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| 1 | Long-term outcome and prognostic factors of patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the long-term outcome and prognostic factors of patients with hilar cholangiocarinoma. METHODS: Ninety-six consecutive patients underwent treatment for malignant hilar bile duct tumors during 1995–2005. Of the 96 patients, 20 were initially treated with surgery (n = 2 R0 / n = 18 R1). In non-operated patients, data analysis was performed retrospectively. RESULTS: Among the 96 patients, 76 were treated with endoscopic transpapillary (ERC, n = 45) and/or percutaneous transhepatic biliary drainage (PTBD, n = 31). The mean survival time of these 76 patients undergoing palliative endoscopic and/or percutaneous drainage was 359 ± 296 d. The mean survival time of patients with initial bilirubin levels > 10 mg/dL was significantly lower (P < 0.001) than patients with bilirubin levels < 10 mg/dL. The mean survival time of patients with Bismuth stage Ⅱ (n = 8), Ⅲ (n = 28) and Ⅳ (n = 40) was 496 ± 300 d, 441 ± 385 d and 274 ± 218 d, respectively. Thus, patients with advanced Bismuth stage showed a reduced mean survival time, but the difference was not significant. The type of biliary drainage had no significant beneficial effect on the mean survival time (ERC vs PTBD, P = 0.806). CONCLUSION: Initial bilirubin level is a significant prognostic factor for survival of patients. In contrast, age, tumor stage according to the Bismuth-Corlette classification, and types of intervention are not significant prognostic parameters for survival. Palliative treatment with endoscopic or percutaneous biliary drainage is still suboptimal, new diagnostic and therapeutic tools need to be evaluated. | Andreas Weber Sonja Landrock Jochen Schneider Manfred Stangl Bruno Neu Peter Born Meinhard Classen Thomas Rsch Roland M Schmid Christian Prinz | 2007 | World Journal of Gastroenterology2007，13，9： | 23 |
| 2 | 柏林中央火车站显示文摘在曾为选帝侯冯伯兰登堡狩猎场的洪堡港以西,一个集长途交通、地区交通及短途交通于一身的欧洲最大的火车站:新的柏林中央火车站,已竣工于它的历史故址。东西向呈弧线的铁道线与地下南北向的新城际快车线交汇于此;2个方向上的轻轨和连接南北的地铁也在此相交。南北向的轨道线通向地下15m的隧道,向前横穿施普雷河和提尔加藤区。这里被建设成一个地下的长途火车站, | 麦哈德·冯-格康(Meinhard von Gerkan) 于尔根·希尔默(Jǜgen Hillmer) | 2009 | 建筑学报2009，，4： | 8 |
| 3 | Eradication of H pylori infection in a rural population: One-day quadruple therapy versus 7-day triple therapy显示文摘瞄准:比较有标准 7-d 的四倍的治疗增加两倍的一天为在中国的一张农村人口的 H pylori 根除的治疗。方法:396 个病人与的一个总数(13 ) pylori 被分配进二的为 H 阳性的 C 脲呼吸测试组织:239 个病人收到了一天四倍的治疗(amoxicillin 2000 mg qid;灭滴灵 500 mg qid;枸橼酸铋 900 mg qid 和 lansoprazole 60 mg 从前每日) 并且 157 个病人收到了 7-d 标准三元组治疗(amoxicillin 1000 mg 出价;clarithromycin 500 mg 出价和 lansoprazole 30 mg 出价) 。所有病人经历了一(13 ) 六个星期估计 H pylori 感染的根除的 C-UBT 术后疗法。结果:229 个病人完成了一天治疗(95.8%) , 148 个病人完成了 7-d 治疗(94.2%) 。一天治疗根除了在 64 个病人(27.95%) 的 H pylori 感染。相反, 103 个病人(69.59%) 是在 7-d 治疗以后否定的 H pylori (P <
0.01 ) 。结论:这个预研项目建议与 7-d 标准治疗相比没有在 H pylori 感染的治疗的一天治疗的有益的效果。 | Lian Zhang Lin Shen Jun-Ling Ma Kai-Feng Pan Wei-Dong Liu Jie Li Shu-Dong Xiao San-Ren Lin Meinhard Classen Wei-Cheng You | 2006 | World Journal of Gastroenterology2006，12，24： | 6 |
| 4 | Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inlammatory bowel disease显示文摘AIM:To determine free and conjugated serum bile acid (BA) levels in in? ammatory bowel disease (IBD) subgroups with defi ned clinical manifestations.METHODS: Comprehensive serum BA profiling was performed in 358 IBD patients and 310 healthy controls by liquid chromatography coupled to electrospray ionization tandem mass spectrometry.RESULTS: Serum levels of hyodeoxycholic acid, the CYP3A4-mediated detoxification product of the secondary BA lithocholic acid (LCA), was increased significantly in Crohn's disease (CD) and ulcerative colitis (UC), while most other serum BA species were decreased significantly. Total BA, total BA conjugate, and total BA glycoconjugate levels were decreased only in CD, whereas total unconjugated BA levels were decreased only in UC. In UC patients with hepatobiliary manifestations, the conjugated primary BAs glycocholic acid, taurocholic acid, and glycochenodeoxycholic acid were as significantly increased as the secondary BAs LCA, ursodeoxycholic acid, and tauroursodeoxycholic acid compared to UC patients without hepatobiliary manifestations. Finally, we found that in ileocecal resected CD patients, the unconjugated primary BAs, cholic acid and chenode-oxycholic acid, were increased significantly compared to controls and patients without surgical interventions.CONCLUSION: Serum BA profiling in IBD patients that indicates impaired intestinal barrier function and increased detoxification is suitable for advanced diagnostic characterization and differentiation of IBD subgroups with defined clinical manifestations. | Carsten Gnewuch Gerhard Liebisch Thomas Langmann Benjamin Dieplinger Thomas Mueller Meinhard Haltmayer Hans Dieplinger Alexandra Zahn Wolfgang Stremmel Gerhard Rogler Gerd Schmitz | 2009 | World Journal of Gastroenterology2009，15，25： | 4 |
