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| 1 | Effect of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in colorectal liver metastases显示文摘AIM:To evaluate the influence of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in liver metastases of stage Ⅳ colorectal cancer(CRC) patients.METHODS:Using Real Time-PCR,enzyme-linked immunosorbent assay,Western Blots and immunohistochemistry,we have analyzed the expression of CCL20,CCR6 and proliferation marker Ki-67 in colorectal liver metastasis(CRLM) specimens from stage Ⅳ CRC patients who received preoperative FOLFOX chemotherapy(n = 53) and in patients who did not receive FOLFOX chemotherapy prior to liver surgery(n = 29).RESULTS:Of the 53 patients who received FOLFOX,time to liver surgery was ≤ 1 mo in 14 patients,≤ 1 year in 22 patients and > 1 year in 17 patients,respectively.In addition,we investigated the proliferation rate of CRC cells in liver metastases in the different patient groups.Both CCL20 and CCR6 mRNA and protein expression levels were significantly increased in patients who received preoperative FOLFOX chemotherapy ≤ 12 mo before liver surgery(P < 0.001) in comparison to patients who did not undergo FOLFOX treatment.Further,proliferation of CRLM cells as measured by Ki-67 was increased in patients who underwent FOLFOX treatment.CCL20 and CCR6 expression levels were significantly increased in CRLM patients who had undergone preoperative FOLFOX chemotherapy.CONCLUSION:This chemokine/receptor up-regulation could lead to increased proliferation/migration through an autocrine mechanism which might be used by surviving metastatic cells to escape cell death caused by FOLFOX. | Claudia Rubie Vilma Oliveira Frick Pirus Ghadjar Mathias Wagner Christoph Justinger Stefan Graeber Jens Sperling Otto Kollmar Martin K Schilling | 2011 | World Journal of Gastroenterology2011，17，26： | 5 |
| 2 | Antibiotic coating of abdominal closure sutures and wound infection显示文摘 | Justinger C Moussavian MR Schlueter C | 2009 | Surgery2009，145，3： | 1 |
| 3 | On thecorrelation between crystallographic grain size andsurface evolution in metal forming processes显示文摘 | GROCHE P SCHAFER R JUSTINGER H | 2010 | International Journal of Mechanical Sciences2010，52，3： | 1 |
| 4 | The standardized surgical approach improves outcome of gall- bladder cancer显示文摘 | Scheingraber S Justinger C Stremovskaia T | 2007 | World J Surg Oncol2007，5，： | 1 |
| 5 | Liver injury following blunt abdominal trauma: a new mechanism-driven classification显示文摘 | Slotta JE Justinger C Kollmar O | 2014 | Surg Today2014，44，： | 1 |
| 6 | The standardized surgical approach improves outcome of gall-bladder cancer显示文摘 | Scheingraber S Justinger C Stremovskaia T | 2007 | World J Surg Oncol2007，5，： | 1 |
| 7 | Increased growth factor expression after hepatic and pancreatic resection 显示文摘 | Justinger C Schluter C Oliviera-Frick V | 2008 | Oucol Rep2008，20，6： | 1 |
| 8 | Incisional hernia after abdominal closure with slowly absorbable versus fast absorbable, antibacterial-coated sutures显示文摘 | Justinger C Slotta JE Schilling MK | 2012 | Surgery2012，151，3： | 1 |
| 9 | Thoracotomy procedures effect cytokine levels after thoraco abdominal esophagectomy显示文摘 | Frick VO Justinger C Rubie C | 2012 | Oncol Rep2012，27，： | 1 |
| 10 | Liver injury following blunt abdominal trauma: a new mechanism-driven classifica- tion 显示文摘 | Slotta JE Justinger C Kollmar O | 2014 | Surg Today2014，44，2： | 1 |
| 11 | Closing the Abdominal Wall-Challenges and possible solutions 显示文摘 | Justinger C Schilling MK | 2011 | Zentralbl Chit2011，136，6： | 1 |
| 12 | Impact of Postoperative Pancreatic Fistula on Surgical Outcome—The Need for a Classification-driven Risk Management显示文摘 | Andreas Schmid Frymerman Jochen Schuld Patrick Ziehen Otto Kollmar Christoph Justinger Marco Merai Sven Richter Martin Karl Schilling Mohammed Reza Moussavian | 2010 | Journal of Gastrointestinal Surgery2010，，4： | 1 |
| 13 | Retroperitoneal abscess with consecutive acute renal failure caused by a lost gallstone 2 years after laparoscopic eholecystectomy显示文摘 | Justinger C Sperling J Katoh M | 2010 | Langenbeck'' s Archives of Surgery2010，395，3： | 1 |
| 14 | Incisional hernia afterabdominal closure with ‘slowly absorbable versus fast ab-sorbable antibacterial-coated sutures显示文摘 | Justinger C Slotta JE Schilling MK | 2012 | Surgery2012，151，3： | 1 |
| 15 | Intraarterial thrombolysis in acute limb ischemia:alternative treatment and basic principles of further interventions显示文摘 | Weinrich M Justinger C K(o)hler MF | 2008 | Zentralbl Chir2008，133，： | 1 |
| 16 | On the correlation between crystallographic grain size and surface evolution in metal forming processes显示文摘 | GROCHE P SCHAFER R JUSTINGER H LUDWIG M | 2010 | International Jottmal of Mechanical Sciences2010，52，： | 1 |
| 17 | CXC receptor-4 m RNA silencing abrogates CXCL12-induced migration of colorectal cancer cel s显示文摘 | Rubie C Frick VO Ghadjar P Wagner M Justinger C Faust SK | 2011 | J Transl Med2011，9，： | 1 |
| 18 | Triclosan-coated su- tures reduce wound infections after hepatohiliary surgery-a prospective nomrandomized clinical pathway driven study显示文摘 | Justinger C Schuld J Sperling J | 2011 | Langenbeck''s Arch Surg2011，396，6： | 1 |
| 19 | Antibacterial coating of abdominal closure sutures and wound infection 显示文摘 | Justinger C Moussavian MR Schlueter C | 2009 | Surgery2009，145，3： | 1 |
| 20 | Antibiotic coat- ing of abdominal closure sutues and wound infection 显示文摘 | Justinger C Moussavian MR Sehlueter C | 2009 | Sur- gery2009，145，3： | 1 |
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