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| 1 | Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer显示文摘Metformin is currently a strong candidate anti-tumor agent in multiple cancers.However,its anti-tumor effectiveness varies among different cancers or sub-populations,potentially due to tumor heterogeneity.It thus remains unclear which hepatocellular carcinoma(HCC)patient subpopulation(s)can benefit from met-formin treatment.Here,through a genome-wide CRISPR-Cas9-based knockout screen,we find that DOCK1 levels determine the anti-tumor effects of met-formin and that DOCK1 is a synthetic lethal target of metformin in HCC.Mechanistically,metformin promotes DOCK1 phosphorylation,which activates RAC1 to facilitate cell survival,leading to metformin resistance.The DOCK1-selective inhibitor,TBOPP,potentiates anti-tumor activity by metformin in vitro in liver cancer cell lines and patient-derived HCC organoids,and in vivo in xenografted liver cancer cells and immunocompetent mouse liver cancer models.Notably,metformin improves overall survival of HCC patients with low DOCK1 levels but not among patients with high DOCK1 expression.This study shows that metformin effective-ness depends on DOCK1 levels and that combining metformin with DOCK1 inhibition may provide a promising personalized therapeutic strategy for met-formin-resistant HCC patients. | Junru Feng Hui Lu Wenhao Ma Wenjing Tian Zhuan Lu Hongying Yang Yongping Cai Pengfei Cai Yuchen Sun Zilong Zhou Jiaqian Feng Jiazhong Deng Ying Shu Kun Qu Weidong Jia Ping Gao Huafeng Zhang | 2022 | Protein & Cell2022，13，11： | 5 |
| 2 | Comparison of dominant frequency attenuation of blasting vibration for different charge structures显示文摘Dominant frequency attenuation is a significant concern for frequency-based criteria of blasting vibration control.It is necessary to develop a concise and practical prediction equation describing dominant frequency attenuation.In this paper,a prediction equation of dominant frequency that accounts for primary parameters influencing the dominant frequency was proposed based on theoretical and dimensional analyses.Three blasting experiments were carried out in the Chiwan parking lot for collecting blasting vibration data used to conduct regression analysis of the proposed prediction equation.The fitting equations were further adopted to compare the reliability of three different types of dominant frequencies in the proposed equation and to explore the effects of different charge structures on the dominant frequency attenuation.The apparent frequency proved to be more reliable to express the attenuation law of the dominant frequency.The reliability and superiority of the proposed equation employing the apparent frequency were verified by comparison with the other five prediction equations.The smaller blasthole diameter or decoupling ratio leads to the higher initial value and corresponding faster attenuation of the dominant frequency.The blasthole diameter has a greater influence on the dominant frequency attenuation than the decoupling ratio does.Among the charge structures applied in the experiments,the charge structure with decoupling ratio of 1.5 and blasthole diameter of 48 mm results in the greatest initial value and corresponding fastest attenuation of the dominant frequency. | Pengchang Sun Wenbo Lu Junru Zhou Xincheng Huang Ming Chen Qi Li | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，2： | 2 |
| 3 | Everolimus enhances the cytotoxicity of bendamustine in multiple myeloma cells through a network of pro-apoptotic and cell-cycle-progression regulatory proteins显示文摘Bendamustine 是有在治疗的一些功效的一个 bifunctional alkylating 代理人最新诊断了并且 relapsed/refractorymultiple 骨髓瘤(公里) 。Everolimus, rapamycin (mTOR ) 的一个哺乳动物的目标禁止者,是在许多癌症有功效的另外的答应 chemotherapeuticagent。我们调查了个人和 combinational 在公里房间线(RPMI8226 和 MM1.S ) 和主要公里房间的 thesedrugs 的细胞毒素的效果。我们的结果表明了这些药的 synergistic 效果,它为 p53-wild-type 和 p-53-deleted 公里房间是有效的,但是在从 healthydonor 的 mononuclear 房间是最小的。有二个代理人的联合治疗禁止了增长并且作为 assessedby Annexin-V/PI 染色, caspase-3 降级,和 PARP 劈开支持了 cytotoxicity 和 apoptosis。房间死亡与 thepro-apoptotic 蛋白质 Bax 的起来规定和 anti-apoptotic 蛋白质 Mcl-1 和 survivin 的下面规定被联系。联合 drugtreatment 也在 mTOR 的下游的目标蛋白质的层次支持了减少小径, p70s6k,和 4EBP-1,以及在 MM1.S 房间的肿瘤 suppressor 蛋白质 p53 的 phosphorylation 的水平的增加。p21 也是有二药的 down-regulatedupon 治疗,建议通过房间周期拘捕的版本的促进感受性的机制。我们的 resultsdemonstrate 可以贡献 everolimus 和 bendamustine 的 synergistic cytotoxicity,并且为公里的组合处理为申请向一个基本原理提供 alkylating 代理人和 mTOR 禁止者 infuture 的规章的因素的一个网络临床的实践。 | Bo Lu Juan Li Jingxuan Pan Beihui Huang Junru Liu Dong Zheng | 2013 | Acta Biochimica et Biophysica Sinica2013，45，8： | 1 |
| 4 | Paclitaxel-liposome–microbubble complexes as ultrasound-triggered therapeutic drug delivery carriers显示文摘 | Fei Yan Lu Li Zhiting Deng Qiaofeng Jin Juanjuan Chen Wei Yang Chih-Kuang Yeh Junru Wu Robin Shandas Xin Liu Hairong Zheng | 2013 | Journal of Controlled Release2013，，3： | 1 |
| 5 | Paclitaxel-liposome–microbubble complexes as ultrasound-triggered therapeutic drug delivery carriers显示文摘 | Fei Yan Lu Li Zhiting Deng Qiaofeng Jin Juanjuan Chen Wei Yang Chih-Kuang Yeh Junru Wu Robin Shandas Xin Liu Hairong Zheng | 2013 | Journal of Controlled Release2013，，3： | 1 |