| 5 | The management of the soft tissues in Pilon fractures显示文摘 | Ruland RT Meinhard BP | 1993 | Clin Orthop1993，292，： | 1 |
| 6 | Power,Rules and Principles-Which Orientation for WTO/GATT Law?显示文摘 | Meinhard Hilf | 2001 | Journal of International Economic Law2001，，1： | 1 |
| 7 | ERCP or EUS for tissue diagnosis of biliary strictures? a prospective comparative study显示文摘 | Thomas R?sch Kim Hofrichter Eckart Frimberger Alexander Meining Peter Born Norbert Weigert Hans-Dieter Allescher Meinhard Classen Marius Barbur Ulrich Schenck Martin Werner | 2004 | Gastrointestinal Endoscopy2004，，3： | 1 |
| 8 | A prospective comparison of the diagnostic accuracy of ERCP, MRCP, CT, and EUS in biliary strictures显示文摘 | Thomas R?sch Alexander Meining Silke Frühmorgen Christian Zillinger Volker Schusdziarra Karin Hellerhoff Meinhard Classen Hermann Helmberger | 2002 | Gastrointestinal Endoscopy2002，，7： | 1 |
| 9 | Steerable Versus Nonsteerable Sheath Technology in Atrial Fibrillation Ablation: A Prospective, Randomized Study显示文摘 | Christopher Piorkowski Charlotte Eitel Sascha Rolf Kerstin Bode Philipp Sommer Thomas Gaspar Simon Kircher Ulrike Wetzel Abdul Shokor Parwani Leif-Hendrik Boldt Meinhard Mende Andreas Bollmann Daniela Husser Nikolaos Dagres Masahiro Esato Arash Arya Wilhe | 2011 | Circulation: Arrhythmia and Electrophysiology2011，，： | 1 |
| 10 | Spatial distribution of light absorption in organic photovoltaic devices显示文摘 | Gruber D P Meinhard G Papousek W | 2005 | Solar Energy2005，79，： | 1 |
| 11 | Identification of Ductile Damage and Fracture Parameters from the Small Punch Test using Neural Networks显示文摘 | Martin Abendroth Meinhard Kuna | 2006 | Engineering Fracture Mechanics2006，73，6： | 1 |
| 12 | Hydrogen peroxide is a regulator of ABI1,a protein phosphatase 2C from Arabidopsis显示文摘 | Meinhard M Grill E | 2001 | FEBS Lett2001，508，： | 1 |
| 13 | Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled trial显示文摘 | Nazzareno Galiè Marc Humbert Jean-Luc Vachiéry CarmineDario Vizza Meinhard Kneussl Alessandra Manes Olivier Sitbon Adam Torbicki Marion Delcroix Robert Naeije Marius Hoeper Ari Chaouat Sophie Morand Bruno Besse Gerald Simonneau | 2002 | Journal of the American College of Cardiology2002，，9： | 1 |
| 14 | The sensitivity of ABI2 to hydrogen peroxide links the abscisic acid-response regulator to redox signaling显示文摘 | Meinhard M Rodriguez P L Grill F | 2002 | Planta2002，214，： | 1 |
| 15 | Identification of ductile damage and fracture parameters from the small punch test using neural networks显示文摘 | Martin Abendroth Meinhard Kuna | 2006 | Engineering Fracture Mechanics2006，73，6： | 1 |
| 16 | Determination of deformation and failure properties of ductile materials by means of the small punch test and neural networks显示文摘 | Martin Abendroth Meinhard Kuna | 2003 | Computational Materials Science2003，28，34： | 1 |
| 17 | Long-term stability of endogenous B-type natriuretic peptide (BNP) and amino terminal proBNP (NT-proBNP) in frozen plasma samples显示文摘 | Thomas Mueller Alfons Gegenhuber Benjamin Dieplinger Werner Poelz Meinhard Haltmayer | 2004 | Clinical Chemistry and Laboratory Medicine2004，，8： | 1 |
| 18 | New nickel (Ⅱ) diimine complexes and the control of polyethylene microstructure by catalyst design 显示文摘 | MEINHARD D WEGNER M KIPIANI G | 2007 | J AmChemSoc2007，129，29： | 1 |
| 19 | Modern imaging methods versus clinical assessment in the evaluation of hospital in-patients with suspected pancreatic disease显示文摘 | Thomas R?sch Volker Schusdziarra Peter Born Werner Bautz Markus Baumgartner Kurt Ulm Reinhard Lorenz Hans-Dieter Allescher Paul Gerhardt J?rg-Rüdiger Siewert Meinhard Classen | 2000 | The American Journal of Gastroenterology2000，，9： | 1 |
| 20 | New Nickel(Ⅱ) Diimine Complexes and the Control of Polyethylene Micro- structure by Catalyst Design 显示文摘 | Meinhard D Wegner M Kipiani G | 2007 | JAm Chem Soe2007，129，29： | 1 |
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