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| 1 | MiR-29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6显示文摘Osteosarcoma 是骨头的最普通的主要肉瘤,并且它是在青少年和年轻成年人之中的癌症死亡的一个领先的原因。然而,糟糕位于 osteosarcoma carcinogenesis 遗体下面的分子的机制理解。最近, cyclin 依赖的 kinase (CDK6 ) 6 作为重要 oncogene 被识别。我们发现了那 CDK6 蛋白质水平,而非 CDK6 mRNA 水平,比的在 osteosarcoma 纸巾是高得多的在正常邻近的纸巾,它显示在 osteosarcoma 涉及 CDK6 规定的 post-transcriptional 机制。MiRNAs 是镇压的小非编码的 RNA 在 post-transcriptional 水平的基因表示并且广泛地被显示了在许多人的癌症起重要作用。在这研究,我们用生物信息学方法作为 CDK6 的一个新奇管理者调查了 miR-29b 的角色。我们证明 CDK6 能是由经由到在 osteosarcoma 房间的 3-UTR 区域的绑定的 miR-29b 的 downregulated。而且,我们在 osteosarcoma 纸巾识别了在 miR-29b 和 CDK6 蛋白质层次之间的反的关联。最后,我们在 osteosarcoma 房间检验了 CDK6 表示的 miR-29b-driven 压抑的功能。结果表明 miR-29b 由在增长和移植进程指向 CDK6 充当 osteosarcoma 的肿瘤 suppressor。一起拿,我们的结果在 osteosarcoma 在 CDK6 的规定为 miR-29b 加亮一个重要角色并且可以为未来 osteosarcoma 治疗打开新大街。 | Kegan Zhu Lei Liu Junliang Zhang Yanbo Wang Hongwei Liang Gentao Fan Zhenhuan Jiang Chen-Yu Zhang Xi Chen Guangxin Zhou | 2016 | Protein & Cell2016，7，6： | 18 |
| 2 | Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19:a phase 1 clinical trial显示文摘No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19. | Fanping Meng Ruonan Xu Siyu Wang Zhe Xu Chao Zhang Yuanyuan Li Tao Yang Lei Shi Junliang Fu Tianjun Jiang Lei Huang Peng Zhao Xin Yuan Xing Fan Ji-Yuan Zhang Jinwen Song Dawei Zhang Yanmei Jiao Limin Liu Chunbao Zhou Markus Maeurer Alimuddin Zumla Ming Shi Fu-Sheng Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 16 |
| 3 | Mulching mode and planting density affect canopy interception loss of rainfall and water use efficiency of dryland maize on the Loess Plateau of China显示文摘High and efficient use of limited rainwater resources is of crucial importance for the crop production in arid and semi-arid areas. To investigate the effects of different soil and crop management practices(i.e., mulching mode treatments: flat cultivation with non-mulching, flat cultivation with straw mulching, plastic-covered ridge with bare furrow and plastic-covered ridge with straw-covered furrow; and planting density treatments: low planting density of 45,000 plants/hm^2, medium planting density of 67,500 plants/hm^2 and high planting density of 90,000 plants/hm^2) on rainfall partitioning by dryland maize canopy, especially the resulted net rainfall input beneath the maize canopy, we measured the gross rainfall, throughfall and stemflow at different growth stages of dryland maize in 2015 and 2016 on the Loess Plateau of China. The canopy interception loss was estimated by the water balance method. Soil water storage, leaf area index, grain yield(as well as it components) and water use efficiency of dryland maize were measured or calculated. Results showed that the cumulative throughfall, cumulative stemflow and cumulative canopy interception loss during the whole growing season accounted for 42.3%–77.5%, 15.1%–36.3% and 7.4%–21.4% of the total gross rainfall under different treatments, respectively. Soil mulching could promote the growth and development of dryland maize and enhance the capability of stemflow production and canopy interception loss, thereby increasing the relative stemflow and relative canopy interception loss and reducing the relative throughfall. The relative stemflow and relative canopy interception loss generally increased with increasing planting density, while the relative throughfall decreased with increasing planting density. During the two experimental years, mulching mode had no significant influence on net rainfall due to the compensation between throughfall and stemflow, whereas planting density significantly affected net rainfall. The highest grain yield and water use efficiency of dryland maize were obtained under the combination of medium planting density of 67,500 plants/hm^2 and mulching mode of plastic-covered ridge with straw-covered furrow. Soil mulching can reduce soil evaporation and retain more soil water for dryland maize without reducing the net rainfall input beneath the maize canopy, which may alleviate the contradiction between high soil water consumption and insufficient rainfall input of the soil. In conclusion, the application of medium planting density(67,500 plants/hm^2) under plastic-covered ridge with bare furrow is recommended for increasing dryland maize production on the Loess Plateau of China. | ZHENG Jing FAN Junliang ZHANG Fucang YAN Shicheng GUO Jinjin CHEN Dongfeng LI Zhijun | 2018 | Journal of Arid Land2018，10，5： | 6 |
