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| 1 | Functional exhaustion of antiviral lymphocytes in COVID-19 patients显示文摘In December 2019,a novel coronavirus was first reported in Wuhan,China.1 It was named by the World Health Organization as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and is responsible for coronavirus disease 2019(COVID-19).Up to 28 February 2020,79,394 cases have been confirmed according to China’s National Health Commission.Outside China,the virus has spread rapidly to over 36 countries and territories. | Yuanhong Xuand Zhigang Tian Meijuan Zheng Yong Gao Gang Wang Guobin Song Siyu Liu Dandan Sun Yuanhong Xu Zhigang Tian | 2020 | Cellular & Molecular Immunology2020，17，5： | 54 |
| 2 | Photodegradation of fluoroquinolone antibiotic gatifloxacin in aqueous solutions显示文摘Fluoroquinolone antibiotics (FQs) are frequently detected as emerging pollutants in aqueous environments.In this study,kinetics,influencing factors and mechanisms on the photodegradation of gatifloxacin,a representative FQ,were investigated.The photodegradation follows the pseudo-first-order kinetics.Gatifloxacin photodegrades with a quantum yield of (5.94 ± 0.95) × 10 3 in pure water and undergoes direct photolysis as well as self-sensitized photodegradation.The FQ photodegrades slower in freshwater and seawater than in pure water,which is attributed to the integrative effects of pH and the aqueous dissolved matter (e.g.,humic acids and NO 3-) on the photodegradation.A toxicity test using Vibrio fischeri revealed the formation of hazardous photoproducts. | GE LinKe CHEN JingWen ZHANG SiYu CAI XiYun WANG Zhuang WANG ChunLing | 2010 | Chinese Science Bulletin2010，55，15： | 17 |
| 3 | Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19:a phase 1 clinical trial显示文摘No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19. | Fanping Meng Ruonan Xu Siyu Wang Zhe Xu Chao Zhang Yuanyuan Li Tao Yang Lei Shi Junliang Fu Tianjun Jiang Lei Huang Peng Zhao Xin Yuan Xing Fan Ji-Yuan Zhang Jinwen Song Dawei Zhang Yanmei Jiao Limin Liu Chunbao Zhou Markus Maeurer Alimuddin Zumla Ming Shi Fu-Sheng Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 16 |
| 4 | Hanning self-convolution window and its application to harmonic analysis显示文摘The Hanning self-convolution window (HSCW) is proposed in this paper. And the phase difference correction algorithm based on the discrete spectrum and the HSCW is given. The HSCW has a low peak side lobe level, a high side lobe roll-off rate, and a simple spectrum representation. Hence, leakage errors and harmonic interferences can be considerably reduced by weighting samples with the HSCW, the parameter estimation by the HSCW-based phase difference correction algorithm is free of solving high order equations, and the overall method can be easily implemented in embedded systems. Simulation and application results show that the HSCW-based phase difference correction algorithm can suppress the impacts of fundamental frequency fluctuation and white noise on harmonic parameter estimation, and the HSCW is advantageous over existing combined cosine windows in terms of harmonic analysis performance. | WEN He TENG ZhaoSheng GUO SiYu WANG JingXun YANG BuMing WANG Yi CHEN Tao | 2009 | Science China(Technological Sciences)2009，52，2： | 15 |
| 5 | Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Treatment of severe Coronavirus Disease 2019(COVID-19)is challenging.We performed a phase 2 trial to assess the efficacy andsafety of human umbilical cord-mesenchymal stem cells(UC-MScs)to treat severe coViD-19 patients with lung damage,based onour phase 1 data.In this randomized,double-blind,and placebo-controlled trial,we recruited 101 severe coVID-19 patients withlung damage.They were randomly assigned at a 2:1 ratio to receive either UC-MSCs(4×10^(7)cells per infusion)or placebo on day 0,3,and 6.The primary endpoint was an altered proportion of whole lung lesion volumes from baseline to day 28.Other