Andrea Alù Tie Jun Cui | 2019 | National Science Review2019，6，2： | 46 |
| 2 | Influence of dexamethasone on mesenteric lymph node of rats with severe acute pancreatitis显示文摘AIM: To study the influence and mechanisms of dexamethasone on mesenteric lymph node of rats with severe acute pancreatitis (SAP). METHODS: The SAP rats were assigned to model, treated or sham-operated groups. The mortality, pathological changes of mesenteric lymph nodes, expression levels of NF-kB, P-selectin, Bax, Bcl-2 and caspase-3 protein and changes in apoptotic indexes in lymph nodes were observed at 3, 6 and 12 h after operation. The blood levels of endotoxin, superoxide dismutase (SOD), malondialdehyde (MDA), and endothelin-1 (ET-1) in blood were determined. RESULTS: SOD content, expression of Bax protein and apoptotic index were significantly higher in the treated group than in the model group at different time points (P < 0.05 or P < 0.01). Other blood-detecting indexes and histopathological scores of mesenteric lymphnodes were lower in the treated than in the model group (P < 0.05, P < 0.01 or P < 0.01). NF-kB protein expression was negative in all groups. Comparing P-selectin and caspase-3 expression levels among all three groups, there was no marked difference between the model and treated group. CONCLUSION: Dexamethasone can protect mesen-teric lymph nodes. The mechanism may be by reducing the content of inflammatory mediators in the blood and inducing lymphocyte apoptosis. | Xi-Ping Zhang Hong-Miao Xu Yi-Yu Jiang Shuo Yu Yang Cai Bei Lu Qi Xie Tong-Fa Ju | 2008 | World Journal of Gastroenterology2008，14，22： | 14 |
| 3 | Structural insights into a novel histone demethylase PHF8显示文摘histone methylation/demethylation 的动态规定在开发期间起一个重要作用。在人的植物 homeodomain (哲学博士) 的变化和截断摸蛋白质 8 (PHF8 ) 与 X 连接智力迟钝和面部异例被联系,例如一张长脸,宽广鼻音尖端,劈开 lip/cleft 腭和大手,然而,它的分子的功能和结构的基础仍然保持不清楚。这里,我们在高分辨率报导 PHF8 的催化核心的水晶结构与或没有伪 - ketoglutarate (伪 - KG ) 。生物化学、结构的研究表明 PHF8 是为甲醇化物 di 、单音甲醇化物的 histone H3 离氨酸 9,然而并非为 H3K9me3 特定的新奇 histone demethylase (H3K9me2/1 ) 。我们的分析也揭示人的 PHF8 怎么在 methylation 状态之间区别并且为 methylated H3K9 完成顺序特性。在里面 vitro demethylation 试金也证明在临床的病人观察的 F279S 异种不拥有 demethylation 活动,建议酶的活动的那损失为 PHF8 病人的致病是关键的。一起拿,这些结果将使位于联系 PHF8 的发展、神经病学的疾病下面的分子的机制清楚些。 | Lin Yu Yang wang Shuo Huang Jianjun Wang Zengqin Deng Qi Zhang Wei Wu Xingliang Zhang Zhao Liu Weimin Gong Zhongzhou Chen | 2010 | Cell Research2010，20，2： | 11 |
| 4 | Outcomes in refractory diffuse large B-cell lymphoma:results fromamulticenter real-world study in China显示文摘Background:Diffuse large B-cell lymphoma(DLBCL)patients refractory to rituximab-based immunochemotherapy have a dismal prognosis.However,the definition of refractory DLBCL remains inconsistent and no large cohort study data is available from Asian countries.To validate the definition and outcomes of refractory DLBCL in China,we conducted a multicenter,retrospective cohort study.Methods:The REtrospective AnaLysis of Treatment REspoNse of refractory DLBCL(REAL-TREND)study was performed using real-world data from 8 centers in China.DLBCL patients with curative intent were included in the REAL-TREND dataset.Overall survival(OS)was estimated using the Kaplan-Meier method and compared by the log-rank test.Due to heterogeneity in response rates among different centers,the response rates of refractory patients were pooled using random-effect models.Multivariate survival analysis was performed using the Cox regression model.Results:A total of 2778 DLBCL patients diagnosed between January,2010 and December,2015 were enrolled to this study.After validating previous definitions,the SCHOLAR-1 study was most suitable to define refractory DLBCL.The estimated 5-year cumulative incidence of refractory patients was 20%(95% confidence Interval[CI]=18%-22%).After the determination of refractory disease,overall response rate and complete remission rate were 30%(95%CI=22%-38%)and 9%(95%CI=4%-15%),respectively.Patients with either no response to immunochemotherapy or relapse within 12 months