| 4 | Ridge-furrow plastic mulching with a suitable planting density enhances rainwater productivity,grain yield and economic benefit of rainfed maize显示文摘Soil surface mulching and planting density regulation are widely used for effective utilization of limited rainwater resources and improvement of crop productivity in dryland farming.However,the combined effects of mulching type and planting density on maize growth and yield have been seldom studied,especially in different hydrological years.A field experiment was conducted to evaluate the effects of mulching type and planting density on the soil temperature,growth,grain yield(GY),water use efficiency(WUE)and economic benefit of rainfed maize in the drylands of northern China during 2015-2017.Precipitation fluctuated over the three years.There were four mulching types(NM,flat cultivation with non-mulching;SM,flat cultivation with straw mulching;RP,plastic-mulched ridge plus bare furrow;RPFS,plastic-mulched ridge plus straw-mulched furrow)and three planting densities(LD,low planting density,45.0×10^3 plants/hm^2;MD,medium planting density,67.5×10^3 plants/hm^2;HD,high planting density,90.0×10^3 plants/hm^2).Results showed that soil temperature was higher with RP and lower with SM compared with NM,but no significant difference was found between RPFS and NM.More soil water was retained by soil mulching at the early growth stage,but it significantly varied at the middle and late growth stages.Maize growth was significantly improved by soil mulching.With increasing planting density,stem diameter,net photosynthetic rate and chlorophyll content tended to decline,whereas a single-peak trend in biomass yield was observed.Mulching type and planting density did not have significant effect on evapotranspiration(ET),but GY and WUE were significantly affected.There were significant interacting effects of mulching type and planting density on biomass yield,GY,ET and WUE.Compared with NM,RPFS,RP and SM increased GY by 57.5%,50.8%and 18.9%,and increased WUE by 66.6%,54.3%and 18.1%,respectively.At MD,GY increased by 41.4%and 25.2%,and WUE increased by 38.6%and 22.4%compared with those of at LD and HD.The highest maize GY(7023.2 kg/hm^2)was observed under MD+RPFS,but the value(6699.1 kg/hm^2)was insignificant under MD+RP.Similar trends were observed for WUE under MD+RP and MD+RPFS,but no significant difference was observed between these two combinations.In terms of economic benefit,net income under MD+RP was the highest with a 9.8%increase compared with that of under MD+RPFS.Therefore,we concluded that RP cultivation pattern with a suitable planting density(67.5×10^3 plants/hm^2)is promising for rainwater resources utilization and maize production in the drylands of northern China. | ZHENG Jing FAN Junliang ZOU Yufeng Henry Wai CHAU ZHANG Fucang | 2020 | Journal of Arid Land2020，12，2： | 3 |
| 5 | Branched Fluorine/Adamantane Interfacial Compatibilizer for PBO Fibers/Cyanate Ester Wave-Transparent Laminated Composites显示文摘Comprehensive Summary Branched fluorine/adamantane PBO precursor(preFABPBO),synthesized via random co-condensation between 2,2-bis(3-amino-4-hydroxyphenyl)hexafluoro propane,1,3-adamantanedicarbonyl dichloride,and trimesoyl chloride,is performed as interfacial compatibilizer,bisphenol A dicyanate ester(BADCy)resin as polymer matrix,and poly(p-phenylene-2,6-benzobisoxazole)(PBO)fibers as reinforcements to prepare PBO fibers/FABPBO-BADCy wave-transparent laminated composites by high temperature molding.The mechanical properties,wave-transparent performances,and heat resistances of PBO fibers/BADCy composites are simultaneously improved by the addition of preFABPBO.The