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| 1 | Synthesis of pillar[7]arene显示文摘支柱的第一合成[7 ] arene 与二个方法被报导。方法 A:有在 CHCl3 的 paraformaldehyde 的 1,4-dimethoxybenzene (1 ) 的催化 FeCl3 的冷凝作用反应给了 dimethoxypillar [7 ] arene (3 ) 。方法 B:p-toluenesulfonic 酸催化在 CH2Cl2 的 -1,4-dimethoxybenzene (2 ) 给了化合物 3 的 2,5 二度(benzyloxymethyl ) 的冷凝作用反应。有 BBr3 的 3 的 Demethylation 给了支柱[7 ] arene (4 ) 。支柱[7 ] arene 可能是在 hostguest 化学的一位观点 macrocyclic 主人。 | Yu Chen Hong Qi Tao Yu Hui Kou Herbert Meier Jian Long Fu De Rong Cao | 2012 | Chinese Chemical Letters2012，23，5： | 3 |
| 2 | Enhanced activity and stability of Pt catalysts on functionalized graphene sheets for electrocatalytic oxygen reduction显示文摘 | Rong Kou Yuyan Shao Donghai Wang Mark H. Engelhard Ja Hun Kwak Jun Wang Vilayanur V. Viswanathan Chongmin Wang Yuehe Lin Yong Wang Ilhan A. Aksay Jun Liu | 2009 | Electrochemistry Communications2009，，5： | 1 |
| 3 | Enhanced activity and stability of Pt catalysts on functionalized graphene sheets for electrocatalyticoxygen reduction显示文摘 | Rong Kou Yuyan Shao Donghai Wang | 2009 | Electrochemistry Communications2009，115，： | 1 |
| 4 | Ternary self-as-sembly of ordered metal oxide graphene nanocomposites for elec-trochemical energy storage显示文摘 | WANG Dong-hai KOU Rong CHOI D | 2010 | ACS Nano2010，4，3： | 1 |
| 5 | Ternary Self-Assembly of OrderedMetal Oxide Graphene Nanocomposites for Electrochemical Energy Storage显示文摘 | Donghai Wang Rong Kou Daiwon Choi Zhenguo Yang Zimin Nie Juan Li | 2010 | ACS NANO2010，3，： | 1 |
| 6 | 3-溴丙酮酸对秀丽隐杆线虫的毒性和代谢的影响(英文)显示文摘目的:通过3-溴丙酮酸(3-BrPA)处理秀丽隐杆线虫(Caenorhabditis elegans),观察3-BrPA对线虫的毒性和生存周期的影响。通过秀丽隐杆线虫RNA干扰(RNAi)和突变株,分析3-BrPA对线虫糖酵解途径己糖激酶家族和药物代谢的关键酶细胞色素P450(cytochrome P450,CYP)家族的影响。创新点:首次报道了3-BrPA对秀丽隐杆线虫有毒性作用,己糖激酶是3-BrPA对线虫作用的重要靶点,而CYP-35A家族是线虫代谢3-BrPA的主要酶类。方法:用不同浓度的3-BrPA处理秀丽隐杆线虫,每24 h监测一次存活率;用实时荧光定量聚合酶链反应(qPCR)检测代谢相关基因的表达;通过RNAi沉默己糖激酶家族基因hxk-1、hxk-2和hxk-3;计算3-BrPA处理hxk家族RNAi株和细胞色素P450 cyp-35家族突变株后的致死中浓度(LC50)。结论:3-BrPA对线虫有明显的毒性效应(图1);与对照组比较,3-BrPA处理组的线虫平均寿命明显缩短(图2);3-BrPA处理线虫后hxk-1、hxk-2和hxk-3的信使RNA(mRNA)表达明显升高(P<0.05,图5);3-BrPA处理hxk RNAi株后的LC50均减小(P<0.05,表5);3-BrPA处理cyp-35突变株后的LC50也均减小(P<0.05,表6)。综上所述,3-BrPA的毒性与其对秀丽隐杆线虫己糖激酶代谢的影响密切相关;CYP-35家族在线虫中对3-BrPA代谢中起着关键作用。 | Qiao-ling GU Yan ZHANG Xi-mei FU Zhao-lian LU Yao YU Gen CHEN Rong MA Wei KOU Yong-mei LAN | 2020 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2020，21，1： | 1 |
| 7 | Enhanced activity and stability of Pt catalysts on functionalized graphene sheets for electrocatalytic oxygen reduction显示文摘 | Rong Kou Yuyan Shao Donghai Wang Mark H. Engelhard Ja Hun Kwak Jun Wang Vilayanur V. Viswanathan Chongmin Wang Yuehe Lin Yong Wang Ilhan A. Aksay Jun Liu | 2009 | Electrochemistry Communications2009，，5： | 1 |
| 8 | Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial–mesenchymal transition in hepatocellular carcinoma显示文摘 | Qing-Min Fan Ying-Ying Jing Guo-Feng Yu Xing-Rui Kou Fei Ye Lu Gao Rong Li Qiu-Dong Zhao Yang Yang Zheng-Hua Lu Li-Xin Wei | 2014 | Cancer Letters2014，，： | 1 |
| 9 | Stabilization of electrocatalytic metal nanoparticles at metal-metal oxide-gra- phene triple junction points 显示文摘 | KOU Rong SHAO Yuyan MEI Donghai | 2011 | J Am Chem Soc2011，133，8： | 1 |
