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| 1 | Proteolytic-antiproteolytic balance and its regulation in carcinogenesis显示文摘Cancer development is essentially a tissue remodeling process in which normal tissue is substituted with cancer tissue. A crucial role in this process is attributed toproteolytic degradation of the extracellular matrix (ECM).Degradation of ECM is initiated by proteases, secreted by different cell types, participating in tumor cell invasion and increased expression or activity of every known class of proteases (metallo-, serine-, aspartyl-, and cysteine)has been linked to malignancy and invasion of tumor cells.Proteolytic enzymes can act directly by degrading ECM or indirectly by activating other proteases, which then degrade the ECM. They act in a determined order, resulting from the order of their activation. When proteases exert their action on other proteases, the end result is a cascade leading to proteolysis. Presumable order of events in this complicated cascade is that aspartyl protease (cathepsin D) activates cysteine proteases (e.g. cathepsin B) that can activate pro-uPA. Then active uPA can convert plasminogen into plasmin. Cathepsin B as well as plasmin are capable of degrading several components of tumor stroma and may activate zymogens of matrix metalloproteinases, the main family of ECM degrading proteases. The activities of these proteases are regulated by a complex array of activators,inhibitors and cellular receptors. Tn physiological conditions the balance exists between proteases and their inhibitors.Proteolytic-antiproteolytic balance may be of major significance in the cancer development. One of the reasons for such a situation is enhanced generation of free radicals observed in many pathological states. Free radicals react with main cellular components like proteins and lipids and in this way modify proteolytic-antiproteolytic balance and enable penetration damaging cellular membrane. All these lead to enhancement of proteolysis and destruction of ECM proteins and in consequence to invasion and metastasis. | Elzbieta Skrzydlewska Mariola Sulkowska Mariusz Koda Stanislaw Sulkowski | 2005 | World Journal of Gastroenterology2005，11，9： | 14 |
| 2 | Lipid peroxidation and antioxidant status in colorectal cancer显示文摘AIM: Reactive oxygen species (ROS) can induce carcinogenesis via DNA injury. Both enzymatic and non-enzymatic parameters participate in cell protection against harmful influence of oxidative stress. The aim of the present study was to assess the levels of final lipid peroxidation products like malondialdehyde (MDA) and 4-hydroxy-2-nonenal (4-HNE) in primary colorectal cancer. Moreover, we analysed the activity of main antioxidative enzymes, superoxide dismutase (Cu, Zn-SOD),catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione reductase (GSSRG-R) and the level of nonenzymatic antioxidants (glutathione, vitamins C and E).METHODS: Investigations were conducted in 81 primary colorectal cancers. As a control, the same amount of sample was collected from macroscopically unchanged colon regions of the most distant location to the cancer.Homogenisation of specimens provided 10% homogenates for our evaluations. Activity of antioxidant enzymes and level of glutathione were determined by spectrophotometry.HPLC revealed levels of vitamins C and E and served as a method to detect terminal products of lipid peroxidation in colorectal cancer.RESULTS: Our studies demonstrated a statistically significant increase in the level of lipid peroxidation products (MDA-Adc.muc.