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| 1 | Up-regulation of divalent metal transporter 1 in 6-hydroxydopamine intoxication is IRE/IRP dependent显示文摘铁在 Parkinson 的疾病(PD ) 起一个关键作用。substantia nigra (SN ) 的增加的铁内容在 PD 病人,和二价的金属 transporter 被发现了(DMT1 ) 1 被显示了在两个导致 MPTP 的 PD 模型和 PD 病人的 SN 起来调整。然而,位于 DMT1 起来规定下面的机制大部分是未知的。在现在的学习,我们观察到那在 6-hydroxydopamine ( 6-OHDA )的 SN 导致了 PD 老鼠,有铁的 DMT1 应答的元素(怒火, DMT1+IRE ),然而并非没有怒火( DMT1?IRE )的 DMT1 ,是起来调整的,建议那增加的 DMT1+IRE 表情可能在 PD 老鼠说明 nigral 铁累积。这可能性进一步被估计在一在里面 vitro 学习使用 6-OHDA-treated 和 DMT1+IRE-over-expressing MES23.5 房间。在 6-OHDA-treated MES23.5 房间,增加了铁规章的蛋白质(IRP ) 1 并且 IRP2 表示被观察,当 IRP 的 silencing 戏剧性地减少了时 6-OHDA-induced DMT1+IRE 起来规定。有 N-acetyl-L-cysteine 的预告的处理充分由 6-OHDA-induced 的抑制压制了 IRP 起来规定氧化应力。增加的 DMT1+IRE 表示由 MES23.5 房间导致了增加的铁流入。我们的数据提供 DMT1+IRE 起来规定能说明细胞内部的氧化应力和那增加了的 6-OHDA-induced 开始的 IRE/IRP-dependent 6-OHDA-induced 铁累积的直接证据细胞内部的铁的层次导致加重的氧化应力。这研究的结果提供在 PD 的处理支持抗氧化剂的使用的新奇证据,旨在禁止由 DMT1 表示的规定的铁累积。 | Hong Jiang Ning Song Huamin Xu Shuzhen Zhang Jun Wang Junxia Xie | 2010 | Cell Research2010，20，3： | 25 |
| 2 | Iron, Dopamine, and α-Synuclein Interactions in at-Risk Dopaminergic Neurons in Parkinson's Disease显示文摘Parkinson's disease (PD) is recognized as the second mostcommon neurodegenerative disorder after Alzheimer dis-ease. Although a fascinating 200-year journey of researchhas revealed the multifaceted nature of PD [1, 2], itsfundamental features are the loss of dopaminergic neuronsin the substantia nigra pars compacta (SNpc) and depletionof dopamine (DA) in the striatum. | Ning Song Junxia Xie | 2018 | Neuroscience Bulletin2018，34，2： | 12 |
| 3 | The Ce doping Cu/ZSM-5 as a new superior catalyst to remove NO from diesel engine exhaust显示文摘 | Lei Pang Chi Fan Lina Shao Kunpeng Song Junxia Yi Xing Cai Jian Wang Ming Kang Tao Li | 2014 | Chemical Engineering Journal2014，，： | 1 |
| 4 | An in- vestigation into cyclohexanone ammoximation over Ti-MWW in a continuous slurry reactor显示文摘 | Zhao Song Xie Wei Yang Junxia | 2011 | Applied Catalysis A: General2011，394，： | 1 |
| 5 | Rewiring ERBB3 and ERK signaling confers resistance to FGFR1 inhibition in gastrointestinal cancer harbored an ERBB3-E928G mutation显示文摘Dear Editor,Recently,a large number of studies found that activation of ERBB3(Erb-B2 receptor tyrosine kinase 3,also known as HER3)may be one of the major mechanisms underlying resistance to therapies that target the EGFR(epidermal growth factor receptor),HER2,and other receptor tyrosine kinases(RTKs)(Chen et al.,2011;Choi et al.,2012;Ross et al.,2018).Interestingly,mutations in ERBB3 are commonly reported in gastrointestinal(Gl)cancer,with mutations identified in approximately 12%of stomach and colorectal cancer cases(Jaiswal et al.,2013). | Xiang Yang Hongxiao Wang Enjun Xie Biyao Tang Qingdian Mu Zijun Song Junyi Chen Fudi Wang Junxia Min | 2020 | Protein & Cell2020，11，12： | 1 |
| 6 | Astrocyte dysfunction in Parkinson's Check for updates disease:from the perspectives of transmittedα-synuclein and genetic modulation显示文摘Parkinson's disease(PD)is a common neurodegenerative disorder that primarily affects the elderly.While the etiology of PD is likely multifactorial with the involvement of genetic,environmental,aging and other factors,α-synuclein(α-syn)pathology is a pivotal mechanism underlying the development of PD.In recent years,astrocytes have attracted considerable attention in the field.Although astrocytes perform a variety of physiological functions in the brain,they are pivotal mediators ofα-syn toxicity since they internalizeα-syn released from damaged neurons,and this triggers an inflammatory response,protein degradation dysfunction,mitochondrial dysfunction and endoplasmic reticulum stress.Astrocytes are indispensable coordinators in the background of several genetic mutations,including PARK7,GBA1,LRRK2,ATP13A2,PINK1,PRKN and PLA2G6.As the most abundant glial cells in the brain,functional astrocytes can be replenished and even converted to functional neurons.In this review,we discuss astrocyte dysfunction in PD with an emphasis onα-syn toxicity and genetic modulation and conclude that astrocyte replenishment is a valuable therapeutic approach in PD. | Changjing Wang Tongtong Yang Meiyu Liang Junxia Xie Ning Song | 2021 | Translational Neurodegeneration2021，10，4： | 1 |