after stem-cell transplantation had inferior survival with a median OS of 5.9 months(95%CI=5.5-7.1 months)and 2-year OS rate of 16%(95%CI=12%-20%).International prognostic index score 4-5(hazard ratio[HR]=2.22;95%CI=1.47-3.35),central nervous systemrelapse(HR=1.43;95%CI=1.04-1.97),and best response status(HR=2.68;95%CI=1.42-5.03 for partial remission.HR=5.97,95%CI=3.21-11.11 for stable disease/progressive disease)were independent unfavorable prognostic factors.Conclusions:This is the first large-scale Asian cohort study focusing on outcomes of refractory DLBCL.The definition of the SCHOLAR-1 study identifies patients with homogenously inferior survival,thus is appropriate to select refractory DLBCL.Due to poor clinical outcomes in the rituximab era,patients with refractory DLBCL may be potential candidates for novel treatment modalities. | Shuo Wang Li Wang Jianda Hu Wenbin Qian Xi Zhang Yu Hu Qi Zhu Bobin Chen Depei Wu Chung-Chou H.Chang Pengpeng Xu Xiaoyun Zheng Juying Wei Yao Liu Guohui Cui Yong Tang Yan Ma Haiwen Huang Hongmei Yi Weili Zhao | 2021 | Cancer Communications2021，41，3： | 10 |
| 5 | Predictive Values of Postoperative and Dynamic Changes of Inflammation Indexes in Survival of Patients with Resected Colorectal Cancer显示文摘The aim of the present study was to evaluate the prognostic potential of postoperative scores of inflammation indexes and the dynamic changes of scores before and after tumor resection in colorectal cancer patients.The study included 516 colorectal cancer patients with primary colorectal tumor resection.Cox regression was applied to estimate the associations of postoperative and dynamic changes of inflammation indexes with progression-free survival and overall survival.As results,we found that higher postoperative neutrophil to lymphocyte ratio (NLR),neutrophil and monocyte to lymphocyte ratio (NMLR),platelet to lymphocyte ratio (PLR) and systemic immune inflammation index (SII)were associated with shorter progression-free survival.The increased NLR,NMLR,PLR,SII and C-reaction protein (CRP)to albumin (ALB) ratio (CAR)were associated with poor progression-free survival,with HRs (95% CIs)of 1.92 (1.27-2.90),1.46(1.11-2.09),2.10(1.34-3.30),1.81(1.22-2.70)and 1.65(1.03-2.67), respectively.Postoperative NMLR,SII,CAR,and their dynamic changes were also significantly correlated with overall survival,with the HRs (95% CIs)of 2.63(1.30-3.97), 2.44(1.43-4.17),2.74(1.31-5.74),2.08(1.21-3.60),1.97(1.12-3.45)and 2.55(1.21-5.38)respectively.In conclusion,postoperative inflammation indexes and their dynamic changes,particularly for NMLR,SII and CAR are promising prognostic predictors of CRC patients. | Zi-quan ZHOU Shuo PANG Xing-chen YU Qi XUE Hong-yu JIANG Xin-jun LIANG Li LIU | 2018 | Current Medical Science2018，38，5： | 10 |
| 6 | Dynamic mechanical characteristics and application of constant resistance energy-absorbing supporting material显示文摘In deep underground engineering,rock burst and other dynamic disasters are prone to occur due to stress concentration and energy accumulation in surrounding rock.The control of dynamic disasters requires bolts and cables with high strength,high elongation,and high energy-absorbing capacity.Therefore,a constant resistance energy-absorbing(CREA)material is developed.In this study,the dynamic characteristics of the new material are obtained via the drop hammer tests and the Split Hopkinson Pressure Bar(SHPB)tests of the new material and two common bolt(CB)materials widely used in the field.The test results of drop hammer test and SHPB test show that the percentage elongation of CREA material is more than 2.64 and 3.22 times those of the CB material,and the total impact energy acting on CREA material is more than 18.50 and 21.84 times,respectively,indicating that the new material has high elongation and high energy-absorbing capacity.Subsequently,the CREA bolts and cables using the new material are developed,which are applied in roadways with high stress and strong dynamic disturbance.The field monitoring results show that CREA bolts and cables can effectively control the surrounding rock deformation and ensure engineering safety. | Qi Wang Shuo Xu Manchao He Bei Jiang Huayong Wei Yue Wang | 2022 | International Journal of Mining Science and Technology2022，32，3： | 9 |