imagingoutcomes,6-minute walk test(6-MWT),maximum vital capacity,diffusing capacity,and adverse events were recorded and analyzed.In all,100 COVID-19 patients were finally received either UC-MSCs in=65)or placebo(n=35).UC-MSCs administrationexerted numerical improvement in whole lung lesion volume from baseline to day 28 compared with the placebo(the mediandifference was-13.31%,95%Cl-29.14%,2.13%,P=0.08).UC-MSCs significanty reduced the proportions of solid componentlesion volume compared with the placebo(median difference:-15.45%;95%CI-30.82%,-0.39%;P=0.043).The 6-MWT showedan increased distance in patients treated with UC-MSCs(difference:27.00 m;95%CI 0.00,57.00;P=0.057).The incidence of adverseevents was similar in the two groups.These results suggest that UC-MSCs treatment is a safe and potentially effective therapeuticapproach for COVID-19 patients with lung damage.A phase 3 trial is required to evaluate effects on reducing mortality andpreventing long-term pulmonary disability. | Lei Shi Hai Huang Xuechun Lu Xiaoyan Yan Xiaojing Jiang Ruonan Xu Siyu Wang Chao Zhang Xin Yuan Zhe Xu Lei Huang Jun-Liang Fu Yuanyuan Li Yu Zhang Wei-Qi Yao Tianyi Liu Jinwen Song Liangliang Sun Fan Yang Xin Zhang Bo Zhang Ming Shi Fanping Meng Yanning Song Yongpei Yu Jiqiu Wen Qi Li Qing Mao Markus Maeurer Alimuddin Zumla Chen Yao Wei-Fen Xie Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 13 |
| 6 | Recent development in quantum communication显示文摘In this review article,we will review the recent process of quantum communications.In the past decades,there are many developments in quantum communication,for instance,quantum key distribution,quantum teleportation,quantum secure direct communication,deterministic secure quantum communication,quantum secret sharing and so on.And we focus our attention on the recent developments in quantum communication protocols. | SONG SiYu WANG Chuan | 2012 | Chinese Science Bulletin2012，57，36： | 10 |
| 7 | Complement 5a receptor-mediated neutrophil dysfunction is associated with a poor outcome in sepsis显示文摘补充 5a (C5a ) 被导致 neutrophils 的功能的缺陷在败血的致病含有;然而, C5a 受体的用途(C5aRs;C5aR 和 C5L2 ) 因为为败血的管理的 biomarkers 是不明确的。这研究在嗜中性的功能上在 neutrophils 和他们的效果上调查了 C5aR 和 C5L2 的动态表示。我们发现败血病人与健康、全身的煽动性的反应相比在 neutrophils 上显示了 C5aR 和 C5L2 的低表示层次症候群(先生) 题目,和这个表示模式与疾病严厉被相关。另外, C5aR 和 C5L2 的表示层次与败血病人的幸存被联系。在 vitro, C5a 的增加显著地从败血病人在 neutrophils 减少了 C5aR 和 C5L2 表示层次和 IL-8 生产。那些调查结果建议 C5aRs 的减少的表示为败血病人与 neutrophils 和差的预后的功能的缺陷被联系。总的来说,这些调查结果可以帮助作为早标记建立 C5aRs 表示层次预言败血的严厉。 | Ruonan Xu Fang Lin Chunmei Bao Huihuang Huang Chengcheng Ji Siyu Wang Lei Jin Lijian Sun Ke Li Zheng Zhang Fu-Sheng Wang | 2016 | Cellular & Molecular Immunology2016，13，1： | 10 |
| 8 | S and Pb Isotopic Constraints on the Relationship between the Linong Granodiorite and the Yangla Copper Deposit,Yunnan,China显示文摘The Yangla copper deposit, located in western Yunnan Province, China, is a typical giant, newly started mining copper deposit with an estimated Cu reserves of about 1,200,000 tons. The deposit is spatially and temporally associated with the Linong granodiorite, which is rich in SiO2 (SiO2=58.25 wt%-69.84 wt%) and alkalis (Na2O+K2O=5.98 wt%-8.34 wt%), indicating an association with shoshonitic series to high-K calc-alkaline series granites, and shows low contents of TiO2 (0.35 wt%-0.48 wt%), MgO (1.51 wt%-1.72 wt%), and Al2O3 (13.38 wt%-19.75 wt%). The δ34S values of sulfides of the main ore stage from copper ores vary range from ?4.2‰ to ?0.9‰, indicating a much greater contribution from the mantle to the ore-forming fluids. The δ34S values of the late ore stage is 9.8‰, indicating enrichment of biogenic sulfur which may derive from the crustal hydrothermal fluid. The 208Pb/204Pb, 207Pb/204Pb and 206Pb/204Pb of sulfides of the main ore stage from copper ores range within 38.66-38.73, 15.71-15.74 and 18.35-19.04, respectively, implying that the Pb was derived from the mantle, with the crustal component, probably representing mixtures of mantle lead and crustal