| 7 | An investigation into cyclohexanone ammoximation over Ti-MWW in a continuous slurry reactor显示文摘 | Zhao Song Xie Wei Yang Junxia | 2011 | Applied Catalysis A: General2011，394，12： | 1 |
| 8 | Alpha-Synuclein Handling by Microglia: Activating, Combating,and Worsening显示文摘Neuroinflammation and a-synuclein (a-syn) aggregation are both neuropathological hallmarks of Parkinson’s disease (PD). Microglia are crucial participants in eliciting neuroinflammatory responses themselves, as well as modulating neurotoxic activity in astrocytes, therefore forming a pathway to neurodegeneration induced by both central and peripheral insults [1, 2]. | Ning Song Leilei Chen Junxia Xie | 2021 | Neuroscience Bulletin2021，37，5： | 1 |
| 9 | Expanding Views of Mitochondria in Parkinson's Disease: Focusing on PINK1 and GBA1 Mutations显示文摘A new conceptual model has been proposed for Parkinson's disease(PD)pathogenesis,which can be divided into triggering,facilitating,and aggravating processes[1].Mitochondria are believed to participate in all three phases:pesticides(one of the definite triggers in PD pathogenesis)inhibit mitochondrial complex I(MCI). | Yu Yuan Xizhen Ma Ning Song Junxia Xie | 2022 | Neuroscience Bulletin2022，38，7： | 0 |
| 10 | Differences in the involved sites among different types of demyelinating optic neuritis in traditional MRI examination:A systematic review and meta-analysis显示文摘Background:Magnetic resonance imaging(MRI)plays a significant role in assessing optic neuropathy and providing more detailed information about the lesion of the visual pathway to help differentiate optic neuritis from other visual disorders.This study aims to systematically review the literature and verify if there is a real difference in lesion location among different demyelinating optic neuritis(DON)subtypes.Methods:A systematic search was conducted including 8 electronic databases and related resources from the establishment of the database to August 25th,2020.We classified DON into 5 subtypes and divided the visual pathways into five segments mainly comparing the differences in the involved visual pathway sites of different subtypes.Results:Fifty-five studies were included in the analysis,and the abnormal rate was as high as 92%during the acute phase(within 4 weeks of symptom onset).With respect to lesion location,the orbital segment of the optic nerve was the most frequently involved(87%),whereas optic tract involvement was very rare.Involvement of the orbital segment was more common in myelin oligodendrocyte glycoprotein antibody-related optic neuritis(MOGON)(78%)and chronic relapsing inflammatory optic neuropathy(CRION)(81%),while the lesion was found to be located more posteriorly in neuromyelitis optica spectrum disorder-related optic neuritis(NMOSD-ON).With respect to lesion length,approximately 77%of MOG-ON patients had lesions involving more than half of the optic nerve length.Conclusions:MRI examination is recommended for DON patients in the acute phase.In MOG-ON,anterior involvement is more common and the involved length is mostly more than 1/2 of the optic nerve length,whereas posterior involvement,intracranial segment,optic chiasm,or optic tract,is more common in NMOSD-ON. | Yongping Wang Junxia Fu Honglu Song Quangang Xu Huanfen Zhou Shihui Wei | 2021 | Advances in Ophthalmology Practice and Research2021，1，2： | 0 |
| 11 | Linking Genetic Risks to Pathologicalα-Synuclein Transmission in Parkinson's Disease显示文摘Misfoldedα-synuclein(α-syn)hallmarks the neuropathological characteristics of Parkinson's disease(PD)and acts as a'pathological seed'that promotes the progression of the disease[1].About 15%of PD patients have a family history,5%-10%have a monogenic disorder with a Mendelian pattern of inheritance[2],and>90 independent risk signals identified by genome-wide association studies(GWASs)can be used to explain the non-monogenic risk of PD[3]. | Xiaoqing Mi Lei Chen Junxia Xie Ning Song | 2023 | Neuroscience Bulletin2023，39，7： | 0 |
