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| 1 | A novel bioremediation strategy for petroleum hydrocarbon pollutants using salt tolerant Corynebacterium variabile HRJ4 and biochar显示文摘The present work aimed to develop a novel strategy to bioremediate the petroleum hydrocarbon contaminants in the environment.Salt tolerant bacterium was isolated from Dagang oilfield,China and identified as Corynebacterium variabile HRJ4 based on 16 S r RNA gene sequence analysis.The bacterium had a high salt tolerant capability and biochar was developed as carrier for the bacterium.The bacteria with biochar were most effective in degradation of n-alkanes(C16,C18,C19,C26,C28) and polycyclic aromatic hydrocarbons(NAP,PYR) mixture.The result demonstrated that immobilization of C.variabile HRJ4 with biochar showed higher degradation of total petroleum hydrocarbons(THPs) up to 78.9%after 7-day of incubation as compared to the free leaving bacteria.The approach of this study will be helpful in clean-up of petroleum-contamination in the environments through bioremediation process using eco-friendly and cost effective materials like biochar. | Hairong Zhang Jingchun Tang Lin Wang Juncheng Liu Ranjit Gajanan Gurav Kejing Sun | 2016 | Journal of Environmental Sciences2016，28，9： | 25 |
| 2 | An Outbreak of the SARS-CoV-2 Omicron Variant BA.1—Zhuhai City,Guangdong Province,China,January 13,2022显示文摘On January 13,2022,Zhuhai CDC received a notification that a coronavirus disease 2019(COVID-19)case was found in the fever clinic in nearby Zhongshan City.Zhuhai CDC promptly carried out large-scale population screening in three nearby counties.A total of 4 COVID-19 cases were found in Nanping County.34 cases were screened from close contacts,and 2 cases were reported from close contacts in other cities of Guangdong Province.The 20 cases were sequenced by Guangdong CDC and identified as the variant of concern(VOC)/Omicron variant BA.1.Since January 14,Zhuhai has carried out 8 rounds of nucleic acid screening for COVID-19 in the county where the cases occurred.Four large-scale nucleic acid screening tests for COVID-19 were conducted across the city,and no new community cases were reported after January 15. | Feng Ruan Xuebao Zhang Songjian Xiao Xihe Ni Xiling Yin Zhongwen Ye Guorong Chen Tingting Zhu Zeling Chen Gang Yao Long Chen Sichen Huang Huitao Huang Yi Zhou Heyan Wu Hui Huang Kejing Zhu Shanzi Huang Xiaoou Tang Min Kang Bosheng Li Wenhua Mei | 2022 | China CDC weekly2022，4，30： | 2 |
| 3 | Catalytic hydrothermal liquefaction of microalgae over metal incorporated mesoporous SBA-15 with high hydrothermal stability显示文摘Hydrothermal liquefaction(HTL)is one of the most promising technologies for conversion of microalgae,and catalysts with high hydrothermal stability are required for controllable HTL.In this article,SBA-15 incorporated with transition metals(Ni,Pd,Co and Ru)were synthetized via double-template method for catalytic HTL of microalgae.The results showed that metal incorporated SBA-15 represented high hydrothermal stability at 613 K.The incorporated Ni,Co and Ru was dispersed in SBA-15 enhancing the hydrothermal stability.The catalysts greatly influenced the chemical composition of the obtained bio-oil,which contained a higher percentage of furfural derivatives and a lower content of fatty acids and N-containing compounds,thus bio-oil quality was improved significantly.Higher hydrothermal stability and specific surface areas of Co-SBA-15 contribute to the highest preformation with 78.78%conversion and 24.11 wt%bio-oil yield.Metal incorporated SBA-15 provides a potential application for biomass conversion in high-temperature aqueous phase. | Yu Chen Kejing Wu Qisong Lin Yulong Wu Yin Tang Mingde Yang | 2018 | Carbon Resources Conversion2018，1，3： | 1 |
| 4 | iASPPsv antagonizes apoptosis induced by chemotherapeutic agents in MCF-7 cells and mouse thymocytes显示文摘 | Lin Wang Haiyan Xing Zheng Tian Leiwen Peng Yan Li Kejing Tang Qing Rao Min Wang Jianxiang Wang | 2012 | Biochemical and Biophysical Research Communications2012，，3： | 1 |
