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| 1 | Complications and risk factors for complications of implanted subcutaneous ports for intraperitoneal chemotherapy in gastric cancer with peritoneal metastasis显示文摘Objective:Intraperitoneal(IP)chemotherapy through subcutaneous port is an effective treatment for gastric cancer(GC)patients with peritoneal metastasis(PM).The objective of this study is to assess the port complications and risk factors for complications in GC patients with PM.Methods:In retrospective screening of 301 patients with subcutaneous ports implantation,249 GC patients with PM who received IP chemotherapy were screened out for analysis.Port complications and risk factors for complications were analyzed.Results:Of the 249 analyzed patients,57(22.9%)experienced port complications.Subcutaneous liquid accumulation(42.1%)and infection(28.1%)were the main complications,and other complications included port rotation(14.1%),wound dehiscence(12.3%),inflow obstruction(1.7%)and subcutaneous metastasis(1.7%).The median interval between port implantation and occurrence of complications was 3.0 months.Eastern Cooperative Oncology Group(ECOG)performance status[odds ratio(OR),1.74;95%confidence interval(95%CI),1.12-2.69],albumin(OR,3.67;95%CI,1.96-6.86),implantation procedure optimization(OR,0.33;95%CI,0.18-0.61)and implantation groups(OR,0.37;95%CI,0.20-0.69)were independent risk factors for port complications(P<0.05).ECOG performance status was the only factor that related to the grades of port complications(P=0.016).Conclusions:Port complications in GC patients who received IP chemotherapy are manageable.ECOG performance status,albumin,implantation procedure and implantation group are independent risk factors for port complications in GC patients with PM. | Zhongyin Yang Chen Li Wentao Liu Yanan Zheng Zhenglun Zhu Ziehen Hua Zhentian Ni Sheng Lu Min Yan Chao Yan Zhenggang Zhu | 2020 | Chinese Journal of Cancer Research2020，32，4： | 5 |
| 2 | Multivalent Sn species synergistically favours the CO_(2)-into-HCOOH conversion显示文摘Although Sn-based catalysts have recently achieved considerable improvement in selective electro-catalyzing CO_(2)into HCOOH,the role of various valence Sn species is not fully understood due to the complexity and uncertainty of their evolution during the reaction process.Here,inspired by the theoretical simulations that the concomitant multivalent Sn(Sn^(0),Sn^(Ⅱ)and Sn^(Ⅳ))can significantly motivate the intrinsic activity of Sn-based catalyst,the Sn/SnO/SnO_(2)nanosheets were proposed to experimentally verify the synergistic effect of multivalent Sn species on the CO_(2)-into-HCOOH conversion.During CO_(2)reduction reaction,the Sn/SnO/SnO_(2)nanosheets,which are prepared by the sequential hydrothermal reaction,calcined crystallization and low-temperature H_(2)treatment,exhibit a high FEHCOOH of 89.6%at-0.9 VRHE as well as a large cathodic current density.Systematic experimental and theoretical results corroborate that multivalent Sn species synergistically energize the CO_(2)activation,the HCOO*adsorption,and the electron transfer,which make Sn/SnO/SnO_(2)favour the conversion from CO_(2)into HCOOH in both thermodynamics and kinetics.This proof-of-concept study establishes a relationship between the enhanced performance and the multivalent Sn species,and also provides a practicable and scalable avenue for rational engineering high-powered electrocatalysts. | Jun Wu Xue Bai Zhiyu Ren Shichao Du Ziehen Song Lei Zhao Bowen Liu Guiling Wang Honggang Fu | 2021 | Nano Research2021，14，4： | 4 |
| 3 | Miniature Fluorescence Microscopy for Imaging Brain Activity in Freely-Behaving Animals显示文摘An ultimate goal of neuroscience is to decipher the principles underlying neuronal information processing at the molecular,cellular,circuit,and system levels.The advent of miniature fluorescence microscopy has furthered the quest by visualizing brain activities and structural dynamics in animals engaged in self-determined behaviors.In this brief review,we summarize recent advances in miniature fluorescence microscopy for neuroscience,focusing mostly on two mainstream solutions-miniature single-photon microscopy,and miniature two-photon microscopy.We discuss their technical advantages and limitations as well as unmet challenges for future improvement.Examples of preliminary applications are also presented to reflect on a new trend of brain imaging in experimental paradigms involving body movements,long and complex protocols,and even disease progression and aging. | Shiyuan Chen Ziehen Wang Dong Zhang Aiming Wang Liangyi Chen Heping Cheng Runlong Wu | 2020 | Neuroscience Bulletin2020，36，10： | 2 |