-2.65±0.48 nmol/g, Adc. G3-2.15±0.44 nmol/g, clinical Ⅳ stage 4.04±0.47 nmol/g, P<0.001 and 4-HNE-Adc.muc.-0.44±0.07 nmol/g, Adc. G3-0.44±0.10 nmol/g, clinical Ⅳstage 0.52±0.11 nmol/g, P<0.001) as well as increase of Cu,Zn-SOD (Adc.muc.-363±72 U/g, Adc. G3-318±48 U/g,clinical Ⅳ stage 421±58 U/g, P<0.001), GSH-Px (Adc.muc.-2143±623 U/g, Adc. G3-2005±591 U/g, clinical Ⅳ stage 2467±368 U/g, P<0.001) and GSSG-R (Adc. muc.-880±194 U/g,Adc. G3-795±228 U/g, dinical Ⅳ stage 951±243 U/g, P<0.001)in primary tumour comparison with normal colon (MDA1.39±0.15 nmol/g, HNE-0.29±0.03 nmol/g, Cu, Zn-SOD-117±25 U/g, GSH-Px-1723±189 U/g, GSSG-R-625±112 U/g)especially in mucinous and G3-grade adenocarcinomas as well as clinical Ⅳ stage of colorectal cancer. We also observed a decrease of CAT activity (Adc.muc. -40±14 U/g,clinical Ⅳ stage 33±18 U/g vs84±17 U/g, P<0.001) as well as a decreased level of reduced glutathione (clinical Ⅳ stage 150±48 nmol/g vs 167±15 nmol/g, P<0.05) and vitamins C and E (vit. C-clinical Ⅳ stage 325±92 nmol/g vs 513±64 nmol/g, P<0.001; vit. E-clinical Ⅳ stage 13.3±10.3nmol/g vs37.5±5.2 nmol/g).CONCLUSION: Colorectal carcinogenesis is associated with serious oxidative stress and confirms that gradual advancement of oxidative-antioxidative disorders is followed by progression of colorectal cancer. | Elzbieta Skrzydlewska Stanislaw Sulkowski Mariusz Koda Bogdan Zalewski Luiza Kanczuga-Koda Mariola Sulkowska | 2005 | World Journal of Gastroenterology2005，11，3： | 12 |
| 3 | Monocyte-to-lymphocyte ratio as a prognostic factor in peripheral whole blood samples of colorectal cancer patients显示文摘BACKGROUND Colorectal cancer is the third most common malignancy worldwide.Therefore,it is critically important to identify new useful markers that can be easily obtained in routine practice.Inflammation is a crucial issue in the pathogenesis and development of cancer.AIM To evaluate the prognostic value of absolute monocyte count,monocyte to lymphocyte ratio(MLR),the combination of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio(NLR-PLR),and combined platelet and neutrophilto-lymphocyte ratio(PLT-NLR)in peripheral blood samples of patients with colorectal cancer undergoing surgery.METHODS We conducted a retrospective study of 160 patients with colorectal cancer who underwent surgery,and 42 healthy controls.The status of absolute monocyte count,MLR,NLR-PLR and PLT-NLR was calculated on the basis of blood samples obtained before and after surgery.Haematologic factors were examined in correlation with the type of tumour growth,tumour size,histological type,percentage of mucinous component,grade of malignancy,Tumour-Node-Metastasis stage,venous,lymphatic and perineural invasion of cancer cells,status of lymph node invasion and the presence of cancer cell deposits.The Kaplan-Meier method and the long-rank test were used to compare survival curves.To determine independent prognostic factors,univariate and multivariate Cox proportional hazards regression models were applied.RESULTS The PLT-NLR status was correlated with tumour size and the presence of perineural invasion(P=0.015;P=-0.174,P=0.037).Moreover,high NLR-PLR and PLR-NLR ratios in the blood samples obtained after surgery were positively associated with histological type of cancer and percentage of the mucinous component(NLR-PLR:P=0.002;P=0.009;PLR-NLR status:P=0.002;P=0.007).The analysis of 5-year disease-free survival showed that the MLR of whole blood obtained after surgery[HR=2.903,95%CI:(1.368-6.158),P=0.005]and the status of lymph node metastasis[HR=0.813,95%CI:(0.653-1.013),P=0.050]were independent prognostic factors in colorectal cancer patients.CONCLUSION The postoperative MLR in whole blood samples can be used as an independent prognostic factor in patients diagnosed with colorectal cancer. | Katarzyna Jakubowska Mariusz Koda Małgorzata Grudzinska Luiza Kanczuga-Koda Waldemar Famulski | 2020 | World Journal of Gastroenterology2020，26，31： | 8 |