lead. Sulfide of the late ore stage in their Pb isotopic composition, 208Pb/204Pb= 38.69, 207Pb/204Pb=15.70, 206Pb/204Pb=18.35, implying that the Pb was derived from the crust. The Linong granodiorite is syn-collisional, produced by partial melting of thickened lower crust, which was triggered by the westward subduction of the Jinshajiang Oceanic plate. During a transition in geodynamic setting from collision-related compression to extension, gently dipping ductile shear zones (related to subduction) were transformed to brittle shear zones, consisting of a series of thrust faults in the Jinshajiang tectonic belt. The tensional thrust faults would have been a favorable environment for ore-forming fluids. The ascending magma provided a channel for the ore-forming fluid from the mantle wedge. After the magma arrived at the base of the early-stage Linong granodiorite, the platy granodiorite at the base of the body would have shielded the late-stage magma from the fluid. The magma would have cooled slowly, and some of the ore-forming fluid in the magma would have entered the gently dipping thrust faults near the Linong granodiorite, resulting in mineralization. | YANG Xi'an LIU Jiajun HAN Siyu WANG Huan CHEN Siyao | 2012 | Acta Geologica Sinica(English Edition)2012，86，6： | 9 |
| 9 | A New Perspective for Parkinson's Disease:Circadian Rhythm显示文摘Circadian rhythm is manifested by the behavioral and physiological changes from day to night,which is controlled by the pacemaker and its regulator. The former is located at the suprachiasmatic nuclei(SCN) in the anterior hypothalamus,while the latter is composed of clock genes present in all tissues. Circadian desynchronization influences normal patterns of day-night rhythms such as sleep and alertness cycles,rest and activity cycles.Parkinson's disease(PD) exhibits diurnal fluctuations.Circadian dysfunction has been observed in PD patients and animal models,which may result in negative consequences to the homeostasis and even exacerbate the disease progression. Therefore,circadian therapies,including light stimulation,physical activity,dietary and social schedules,may be helpful for PD patients. However,the cellular and molecular mechanisms that underlie the circadian dysfunction in PD remain elusive. Further research on circadian patterns is needed. This article summarizes the existing research on the circadian rhythms in PD,focusing on the clinical symptom variations,molecular changes,as well as the available treatment options. | Siyue Li Yali Wang Fen Wang Li-Fang Hu Chun-Feng Liu | 2017 | Neuroscience Bulletin2017，33，1： | 9 |
| 10 | Ultrasensitive terahertz metamaterial sensor based on vertical split ring resonators显示文摘An ultrasensitive metamaterial sensor based on double-slot vertical split ring resonators(DVSRRs) is designed and numerically calculated in the terahertz frequency. This DVSRR design produces a fundament LC resonance with a quality factor of about 20 when the incidence magnetic field component normal to the DVSRR array. The resonant characteristics and sensing performance of the DVSRR array design are systematically analyzed employing a contrast method among three similar vertical split ring resonator(SRRs) structures. The research results show that the elimination of bianisotropy, induced by the structural symmetry of the DVSRR design, helps to achieve LC resonance of a high quality factor. Lifting the SRRs up from the substrate sharply reduces the dielectric loss introduced by the substrate. All these factors jointly result in superior sensitivity of the DVSRR to the attributes of analytes. The maximum refractive index sensitivity is 788 GHz/RIU or 1.04 × 10~5 nm∕RIU.Also, the DVSRR sensor maintains its superior sensing performance for fabrication tolerance ranging from -4% to 4% and wide range incidence angles up to 50° under both TE and TM illuminations. | WEI WANG FENGPING YAN SIYU TAN HONG ZHOU YAFEI HOU | 2017 | Photonics Research2017，5，6： | 9 |