| 12 | Bioinformatics Analysis of Xylanase xynMF13-GH10 Gene from Mangrove Fungi显示文摘[Objectives]The paper was to analyze and predict the structure and characteristics of xylanase xynMF13-GH10 gene and its encoded protein.[Methods]xynMF13-GH10 gene was predicted by NCBI and various information analysis tools in ExPASy website,as well as SignaIP 5.0,DNAman,TMHMM,SOPMA and SWISS-Model,and the characteristics and functions of protein structure encoded by the gene were predicted.[Results]The gene is 1332 bp in length,the coding region is 1-1332 bp,and the gene encodes 443 amino acids.The xynMF13-GH10 gene has high homology with xylanase in many species,and it has the highest homology with Paraphaeosphaeria sporulosa endoxylanase-like protein,with the consistency reaching 78.91%and e-value reaching 2e-159.The secondary structure consists of 48.31%random curl,30.25%α-helix structure,16.70%extended chain and 4.74%β-corner.[Conclusions]The results provide a reference for revealing the physiological function and expression regulation mechanism of xynMF13-GH10 gene in the future. | Junxia SONG Wanting WU Hongbing QI | 2022 | Asian Agricultural Research2022，14，5： | 0 |
| 13 | Study on Solid Fermentation and Antioxidant Function of Natto显示文摘[Objectives]To study the optimum conditions of solid fermentation of natto with antioxidant function as an index.[Methods]Single factor experiment and orthogonal experiment were designed to study the effects of temperature,time,initial pH and inoculum amount on the antioxidant activity of natto solid fermentation.The optimum conditions of natto solid fermentation were determined and the antioxidant ac-tivity of natto extract was compared.[Results]The optimal fermentation conditions were as follows:temperature 32℃,initial pH 7.0,inocu-lation amount 8%,fermentation time 32 h.The hydroxyl radical scavenging rate of natto solid fermentation crude extract was the highest,which was 82.7%.The optimized nato fermentation extract showed stronger scavenging ability for-OH and O,:,and showed obvious dose-effect relationship.ICso was 3.63 and 4.24 mg/mL,respectively,and the scavenging efficiency was 1.3 and 1.9 times higher than that of the unoptimized fermentation extract,respectively.[Conclusions]Natto is rich in nattokinase and other functional factors,and its antioxidant ac-tivity can be improved by optimizing fermentation technology,so that natto products can be widely used,including cosmetic raw materials,nat-to skin care soap,health food and medicine,etc.,and have a broader development prospect. | Junxia SONG Hongbing QI Yanhong MAO | 2024 | Asian Agricultural Research2024，16，1： | 0 |
| 14 | Toward better understanding of the status of mercury in the environment in China and its contribution to the global mercury cycle显示文摘 | Julia LU Xinbin FENG Qi WAN Yongqing JIN Xiaojuan WANG Junxia WANG Xinjie SONG Tangdong YAO Chengxiao ZHANG | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
| 15 | Elementary Application of Schottky Probe in CSRm Commissioning显示文摘Schottky signal analysis plays an important role in the HIRFL-CSR beam diagnostic system. The beam dynamic characteristic in the cooling storage ring is measured with the schottky probes. The relative momentum spreadΔp/p of the beam, the value of the tune Q, the revolution frequency of particles along the ring circumference and particle number can be acquired by the Schottky signal. Two Schottky | Zheng Jianhua, Xiao Guoqing, Mao Ruishi, Zhao Tiecheng, Wang Yanmou Ying Yan, Ma Weinian, Song Haihong and Wu Junxia | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 16 | A GAN-based deep enhancer for quality enhancement of retinal images photographed by a handheld fundus camera显示文摘Objective:Due to limited imaging conditions,the quality of fundus images is often unsatisfactory,especially for images photographed by handheld fundus cameras.Here,we have developed an automated method based on combining two mirror-symmetric generative adversarial networks(GANs)for image enhancement.Methods:A total of 1047 retinal images were included.The raw images were enhanced by a GAN-based deep enhancer and another methods based on luminosity and contrast adjustment.All raw images and enhanced images were anonymously assessed and classified into 6 levels of quality classification by three experienced ophthalmologists.The quality classification and quality change of images were compared.In