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| 1 | High expression of trimethylated histone H3 lysine 4 is associated with poor prognosis in hepatocellular carcinoma显示文摘 | Chuanchao He Junyao Xu Jianlong Zhang Dan Xie Hua Ye Zhiyu Xiao Muyan Cai Kang Xu Yunjie Zeng Haigang Li Jie Wang | 2012 | Human Pathology2012，，9： | 3 |
| 2 | Intramedullary schwannoma of the upper cervical spinal cord:a case study of identification in pathologic autopsy显示文摘Intramedullary schwannoma of the upper cervical spinal cord is rarely reported in forensic medicine.We herein report a case involving a patient who died of compression from an intramedullary schwannoma in the upper cervical spinal cord.A 30-year-old man initially presented with a five-day history of pain in the left chest that progressed to weakening in the left arm.Although the patient was treated with analgesic poultices,he developed inspiratory dyspnoea and died while working the next day without having undergone any medical imaging examination or surgical treatment.Anatomical and histopathological examinations revealed an intramedullary schwannoma in the left cervical spinal cord(C_(3)-C_(5))underneath the spinal nerve root.The cause of death might have been asphyxia secondary to the tumour,which interfered with the nerve function in the respiratory muscles.This finding suggests that an autopsy is essential for pathologists and medicolegists to comprehensively undertake their due obligation to obtain“the first evidence”,especially when there is a lack of directly related evidence.As part of the central nervous system,the spinal cord could be systematically included in a routine pathological autopsy in some cases. | Xianxian Li Guangtao Xu Ruibing Su Junyao Lv Xiaoping Lai Xiaojun Yu | 2017 | Forensic Sciences Research2017，2，1： | 2 |
| 3 | Sphingolipid synthesis inhibitor fumonisin B1 causes verticillium wilt in cotton显示文摘Verticillium wilt caused by Verticillium dahliae is a major disease of cotton. Acidic protein–lipopolysaccharide complexes are thought to be the toxins responsible for its symptoms. Here,we determined that the sphingolipid biosynthesis inhibitor fumonisin B1(FB1) acts as a toxin and phenocopies the symptoms induced by V. dahliae. Knocking out genes required for FB1 biosynthesis reduced V. dahliae pathogenicity. Moreover, we showed that overexpression of a FB1 and V. dahliae both downregulated gene, Gh IQD10, enhanced verticillium wilt resistance by promoting the expression of brassinosteroid and anti-pathogen genes. Our results provide a new strategy for preventing verticillium wilt in cotton. | Fan Xu Li Huang Junyao Wang Caixia Ma Yingqing Tan Fanlong Wang Yanhua Fan Ming Luo | 2022 | Journal of Integrative Plant Biology2022，64，4： | 1 |
| 4 | Transmission of Carbapenem Resistance Between Human and Animal NDM-Positive Escherichia coli Strains显示文摘Although carbapenem use is prohibited in animals in China,carbapenem-resistant Escherichia coli(CREC),especially New Delhi metallo-β-lactamase(NDM)-producing strains,are widely prevalent in foodproducing animals.At present,the impact of livestock-associated CREC strains on human populations at the national level is unknown.Here,we conduct a retrospective cross-sectional study to investigate the prevalence of CREC from clinical settings across 22 Chinese provinces or municipalities and analyze anthropogenic factors associated with their presence.We also ascertain the blaNDMand blaKPCabundance among pig and chicken farms and present a detailed genomic framework for CREC of animal and human origin.Overall,631/29799(2.1%)clinical Escherichia coli(E.coli)isolates were identified as CREC.Multivariable analysis revealed that being male,an age below 1,an age between 13 and 18,provinces with greater chicken production,and provinces with higher pig production were associated with higher odds of CREC infection.In general,73.8%(n=45/61)of pig farms and 62.2%(n=28/45)of chicken farms had a blaNDMabundance of 1×10^(-5)to 1×10^(-3)and 1×10^(-3)to 1×10^(-2),respectively.Among all the Chinese NDM-positive E.coli(n=463)available at the National Center for Biotechnology Information(NCBI),the genomic analysis revealed that blaNDM-5and Inc X3 were the predominant carbapenemase gene-plasmid combination,while a highly homogeneous relationship between NDM-positive isolates from humans and animals was demonstrated at the plasmid and core genome levels.All the findings suggest frequent CREC transmission between humans and animals,indicating that further discussions on the use of antibiotics in animals and humans are needed,both in China and across the globe. | Yingbo Shen Fupin Hu Yongqiang Wang Dandan Yin Lu Yang Yiqiang Chen Chunyan Xu Jiyun Li Junyao Jiang Xueyang Wang Yulin Fu Dongyan Shao Dejun Liu Tengfei Ma Chang Cai Zhangqi Shen Shaolin Wang Juan Li Rong Zhang Yuebin Ke Congming Wu Jianzhong Shen Timothy R.Walsh Yang Wang | 2022 | Engineering2022，8，8： | 0 |