| 4 | Programmed cell death-1 inhibitor-related sclerosing cholangitis:A systematic review显示文摘BACKGROUND Programmed cell death-1(PD-1)inhibitor has been indicated for many types of malignancies.However,these inhibitors also cause immune-related adverse events.Hepatobiliary disorder is a phenotype of immune-related adverse event affecting 0%–4.5%of patients treated with PD-1 inhibitors.Recent studies have reported PD-1 inhibitor-related sclerosing cholangitis(SC);however,the associated clinical and pathological features are unclear.AIM To evaluate the clinical and pathological features of PD-1 inhibitor-related SC through a systematic review of the literature.METHODS The review,conducted using electronic databases in PubMed,was restricted to the period from January 2014 to September 2019 and focused on case reports/series on PD-1 inhibitor-related SC published in English.We scanned the references of the selected literature to identify any further relevant studies.Six cases previously studied by us,including three that have not yet been published,were included in this review.RESULTS Thirty-one PD-1 inhibitor-related SC cases were evaluated.Median age of patients was 67 years(range,43–89),with a male to female ratio of 21:10.The main disease requiring PD-1 inhibitor treatment was non-small cell lung cancer.Agents that caused PD-1 inhibitor-related SC were nivolumab(19 cases),pembrolizumab(10 cases),avelumab(1 case),and durvalumab(1 case).The median number of cycles until PD-1 inhibitor-related SC onset was 5.5(range,1–27).Abdominal pain or discomfort(35.5%,11/31)was the most frequent symptom.Blood serum tests identified liver dysfunction with a notable increase in biliary tract enzymes relative to hepatic enzymes,and a normal level of serum immunoglobulin G4.Biliary dilation without obstruction(76.9%,20/26),diffuse hypertrophy of the extrahepatic biliary tract(90.5%,19/21),and multiple strictures of the intrahepatic biliary tract(30.4%,7/23)were noted.In 11/23(47.8%)cases,pathological examination indicated that CD8+T cells were the dominant inflammatory cells in the bile duct or peribiliary tract.Although corticosteroids were mainly used for PD inhibitor-related SC treatment,the response rate was 11.5%(3/26).CONCLUSION Some clinical and pathological features of PD-1 inhibitor-related SC were revealed.To establish diagnostic criteria for PD-1 inhibitor-related SC,more cases need to be evaluated. | Takumi Onoyama Yohei Takeda Taro Yamashita Wataru Hamamoto Yuri Sakamoto Hiroki Koda Soichiro Kawata Kazuya Matsumoto Hajime Isomoto | 2020 | World Journal of Gastroenterology2020，26，3： | 7 |
| 5 | Evaluation of serum catnepsin B and D in relation to diniGopatnological staging of colorectal cancer显示文摘AIM: Proteolytic degradation of the extracellular matrix facilitates cancer invasion and promotes metastasis. The study aims at evaluation of preoperative and postoperative serum cathepsins B and D levels in correlation with selected anatomoclinical features of colorectal cancer.METHODS: Blood samples were collected from 63colorectal cancer patients before curative operation of the tumor 10 d later. Blood that was obtained from 20healthy volunteers, served as a control. The activity of cathepsin B was measured with Bz-DL-arginine-pNA