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| 1 | Hepatitis C virus genotypes distribution and transmission risk factors in Luxembourg from 1991 to 2006显示文摘AIM:To analyze the Hepatitis C virus (HCV) genotype distribution and transmission risk factors in a population of unselected patients in Luxembourg. METHODS:Epidemiological information (gender, age and transmission risks) were collected from 802 patients newly diagnosed for hepatitis C and living in Luxembourg, among whom 228 patients referred from prison. Genotyping using 5'noncoding (5'NC) sequencing was performed. We compared categorical data using the Fisher's exact F-test and odds ratios (OR) were calculated for evaluating association of HCV genotype and risk factors. RESULTS:The sex ratio was predominantly male (2.2) and individuals aged less than 40 years represented 49.6% of the population. Genotype 1 was predominant (53.4%) followed by genotype 3 (33%). Among risk factors, intravenous drug usage (IVDU) was the most frequently reported (71.4%) followed by medical-related transmission (17.6%) including haemophilia, transfusion recipients and other nosocomial reasons. Genotype 3 was significantly associated to IVDU (OR = 4.84, P < 0.0001) whereas genotype 1 was significantly associated with a medical procedure (OR = 2.42, P < 0.001). The HCV genotype distribution from inmate patients differed significantly from the rest of the population (Chi-square test with four degrees of freedom, P < 0.0001) with a higher frequency of genotype 3 (46.5% vs 27.5%) and a lower frequency of genotype 1 and 4 (44.7% vs 56.8% and 5.3% vs 9.6%, respectively). IVDU was nearly exclusively reported as a risk factor in prison. CONCLUSION:We report the first description of the HCV genotype distribution in Luxembourg. The repartition is similar to other European countries, with one of the highest European prevalence rates of genotype 3 (33%). Since serology screening became available in 1991, IVDU remains the most common way of HCV transmission in Luxembourg. | Francois Roman Karin Hawotte Daniel Struck Anne-Marie Ternes Jean-Yves Servais Vic Arendt Patrick Hoffman Robert Hemmer Thérèse Staub Carole Seguin-Devaux Jean-Claude Schmit | 2008 | World Journal of Gastroenterology2008，14，8： | 3 |
| 2 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Claus R?del Torsten Liersch Heinz Becker Rainer Fietkau Werner Hohenberger Torsten Hothorn Ullrich Graeven Dirk Arnold Marga Lang-Welzenbach Hans-Rudolf Raab Heiko Sülberg Christian Wittekind Sergej Potapov Ludger Staib Clemens Hess Karin Weigang-K?hler G | 2012 | Lancet Oncology2012，，7： | 2 |
| 3 | Salpingotomy versus salpingectomy in women with tubal pregnancy (ESEP study): an open-label, multicentre, randomised controlled trial显示文摘 | Femke Mol Norah M van Mello Annika Strandell Karin Strandell Davor Jurkovic Jackie Ross Kurt T Barnhart Tamer M Yalcinkaya Harold R Verhoeve Giuseppe C M Graziosi Carolien A M Koks Ingmar Klinte Lars Hogstr?m Ineke C A H Janssen Harry Kragt Annemieke Hoek | 2014 | The Lancet2014，，： | 2 |
| 4 | Immunity, inflammation and cancer显示文摘 | Gfivennikov S I Greten F R Karin M | 2010 | Ce112010，140，6： | 1 |
| 5 | Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid 显示文摘 | KARINE B STEPHAN R | 2002 | J Pharmacol Exp Ther2002，302，： | 1 |
| 6 | Neps, Seed Coat Frogments,and Non-seed Impur- tites in Processed Contton 显示文摘 | Karin R Jacobsen Yaffal Grossman You-Lo Hsieh etall | 2001 | The Journal of Cotton Science2001，，5： | 1 |
| 7 | Pri- mary structure and transcription of an amplified ge- netic locus: the CUP1 locus of yeast显示文摘 | KARIN M NAJARIAN R HASLINGER A | 1984 | Proc Natl Acad Sci USA1984，81，2： | 1 |
| 8 | Recurrent lumbar discherniation显示文摘 | Karin R Swartz MD Regory R | 2003 | Neurosurgical Focus2003，15，3： | 1 |
| 9 | NF-kappaB:linking inflammation and immunity to cancer development and progression显示文摘 | Karin M Greten F R | 2005 | Nat Bey Immunol2005，5，10： | 1 |
| 10 | A three-year cohort study of relationship between coping,job stress and burnout after a counseling intervention for help-seeking physicians显示文摘 | Karin E Isaksson R Hoffart R T A | | 0，，10： | 1 |
| 11 | Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators显示文摘 | Ana-Maria Bamberger Karin Milde-Langosch Elena R?ssing Christoph Goemann Thomas L?ning | 2001 | Journal of Cancer Research and Clinical Oncology2001，，9： | 1 |
| 12 | A prospective comparison of the diagnostic accuracy of ERCP, MRCP, CT, and EUS in biliary strictures显示文摘 | Thomas R?sch Alexander Meining Silke Frühmorgen Christian Zillinger Volker Schusdziarra Karin Hellerhoff Meinhard Classen Hermann Helmberger | 2002 | Gastrointestinal Endoscopy2002，，7： | 1 |
| 13 | Highly sulfated dermatan sulfates from ascidiand: Structure versus anticoagulant activity of these glycosaminoglycans显示文摘 | Pavao Mauro S G Aiekko Karin R M Werneck Claudio C | 1998 | J Biol Chem1998，273，27： | 1 |
| 14 | Lipid accumulation , lipid body formation , and acyl coenzyme oxidase of the yeast Yarrowia lipolytica 显示文摘 | KATERINA M EMELINE R KARIN A | 2004 | Applied and Environmental Microbiology2004，70，： | 1 |
| 15 | Influence of aldosterone on collagen synthesis and proliferation of rat cardiac fibroblasts显示文摘 | Krista R Annemie W Karine H | 2001 | Br J Pharmacol2001，134，9： | 1 |
| 16 | Effects of silicon level on rate,quality and progession of bone healing within silicate-substituted porous hydroxyapatite scaffolds显示文摘 | Karin A H Peter A R Smith N | 2006 | Biomaterials2006，29，27： | 1 |
| 17 | Solidstate characterization of nifedipine solid dispersions显示文摘 | SUDHA R VIPPAGUNTA KARIN A | 2002 | International Journal of Pharmaceutics2002，236，： | 1 |
| 18 | Influence of atmospheric turbulence an imaging quality of electro-optical sensors in different cli-mates显示文摘 | R Karin W Weiss | | 0，，： | 1 |
| 19 | First 100 cases with doppler guided hemorrhoidal artery ligation 显示文摘 | Greenberg R Karin E Avital S | 2006 | Dis Colon Rectum2006，49，4： | 1 |
| 20 | NF-KB in cancer: from in-nocent bystander to major culprit 显示文摘 | Karin M Cao Y Greten F R | 2002 | Nature Rev2002，2，： | 1 |
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