| 7 | Contribution of Mass Elevation Effect to the Altitudinal Distribution of Global Treelines显示文摘Alpine treeline, as a prominent ecological boundary between forested mountain slopes and alpine meadow/shrub, is highly complex in altitudinal distribution and sensitive to warming climate. Great efforts have been made to explore their distribution patterns and ecological mechanisms that determine these patterns for more than 100 years, and quite a number of geographical and ecophysiological models have been developed to correlate treeline altitude with latitude or a latitude related temperature. However,on a global scale, all of these models have great difficulties to accurately predict treeline elevation due to the extreme diversity of treeline site conditions.One of the major reasons is that 'mass elevation effect'(MEE) has not been quantified globally and related with global treeline elevations although it has been observed and its effect on treeline elevations in the Eurasian continent and Northern Hemisphere recognized. In this study, we collected and compiled a total of 594 treeline sites all over the world from literatures, and explored how MEE affects globaltreeline elevation by developing a ternary linear regression model with intra-mountain base elevation(IMBE, as a proxy of MEE), latitude and continentality as independent variables. The results indicated that IMBE, latitude and continentality together could explain 92% of global treeline elevation variability, and that IMBE contributes the most(52.2%), latitude the second(40%) and continentality the least(7.8%) to the altitudinal distribution of global treelines. In the Northern Hemisphere, the three factors' contributions amount to 50.4%, 45.9% and 3.7% respectively; in the south hemisphere, their contributions are 38.3%, 53%, and 8.7%, respectively. This indicates that MEE, virtually the heating effect of macro-landforms, is actually the most significant factor for the altitudinal distribution of treelines across the globe, and that latitude is relatively more significant for treeline elevation in the Southern Hemisphere probably due to fewer macro-landforms there. | ZHAO Fang ZHANG Bai-ping ZHANG Shuo QI Wen-wen HE Wen-hui WANG Jing YAO Yong-hui | 2015 | Journal of Mountain Science2015，12，2： | 9 |
| 8 | Long-term follow-up of auditory performance and speech perception and effects of age on cochlear implantation in children with pre-lingual deafness显示文摘Background: The development of auditory and speech perception ability of children with hearing loss is affected by many factors after they undergo cochlear implantation (CI). Age at CI (CI age) appears to play an important role among these factors. This study aimed to evaluate the development of auditory and speech perception ability and explore the impact of CI age on children with pre-lingual deafness present before 3 years of age. Methods: Two hundred and seventy-eight children with pre-lingual deafness (176 boys and 102 girls) were included in this study, and the CI age ranged from 6 to 36 months (mean age, 19 months). Categorical auditory performance (CAP) was assessed to evaluate auditory ability, and the speech intelligibility rating was used to evaluate speech intelligibility. The evaluations were performed before CI and 1, 3, 6, 12, 18, 24, 36, 48, and 60 months after CI. Results: The auditory ability of the pre-lingually hearing-impaired children showed the fastest development within 6 months after CI (k = 0.524, t = 30.992, P < 0.05);then, the progress started to decelerate (k = 0.14, t = 3.704, P < 0.05) and entered a plateau at the 24th month (k = 0.03, t = 1.908, P < 0.05). Speech intelligibility showed the fastest improvement between