interlaminar shear strength(ILSS)and flexural strength of PBO fibers/FABPBO-BADCy composites are 48.9 and 665.3 MPa,respectively,increased by 33.2%and 13.3%compared to those of PBO fibers/BADCy composites(36.7 and 587.4 MPa).The dielectric constant and dielectric loss values at 106 Hz are 2.53 and 0.003,respectively,lower than those of PBO fibers/BADCy composites(3.06 and 0.006),and the corresponding wave transmission efficiency is 94.8%,which also presents excellent stability over the wide temperature(25-200℃)and frequency range(103-107 Hz and 8.2-12.4 GHz).Meanwhile,the heat resistance index and glass transition temperature are 229.9℃and 247.5℃,also better than those of PBO fibers/BADCy composites(229.6℃and 247.1℃). | Zheng Liu Xiaoli Fan Muyi Han Hao Li Junliang Zhang Lixin Chen Qiju Zhu Junwei Gu | 2023 | Chinese Journal of Chemistry2023，41，8： | 2 |
| 6 | PBO fibers/fluorine-containing liquid crystal compound modified cyanate ester wave-transparent laminated composites with excellent mechanical and flame retardance properties显示文摘Bisphenol A dicyanate ester resins modified by fluorine-containing liquid crystal compound(LCFE)are applied as polymer matrix(LCFE-BADCy),poly(p-phenylene-2,6-benzobisoxazole)(PBO)fibers as rein-forcements,and fluorine/adamantane PBO precursor(pre FABPBO)as interfacial compatibilizer to prepare the corresponding PBO fibers/FABPBO/LCFE-BADCy wave-transparent laminated composites.LCFE could improve the order degree of BADCy cured network,in favor of enhancing the wave-transparent perfor-mance,mechanical properties,and intrinsic thermal conductivity.The dielectric constant and dielectric loss of PBO fibers/FABPBO/LCFE-BADCy composites are highly temperature(25–200℃)and frequency(10^(4)–10^(7) Hz and 8.2–12.4 GHz)stable with the value of 2.49 and 0.003 under 10^(6) Hz at 25℃,and the corresponding wave transmission efficiency is 95.0%,higher than that of 92.5%for PBO fibers/BADCy com-posites.The interlamellar shear strength and flexural strength are respectively 50.7 MPa and 682.5 MPa,38.1%and 16.2%higher than those of PBO fibers/BADCy composites.Besides,the volume resistivity,breakdown voltage,heat resistance index,glass transition temperature,flame retardant grade,and ul-timate oxygen index of PBO fibers/FABPBO/LCFE-BADCy composites are respectively 5.3×10^(15)Ωcm,29.75 kV/mm,217.2℃,245.7℃,V-1 grade,and 33.6%,expected to be performed as a new generation of“lightweight/loading/wave-transparent”electromagnetic window materials in advanced military weapons and civil communication base station. | Zheng Liu Xiaoli Fan Junliang Zhang Lixin Chen Yusheng Tang Jie Kong Junwei Gu | 2023 | Journal of Materials Science & Technology2023，，21： | 2 |
| 7 | Hybrid Polymer Membrane Functionalized PBO Fibers/Cyanate Esters Wave‑Transparent Laminated Composites显示文摘Hybrid polymer membrane(TA-APTES),synthesized by tannic acid(TA)and aminopropyl trethoxysilane(APTES)based on the Schif’s base and Michael addition reaction,is deposited on the surface of poly(p-phenylene-2,6-benzobisoxazole)(PBO)fbers,and then grafted with epoxy-terminated polysesquisiloxane(POSS)to obtain POSS-g-PBO@TA-APTES fbers.The POSS-g-PBO@TA-APTES fbers reinforced bisphenol A dicyanate ester(BADCy)resins(POSS-g-PBO@TAAPTES fbers/BADCy)wave-transparent laminated composites are prepared.The interlaminar shear strength and fexural strength of POSS-g-PBO@TA-APTES fbers/BADCy composites are respectively enhanced from 36.7 and 587.4 MPa to 42.8 and 645.8 MPa,increased by 16.6%and 9.9%compared with those of PBO fbers/BADCy composites.At 1 MHz,the corresponding dielectric constant and dielectric loss are reduced to 2.85 and 0.0047,respectively,lower than those of PBO fbers/BADCy(3.06 and 0.006)composites.Meanwhile,the simulated wave transmittance rate of POSS-g-PBO@TA-APTES fbers/BADCy composites with the thicknesses of 1.5–3.5 mm is higher than 86.2%at 0.3–40 GHz.The volume resistivity and breakdown strength of POSS-g-PBO@TA-APTES fbers/BADCy composites are 2.8×10^(15)Ω·cm and 19.80 kV/mm,higher than PBO fbers/BADCy composites(2.2×10^(15)Ω·cm and 17.69 kV/mm),respectively.And the corresponding heat resistant index is 221.5℃,lower than PBO fbers/BADCy composites(229.6℃). | Zheng Liu Xiaoli Fan Lei Cheng Junliang Zhang Lin Tang Yusheng Tang Jie Kong Junwei Gu | 2022 | Advanced Fiber Materials2022，4，3： | 2 |