addition,imagedetailed reading results for the number of dubiously pathological fundi were also compared.Results:After GAN enhancement,42.9% of images increased their quality,37.5%remained stable,and 19.6%decreased.After excluding the images at the highest level(level 0)before enhancement,a large number(75.6%)of images showed an increase in quality classification,and only a minority(9.3%)showed a decrease.The GANenhanced method was superior for quality improvement over a luminosity and contrast adjustment method(P<0.001).In terms of image reading results,the consistency rate fluctuated from 86.6%to 95.6%,and for the specific disease subtypes,both discrepancy number and discrepancy rate were less than 15 and 15%,for two ophthalmologists.Conclusions:Learning the style of high-quality retinal images based on the proposed deep enhancer may be an effective way to improve the quality of retinal images photographed by handheld fundus cameras. | Junxia Fu Lvchen Cao Shihui Wei Ming Xub Yali Song Huiqi Li Yuxia You | 2022 | Advances in Ophthalmology Practice and Research2022，2，3： | 0 |
| 17 | Targeting the LSD1-G9a-ER Stress Pathway as a Novel Therapeutic Strategy for Esophageal Squamous Cell Carcinoma显示文摘Despite recent advances in the management and treatment of esophageal squamous cell carcinoma(ESCC),the prognosis remains extremely poor,and current nonsurgical treatment options are limited.To identify new therapeutic targets,we screened a curated library of epigenetic compounds using a panel of cancer cell lines and found that coinhibiting the histone demethylase LSD1 and the histone methyltransferase G9a potently suppresses cell growth;similar results were obtained by knocking down both LSD1 and G9a expression.Importantly,we also found that inhibiting LSD1 and G9a significantly decreased tumor growth in a xenograft mouse model with ESCC cell lines.To examine the clinical relevance of these findings,we performed immunohistochemical analyses of microarray profiling data obtained from human esophageal squamous cancer tissues and found that both LSD1 and G9a are upregulated in cancer tissues compared to healthy tissues,and this increased expression was significantly correlated with poor prognosis.Mechanistically,we discovered that inhibiting LSD1 and G9a induces cell death via S-phase arrest and apoptosis,and cotargeting ER stress pathways increased this effect both in vitro and in vivo.Taken together,these findings provide compelling evidence that targeting LSD1,G9a,and ER stress-related pathways may serve as a viable therapeutic strategy for ESCC. | Hongxiao Wang Zijun Song Enjun Xie Junyi Chen Biyao Tang Fudi Wang Junxia Min | 2022 | Research2022，，3： | 0 |
| 18 | Fish scale-derived scaffolds with MSCs loading for photothermal therapy of bone defect显示文摘Tissue engineering scaffolds have presented effective value in bone repair.However,the integration of the diverse components,complex structures,multifunction to impart the scaffolds with improved applicability is still a challenge.Here,we propose a novel fish-derived scaffold combined with photothermal therapy and mesenchymal stem cells(MSCs)to promote bone regeneration.The fish-derived scaffold is composed of the decellularized fish scale and gelatin methacrylate synthesized from fish gelatin(fGelMA),which can promote the proliferation and osteogenesis of MSCs with no obvious immunological rejection.Furthermore,the black phosphorus(BP)nanosheets are incorporated into the fGelMA hydrogel network,which can endow the hydrogel with the capacity of photothermal conversion stimulated by near-infrared(NIR)light.The fish-derived scaffold can promote the osteogenesis process of MSCs with higher expression of osteogenic markers and higher mineralization assisted by the NIR light in vitro.The regeneration of mice calvarial defect has also been accelerated by the scaffold with photothermal therapy and MSCs.These results suggest that the fish-derived scaffold,photothermal therapy,MSCs-based regenerative therapy is a promising clinical strategy in bone regeneration. | Siyu Shen Rui Liu Chuanhui Song Tao Shen Yiwen Zhou Junxia Guo Bin Kong Qing Jiang | 2023 | Nano Research2023，16，5： | 0 |
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