|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration显示文摘房间通过 secreting 和释放蛋白质和泡与对方一起交流。许多房间能移居。在这研究,我们报导 migracytosis,为释放细胞的内容的房间迁居依赖者机制,和 migrasomes 的发现,调停的小囊的结构 migracytosis。当移居的房间移动,他们离开长管状的海滨,叫的收回纤维,在他们后面。大泡,包含众多的更小的泡,在收回纤维的尖端和交叉上成长。这些纤维,与主要房间身体连接泡,最后,裂缝,和泡被释放直到细胞外的空间或直接由包围房间收起。因为这些泡的形成是迁居依赖者,我们把他们称为 “ migrasomes”。我们也发现 cytosolic 内容能被搬运进 migrasomes 并且通过 migrasomes 免除了房间。我们把这迁居依赖者版本机制称为 “ migracytosis”。 | Liang Ma Ying Li Junya Peng Danni Wu Xiaoxin Zhao Yitong Cui Lilian Chen Xiaojun Yan Yanan Du Li Yu | 2015 | Cell Research2015，25，1： | 21 |
| 2 | Dapper1 promotes autophagy by enhancing the Beclinl -Vps34-Atg14L complex formation显示文摘 | Benvu Ma Weipeng Cao Wenxia Li Chan Gao Zhen Qi Yan Zhao Jun Du Hua Xue Junya Peng Jun Wen Hua Chen Yuanheng Ning Lei Huang Hong Zhang Xiang Gao Li Yu Ye-Guang Chen | 2014 | Cell Research2014，24，8： | 12 |
| 3 | SKIP Confers Osmotic Tolerance during Salt Stress by Controlling Alternative Gene Splicing in Arabidopsis显示文摘译解位于下面的机制种回答到不能生活的应力为改进植物压力抵抗是关键的。大部分在 transcriptional 水平响应盐应力对基因表示的规定被知道;然而,很少在 posttranscriptional 水平对这个过程被知道。最近,我们证明那个翻斗车是与钟基因 pre-mRNAs 交往并且为调整他们拼接的选择和 mRNA 成熟是必要的 spliceosome 的一个部件。在这研究,我们发现 skip-1 植物对盐和渗透的压力过分敏感,并且那个翻斗车为拼接的选择和几咸忍耐的基因的 mRNA 成熟被要求,包括 NHX1, CBL1, P5CS1, RCI2A,和 PAT10。染色体宽的分析表明那个翻斗车调停在咸压力的条件下面许多基因拼接的选择,和在 skip-1 的其他的拼接事件的那个大多数包含 intron 保留和罐头 generatea 在抄录 mRNA 的早熟的结束 codon。翻斗车也控制由 modulating 的其他的拼接 5 和 3 的识别或劈开拼接在咸压力的条件下面的施主和领受人地点。因此,这研究探讨的基本问题拼接的 mRNA 在植物的机械在 posttranscriptional 水平贡献咸压力的回答,并且提供在其他的拼接和盐忍耐之间的一个连接。 | Jinlin Feng dingjing Li Zhaoxu Gao Yaru Lu Junya Yu Qian Zheng Shuning Yan Wenjiao Zhang Hang He Ligeng Ma Zhengge Zhu | 2015 | Molecular Plant2015，8，7： | 10 |
| 4 | Tribocorrosion behavior of nickel-aluminium bronze sliding against alumina under the lubrication by seawater with different halide concentrations显示文摘The tribocorrosion failure mechanism of nickel-aluminium bronze(NAB) in different halide concentrations of seawater was studied using a pin-on-disc tribometer that was modified to conduct in-situ electrochemical detection during the sliding process. It has been reported that high-halide-concentration seawater provided a good lubricating effect, and thus reduced the coefficient of friction and wear rate of NAB during the tribocorrosion process. However, the existence of halide ions corroded the passive film and hindered the repassivation of the damaged areas in the wear track, resulting in an increased corrosion rate. In addition, the morphology of the wear scar revealed the occurrence of abrasive, delamination, and adhesive wear of NAB in seawater. For the whole range of halide concentration values, a positive synergy between wear and corrosion was proven, and the quantification of this synergy was discussed in detail. The results show that the corrosionwear synergism was decreased with increasing halide concentration in seawater, and the corrosion-induced wear was dominant in the two synergistic components. | Beibei ZHANG Jianzhang WANG Junya YUAN Fengyuan YAN | 2019 | Friction2019，7，5： | 5 |
| 5 | Genome wide association study identifies SNPs associated with fatty acid composition in Chinese Wagyu cattle显示文摘Background: Fatty acids are important traits that affect meat quality and nutritive values in beef cattle. Detection of genetic variants for fatty acid composition can help to elucidate the genetic mechanism underpinning these traits and promote the improvement of fatty acid profiles. In this study, we performed a genome-wide association study(GWAS) on fatty acid composition using high-density single nucleotide polymorphism(SNP) arrays in Chinese Wagyu cattle.Results: In total, we detected 15 and 8 significant genome-wide SNPs for individual fatty acids and fatty acid groups in Chinese Wagyu cattle, respectively. Also, we identified nine candidate genes based on 100 kb regions around associated SNPs. Four SNPs significantly associated with C14:1 cis-9 were embedded with stearoyl-CoA desaturase(SCD), while three SNPs in total were identified for C22:6 n-3 within Phospholipid scramblase family member 5(PLSCR5), Cytoplasmic linker associated protein 1(CLASP1), and Chymosin(CYM). Notably, we found the top candidate SNP within SCD can explain ~ 7.37% of phenotypic variance for C14:1 cis-9.Moreover, we detected several blocks with high LD in the 100 kb region around SCD. In addition, we found three significant SNPs within a 100 kb region showing pleiotropic effects related to multiple FA groups(PUFA,n-6, and PUFA/SFA), which contains BAI1 associated protein 2 like 2(BAIAP2 L2), MAF bZIP transcription factor F(MAFF),and transmembrane protein 184 B(TMEM184 B).Conclusions: Our study identified several significant SNPs and candidate genes for individual fatty acids and fatty acid groups in Chinese Wagyu cattle, and these findings will further assist the design of breeding programs for meat quality in cattle. | Zezhao Wang Bo Zhu Hong Niu Wengang Zhang Ling Xu Lei Xu Yan Chen Lupei Zhang Xue Gao Huijiang Gao Shengli Zhang Lingyang Xu Junya Li | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 4 |