| 6 | The Differences of Physiological Characteristics and Yield of Northern Japonica Rice in Different Nitrogen Application Patterns显示文摘The research performed analysis on differences of physiological property and yield of Tiejing No. 11 by different nitrogen fertilization patterns. The results indicated that while the nitrogen of basal: tillering: panicle was 6 ∶3∶1, the higher amount of nitrogen improved the chlorophyll content, photosynthetic capacity, effective panicle, grain weight and yield; the medium nitrogen level had advantage under the ratio 4:3:3; nitrogen application at lategrowth stage was suitable for low or medium nitrogen level,which could increase photosynthetic capacity and optimize the yield components and increase yield; under the same ratio for basic tiller and ear fertilizer, the increase of nitrogen could improve total nitrogen uptake and protein content, decrease nitrogen physiological efficiency and milled rice and tasting, but nitrogen recovery and harvest index changes had difference; as application at late growth stage in same nitrogen rate, total nitrogen uptake and protein content increased, nitrogen physiological efficiency and milled rice and amylose content and tasting decreased, nitrogen recovery and harvest index increased under low or medium nitrogen level and decreased under high nitrogen level. Nitrogen application 210 kg/hm^2 and the ratio 4 ∶3 ∶3 of basal:tillering: panicle made the yield increase by 2.8%-11.3%, and this is the optimal mode of nitrogen fertilizer application. | Yuefeng CUI Tiegang LU Guocai SUN Junru WANG Xiaoqiu WU Guiyan WANG Jian WANG Wenjia HUANG | 2016 | Agricultural Science & Technology2016，17，4： | 0 |
| 7 | A Classification Method of Imbalanced Data Base on PSO Algorithm显示文摘In order to improve the performance of the resampling algorithm in imbalanced data learning and the optimal combination of the weight coefficients of the base classifiers in the ensemble classification algorithm,a new algorithm based on particle swarm optimization(PSO)is proposed.In traditional sampling method,sampling rate is often set artificially.This would make the final classification can’t get a optimal solution.By using the particle swarm optimization algorithm,the sampling rate of the boundary samples and the safety samples are optimized to obtain the optimal over sampling rate self-adaptivly,the weekness of setting sampling rate of traditional method would be overcome. | Junru Lu Chunkai Zhang Fengxing Shi | 2016 | 国际计算机前沿大会会议论文集2016，，2： | 0 |
| 8 | Identifying User Profile by Incorporating Self-Attention Mechanism based on CSDN Data Set显示文摘With the popularity of social media,there has been an increasing interest in user profiling and its applications nowadays.This paper presents our system named UIR-SIST for User Profiling Technology Evaluation Campaign in SMP CUP 2017.UIR-SIST aims to complete three tasks,including keywords extraction from blogs,user interests labeling and user growth value prediction.To this end,we first extract keywords from a user’s blog,including the blog itself,blogs on the same topic and other blogs published by the same user.Then a unified neural network model is constructed based on a convolutional neural network(CNN)for user interests tagging.Finally,we adopt a stacking model for predicting user growth value.We eventually receive the sixth place with evaluation scores of 0.563,0.378 and 0.751 on the three tasks,respectively. | Junru Lu Le Chen Kongming Meng Fengyi Wang Jun Xiang Nuo Chen Xu Han Binyang Li | 2019 | Data Intelligence2019，1，2： | 0 |
| 9 | Engineering sulfur vacancies for boosting electrocatalytic reactions显示文摘Transition metal sulfides are demonstrated to play an increasingly important role in boosting the deployment of ecofriendly electrocatalytic energy conversion technologies.It is also widely recognized that the introduction of vacancies is now becoming an important and valid approach to promote the electrocatalytic performance.In this review,the significance of sulfur vacancies on the enhancement of catalytic performance via four main functionalities,including tuning the electronic structure,tailoring the active sites,improving the electrical conductivity,and regulating surface reconstruction,is comprehensively summarized.Many effective strategies for the sulfur vacancy engineering,such as plasma treatment,heteroatom doping,and chemical reduction are also comprehensively provided.Subsequently,recent achievements in sulfur vacancy fabrication on various hotspot electrocatalytic reactions are also systematically discussed.Finally,a summary of the recent progress and challenges of this interesting field are organized,which hopes to guide the future development of more efficient metal sulfide electrocatalysts. | Xianxu Chu Yueyu Liao Lu Wang Junru Li Hui Xu | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
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