| 11 | Surveillance of Noise Exposure Level in the Manufacturing Industry—China,2020显示文摘Introduction:Occupational noise exposure is a widespread issue in the manufacturing industry in China.Since 2019,the National Surveillance System for Occupational Hazards in the workplace was established to understand different occupational hazards,especially occupational noise,in workplaces in China.Methods:Both environmental and individual noise exposure levels were measured for 19,378 enterprises according to the Work Plan for Surveillance of Occupational Hazards in the Workplace(2020)issued by National Health Commission of the People’s Republic of China.Median and interquartile range(IQR)were calculated to describe the distribution of the noise exposure level by industry classification,enterprise-scale,and ownership type of the enterprise.Results:Overall,25.14%of the individual noise exposure samples exceeded the Chinese national standard among the selected enterprises.The overall median of environmental noise exposure level was 82.8 dB(A)in selected enterprises,while the median of individual noise exposure level was 81.3 dB(A).The individual noise exposure level in the manufacture of metal products,manufacture of motor vehicles,minisized enterprises,collective enterprises and private enterprises was relatively high.Conclusion:Occupational noise is still one of the occupational hazards that cannot be ignored in the manufacturing industry,especially in mini-sized and private enterprises.The risk of noise exposure in the target industry is still high and will pose a threat to the health of workers. | Jinnan Zheng Siyu Zhang Hongfei Wang Yue Yu Weijiang Hu | 2021 | China CDC weekly2021，3，43： | 9 |
| 12 | Near-infrared emissive carbon dots with 33.96% emission in aqueous solution for cellular sensing and light-emitting diodes显示文摘Near-infrared emissive carbon dots(CDs) were synthesized by hydrothermal method. The as-prepared CDs exhibited a relatively high quantum yield(QY) of 33.96% in an aqueous solution, and the peak toward the near-infrared fluorescence reached 685 nm. The CDs exhibited pH-sensitive characteristics under strong acidic conditions. Even at pH = 0, the as-prepared CDs retained a high fluorescence intensity,which proved that they possessed good acid resistance. More importantly, the CDs were sensitive to the Fe3+changes in living cells. In addition, they could also be used for white and red emissive LEDs.This discovery will expand the use of aqueous-phase high QY CDs in the field of living cell sensing and imaging. | Boyang Wang Jian Li Zhiyong Tang Bai Yang Siyu Lu | 2019 | Science Bulletin2019，64，17： | 9 |
| 13 | Preparation and properties of temperature sensitive paint based on Eu(DBM)_3 phen as probe molecule显示文摘Probe molecule Eu(DBM)3 phen is made up of europium oxide(Eu_2 O_3),dibenzoylmethane(DBM) and1,10-phenanthroline(phen). The temperature sensitive paint(TSP) was compounded by the polymerization of the probe molecule, methyl methacrylate(MMA) and the initiator of benzoyl peroxide(BPO).The structure, morphology, luminescence property of probe molecule and the temperature quenching property of the temperature sensitive paint(TSP) were characterized by infrared spectrometer, UV-vis spectrometer, scanning electron microscopy and fluorescence spectrometer respectively. The infrared spectrum and UV-vis spectra show that Eu and DBM form six membered rings, and Eu-O coordinate bonds form. The nanocrystals are in sphere-like morphology with an average size of approximately100 nm. Fluorescence spectra present that the performance of temperature quenching is excellent,what's more, TSP sample has different temperature sensitivity in various temperature scope. Particularly,under excitation of 286 nm, TSP has a highest temperature sensitivity between 50 and 60 ℃, and the strongest fluorescence emission reaches a peak(615 nm). It indicated that probe molecule(Eu(DBM)_3 phen) has strong luminescent intensity and the temperature quenching properties of Eu(DBM)_3 phen/PMMA is good. | Siyu Lu Jing Sun Yuan Wang Wensheng Yu Mengting Sun Siyuan Cui | 2018 | Journal of Rare Earths2018，36，6： | 8 |