| 5 | Microstructures,mechanical properties and degradability of Mg-2Gd-0.5(Cu/Ni)alloys:A comparison study显示文摘Low alloying Mg-2 Gd-0.5(Cu/Ni)alloys for sealing tools in the oil and gas industry were prepared.The differences in the effects of minor Cu and Ni additions on microstructures and properties of the Mg-2 Gd alloy were compared.The results showed that adding Ni was more effective than adding Cu in refining grain sizes,strengthening the basal fiber texture,and promoting the formation of LPSO phases,resulting in higher strength.The tensile yield strength/elongation of the Mg-2 Gd-0.5 Cu alloy,Mg-2 Gd-0.25 Cu-0.25 Ni alloy,and Mg-2 Gd-0.5 Ni alloy was 146 MPa/23.7%,175 MPa/23.1%,and 248 MPa/18.2%,respectively.The decreased elongation was attributed to the basal fiber texture and the presence of coarse LPSO phases.In terms of the corrosion rate in 3.5 wt.%NaCl solution,it rose from 112 mm y^(-1)for the Mg-2 Gd-0.5 Cu alloy to 269 mm y^(-1)for the Mg-2 Gd-0.25 Cu-0.25 Ni alloy and 490 mm y^(-1)for the Mg-2 Gd-0.5 Ni alloy,indicating that the addition of Ni instead of Cu showed a more significant promoting effect on the degradability of Mg alloys,which was related to more refined grains,the stronger basal fiber texture,and a larger amount of LPSO phases. | Shiyu Zhong Dingfei Zhang Yongqin Wang Sensen Chai Jingkai Feng Yulun Luo Jianrong Hua Qimin Dai Guangshan Hu Junyao Xu Bin Jiang Fusheng Pan | 2022 | Journal of Materials Science & Technology2022，，33： | 0 |
| 6 | Near 30%fractional bandwidth surface acoustic wave filters with novel electrode configuration显示文摘With the rapid progress of the wireless communication technique and the fast growing of the radio frequency(RF)markets,the development of wideband surface acoustic wave(SAW)filter is intensely pursued in RF front-end platforms.In this study,a novel configuration of SAW device was proposed in 15°YX-Li NbO_(3)(300 nm)/SiO_(2)(600 nm)/Si heterostructure,where the series and shunt resonator innovatively adopt Cu electrodes of different thickness to suppress the unwanted Rayleigh mode efficiently.Series and shunt resonators with clean spectrum and high electromechanical coupling coefficients over 20%were experimentally achieved under the guidance of finite element method calculation.Based on the resonator results,a ladder-type SAW filter with a very large 3-dB fractional bandwidth near 30%was successfully designed and fabricated.The minimum insertion loss of device is as small as 1.1 dB while the in-band fluctuation is less than 0.3 dB.The unprecedented wideband property of SAW device indicates that the proposed configuration is expected to become one of the solutions of wideband filter in fifth-generation mobile communication,and possess great application prospects. | Rongxuan Su Sulei Fu Zengtian Lu Junyao Shen Huiping Xu Hongqing Mao Zhibin Xu Cheng Song Fei Zeng Weibiao Wang Feng Pan | 2021 | Progress in Natural Science:Materials International2021，31，6： | 0 |
| 7 | The m^(6)A regulator KIAA1429 stabilizes RAB27B mRNA and promotes the progression of chronic myeloid leukemia and resistance to targeted therapy显示文摘Chronic myeloid leukemia(CML)is a common adult leukemia.Both the acute phase of the disease and the adverse effects of anti-cancer treatments can lead to a poor prognosis.The N6-methyladenine(m^(6)A)modification plays an important regulatory role in various physiological and pathological processes.KIAA1429 is a known m^(6)A regulator,but the biological role of KIAA1429 in CML is unclear.In this study,we observed that the m^(6)A levels and KIAA1429 expression were significantly up-regulated in patients with blast phase CML.Notably,KIAA1429 regulated the total level of RNA m^(6)A modification in the CML cells and promoted the malignant biological behaviors of CML cells,including proliferation,migration,and imatinib resistance.Inhibiting KIAA1429 in CML cells reduced the stability of RAB27B mRNA through the m^(6)A/YTHDF1 axis,consequently inhibiting CML proliferation and drug efflux,ultimately increasing the sensitivity of CML cells to imatinib.Moreover,the knockdown of RAB27B also inhibited the proliferation and drug resistance of CML cells and promoted their apoptosis.Rucaparib,a recently developed anti-cancer agent,suppressed the expression of KIAA1429 and CML cell proliferation and promoted cell apoptosis.Rucaparib also inhibited the tumorigenesis of CML cells in vivo.The combined use of rucaparib and imatinib enhanced the sensitivity of CML cells to imatinib.Our study provides evidence that elevated KIAA1429 expression in the blast phase of CML enhances the stability of RAB27B mRNA through the m^(6)A/YTHDF1 axis to up-regulate RAB27B expression,thereby promoting CML progression.Rucaparib exerts inhibitory effects on KIAA1429 expression and thus reduces CML progression. | Fangyi Yao Fangmin Zhong Junyao Jiang Ying Cheng Shuai Xu Jing Liu Jin Lin Jing Zhang Shuqi Li Meiyong Li Yanmei Xu Bo Huang Xiaozhong Wang | 2024 | Genes & Diseases2024，11，2： | 0 |
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