as a substrate at pH 6.0, while cathepsin D activity was determined with urea-denatured hemoglobin (pH 4.0).RESULTS: The preoperative and postoperative activities of cathepsin B were significantly (P<0.00001) lower in serum of colorectal cancer patients than in control group.However, postoperative values of this protease were significantly increased in comparison with preoperative ones (P = 0.031). Activity of cathepsin D appeared to be significantly higher in colorectal cancer sera (P<0.00001)compared with controls. No statistically significant differences between preoperative and postoperative activity of cathepsin D were noted (P = 0.09). We revealed a strong linkage of cathepsins' levels with lymph node status and pT stage of colorectal cancer.CONCLUSION: Blood serum activities of cathepsin B and D depend on the time of sampling, tumor size and lymph node involvement. Significantly, increased activity of cathepsin D could indicate a malignant condition of the large intestine. In our work, the serum postoperative decrease of cathepsin B activity appears as an obvious concomitant of local lymph node metastasis-the wellknown clinicopathological feature of poor prognosis. | Elzbieta Skrzydlewska Mariola Sulkowska Andrzej Wincewicz Mariusz Koda Stanislaw Sulkowski | 2005 | World Journal of Gastroenterology2005，11，27： | 6 |
| 6 | Connexin 26 correlates with Bcl-xL and Bax proteins expression in colorectal cancer显示文摘AIM: To evaluate of Cx26 in correlation with Bcl-xL and Bax proteins in colorectal cancer.METHODS: Immunohistochemical staining using specific antibodies was performed to evaluate the protein expression of Cx26, Bax and Bcl-xL in 152 colorectal cancer samples and the correlations among studied proteins as well as the relationships between the expression of Cx26,Bax, Bcl-xL and clinicopathological features were analyzed.RESULTS: Both normal epithelial cells and carcinoma cells expressed Cx26, Bax and Bcl-xL, but Cx26 in cancer cells showed aberrant, mainly cytoplasmic staining. Expression of Cx26, Bax and Bcl-xL was observed in 55.9%, 55.5%and 72.4% of evaluated colorectal cancers respectively.We found the positive correlation between Cx26 and Bax expression (r = 0.561, P<0.0001), Cx26 and Bcl-xL (r = 0.409, P<0.0001) as well as between Bax and Bcl-xL (r = 0.486, P<0.0001). Association of Cx26, Bax and Bcl-xL expression with histological G2 grade of tumors was noted (P<0.005, P<0.001 and P<0.002 respectively).CONCLUSION: Cytoplasmic presence of Cx26 and its association with apoptotic markers could indicate a distinct role from physiological functions of Cx26 in cancer cells and it could suggest that connexins might be a target point for modulations of apoptosis with therapeutic implications. | Luiza Kanczuga-Koda Stanislaw Sulkowski Mariusz Koda Elzbieta Skrzydlewska Mariola Sulkowska | 2005 | World Journal of Gastroenterology2005，11，10： | 5 |
| 7 | The influence on liver parenchymal function and complications of radiofrequency ablation or the combination with transcatheter arterial embolization for hepatocellular carcinoma显示文摘 | Masahiko Koda Masaru Ueki Yoshiko Maeda Ken-Ichi Mimura Kinya Okamoto Yoshiko Matsunaga Manri Kawakami Keiko Hosho Yoshikazu Murawaki | 2004 | Hepatology Research2004，，1： | 2 |
| 8 | Ultrasound demonstration of mammographically detected microcalcifications in patients with ductal carcinomain situ of the breast显示文摘 | Takeshi Nagashima Hideyuki Hashimoto Keiko Oshida Shigeharu Nakano Naoto Tanabe Takashi Nikaido Keiji Koda Masaru Miyazaki | 2005 | Breast Cancer2005，，3： | 2 |