| 14 | Multi-omics analyses of 398 foxtail millet accessions reveal genomic regions associated with domestication,metabolite traits,and antiinflammatory effects显示文摘Foxtail millet(Setaria italica),which was domesticatedfromthewild speciesgreenfoxtail(Setaria viridis),isa richsource of phytonutrientsfor humans.To evaluate how breeding changed themetabolome offoxtail millet grains,we generated and analyzed the datasets encompassing the genomes,transcriptomes,metabolomes,and anti-inflammatory indices from 398 foxtail millet accessions.We identified hundreds of common variants that influence numerous secondary metabolites.We observed tremendous differences in natural variations of the metabolites and their underlying genetic architectures between distinct sub-groups of foxtail millet.Furthermore,we found that the selection of the gene alleles associated with yellow grains led to altered profiles of metabolites such as carotenoids and endogenous phytohormones.Using CRiSPR-mediated genome editing wevalidated the function of PHYTOENE SYNTHASE1(PSY1)gene in affecting milletgrain colorand quality.Interestingly,our in vitro cell inflammation assays showed that 83 metabolites in millet grains have anti-inflammatory effects.Taken together,ourmulti-omics study illustrates how the breeding history of foxtail millet has shaped its metabolite profile.The datasets we generated in this study also provide important resources for further understanding how millet grain quality is affected by different metabolites,laying the foundations for future millet genetic research and metabolome-assisted improvement. | Xukai Li Jianhua Gao Jingyi Song Kai Guo Siyu Hou Xingchun Wang Qiang He Yanyan Zhang Yakun Zhang Yulu Yang Jiaoyan Tang Hailang Wang Staffan Persson Mingquan Huang Lishuai Xu Linlin Zhong Dongqin Li Yongming Liu Hua Wu Xianmin Diao Peng Chen Xiaowen Wang Yuanhuai Han | 2022 | Molecular Plant2022，15，8： | 8 |
| 15 | Kilogram-scale synthesis of carbon quantum dots for hydrogen evolution, sensing and bioimaging显示文摘The development of large-scale synthetic methods for high quality carbon quantum dots(CQDs) is fundamental to their applications.However,the macroscopic preparation and scale up synthetic of CQDs is still in its infancy.Here,we report a facile,green,kilogram-scale synthesis of high quality fluorescent CQDs derived from poplar leaves via a one-step hydrothermal method.Notably,the throughput of CQDs can reach a level up to as high as 1.4975 kg in one pot.The structure and properties of the as-prepared CQDs were assessed through TEM,XRD,XPS and various spectroscopic methods.The obtained high quality CQD s with a photoluminescent quantum yield of 10.64% showed remarkable stability in aqueous media,rich functional groups,high photostability,consistent photoluminescence within biological pH range and low cytotoxicity.On account of these good properties,we demonstrated the multifunctional application to electrocatalytic water splitting,Fe^3+ sensing and bioimaging.It showed remarkable electrocatalytic activity,Fe^3+ sensitivity and good biocompatibility.This study provides a green,facile,inexpensive and large-scale method for producing high quality CQDs,which provides application value for large-scale production of CQDs. | Weidong Li Yuan Liu Boyang Wang Haoqiang Song Zhongyi Liu Siyu Lu Bai Yang | 2019 | Chinese Chemical Letters2019，30，12： | 7 |