| 8 | Availability modelling for periodically inspected systems under mixed maintenance policies显示文摘The availability of a periodic inspection system under mixed maintenance policies is studied in this paper.To accommodate the characteristic of multiple failure modes for complex systems,the system failures can be divided into two failure modes:hard failure and soft failure.When hard failure occurs,the corresponding corrective maintenance will be performed,taking a random time under the perfect maintenance policy;in contrast,if the soft failure is found,the corresponding preventive maintenance will be performed,taking a random time under the imperfect maintenance policy.The dynamic age setback model is adopted for imperfect maintenance,which can accurately reflect the fault characteristics of the degraded system.Then an analytical model for system steady state availability and instantaneous availability are derived.Moreover,the optimal method to maximize the system steady-state availability through adjusting the inspection interval is researched.According to the above research,the optimization of system unit time cost,preventive maintenance intervals and availability is researched.Finally,the developed approach is demonstrated by a numerical example. | LI Junliang CHEN Yueliang ZHANG Yong ZHANG Zhuzhu FAN Weijie | 2021 | Journal of Systems Engineering and Electronics2021，32，3： | 2 |
| 9 | Forecasting Multi-Step Ahead Monthly Reference Evapotranspiration Using Hybrid Extreme Gradient Boosting with Grey Wolf Optimization Algorithm显示文摘It is important for regional water resources management to know the agricultural water consumption information several months in advance.Forecasting reference evapotranspiration(ET_(0))in the next few months is important for irrigation and reservoir management.Studies on forecasting of multiple-month ahead ET_(0) using machine learning models have not been reported yet.Besides,machine learning models such as the XGBoost model has multiple parameters that need to be tuned,and traditional methods can get stuck in a regional optimal solution and fail to obtain a global optimal solution.This study investigated the performance of the hybrid extreme gradient boosting(XGBoost)model coupled with the Grey Wolf Optimizer(GWO)algorithm for forecasting multi-step ahead ET_(0)(1-3 months ahead),compared with three conventional machine learning models,i.e.,standalone XGBoost,multi-layer perceptron(MLP)and M5 model tree(M5)models in the subtropical zone of China.The results showed that theGWO-XGB model generally performed better than the other three machine learning models in forecasting 1-3 months ahead ET_(0),followed by the XGB,M5 and MLP models with very small differences among the three models.The GWO-XGB model performed best in autumn,while the MLP model performed slightly better than the other three models in summer.It is thus suggested to apply the MLP model for ET_(0) forecasting in summer but use the GWO-XGB model in other seasons. | Xianghui Lu Junliang Fan Lifeng Wu Jianhua Dong | 2020 | Computer Modeling in Engineering & Sciences2020，，11： | 1 |
| 10 | A Binary Images Watermarking Algorithm Based on Adaptable Matrix显示文摘A watermarking algorithm of binary images using adaptable matrix is presented. An adaptable matrix is designed to evaluate the smoothness and the connectivity of binary images. The watermark is embedded according to the adaptable matrix in this algorithm. In the proposed watermarking algorithm,each im-age block implements a XOR operation with the binary adaptable matrix,which has the same size with the image block,and in order to embed the watermark data,a multiplication operation are also implemented with the weight matrix. The experimental results show that proposed scheme has a good performance. | ZHANG Fan ZHANG Junliang | 2008 | Wuhan University Journal of Natural Sciences2008，13，5： | 1 |