the 12th and 24th months after CI (k = 0.138, t = 5.365, P < 0.05);then, the progress started to decelerate (k = 0.026, t = 1.465, P < 0.05) and entered a plateau at the 48th month (k = 0.012, t = 1.542, P < 0.05). The CI age had no statistical significant effect on the auditory and speech abilities starting at 2 years after CI (P > 0.05). The optimal cutoff age for CI was 15 months. Conclusions: Within 5 years after CI, the auditory and speech ability of young hearing-impaired children continuously improved, although speech development lagged behind that of hearing. An earlier CI age is recommended;the optimal cutoff age for CI is at 15 months. | Jing Lyu Ying Kong Tian-Qiu Xu Rui-Juan Dong Bei-Er Qi Shuo Wang Yong-Xin Li Hai-Hong Liu Xue-Qing Chen | 2019 | Chinese Medical Journal2019，，16： | 9 |
| 9 | Extent of Lung Involvement and Serum Cryptococcal Antigen Test in Non-Human Immunodeficiency Virus Adult Patients with Pulmonary Cryptococcosis显示文摘 | Tao Zhu Wan-Ting Luo Gui-Hua Chen Yue-Sheng Tu Shuo Tang Huo-Jin Deng Wei Xu Wei Zhang Di Qi Dao-Xin Wang Chang-Yi Li He Li Yan-Qiao Wu Shen-Jin Li | 2018 | Chinese Medical Journal2018，，18： | 7 |
| 10 | One-dimensional photonic bandgap structure in abalone shell显示文摘 | LI Bo ZHOU Ji LI Longtu LI Qi HAN Shuo HAO Zhibiao | 2005 | Chinese Science Bulletin2005，50，14： | 6 |
| 11 | Tetramethylpyrazine prevents liver fibrotic injury in mice by targeting hepatocyte-derived and mitochondrial DNA-enriched extracellular vesicles显示文摘Liver fibrosis is the common consequence of almost all liver diseases and has become an urgent clinical problem without efficient therapies.Recent evidence has shown that hepatocytes-derived extracellular vesicles(EVs)play important roles in liver pathophysiology,but little is known about the role of damaged hepatocytes-derived EVs in hepatic stellate cell(HSC)activation and following fibrosis.Tetramethylpyrazine(TMP)from Ligusticum wallichii Franchat exhibits a broad spectrum of biological activities including liver protection.In this study,we investigated whether TMP exerted liver-protective action through regulating EV-dependent intercellular communication between hepatocytes and HSCs.Chronic liver injury was induced in mice by CCl_(4)(1.6 mg/kg,i.g.)twice a week for 8 weeks.In the last 4 weeks of CCl_(4) administration,mice were given TMP(40,80,160 mg·kg^(-1)·d^(-1),i.g.).Acute liver injury was induced in mice by injection of a single dose of CCl_(4)(0.8 mg/kg,i.p.).After injection,mice were treated with TMP(80 mg/kg)every 24 h.We showed that TMP treatment dramatically ameliorated CCl_(4)-induced oxidative stress and hepatic inflammation as well as acute or chronic liver fibrosis.In cultured mouse primary hepatocytes(MPHs),treatment with CCl_(4) or acetaminophen resulted in mitochondrial dysfunction,release of mitochondrial DNA(mtDNA)from injured hepatocytes to adjacent hepatocytes and HSCs through EVs,mediating hepatocyte damage and fibrogenic responses in activated HSCs;pretreatment of MPHs with TMP(25μM)prevented all these pathological effects.Transplanted serum EVs from TMP-treated mice prevented both initiation and progression of liver fibrosis caused by CCl_(4).Taken together,this study unravels the complex mechanisms underlying the protective effects of TMP against mtDNA-containing EV-mediated hepatocyte injury and HSC activation during liver injury,and provides critical evidence inspiring the development of TMP-based innovative therapeutic agents for the treatment of liver fibrosis. | Ya-jing Li Run-ping Liu Ming-ning Ding Qi Zheng Jian-zhi Wu Xiao-yong Xue Yi-qing Gu Bo-ning Ma Ya-jie Cai Shuo Li Sheng Lin Lu-yong Zhang Xiaojiaoyang Li | 2022 | Acta Pharmacologica Sinica2022，43，8： | 5 |
