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| 1 | Quantitation of HBsAg predicts response to entecavir therapy in HBV genotype C patients显示文摘AIM:To analysis the factors that predict the response to entecavir therapy in chronic hepatitis patients with hepatitis B virus (HBV) genotype C. METHODS:Fifty patients [hepatitis B e antigen (HBeAg)-negative:HBeAg-positive = 26:24] with HBV genotype C, who received nave entecavir therapy for > 2 years, were analyzed. Patients who showed HBV DNA levels ≥ 3.0 log viral copies/mL after 2 years of entecavir therapy were designated as slow-responders, while those that showed < 3.0 log copies/mL were termed rapid- responders. Quantitative hepatitis B surface antigen (HBsAg) levels (qHBsAg) were determined by the Architect HBsAg QT immunoassay. Hepatitis B core-related antigen was detected by enzyme immunoassay. Pre-C and Core promoter mutations were determined using by polymerase chain reaction (PCR). Drug-resistance mutations were detected by the PCR-Invader method. RESULTS:At year 2, HBV DNA levels in all patients in the HBeAg-negative group were < 3.0 log copies/mL. In contrast, in the HBeAg-positive group, 41.7% were slow-responders, while 58.3% were rapid-responders. No entecavir-resistant mutants were detected in the slow-responders. When the pretreatment factors were compared between the slow-and rapid-responders; the median qHBsAg in the slow-responders was 4.57 log IU/mL, compared with 3.63 log IU/mL in the rapid-responders (P < 0.01). When the pretreatment factors predictive of HBV DNA-negative status at year 2 in all 50 patients were analyzed, HBeAg-negative status, low HBV DNA levels, and low qHBsAg levels were significant (P < 0.01). Multivariate analysis revealed that the low qHBsAg level was the most significant predictive factor (P = 0.03). CONCLUSION:Quantitation of HBsAg could be a useful indicator to predict response to entecavir therapy. | Etsuro Orito Kei Fujiwara Hiroshi Kanie Tesshin Ban Tomonori Yamada Katsumi Hayashi | 2012 | World Journal of Gastroenterology2012，18，39： | 8 |
| 2 | Oocyte Cryopreservation in Human Assited Reproduction显示文摘Embryo cryopreservation(CP) has became a very important part of the clinical use of in vitro fertilization. Oocyte CP offers more advantages compared with embryo freezing with regard to less ethical, legal and moral problems. However, the efficiency of this procedure is still low, which prevents its clinical application in wide range. The aim of our paper is to review the basic principles, technical and safety aspects and current status of oocyte cryopreservation in human assisted reproduction. | J Konc S Cseh E Varga R Kriston K Kanyó | 2006 | Journal of Reproduction and Contraception2006，17，2： | 7 |
| 3 | Double balloon enteroscopy to retrieve an accidentally swallowed dental reamer deep in the jejunum显示文摘Accidentally swallowed foreign objects are not uncommon but difficult to manage without complications. We describe the case of a 68 year old man who accidentally a swallowed sharp-pointed dental reamer that had reached deep in his jejunum. Double balloon enteroscopic retrieval was performed with polypectomy snare but the reamer was entangled in the wire loop of the snare and penetrated the jejunal wall. After releasing the reamer by pushing and pulling the snare for approximately 30 min, the reamer was retrieved with biopsy forceps. This is the first report of double balloon enteroscopic removal of a dental reamer. Furthermore, this is a novel case with regard to decision making in situations when sharp objects are swallowed. | Shingo Kato Kazuhito Kani Hidehiko Takabayashi Ryuichi Yamamoto Koji Yakabi | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，4： | 4 |
| 4 | Exercise in patients coping with breast cancer: An overview显示文摘Breast cancer is the most common type of cancer in women, but fortunately has high survival rates. Many studies have been performed to investigate the effects of exercise in patients diagnosed with breast cancer. There is evidence that exercise after the diagnosis of breast cancer improves mortality, morbidity, health related quality of life, fatigue, physical functioning, muscle strength, and emotional wellbeing. Based on scientific data, breast cancer patients should be recommended to participate in rehabilitation programs including aerobic and strength training. The aim of this article is to review the recently published data on the effect of exercise in patients with breast cancer in order to present the current perspective on the topic. | Sibel Eyigor Selcen Kany?lmaz | 2014 | World Journal of Clinical Oncology2014，5，3： | 3 |