| 11 | One-pot synthesis of N-doped petroleum coke-based microporous carbon for high-performance CO_(2) adsorption and supercapacitors显示文摘Waste resource utilization of petroleum coke is crucial for achieving global carbon emission reduction.Herein,a series of N-doped microporous carbons were fabricated from petroleum coke using a one-pot synthesis method.The as-prepared samples had a large specific surface area(up to 2512 m^(2)/g),a moderate-high N content(up to 4.82 at.%),and high population(55%)of ultra-micropores(<0.7 nm).Regulating the N content and ultra-microporosity led to efficient CO_(2)adsorption and separation.At ambient pressure,the optimal N-doped petroleum coke-based microporous carbon exhibited the highest CO_(2)uptake of 4.25 mmol/g at 25℃ and 6.57 mmol/g at 0℃.These values are comparable or even better than those of numerous previously reported adsorbents prepared by multistep synthesis,primarily due to the existence of ultra-micropores.The sample exhibited excellent CO_(2)/N_(2)selectivity at 25℃ owing to the abundant basic pyridinic and pyrrolic N species;and showed superior CO_(2)adsorption-desorption cycling performance,which was maintained at 97% after 10 cycles at 25℃.Moreover,petroleum coke-based microporous carbon,with a considerably high specific surface area and hierarchical pore structure,exhibited excellent electrochemical performance over the N-doped sample,maintaining a favorable specific capacitance of 233.25F/g at 0.5 A/g in 6 mol/L KOH aqueous electrolyte.This study provides insight into the influence of N-doping on the porous properties of petroleum coke-based carbon.Furthermore,the as-prepared carbons were found to be promising adsorbents for CO_(2)adsorption,CO_(2)/N_(2)separation and electrochemical application. | Wenfu Zhu Yuqin Wang Fan Yao Xiaohong Wang Haoming Zheng Guangzheng Ye Hairong Cheng Junliang Wu Haomin Huang Daiqi Ye | 2024 | Journal of Environmental Sciences2024，，5： | 0 |
| 12 | Lithium-ion modified cellulose as a water-soluble binder for Li-O2 battery显示文摘An environment-friendly,water-soluble,and cellulose based binder(lithium carboxymethyl cellulose,CMC-Li)was successfully synthesized by using Li+to replace Na+in the commercial sodium carboxymethyl cellulose(CMC-Na).Li-O2 batteries based on the CMC-Li binder present enhanced discharge specific capacities(11151 mAh/g at 100 mA/g)and a superior cycling stability(100 cycles at 200 mA/g)compared with those based on the CMC-Na binder.The enhanced performance may originate from the electrochemical stability of the CMC-Li binder and the ion-conductive nature of CMC-Li,which promotes the diffusion of Li+in the cathode and consequently retards the increase of charge transfer resistance of the cathode during cycling.The results show that the water-soluble CMC-Li binder can be a green substitute for poly(vinylidene fluoride)(PVDF)binder based on organic solvent in the lithium oxygen batteries(LOBs). | Chenyi Hu Aiming Wu Fengjuan Zhu Liuxuan Luo Fan Yang Guofeng Xia Guanghua Wei Shuiyun Shen Junliang Zhang | 2022 | Frontiers in Energy2022，16，3： | 0 |
| 13 | Bi_(0.15)Sr_(0.85)Co_(0.8)Fe_(0.2)O_(3-δ)perovskite:A novel bifunctional oxygen electrocatalyst with superior durability in alkaline media显示文摘Oxygen evolution reaction(OER)and oxygen reduction reaction(ORR)play critical roles in renewable electrochemical energy conversion and storage devices,such as regenerative fuel cells and metal-air batteries[1-4].Up to date,precious metal-based catalysts,e.g.Pt-based materials for ORR,IrO_(2)/RuO_(2)-based catalysts for OER[5-7],lead the way in speeding up the sluggish reaction kinetics due to their high catalytic activities.However,the large-scale commercialization of these catalysts has been seriously restricted by their scarcity and high cost. | Jing Li Fan Yang Yunzhu Du Xiyang Cai Qiaodan Hu Junliang Zhang | 2022 | Journal of Materials Science & Technology2022，，13： | 0 |
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