| 12 | In-situ structural evolution analysis of Zr-doped Na_(3)V_(2)(PO_(4))_(2)F_(3) coated by N-doped carbon layer as high-performance cathode for sodium-ion batteries显示文摘With great superiorities in energy density,rate capability and structural stability,Na_(3)V_(2)(PO_(4))_(2) F_(3)(NVPF)has attracted much attentions as cathode of sodium ion battery(SIB),but it also faces challenges on its poor intrinsic electronic conductivity and the controversial de/sodiation mechanism.Herein,a series of Zr-doped NVPF coated by N-doped carbon layer(~5 nm in thickness,homogenously)materials are fabricated by a sol-gel method,and the optimized heteroatom-doping amounts of Zr and N doping improve intrinsic properties on enlarging lattice distance and enhancing electronic conductivity,respectively.Specifically,among all samples of Na_(3) V_(2-x)Zr_(x)(PO_(4))_(2) F_(3)/NC(NVPF-Zr-x/NC,x=0,0.01,0.02,0.05,and 0.1),the optimized electrode of NVPF-Zr-0.02/NC delivers high reversible capacities(119.2 mAh g^(-1) at0.5 C),superior rate capability(98.1 mA h g^(-1) at 20 C)and excellent cycling performance.The structural evolution of NVPF-Zr-0.02/NC electrode,in-situ monitored by X-ray diffractometer,follows a step-wise Na-extraction/intercalation mechanism with reversible multi-phase changes,not just a solid-solutionreaction one.Full cells of NVPF-Zr-0.02/NC//hard carbon demonstrate high capacity(99.8 mA h g^(-1) at 0.5 C),high out-put voltage(3.5 V)and good cycling stability.This work is favorable to accelerate the development of high-performance cathode materials and explore possible redox reaction mechanisms of SIBs. | Chuan Guo Jianwei Yang Zhiyuan Cui Shuo Qi Qianqian Peng Weiwei Sun Li-Ping Lv Yi Xu Yong Wang Shuangqiang Chen | 2022 | Journal of Energy Chemistry2022，31，2： | 5 |
| 13 | FGF/FGFR signaling in health and disease显示文摘Growing evidences suggest that the fibroblast growth factor/FGF receptor(FGF/FGFR)signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment,differentiation,proliferation,and apoptosis of various types of cells.In this review,we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development,injury repair,and the pathophysiology of spectrum of diseases,which is a consequence of FGF signaling dysregulation,including cancers and chronic kidney disease(CKD).In this context,the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems. | Yangli Xie Nan Su Jing Yang Qiaoyan Tan Shuo Huang Min Jin Zhenhong Ni Bin Zhang Dali Zhang Fengtao Luo Hangang Chen Xianding Sun Jian Q.Feng Huabing Qi Lin Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 14 | Safety and effectiveness of Traditional Chinese Medicinal herbs for diabetic foot:a systematic review and Meta-analysis显示文摘OBJECTIVE: To evaluate the safety and effectiveness of traditional Chinese medicinal herbs(TCMHs) as an adjunctive treatment for diabetic foot(DF).METHODS: The sources used were Pub Med(1966 to August 2015), the Cochrane Library(1988 to August 2015), the Excerpta Medica Database(1974 to August 2015), Wiley(1807 to August 2015), Ovid(1988 to August 2015), Clinical Trials.gov(1993 to August 2015), the Cochrane Central Register of Controlled Trials(1966 to August 2015), China Science and Technology Journal Database(1994 to August2015), Chi CTR(2007 to August 2015), Sino Med(1978 to August 2015), the China National Knowledge Infrastructure(1984 to August 2015), Wanfang Data Knowledge Service Platform(1998 to August 2015), and the Traditional Chinese Medical Literature Analysis and Retrieval System(TCMLARS)(1984 to August 2015). Studies were identified and selected, and the data were extracted by two independent reviewers. The Cochrane Risk of Bias tool was used to assess the quality of studies. Revman 5.2 software was used for data synthesis and analysis.RESULTS: Sixteen studies were included based on the selection criteria. Of these, seven studies had low bias risk and one had high bias risk. In the overall analysis, TCMHs resulted in a significantly higher total effective rate(OR 5.08; 95% CI 3.50 to7.36; P < 0.000 01), cure rate(OR 2.12; 95% CI1.63 to 2.77; P < 0.000 01), and shorter time to ulcer healing(SMD-0.64; 95% CI-0.89 to-0.40;P < 0.000 01) when compared with non-TCMHs treated DF. The analysis also revealed that significantly fewer amputations occurred in TCMHs patients(OR 0.36; 95% CI 0.20 to 0.65; P = 0.0007).Sensitivity analysis indicated that the findings of the Meta-analysis were robust to study quality,and the funnel plot of the Egger test showed no publication bias.CONCLUSION: TCMHs intervention appears to be more effective for DF, with a similar safety profile,when compared with non-TCMHs treatments, although this result requires further verification with more well-designed studies. | Chen Shuo Ma Jianwei Xu Limei Niu Tianhui Dong Jing Liu Wenjun Han Qi | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 5 |