| 16 | Interface electron collaborative migration of Co–Co3O4/carbon dots:Boosting the hydrolytic dehydrogenation of ammonia borane显示文摘Ammonia borane(AB)is an excellent candidate for the chemical storage of hydrogen.However,its practical utilization for hydrogen production is hindered by the need for expensive noble-metal-based catalysts.Herein,we report Co-Co3O4 nanoparticles(NPs)facilely deposited on carbon dots(CDs)as a highly efficient,robust,and noble-metal-free catalyst for the hydrolysis of AB.The incorporation of the multiinterfaces between Co,Co3O4 NPs,and CDs endows this hybrid material with excellent catalytic activity(rB=6816 mLH2 min^-1 gCo^-1)exceeding that of previous non-noble-metal NP systems and even that of some noble-metal NP systems.A further mechanistic study suggests that these interfacial interactions can affect the electronic structures of interfacial atoms and provide abundant adsorption sites for AB and water molecules,resulting in a low energy barrier for the activation of reactive molecules and thus substantial improvement of the catalytic rate. | Han Wu Min Wu Boyang Wang Xue Yong Yushan Liu Baojun Li Baozhong Liu Siyu Lu | 2020 | Journal of Energy Chemistry2020，29，9： | 7 |
| 17 | An Overview of Mineral Dust Modeling over East Asia显示文摘East Asian dust(EAD) exerts considerable impacts on the energy balance and climate/climate change of the earth system through its influence on solar and terrestrial radiation, cloud properties, and precipitation efficiency. Providing an accurate description of the life cycle and climate effects of EAD is therefore critical to better understanding of climate change and socioeconomic development in East Asia and even worldwide. Dust modeling has undergone substantial development since the late 1990 s, associated with improved understanding of the role of EAD in the earth system. Here, we review the achievements and progress made in recent decades in terms of dust modeling research,including dust emissions, long-range transport, radiative forcing(RF), and climate effects of dust particles over East Asia. Numerous efforts in dust/EAD modeling have been directed towards furnishing more sophisticated physical and chemical processes into the models on higher spatial resolutions. Meanwhile, more systematic observations and more advanced retrieval methods for instruments that address EAD related science issues have made it possible to evaluate model results and quantify the role of EAD in the earth system, and to further reduce the uncertainties in EAD simulations. Though much progress has been made, large discrepancies and knowledge gaps still exist among EAD simulations. The deficiencies and limitations that pertain to the performance of the EAD simulations referred to in the present study are also discussed. | Siyu CHEN Jianping HUANG Yun QIAN Chun ZHAO Litai KANG Ben YANG Yong WANG Yuzhi LIU Tiangang YUAN Tianhe WANG Xiaojun MA Guolong ZHANG | 2017 | Journal of Meteorological Research2017，31，4： | 7 |
| 18 | Repair of abnormal perfusion foci in idiopathic epilepsy patients under long-term antiepileptic treatment显示文摘Epileptic seizure control and the disappearance of epileptiform discharge are not indicative of the absence of abnormal perfusion foci.Perfusion abnormalities are a major cause of epileptic discharge,and the existence of abnormal perfusion foci implies possible relapse.Very little is known about perfusion abnormality repair in epilepsy.The present study selected 43 cases of idiopathic epilepsy under antiepileptic drug control for an average of 24 months.Comparisons between interictal single-photon emission CT(SPECT)images and long-term electroencephalogram(EEG)pre-and post-treatment showed that cases of normal SPECT increased by 48%(12/25)following treatment,with a total number of 15 reduced foci(36%,15/41).Perfusion foci,i.e.,region of interest,were altered following treatment.These changes included:normal to abnormal in 3 cases(7%,3/43;2 hyperperfusion and 1 hypoperfusion);abnormal to normal in 14 cases(32%,14/43;10 pre-treatment hypoperfusion and 4 hyperperfusion);abnormal to abnormal in 7 cases(16%,7/43;hyperperfusion to hypoperfusion in 5 cases,hypoperfusion to hyperperfusion in 2 cases).Long-term EEG revealed in an increase in the number of normal cases by 20(40%,20/39),and there were 25 fewer cases with epileptiform discharges(66%,25/38).These findings demonstrate that long-term control of anti-epileptic drugs partially repaired cerebral perfusion abnormalities and reduced epileptiform discharges in idiopathic epilepsy. | Weimin Wang Siyu Zhao Yaqing Liu | 2011 | Neural Regeneration Research2011，6，2： | 7 |