| 9 | 表现为透壁生长的局部侵袭性回肠炎性纤维样息肉显示文摘Morphologically,an inflammatory fibroid polyp(IFP)is usually centred in the submucosa.Extension of an IFP to the subserosa with destruction of the muscularis propria is exceedingly rare.Herein,we describe a 70-year-old woman who presented with right lower abdominal pain but was finally diagnosed with an IFP.Contrast-enhanced computed tomography revealed a target-like structure with a hypovascular mass at the leading edge,which was consistent with intussusception due to a tumour.Following surgery,the resected specimen displayed a mass measuring 4×3×3 cmthat was protruding into the lumen.Microscopically,the mass was centred in the submucosa,extending up to the mucosal surface and down to the subserosa and serosa.The muscularis mucosae and muscularis propria were destroyed focally.A PDGFRA gene mutation in exon 2(1837_1851 del)that was found in this case,as well as a highly infiltrative growth pattern,strongly supported the neoplastic nature of IFP. | Shogo Tajima Kenji Koda | 2018 | Gastroenterology Report2018，6，2： | 2 |
| 10 | Alphabetic and nonalphabetic L1 effects in English word identification: a comparison of Korean and Chinese English L2 learners显示文摘 | Min Wang Keiko Koda Charles A Perfetti | 2002 | Cognition2002，，2： | 2 |
| 11 | 第一语言对第二语言阅读能力发展的促进作用显示文摘元语言意识指的是对抽象语言的具体表征,能帮助学习者分析词语的语音及语素成分。元语言意识反映了学习者对语言结构的敏感度,对不同类型语言的阅读发展均有重要意义,且元语言意识能够在不同语言内相互迁移。基于第二语言(二语)阅读的研究表明,二语阅读者只要在一门语言中建立了元语言意识,就能有助于另一门语言的阅读发展。本文首先简要回顾语言共性与特性对阅读能力发展的影响及其与元语言意识发展之间的关系,然后描述第一语言(一语)元语言意识对二语阅读能力发展的促进作用,最后探讨二语语言知识如何改变一语的作用。 | Keiko Koda 柯思慧 | 2018 | 国际汉语教学研究2018，，2： | 2 |
| 12 | Effects of Brain-Derived Neurotrophic Factor (BDNF) on Compression-Induced Spinal Cord Injury: BDNF Attenuates Down-Regulation of Superoxide Dismutase Expression and Promotes Up-Regulation of Myelin Basic Protein Expression显示文摘 | OSAMU IKEDA MASAZUMI MURAKAMI HIDETOSHI INO MASASHI YAMAZAKI MASAO KODA CHIKAO NAKAYAMA HIDESHIGE MORIYA | 2002 | JNEN: Journal of Neuropathology & Experimental Neurology2002，，2： | 2 |
| 13 | Slug expression is an independent prognostic parameter for poor survival in colorectal carcinomapatients显示文摘 | Shioiri M Shida T Koda K | 2006 | Br J Cancer2006，94，17： | 1 |
| 14 | Delayed treatment with Rho-kinase inhibitor dose not enhance axonal regeneration or functional recovery after spinal cord injury in rats显示文摘 | Nisho Y Koda M Kitajo K | 2006 | Exp Neurol2006，200，： | 1 |
| 15 | Analyses of work-relatedness of health problems among truck drivers by questionnaire survey显示文摘 | Koda S Yasuda N Sugihara Y | 2000 | Sangyo Eiseigaku Zasshi2000，42，1： | 1 |
| 16 | Comparative effect of diferent types of cytokinin for shoot formation and plant regeneration from leaf-derived callus oflavender(Lavandula vera DC) 显示文摘 | Tsuro M Koda M | 1999 | Scientia Horticultume1999，81，3： | 1 |
| 17 | Hepatocellular careinoma with sarcomatous change arising after radiofrequency ablation for well differentiated hepatocellular carcinoma 显示文摘 | Koda M Maeda Y Matsunaga Y | 2003 | Hepatol Res2003，27，2： | 1 |
| 18 | Peripheral bloods levels of matrix metalloproteinase-9 and-2 are elevated in parients with acute coronary syndromes显示文摘 | Hisashi Kai Hisao I koda Hida | 1998 | Am Coll Cardial1998，32，2： | 1 |
| 19 | Brain-derived neurotrophic factor suppresses anoikis-indueed death of Schwaan cells显示文摘 | Koda M Someya Y Nishio Y | 2008 | Neu- rosci Lett2008，444，2： | 1 |
| 20 | Expression of leptin, leptin receptor, and hypoxia-inducible factor 1 alpha in human endometrial cancer 显示文摘 | Koda M Sulkowska M Wincewicz A | 2007 | Ann N Y Acad Sci2007，1095，： | 1 |
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