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| 1 | Rectal cancer: An evidence-based update for primary care providers显示文摘Rectal adenocarcinoma is an important cause of cancer-related deaths worldwide, and key anatomic differences between the rectum and the colon have significant implications for management of rectal cancer. Many advances have been made in the diagnosis and management of rectal cancer. These include clinical staging with imaging studies such as endorectal ultrasound and pelvic magnetic resonance imaging, operative approaches such as transanal endoscopic microsurgery and laparoscopic and robotic assisted proctectomy, as well as refined neoadjuvant and adjuvant therapies. For stage Ⅱ and Ⅲ rectal cancers, combined chemoradiotherapy offers the lowest rates of local and distant relapse, and is delivered neoadjuvantly to improve tolerability and optimize surgical outcomes, particularly when sphincter-sparing surgery is an endpoint. The goal in rectal cancer treatment is to optimize diseasefree and overall survival while minimizing the risk of local recurrence and toxicity from both radiation and systemic therapy. Optimal patient outcomes depend on multidisciplinary involvement for tailored therapy. The successful management of rectal cancer requires a multidisciplinary approach, with the involvement of enterostomal nurses, gastroenterologists, medical and radiation oncologists, radiologists, pathologists and surgeons. The identification of patients who are candidates for combined modality treatment is particularly useful to optimize outcomes. This article provides an overview of the diagnosis, staging and multimodal therapy of patients with rectal cancer for primary care providers. | Wolfgang B Gaertner Mary R Kwaan Robert D Madoff Genevieve B Melton | 2015 | World Journal of Gastroenterology2015，21，25： | 13 |
| 2 | Surgical Management of Bile Duct Injuries Sustained During Laparoscopic Cholecystectomy: Perioperative Results in 200 Patients显示文摘 | Jason K. Sicklick Melissa S. Camp Keith D. Lillemoe Genevieve B. Melton Charles J. Yeo Kurtis A. Campbell Mark A. Talamini Henry A. Pitt JoAnn Coleman Patricia A. Sauter John L. Cameron | 2005 | Annals of Surgery2005，，5： | 3 |
| 3 | Risk of Intestinal Cancer in Inflammatory Bowel Disease: A Population-Based Study From Olmsted County, Minnesota显示文摘 | Tine Jess Edward V. Loftus Fernando S. Velayos W. Scott Harmsen Alan R. Zinsmeister Thomas C. Smyrk Cathy D. Schleck William J. Tremaine L. Joseph Melton Pia Munkholm William J. Sandborn | 2006 | Gastroenterology2006，，4： | 3 |
| 4 | SQL多媒体及应用包(SQL/MM)显示文摘文章对新的国际标准“SQL多媒体及应用包-SQL/MM”作了概括性的介绍。这一国际标准包含了四个领域的内容:全文数据库、空间、静态图像和数据挖掘。标准在以上的四个领域定义了相当多的结构化用户定义类(即UDTs),使得今后在这方面的软件开发能极大地提高效率,并使软件更加规范、兼容性更好且易于管理。目前,数据挖掘、智能化全文数据库等领域在我国受到了有关部门和软件业相关领域人士极大的关注,这些领域的研究在我国仍处于起步阶段。目前我国还没有这方面的标准。文章通过较短的篇幅非常清晰地介绍了整个标准在这四个领域的内容,实属难能可贵。对于想了解这些内容的读者来说不失为一份很好的材料。 | Jim Melton Andrew Eisenberg 王鹤龙 | 2004 | 计算机时代2004，，1： | 3 |
| 5 | Prevalence and clinical spectrum of gastroesophageal reflux: A population-based study in Olmsted County, Minnesota显示文摘 | GR Locke NJ Talley SL Fett AR Zinsmeister LJ Melton | 1997 | Gastroenterology1997，，5： | 2 |
| 6 | Body mass index as a predictor of fracture risk: A meta-analysis显示文摘 | C. Laet J. A. Kanis A. Odén H. Johanson O. Johnell P. Delmas J. A. Eisman H. Kroger S. Fujiwara P. Garnero E. V. McCloskey D. Mellstrom L. J. Melton P. J. Meunier H. A. P. Pols J. Reeve A. Silman A. Tenenhouse | 2005 | Osteoporosis International2005，，11： | 2 |
| 7 | Epidemiology and outcomes of osteoporotic fractures显示文摘 | Steven R Cummings L Joseph Melton | 2002 | The Lancet2002，，9319： | 2 |
| 8 | The Evolving Role of Laparoscopy in Colonic Diverticular Disease: A Systematic Review显示文摘 | Wolfgang B. Gaertner Mary R. Kwaan Robert D. Madoff David Willis George E. Belzer David A. Rothenberger Genevieve B. Melton | 2013 | World Journal of Surgery2013，，3： | 2 |
| 9 | Epidemiology and outcomes of osteoporotic fractures显示文摘 | Steven R Cummings L Joseph Melton | 2002 | The Lancet2002，，9319： | 2 |
| 10 | Direct evidence for the pancreatic lineage: NGN3 + cells are islet progenitors and are distinct duct progenitors 显示文摘 | Gu GQ Dubauskaite J Melton DA | 2002 | Development2002，129，： | 2 |
| 11 | Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation显示文摘 | Peng Yi Ji-Sun Park Douglas A. Melton | 2013 | Cell2013，，4： | 2 |
| 12 | Fractures attributable to osteoporosis:report from the National Osteoporosis Foundation显示文摘 | Melton LJ 3rd Thamer M Ray NF | 1997 | J Bone Miner Res1997，12，1： | 1 |
| 13 | Major bile duct injuries associated with laparoscopic cholecystectomy: effect of surgical repair on quality of life 显示文摘 | Melton GB Lillemoe KD Cameron JL | 2002 | Ann Surg2002，235，6： | 1 |
| 14 | Recovery from diabetes in mice by beta cell regeneration显示文摘 | Nir Melton DA Dot Y | 2007 | Clin Invest2007，117，： | 1 |
| 15 | The diagnosis of osteoporosis显示文摘 | Kanis J A Melton L J 3rd Christiansen C | 1994 | J Bone Miner Res1994，9，8： | 1 |
| 16 | Anatomical and histological features of C - shaped canals in mandibular second molars显示文摘 | Melton DC Krell KV Ftdler MW | 1991 | J Endod1991，17，8： | 1 |
| 17 | SQLXML Is Making Good Progress显示文摘 | J Melton | 2002 | ACM SIGMOD Record2002，31，2： | 1 |
| 18 | Epidemiology and outcomes of osteoporotic fractures显示文摘 | Cummings SR Melton LJ | 2002 | Lancet2002，359，9319： | 1 |
| 19 | Epidemiology and out- comes of osteoporotic {ractures显示文摘 | Cummings SR Melton LJ | 2002 | Cancet2002，359，9310： | 1 |
| 20 | Monitoring of heart failure: comparison of left atrial pressure with intrathoracie impedance and na- triuretie peptide measurements in an experimental model of ovine heart failure 显示文摘 | Rademaker MT Charles CJ Melton IC | 2011 | Clin Sei(Lond)2011，120，5： | 1 |
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