| 19 | Metabolomics mechanism of traditional soy sauce associated with fermentation time显示文摘Given that fermentation time has significant impact on quality and flavor of soy sauce,a global understanding of the metabolic mechanism as fermentation time prolonged is essential for producing satisfactory and consistent quality of traditional soy sauce.Herein,the metabolic compounds changes of soy sauce associated with fermentation time up to 10 years were comprehensively investigated by using Chinese traditional fermented soy sauce(CTFSS)as a demonstration.Results showed that formaldehyde nitrogen,total soluble nitrogen(TSN),non-salt soluble solids,amino acids,free 5’-nucleotides and volatile compounds in CTFSS changed obviously during fermentation.Specifically,glutamic acid and aspartic acid were prominent in CTFSS.Continuous decrease in content of hypoxanthine(Hx)was found from 1 M(1-month soy sauce)to7 M(7-months soy sauce).Furthermore,a significant opposite tendency for changes between some volatile compounds and amino acids was indicated that there was a transformation between these two components.Therefore,a better understanding to the influence of fermentation time on soy sauce had been proposed.As the formation and conversion of amino acids and sugars might be mainly responsible for flavor formation in CTFSS,the ratio of these two reactions rate led the metabolism to be divided into three steps,degradation,conversion and balance. | Li Zhu Siyu He Ying Lu Jianhong Gan Ningping Tao Xichang Wang Zaoli Jiang Yuanxiang Hong Changhua Xu | 2022 | Food Science and Human Wellness2022，11，2： | 7 |
| 20 | Biofilm Microenvironment-Responsive Nanotheranostics for Dual-Mode Imaging and Hypoxia-Relief-Enhanced Photodynamic Therapy of Bacterial Infections显示文摘The formation of bacterial biofilms closely associates with infectious diseases.Until now,precise diagnosis and effective treatment of bacterial biofilm infections are still in great need.Herein,a novel multifunctional theranostic nanoplatform based on MnO_(2)nanosheets(MnO_(2)NSs)has been designed to achieve pH-responsive dual-mode imaging and hypoxia-relief-enhanced antimicrobial photodynamic therapy(aPDT)of bacterial biofilm infections.In this study,MnO_(2)NSs were modified with bovine serum albumin(BSA)and polyethylene glycol(PEG)and then loaded with chlorin e_(6)(Ce_(6))as photosensitizer to form MnO_(2)-BSA/PEG-Ce_(6)nanosheets(MBP-Ce_(6)NSs).After being delivered into the bacterial biofilm-infected tissues,the MBP-Ce_(6)NSs could be decomposed in acidic biofilm microenvironment and release Ce_(6)with Mn^(2+),which subsequently activate both fluorescence(FL)and magnetic resonance(MR)signals for effective dual-mode FL/MR imaging of bacterial biofilm infections.Meanwhile,MnO_(2)could catalyze the decomposing of H2O_(2)in biofilm-infected tissues into O_(2)and relieve the hypoxic condition of biofilm,which significantly enhances the efficacy of aPDT.An in vitro study showed that MBP-Ce_(6)NSs could significantly reduce the number of methicillin-resistant Staphylococcus aureus(MRSA)in biofilms after 635nm laser irradiation.Guided by FL/MR imaging,MRSA biofilm-infected mice can be efficiently treated by MBP-Ce_(6)NSs-based aPDT.Overall,MBP-Ce_(6)NSs not only possess biofilm microenvironment-responsive dual-mode FL/MR imaging ability but also have significantly enhanced aPDT efficacy by relieving the hypoxia habitat of biofilm,which provides a promising theranostic nanoplatform for bacterial biofilm infections. | Weijun Xiu Siyu Gan Qirui Wen Qiu Qiu Sulai Dai Heng Dong Qiang Li Lihui Yuwen Lixing Weng Zhaogang Teng Yongbin Mou Lianhui Wang | 2020 | Research2020，，1： | 7 |
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