| 4 | Endogenous Fe^(2+)-activated ROS nanoamplifier for esterase-responsive and photoacoustic imaging-monitored therapeutic improvement显示文摘Chemodynamic therapy(CDT)is well acknowledged as potent reactive oxygen species(ROS)-mediated anticancer strategy.Especially,the study about labile iron pool(LIP)as endogenous ferrous catalyzer has paved the way for future CDT development.However,limited H_(2)O_(2) expression,mild acidity,reduced glutathione(GSH)ablation of ROS,etc.,all require employing alternate peroxo-complex to achieve enhanced CDT effect.As a non-Fenton-type substrate,artesunate(ART)has been utilized as a source of free radicals through decomposition of endoperoxide bridges catalyzed by ferrous ions,nonetheless,the non-tumor-specific delivery,inferior pharmacokinetics,and hydrophobic nature minimize the efficacy of ART in physiological systems.Herein,we devise a PPA nanoamplifier by conjugating ART with PEG-functionalized Pd@Pt nanoplates(PP NPs)to form ester linkage,ensuring specific intratumoral esterase-responsive ART release.Significantly,the PPA nanoamplifier combines the in situ decomposition of ARTs endoperoxide bridges by Fe^(2+) to superoxide anions(O_(2)^(·-))and peroxidase(POD)-like enzymatic catalysis of endogenous H_(2)O_(2) by PP to hydroxyl radicals(*OH),thus achieving amplified ROS-mediated tumor therapy.Besides,PPA displays GSH destruction potential,thereby protecting ROS from the cleavage by GSH oxidation.In addition,the strong absorption of PPA in near-infrared(NIR)region also endows PPA with photoacoustic property to realize imaging-guided CDT.In short,by taking advantages of the high enrichment and esterase-responsive drug release at tumor sites,PPA amplified ROS signals via dual pathways,killing tumor cells in vitro are inhibiting tumor growth in vivo,thereby realizing high-efficiency non-Fenton CDT.We believe our novel anti-tumor strategy based on PPA will broaden the future of ROS-mediated tumor-targeted therapy. | Sijin Xiang Zhongxiong Fan Ziehen Ye Tianbao Zhu Dao Shi Shefang Ye Zhenqing Hou Xiaolan Chen | 2022 | Nano Research2022，15，2： | 2 |
| 5 | RNA-binding protein QKI regulates contact inhibition via Yes-associate protein in ccRCC显示文摘Contact inhibition adjusts organ size to the proper size and ensures the cultured cells growing to a monolayer.By regulating the downstream coordinator YAP,the evolutionarily conserved Hippo transduction pathway attunes cell growth and death in response to cell contact inhibition,polarity,self-renewal,and differentiation.Dysregulation of this pathway is involved in various diseases such as cancer.RNA-binding protein QKI regulates cell proliferation,metabolism,division,and immunity in various cancer models,but its role in cancer cell contact inhibition remains unclear.In this study,we aimed to clarify the relationship between QKI and YAP,and the role of their interaction in cell contact inhibition.We found a lower QKI expression level in sparse condition,whereas a higher expression level in confluent condition by western blot analysis and immunofluorescence assay.QKI knockdown elevated cell proliferation and invasion both in vitro and in vivo.Strikingly,the results of CCK-8 assay,colony formation assay,and transwell assay showed that the phenomenon was in accord with the expression level of pYAP and reverse with YAP.Higher levels of Wnt3a and β-catenin were also found in xenografts of QKI-knockdown clear cell renal cell carcinoma (ccRCC) CAKI-1 cells by western blot analysis and immumohistochemical staining.Finally,a positive correlation between QKI and pYAP was found in clinical specimens by immunohistochemistry.Thus,as a negative regulator of YAP,QKI attuned the cell contact inhibition,leading to inhibition of cancer cell proliferation and invasion through Wnt and GPCR pathway. | Zheng Zhu Di Wei Xi'an Li Fuli Wang Fei Yan Zibao Xing Zhao Yan Huanyu Lu Dongsheng Zhai Ziehen Ye Geng Zhang Ping Meng Yu Zheng Jiarui Yuan Zifan Lu Jianlin Yuan | 2019 | Acta Biochimica et Biophysica Sinica2019，51，1： | 2 |