| 15 | Clinical characteristics and surgical treatment of patients with giant intracranial aneurysms显示文摘背景与更小的动脉瘤相比,巨大的 intracranial 动脉瘤( GICA )有更差的预后并且要求从 circulation.GICAs 排除他们的更过细的外科的计划和技术继续与 GICA 质问 170 个病人的 neurosurgical techniques.A 系列的限制为理解有 GICAs.Methods 的病人的临床的 characteristics.surgical 治疗和结果收集了 170 的数据被考察有到7月20日的从1995年1月的 GICA | QI Wei WANG Shuo ZHAO Yuan-li YANG Hai-bo ZHAO Ji-zong | 2008 | Chinese Medical Journal2008，，12： | 4 |
| 16 | Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome显示文摘To unravel the genetic mechanisms of disease and physiological traits,it requires comprehensive sequencing analysis of large sample size in Chinese populations.Here,we report the primary results of the Chinese Academy of Sciences Precision Medicine Initiative(CASPMI)project launched by the Chinese Academy of Sciences,including the de novo assembly of a northern Han reference genome(NH1.0)and whole genome analyses of 597 healthy people coming from most areas in China.Given the two existing reference genomes for Han Chinese(YH and HX1)were both from the south,we constructed NH1.0,a new reference genome from a northern individual,by combining the sequencing strategies of PacBio,10×Genomics,and Bionano mapping.Using this integrated approach,we obtained an N50 scaffold size of 46.63 Mb for the NH1.0 genome and performed a comparative genome analysis of NH1.0 with YH and HX1.In order to generate a genomic variation map of Chinese populations,we performed the whole-genome sequencing of 597 participants and identified 24.85 million(M)single nucleotide variants(SNVs),3.85 M small indels,and 106,382 structural variations.In the association analysis with collected phenotypes,we found that the T allele of rs1549293 in KAT8 significantly correlated with the waist circumference in northern Han males.Moreover,significant genetic diversity in MTHFR,TCN2,FADS1,and FADS2,which associate with circulating folate,vitamin B12,or lipid metabolism,was observed between northerners and southerners.Especially,for the homocysteine-increasing allele of rs1801133(MTHFR 677T),we hypothesize that there exists a “comfort”zone for a high frequency of 677T between latitudes of 35–45 degree North.Taken together,our results provide a high-quality northern Han reference genome and novel population-specific data sets of genetic variants for use in the personalized and precision medicine. | Zhenglin Du Liang Ma Hongzhu Qu Wei Chen Bing Zhang Xi Lu Weibo Zhai Xin Sheng Yongqiao Sun Wenjie Li Meng Lei Qiuhui Qi Na Yuan Shuo Shi Jingyao Zeng Jinyue Wang Yadong Yang Qi Liu Yaqiang Hong Lili Dong Zhewen Zhang Dong Zou Yanqing Wang Shuhui Song Fan Liu Xiangdong Fang Hua Chen Xin Liu Jingfa Xiao Changqing Zeng | 2019 | Genomics, Proteomics & Bioinformatics2019，17，3： | 4 |
| 17 | The enhanced performance of piezoelectric nanogenerator via suppressing screening effect with Au particles/ZnO nanoarrays Schottky junction显示文摘这份报纸描述新奇策略削弱由通过 Au 粒子的介绍在 ZnO 表面上形成 Schottky 连接到表面上屏蔽效果的 piezopotential。与这条途径, piezoelectric-energyconversion 表演极大地被提高。产量电压和 Au@ZnO 基于 nanoarray 的压电的 nanogenerator 的当前的密度分别地到达了 2 V 和 1 A/ 厘米 2, ,比太古的 ZnO 基于 nanoarray 的压电的 nanogenerators 的产量高 10 倍。我们由于减少的搬运人集中把这改进归因于屏蔽效果的戏剧的抑制,作为由扫描凯尔文探查显微镜大小和阻抗分析决定了。Au@ZnO nanoarraybased 的降低的电容压电的 nanogenerator 也贡献改进产量。这个工作提供一个新奇方法提高压电的 nanogenerators 的表演并且可能延长到 piezotronics 和 piezophototronics。 | Shengnan Lu Qingliang Liao Junjie Qi Shuo Liu Yichong Liu Qijie Liang Guangjie Zhang Yue Zhang | 2016 | Nano Research2016，9，2： | 4 |