| 5 | Transplantation Therapy of Cats with Chronic Renal Failure显示文摘Dialysis therapy is not a radical cure of chronic renal failure in cats,while renal transplantation is the cure method.Renal transplanta-tion requires rigorous examination of donor and receptor,and the procedure is strictly sterile.The main points of renal transplantation are:renal artery and vein sutured to abdominal aorta and posterior vena cava,respectively;ureter sutured to bladder;minimizing the time of thermal ischemia.Cats should be given immunosuppressant before the operation,and the drug should be administered throughout the life.Various indicators should be monitored regularly to prevent the occurrence of immunological rejection. | Zuo Kejing Huang Mian Tang Xiaojun Chen Xuanjiao Wen Yan Chen Tanzipeng Sa Jiaqi Liang Yuzhen Zhang Malong Peng Shiming Zhi Guanglin Wu Qirui | 2018 | Animal Husbandry and Feed Science2018，10，2： | 1 |
| 6 | A novel multimodal prediction model based on DNA methylation biomarkers and low-dose computed tomography images for identifying early-stage lung cancer显示文摘Objective:DNA methylation alterations are early events in carcinogenesis and immune signalling in lung cancer.This study aimed to develop a model based on short stature homeobox 2 gene (SHOX2)/prostaglandin E receptor 4gene (PTGER4) DNA methylation in plasma,appearance subtype of pulmonary nodules (PNs) and low-dose computed tomography (LDCT) images to distinguish early-stage lung cancers.Methods:We developed a multimodal prediction model with a training set of 257 individuals.The performance of the multimodal prediction model was further validated in an independent validation set of 42 subjects.In addition,we explored the association between SHOX2/PTGER4 DNA methylation and driver gene mutations in lung cancer based on data from The Cancer Genome Atlas (TCGA) portal.Results:There were significant differences between the early-stage lung cancers and benign groups in the methylation levels.The area under a receiver operator characteristic curve (AUC) of SHOX2 in patients with solid nodules,mixed ground-glass opacity nodules and pure ground-glass opacity nodules were 0.693,0.497 and 0.864,respectively,while the AUCs of PTGER4 were 0.559,0.739 and 0.619,respectively.With the highest AUC of0.894,the novel multimodal prediction model outperformed the Mayo Clinic model (0.519) and LDCT-based deep learning model (0.842) in the independent validation set.Database analysis demonstrated that patients with SHOX2/PTGER4 DNA hypermethylation were enriched in TP53 mutations.Conclusions:The present multimodal prediction model could more efficiently distinguish early-stage lung cancer from benign PNs.A prognostic index based on DNA methylation and lung cancer driver gene alterations may separate the patients into groups with good or poor prognosis. | Jing Zhang Haohua Yao Chunliu Lai Xue Sun Xiujuan Yang Shurong Li Yubiao Guo Junhang Luo Zhihua Wen Kejing Tang | 2023 | Chinese Journal of Cancer Research2023，35，5： | 0 |
| 7 | Bronchoalveolar lavage fluid metagenomic next-generation sequencing assay for identifying pathogens in lung cancer patients显示文摘Background:For patients with lung cancer,timely identification of new lung lesions as infectious or non-infectious,and accurate identification of pathogens is very important in improving OS of patients.As a new auxiliary examination,metagenomic next-generation sequencing(mNGS)is believed to be more accurate in diagnosing infectious diseases in patients without underlying diseases,compared with conventional microbial tests(CMTs).We designed this study tofind out whether mNGS has better performance in distinguishing infectious and non-infectious diseases in lung cancer patients using bronchoalveolar lavagefluid(BALF).Materials and Methods:This study was a real-world retrospective review based on electronic medical records of lung cancer patients with bronchoalveolar lavage(BAL)and BALF commercial mNGS testing as part of clinical care from 1 April 2019 through 30 April 2022 at The First Affiliated Hospital of Sun Yat-sen University.164 patients were included in this study.Patients were categorized into the pulmonary non-infectious disease(PNID)group(n=64)and the pulmonary infectious disease(PID)group(n=100)groups based onfinal diagnoses.Results:BALF mNGS increased the sensitivity rate by 60%compared to CMTs(81%vs.21%,p<0.05),whereas there was no significant difference in specificity(75%vs.98.4%,p>0.1).Among the patients with PID,bacteria were the most common cause of infection.Fungal infections