| 6 | On-lineChatter Detection and Identification Based on Wave-let and Support Vector Machine显示文摘 | Yao Zhehe Mei Deqing Chen Ziehen | 2010 | Journal of Ma-terials Processing Technology2010，210，5： | 1 |
| 7 | Impact of Postoperative Pancreatic Fistula on Surgical Outcome—The Need for a Classification-driven Risk Management显示文摘 | Andreas Schmid Frymerman Jochen Schuld Patrick Ziehen Otto Kollmar Christoph Justinger Marco Merai Sven Richter Martin Karl Schilling Mohammed Reza Moussavian | 2010 | Journal of Gastrointestinal Surgery2010，，4： | 1 |
| 8 | Impact of postoperative pancreatic fistula on surgical outcome-the need for a classification driven risk management显示文摘 | Frymerman AS Schuld J Ziehen P | | 0，，04： | 1 |
| 9 | Paraffin and paraffin/a- luminum foam composite phase change material heat storage experi- mental study based on thermal management of H-ion battery 显示文摘 | Wang Ziehen Zhang Zhuqian Jia Li | 2015 | Applied Thermal Engineering2015，78，5： | 1 |
| 10 | Impact of postoperative pancreatic fistula on surgical outcome -- the need for a classification-driven risk management显示文摘 | Frymerman AS Schuld J Ziehen P | 2010 | J Gastrointest Surg2010，14，4： | 1 |
| 11 | Impact of on surgical outcome-the need management 显示文摘 | Frymerman A S Schuld J postoperative pancreatic fistula for a classification-driven risk Surg 2010 14(4): 711-718 Ziehen P | 2010 | J Gastrointest2010，，： | 1 |
| 12 | Impact of postoperative pancreatic fistula on surgical outcome-the need for a classification-driven risk management显示文摘 | Frymerman AS Schuld J Ziehen P | | 0，，： | 1 |
| 13 | Impact of postopera-live pancreatic* fistula on surgical outcome-the need for a clas-sification-driven risk management 显示文摘 | Frymerman AS Srhuld J Ziehen P | 2010 | J Gastrointest Surg2010，14，4： | 1 |
| 14 | Inflammatory conversion of quiescent osteoblasts by metastatic breast cancer cells through pERKl/2 aggravates cancer-induced bone destruction显示文摘Disruption of bone homeostasis caused by metastatic osteolytic breast cancer cells increases inflammatory osteolysis and decreases bone formation,thereby predisposing patients to pathological fracture and cancer growth.Alteration of osteoblast function induces skeletal diseases due to the disruption of bone homeostasis.We observed increased activation of pERK1/2 in osteolytic breast cancer cells and osteoblasts in human pathological specimens with aggressive osteolytic breast cancer metastases.We confirmed that osteolytic breast cancers with high expression of pERK1/2 disrupt bone homeostasis via osteoblastic ERK1/2 activation at the bone-breast cancer interface.The process of inflammatory osteolysis modulates ERK1/2 activation in osteoblasts and breast cancer cells through dominant-negative MEK1 expression and constitutively active MEK1 expression to promote cancer growth within bone.Trametinib,an FDA-approved MEK inhibitor,not only reduced breast cancer-induced bone destruction but also dramatically reduced cancer growth in bone by inhibiting the inflammatory skeletal microenvironment.Taken together,these findings suggest that ERK1/2 activation in both breast cancer cells and osteoblasts is required for osteolytic breast cancer-induced inflammatory osteolysis and that ERK1/2 pathway inhibitors may represent a promising adjuvant therapy for patients with aggressive osteolytic breast cancers by altering the shared cancer and bone microenvironment. | Jungho Back Minh Nam Nguyen Lu Li Saelim Lee Inkyu Lee Fancheng Chen Lauren Gillinov Yeon-Ho Chung Kareme D.Alder Hyuk-Kwon Kwon Kristin E.Yu Christopher M.Dussik Ziehen Hao Michael J.Flores Yoseph Kim Izuchukwu K.Ibe Alana M.Munger Sung Wook Seo Francis Y.Lee | 2021 | Bone Research2021，9，4： | 0 |
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