| 18 | An Aware-Scheduling Security Architecture with Priority-Equal Multi-Controller for SDN显示文摘Current SDN controllers suffer from a series of potential attacks. For example, malicious flow rules may lead to system disorder by introducing unexpected flow entries. In this paper, we propose Mcad-SA, an aware decision-making security architecture with multiple controllers, which could coordinate heterogeneous controllers internally as a 'big' controller. This architecture includes an additional plane, the scheduling plane, which consists of transponder, sensor, decider and scheduler. Meanwhile it achieves the functions of communicating, supervising and scheduling between data and control plane. In this framework, we adopt the vote results from the majority of controllers to determine valid flow rules distributed to switches. Besides, an aware dynamic scheduling(ADS) mechanism is devised in scheduler to intensify security of Mcad-SA further. Combined with perception, ADS takes advantage of heterogeneity and redundancy of controllers to enable the control plane operate in a dynamic, reliable and unsteady state, which results in significant difficulty of probing systems and executing attacks. Simulation results demonstrate the proposed methods indicate better security resilience over traditional architectures as they have lower failure probability when facing attacks. | Chao Qi Jiangxing Wu Guozhen Cheng Jianjian Ai Shuo Zhao | 2017 | China Communications2017，14，9： | 4 |
| 19 | Temporal regulation of prenatal embryonic development by paternal imprinted loci显示文摘Paternal imprinted genes(H19 and Gtl2)are pivotal for prenatal embryonic development in mice.Nongrowing oocytes and sperm-or oocyte-originated haploid embryonic stem cells(ha ESCs)carrying both H19-DMR(differentially DNA-methylated region)and IG(intergenic)-DMR deletions that partially mimic paternal imprinting of H19-Igf2 and Dlk1-Dio3 can be employed as sperm replacement to efficiently support full-term embryonic development.However,how H19-DMR and IG-DMR act together to regulate embryonic development is still largely unknown.Here,using androgenetic ha ESC(AG-ha ESC)-mediated semi-cloned(SC)technology,we showed that paternal H19-DMR and IG-DMR are not essential for pre-implantation development of SC embryos generated through injection of AG-ha ESCs into oocytes.H19-DMR plays critical roles before 12.5 days of gestation while IG-DMR is essential for late-gestation of SC embryos.Interestingly,we found that combined deletions of H19 and H19-DMR can further improve the efficiency of normal development of SC embryos at mid-gestation compared to DKO SC embryos.Transcriptome and histology analyses revealed that H19 and H19-DMR combined deletions rescue the placental defects.Furthermore,we showed that H19,H19-DMR and IG-DMR deletions(TKO)give rise to better prenatal and postnatal embryonic development of SC embryos compared to DKO.Together,our results indicate the temporal regulation of paternal imprinted loci during embryonic development. | Qing Li Yuanyuan Li Qi Yin Shuo Huang Kai Wang Liangchai Zhuo Wei Li Boran Chang Jinsong Li | 2020 | Science China(Life Sciences)2020，63，1： | 4 |
| 20 | Omni-Directional Distribution Patterns of Montane Coniferous Forest in the Helan Mountains of China显示文摘斜坡方面在山区的森林的发展和分发有重要效果,特别在干旱、半干旱的区域。用 SPOT5 图象和 1:50,000 DEM ,这份报纸数字地提取并且分析山区的具球果的森林的空间信息(主要 Qinghai 云杉),并且从而探索上面、更低的限制和具球果的森林的高度的范围怎么变化并且具球果的森林的区域怎么与有在 Helan 山的所有方面的年度曝晒是相关的。结果显示出那:1 ) 在东方胁腹,具球果的森林的更低的限制在 1,600 m 和 2,000 m 之间是 a.s.l 和 3,000 m a.s.l;在西方的胁腹,具球果的森林的更低的限制在 2,000 m 和 2,300 m 之间是 a.s.l 和 3,100 m a.s.l 2 ) 具球果的森林的高度的范围分别地是 8061,435 m,为东方胁腹的 4381,140 m 和西方的胁腹。3 ) 具球果的森林的区域与方面呈现正常分布,并且它与年度曝晒有一种靠近的关系。在这纸份量上开发的这个分发模型在干旱、半干旱的土地在具球果的森林的分发上揭示斜坡方面的重要效果。 | PANG Yu ZHANG Bai-ping ZHAO Fang YAO Yong-hui ZHANG Shuo QI Wen-wen | 2013 | Journal of Mountain Science2013，10，5： | 4 |
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