occurred in 32%of patients,and Pneumocystis Yersini was most common.Patients with Tyrosine kinase inhibitors(TKIs)therapy possess longer overall survival(OS)than other anti-cancer agents,the difference between TKIs and immuno-checkpoint inhibitors(ICIs)was insignificant(median OS TKIs vs.ICIs vs.Anti-angiogenic vs.Chemo vs.Radiotherapy=76 vs.84 vs.61 vs.58 vs.60).Conclusions:our study indicates that BALF mNGS can add value by improving overall sensitivity in lung cancer patients with potential pulmonary infection,and was outstanding in identifying Pneumocystis infection.It could be able to help physicians adjust the follow-up treatment to avoid the abuse of antibiotics. | JIYU WANG HUIXIA LI DEYUAN ZHOU LIHONG BAI KEJING TANG | 2024 | BIOCELL2024，48，4： | 0 |
| 8 | Electroacupuncture stimulating Zusanli(ST36),Sanyinjiao(SP6)in mice with collagen-induced arthritis leads to adenosine A2A receptor-mediated alteration of p38αmitogen-activated protein kinase signaling and inhibition of osteoclastogenesis显示文摘OBJECTIVE:To observe the effect of electroacupuncture(EA)stimulating Zusanli(ST36),Sanyinjiao(SP6)on inhibition of osteoclastogenesis and the role of the adenosine A2A receptor(A2AR)and the p38αMitogen-Activated Protein Kinase(MAPK)signaling pathway in mediating this effect.METHODS:Mice with collagen induced arthritis(CIA)received different treatments.Immunohistochemistry and western blotting were used to determine the levels of multiple signaling molecules in these joints[receptor activator of nuclear transcription factor-κB(NF-κB)ligand(RANKL),receptor activator of NF-κB(RANK),tumor necrosis factor receptor associated factor 6(TRAF6),p38α,NF-κB,and nuclear factor of activated T cells C1(NFATc1)].Osteoclasts were identified using tartrate-resistant acid phosphatase(TRAP)staining.RESULTS:The immunohistochemistry results indicated upregulation of p38α,NF-κB,and NFATc1 in the CIA-control and CIA-EA-SCH58261 groups,but reduced levels in the CIA-EA group.Western blotting indicated upregulation of RANKL,RANK,TRAF6,p38α,NF-κB,and NFATc1 in the CIA-control and CIA-EA-SCH58261 groups,but reduced expression in the CIA-EA group.Osteoclasts were more abundant in the CIA-control and CIA-EA-SCH58261 groups than in the CIA-EA group.CONCLUSIONS:EA treatment enhanced the A2AR activity and inhibited osteoclast formation by inhibition of RANKL,RANK,TRAF6,p38α,NF-κB,and NFATc1.SCH58261 reversed the effect of EA.These results suggest that EA regulated p38α-MAPK signaling by increasing A2AR activity,which inhibited osteoclastogenesis. | DU Zhongheng CONG Wenjie TANG Kejing ZHENG Qiqi SONG Zhiwei CHEN Yong YANG Su ZHANG Chunwu YE Tianshen | 2023 | Journal of Traditional Chinese Medicine2023，43，6： | 0 |
| 9 | De-emulsification of 2-ethyl-1-hexanol/water emulsion using oil-wet narrow channel combined with low-speed rotation显示文摘Low-speed rotation of disc in an internal circulation of a novel de-emulsification with rotation-dise horizental contactor(RHC-D) realized de-emulsification for O/W emulsions due to repeated coalescence in oil-wet narrow channels at a low rotation speed. For three emulsions included ethanol/water/2-ethyl-1-hexanol, ethanol/water/2-ethyl-1-hexanol/SDS(Sodium Dodecyl Sulfonate) and 2-ethyl-1-hexanol/water/SDS emulsion, deemulsification ratios of oil phase could reach 1, 1 and 0.67 respectively at 170 r·min-1, and de-emulsification ratios increased obviously after agitating 10 min. De-emulsification experiment in the seam indicated that oil droplet sizes in O/W emulsion became larger after de-emulsification. The main de-emulsification mechanism in RHCD was the coalescence of oil droplets in oil-wet narrow channels. With increase of the rotation speed, oil droplets dispersed better in the aqueous phase. However, de-emulsification effect enhanced due to the increase of the coalescence rate at a bit higher rotation speed. In addition, internal circulation made those O/W emulsions to be broken repeatedly, consequently de-emulsification ratio increased. Repeated de-emulsification through internal circulation might make continuous extraction of ethanol come true at a low rotation speed. | Ling Lü Kejing Wu You Tang Siyang Tang Bin Liang | 2018 | Chinese Journal of Chemical Engineering2018，26，10： | 0 |