| 6 | Two transposable element insertions are causative mutations for the major domestication gene teosinte branched 1 in modern maize显示文摘 | Liangliang Zhou Junya Zhang Jianbing Yan Rentao Song | 2011 | Cell Research2011，21，8： | 3 |
| 7 | Cagelike mesoporous silica encapsulated with microcapsules for immobilized laccase and 2,4-DCP degradation显示文摘In this study,cage-like mesoporous silica was used as the carrier to immobilize laccase by a physical approach,followed by encapsulating with chitosan/alginate microcapsule membranes to form microcapsules of immobilized laccase based on layer-by-layer technology.The relationship between laccase activity recovery/leakage rate and the coating thickness was simultaneously investigated.Because the microcapsule layers have a substantial network of pores,they act as semipermeable membranes,while the laccase immobilized inside the microcapsules acts as a processing plant for degradation of2,4-dichlorophenol.The microcapsules of immobilized laccase were able to degrade 2,4-dichlorophenol within a wide range of 2,4-dichlorophenol concentration,temperature and p H,with mean degradation rate around 62%.Under the optimal conditions,the thermal stability and reusability of immobilized laccase were shown to be improved significantly,as the removal rate and degradation rate remained over 40.2% and 33.8% respectively after 6 cycles of operation.Using mass spectrometry(MS) and nuclear magnetic resonance(NMR),diisobutyl phthalate and dibutyl phthalate were identified as the products of 2,4-dichlorophenol degradation by the microcapsules of immobilized laccase and laccase immobilized by a physical approach,respectively,further demonstrating the degradation mechanism of 2,4-dichlorophenol by microcapsule-immobilized laccase. | Junya Yang Yan Huang Yuxiang Yang Hongming Yuan Xiangnong Liu | 2015 | Journal of Environmental Sciences2015，27，12： | 2 |
| 8 | Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area-and length-based approaches显示文摘 | Junya Takagawa Yan Zhang Maelene L | 2007 | J Appl Physiol2007，102，： | 1 |
| 9 | Water environment protection and sustainable development in townlet of China: A case study in Taicang显示文摘The Environmental Kuznets Curve(EKC) model was applied to investigate the relationship between economic growth and water environment quality based on panel data of Taicang during 2010–2017. The typical inversed-U shaped relationship has been obtained between GDP(gross domestic product) and indicators of ammonia, total nitrogen(TN) and total phosphorus(TP), respectively. The EKC turning point appeared when the GDP per capita was around US$2270, which was much lower than those in some developed countries(US$11,200). However, the decoupling between chemical oxygen demand(COD) and GDP per capita occurred even before this period, which should be attributed to the strict COD emission regulation being implemented since 2010. Further, analysis based on the Tapio decoupling coefficient elasticity model analyzed the ammonia nitrogen and economic development of each industry. We found that the agriculture no-point was strong decoupling in 2011–2014, then came to Recessive decoupling. The domestic wastewater had been in a strong decoupling state;Both urban non-point and industry experienced expansive negative decoupling, due to strict policy that prioritizes the environment over development and the investment in improvement of environment and techniques, both of them gradually came to strong decoupling. The result demonstrated that the EKC turning point could be appear in earlier economic stage and the decoupling coefficient elasticity could be improved through taking strong regulation measures. | Wenli Zhou Mengmeng Liu Xu Shang Meixue Chen Guorong Wang Hui Zhong Junya Zhang Yuansong Wei Yan Yan Min Yang | 2021 | Journal of Environmental Sciences2021，33，12： | 1 |