| 5 | The Rise of Private Tutoring in Denmark:An Entrepreneur's Perspectives and Experiences显示文摘This article sheds light on the emergence of private tutoring in Denmark.Written from the perspective of a tutoring entrepreneur,it discusses the challenges and opportunities faced by a fledgling tutoring company in present-day Danish society.The article is a personal narrative of the author's experience with establishing the first major Danish tutoring company.The enthusiastic response by parents to the services offered by the author's company shows that there has long existed a hitherto unmet need for private tutoring in Denmark.However,the author also argues that the political turmoil surrounding the 2013 Danish school reform made parents increasingly sceptical that mainstream schools could effectively address the needs of their children.It thereby prepared the ground for launching a private tutoring concept.It is only in the last decade that private tutoring has emerged in Denmark.The article provides a unique insider's perspective on this largely unexplored development. | Nicklas Kany | 2021 | ECNU Review of Education2021，4，3： | 3 |
| 6 | Body mass index as a predictor of fracture risk: A meta-analysis显示文摘 | C. Laet J. A. Kanis A. Odén H. Johanson O. Johnell P. Delmas J. A. Eisman H. Kroger S. Fujiwara P. Garnero E. V. McCloskey D. Mellstrom L. J. Melton P. J. Meunier H. A. P. Pols J. Reeve A. Silman A. Tenenhouse | 2005 | Osteoporosis International2005，，11： | 2 |
| 7 | Spontaneous regression of gastric gastrinoma after resection of metastases to the lesser omentum:A case report and review of literature显示文摘BACKGROUND Gastric gastrinoma and spontaneous tumor regression are both very rarely encountered.We report the first case of spontaneous regression of gastric gastrinoma.CASE SUMMARY A 37-year-old man with a 9-year history of chronic abdominal pain was referred for evaluation of an 8 cm mass in the lesser omentum discovered incidentally on abdominal computed tomography.The tumor was diagnosed as grade 2 neuroendocrine neoplasm(NEN)on endoscopic ultrasound-guided fine-needle aspiration.Screening esophagogastroduodenoscopy revealed a 7 mm red polypoid lesion with central depression in the gastric antrum,also confirmed to be a grade 2 NEN.Laparoscopic removal of the abdominal mass confirmed it to be a metastatic gastrinoma lesion.The gastric lesion was subsequently diagnosed as primary gastric gastrinoma.Three months later,the gastric lesion had disappeared without treatment.The patient remains symptom-free with normal fasting serum gastrin and no recurrence of gastrinoma during 36 mo of follow-up.CONCLUSION Gastric gastrinoma may arise as a polypoid lesion in the gastric antrum.Spontaneous regression can rarely occur after biopsy. | Takeshi Okamoto Takaaki Yoshimoto Nobuyuki Ohike Aoi Fujikawa Takayoshi Kanie Katsuyuki Fukuda | 2021 | World Journal of Gastroenterology2021，27，1： | 2 |
| 8 | Trabecular Bone Score: A Noninvasive Analytical Method Based Upon the DXA Image显示文摘 | Barbara C Silva William D Leslie Heinrich Resch Olivier Lamy Olga Lesnyak Neil Binkley Eugene V McCloskey John A Kanis John P Bilezikian | 2014 | J Bone Miner Res2014，，3： | 2 |
| 9 | World-wide Projections for Hip Fracture显示文摘 | B. Gullberg O. Johnell J.A. Kanis | 1997 | Osteoporosis International1997，，5： | 2 |
| 10 | 老年原发性骨质疏松患者掌骨皮质指数和骨密度与全身骨量关系的研究显示文摘目的 评价计算机X线密度测量方法的有效性和实用性。方法 对 84例老年原发性骨质疏松患者使用计算机X线密度测量方法测定掌骨皮质指数和骨密度 ,并与双能X线吸收法测定腰椎 ,髋部骨密度和与定量超声技术测量胫骨超声速度进行比较。结果 老年骨质疏松患者掌骨皮质指数和骨密度与腰椎 ,髋部骨密度和胫骨超声骨速度有相关 ,而与年龄和绝经年限呈负相关 ,与BMI无相关关系。结论 计算机X线密度测量方法 ,有价廉 ,非侵入性和广泛易获得的优点 ,是一种新的定量的骨量测定方法 。 | 张冬梅 Eugene McCloskey John Kanis | 2001 | 中国骨质疏松杂志2001，7，3： | 2 |
| 11 | The diagnosis of osteoporosis显示文摘 | Kanis J A Melton L J 3rd Christiansen C | 1994 | J Bone Miner Res1994，9，8： | 1 |
| 12 | World-wide projections for hip fracture显示文摘 | Gullberg B Johnell O Kanis JA | 1997 | Osteoporos Int1997，7，： | 1 |
| 13 | Assessment of fracture risk显示文摘 | Kanis JA Borgstrom F DeLaet C | 2005 | Osteoporos Int2005，16，5： | 1 |
| 14 | Dual-phase 3D CT angiography during a single breath-hold using MDCT:assessment of vascular anatomy before laparoscopic gastrectorny 显示文摘 | Matsuki M Tanikake M Kani H | 2006 | Am J Roentgenol2006，186，4： | 1 |
| 15 | Assessment of fracture risk显示文摘 | Kanis ]A Borgstrom F De Laet C | 2005 | Osteopoms Int2005，，16： | 1 |
| 16 | A meta-analysis of the effect of strontium ranelate on the risk ot' vertebral and non-vertebral fracture in postmenopausal osteoporosis and the interaction with FRAXR显示文摘 | Kanis JA Johansson H Oden A | | Osteoporos Int0，22，8： | 1 |
| 17 | Thediagnosis of osteoporosis显示文摘 | Kanis JA Melton LJ Christiansen C | 1994 | J Bone Miner Res1994，9，8： | 1 |
| 18 | Diagnosis of osteoporosis and assessment of fi-acture risk 显示文摘 | Kanis JA | 2002 | Lancet2002，359，9321： | 1 |
| 19 | The components of excess mortality after hip fracture显示文摘 | Kanis JA OdencA Johnell O | 2003 | Bone2003，32，5： | 1 |
| 20 | Economic values of optimum traits zThe example of meat quality in pigs显示文摘 | Hovenier R Brascamp EW Kanis E | 1993 | J Anim Sci1993，71，6： | 1 |
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