| 10 | Loop CD20/CD19 CAR-T cells eradicate B-cell malignancies efficiently显示文摘CD19 chimeric antigen receptor(CAR)T cells have shown robust efficacy in relapsed and refractory acute lymphoblastic leukemia(R/R ALL),but compromising result in chronic lymphoblastic leukemia(CLL)and non-Hodgkin’s lymphoma(NHL).CD19-relapse and the lack of CAR-T cell persistence which result in treatment failure are considerable obstacles to overcome.CAR-T targeting CD20 is an option for salvaging CD19 CAR-T failure.Previous studies have established variant structures of bispecific CAR-T which could avoid antigen-loss and immune escape.Here,we constructed tandem and loop CAR structures targeting both CD19 and CD20 antigen.Bispecific CAR-T cells could eliminate either CD19 or CD20 negative lymphoma cells,suggesting they exhibited dual antigen targeting of CD19 and CD20.By comparing the efficiency of four bispecific CAR modified T cells,it was found that loop2019 CAR was the best structure among them to eradicate lymphoma cell lines and patients’primary lymphoma or CLL cells in a very low dose in vitro and prolong the survival time dramatically in lymphoma xenograft mice model.These data highlighted the potential of loop2019 CAR-T in clinical treatment. | Zhaoqi Chen Yan Liu Nianci Chen Haiyan Xing Zheng Tian Kejing Tang Qing Rao Yingxi Xu Ying Wang Min Wang Jianxiang Wang | 2023 | Science China(Life Sciences)2023，66，4： | 0 |
| 11 | Diverse molecular compositions of dissolved organic matter derived from different composts using ESI FT-ICR MS显示文摘Dissolved organic matter(DOM)derived from various composts can promote significant changes of soil properties.However,little is known about the DOM compositions and their similarities and differences at the molecular level.In this study,the molecular compositions of DOM derived from kitchen waste compost(KWC),green waste compost(GWC),manure waste compost(MWC),and sewage sludge compost(SSC)were characterized by electrospray ionization coupled with Fourier transform ion cyclotron resonance mass spectrometry(ESI FT-ICR MS).The molecular formulas were classified into four subcategories:CHO,CHON,CHOS,and CHONS.The KWC,MWC,and SSC DOM represented the highest fraction(35.8%-47.4%)of CHON subcategory,while the GWC DOM represented the highest fraction(68.4%)of CHO subcategory.The GWC DOM was recognized as the nitrogen-and sulfurdeficient compounds that were less saturated,more aromatic,and more oxidized compared with other samples.Further analysis of the oxygen,nitrogen-containing(N-containing),and sulfur-containing(S-containing)functional groups in the four subcategories revealed higher organic molecular complexity.Comparison of the similarities and differences of the four samples revealed 22.8%ubiquitous formulas and 17.4%,11.1%,10.7%,and 6.3%unique formulas of GWC,KWC,SSC,and MWC DOM,respectively,suggesting a large proportion of ubiquitous DOM as well as unique,source-specific molecular signatures.The findings presented herein provide new insight into the molecular characterization of DOM derived from various composts and demonstrated the potential role of these different compounds for agricultural utilization. | Minru Liu Yunkai Tan Kejing Fang Changya Chen Zhihua Tang Xiaoming Liu Zhen Yu | 2021 | Journal of Environmental Sciences2021，33，1： | 0 |
| 12 | Novel CD123×CD33 bicistronic chimeric antigen receptor(CAR)-T therapy has potential to reduce escape from single-target CAR-T with no more hematotoxicity显示文摘Dear Editor,Antigen escape is responsible for resistance[1]or disease relapse[2]from single-target chimeric antigen receptor(CAR)-T therapy.Dual-target CAR-T therapy has the potential to overcome the escape problem.However,the efficacy and safety assessment of dual-target CAR-T therapy in treating acute myeloid leukemia(AML)need further investigation.Tandem CAR-T therapy has been widely used in research and clinic.However,clustering of two connected single-chain variable fragments(scFvs)[3]and the inappropriate conjugation distance[4]pose a risk of damaging tandem CAR-T cells’function. | Zhenzhen Wang Yang Lu Yu Liu Junli Mou Xiaoyu Liu Manling Chen Ying Wang Yingxi Xu Qing Rao Haiyan Xing Kejing Tang Zheng Tian Bing Wang Wei Qi Min Wang Shaowei Qiu Dongsheng Xiong Jianxiang Wang | 2023 | Cancer Communications2023，43，10： | 0 |
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