| 10 | DNA damage response-related immune activation signature predicts the response to immune checkpoint inhibitors: from gastrointestinal cancer analysis to pan-cancer validation显示文摘Objective: DNA damage response(DDR) deficiency has emerged as a prominent determinant of tumor immunogenicity. This study aimed to construct a DDR-related immune activation(DRIA) signature and evaluate the predictive accuracy of the DRIA signature for response to immune checkpoint inhibitor(ICI) therapy in gastrointestinal(GI) cancer.Methods: A DRIA signature was established based on two previously reported DNA damage immune response assays. Clinical and gene expression data from two published GI cancer cohorts were used to assess and validate the association between the DRIA score and response to ICI therapy. The predictive accuracy of the DRIA score was validated based on one ICI-treated melanoma and three pan-cancer published cohorts.Results: The DRIA signature includes three genes(CXCL10, IDO1, and IFI44L). In the discovery cancer cohort, DRIA-high patients with gastric cancer achieved a higher response rate to ICI therapy than DRIA-low patients(81.8% vs. 8.8%;P < 0.001), and the predictive accuracy of the DRIA score [area under the receiver operating characteristic curve(AUC) = 0.845] was superior to the predictive accuracy of PD-L1 expression, tumor mutational burden, microsatellite instability, and Epstein–Barr virus status. The validation cohort demonstrated that the DRIA score identified responders with microsatellite-stable colorectal and pancreatic adenocarcinoma who received dual PD-1 and CTLA-4 blockade with radiation therapy. Furthermore, the predictive performance of the DRIA score was shown to be robust through an extended validation in melanoma, urothelial cancer, and pan-cancer.Conclusions: The DRIA signature has superior and robust predictive accuracy for the efficacy of ICI therapy in GI cancer and pancancer, indicating that the DRIA signature may serve as a powerful biomarker for guiding ICI therapy decisions. | Junya Yan Shibo Wang Jing Zhang Qiangqiang Yuan Xianchun Gao Nannan Zhang Yan Pan Haohao Zhang Kun Liu Jun Yu Linbin Lu Hui Liu Xiaoliang Gao Sheng Zhao Wenyao Zhang Abudurousuli Reyila Yu Qi Qiujin Zhang Shundong Cang Yuanyuan Lu Yanglin Pan Yan Kong Yongzhan Nie | 2024 | Cancer Biology & Medicine2024，21，3： | 0 |
| 11 | The eQTL colocalization and transcriptome‑wide association study identify potentially causal genes responsible for economic traits in Simmental beef cattle显示文摘Background A detailed understanding of genetic variants that affect beef merit helps maximize the efficiency of breeding for improved production merit in beef cattle.To prioritize the putative variants and genes,we ran a com-prehensive genome-wide association studies(GWAS)analysis for 21 agronomic traits using imputed whole-genome variants in Simmental beef cattle.Then,we applied expression quantitative trait loci(eQTL)mapping between the genotype variants and transcriptome of three tissues(longissimus dorsi muscle,backfat,and liver)in 120 cattle.Results We identified 1,580 association signals for 21 beef agronomic traits using GWAS.We then illuminated 854,498 cis-eQTLs for 6,017 genes and 46,970 trans-eQTLs for 1,903 genes in three tissues and built a synergistic network by integrating transcriptomics with agronomic traits.These cis-eQTLs were preferentially close to the transcription start site and enriched in functional regulatory regions.We observed an average of 43.5%improvement in cis-eQTL discovery using multi-tissue eQTL mapping.Fine-mapping analysis revealed that 111,192,and 194 variants were most likely to be causative to regulate gene expression in backfat,liver,and muscle,respectively.The transcriptome-wide association studies identified 722 genes significantly associated with 11 agronomic traits.Via the colocalization and Mendelian randomization analyses,we found that eQTLs of several genes were associated with the GWAS signals of agronomic traits in three tissues,which included genes,such as NADSYN1,NDUFS3,LTF and KIFC2 in liver,GRAMD1C,TMTC2 and ZNF613 in backfat,as well as TIGAR,NDUFS3 and L3HYPDH in muscle that could serve as the candidate genes for economic traits.Conclusions The extensive atlas of GWAS,eQTL,fine-mapping,and transcriptome-wide association studies aid in the suggestion of potentially functional variants and genes in cattle agronomic traits and will be an invaluable source for genomics and breeding in beef cattle. | Wentao Cai Yapeng Zhang Tianpeng Chang Zezhao Wang Bo Zhu Yan Chen Xue Gao Lingyang Xu Lupei Zhang Huijiang Gao Jiuzhou Song Junya Li | 2023 | Journal of Animal Science and Biotechnology2023，14，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员