| 10 | A brain structural connectivity biomarker for autism spectrum disorder diagnosis in early childhood显示文摘Background:Autism spectrum disorder(ASD)is associated with altered brain development,but it is unclear which specific structural changes may serve as potential diagnostic markers,particularly in young children at the age when symptoms become fully estab-lished.Furthermore,such brain markers need to meet the requirements of precision medicine and be accurate in aiding diagnosis at an individual rather than only a group level.Objective:This study aimed to identify and model brain-wide differences in structural connectivity using diffusion tensor imaging(DTI)in young ASD and typically developing(TD)children.Methods:A discovery cohort including 93 ASD and 26 TD children and two independent validation cohorts including 12 ASD and 9 TD children from three different cities in China were included.Brain-wide(294 regions)structural connectivity was measured using DTI(fractional anisotropy,FA)together with symptom severity and cognitive development.A connection matrix was constructed for each child for comparisons between ASD and TD groups.Pattern classification was performed on the discovery dataset and the resulting model was tested on the two independent validation datasets.Results:Thirty-three structural connections showed increased FA in ASD compared to TD children and associated with both autistic symptom severity and impaired general cognitive development.The majority(29/33)involved the frontal lobe and comprised five different networks with functional relevance to default mode,motor control,social recognition,language and reward.Overall,clas-sification achieved very high accuracy of 96.77%in the discovery dataset,and 91.67%and 88.89%in the two independent validation datasets.Conclusions:Identified structural connectivity differences primarily involving the frontal cortex can very accurately distinguish novel individual ASD from TD children and may therefore represent a robust early brain biomarker which can address the requirements of precision medicine. | Xi Jiang Xiao-Jing Shou Zhongbo Zhao Yuzhong Chen Fan-Chao Meng Jiao Le Tian-Jia Song Xin-Jie Xu Weitong Guo Xiaoyan Ke Xiao-E Cai Weihua Zhao Juan Kou Ran Huo Ying Liu Hui-Shu Yuan Yan Xing Ji-Sheng Han Song-Ping Han Yun Li Hua Lai Lan Zhang Mei-Xiang Jia Jing Liu Xuan Liu Keith M.Kendrick Rong Zhang | 2023 | Psychoradiology2023，3，1： | 0 |
| 11 | Prediction of pandemic risk for animal-origin coronavirus using a deep learning method显示文摘Background:Coronaviruses can be isolated from bats,civets,pangolins,birds and other wild animals.As an animalorigin pathogen,coronavirus can cross species barrier and cause pandemic in humans.In this study,a deep learning model for early prediction of pandemic risk was proposed based on the sequences of viral genomes.Methods:A total of 3257 genomes were downloaded from the Coronavirus Genome Resource Library.We present a deep learning model of cross-species coronavirus infection that combines a bidirectional gated recurrent unit network with a one-dimensional convolution.The genome sequence of animal-origin coronavirus was directly input to extract features and predict pandemic risk.The best performances were explored with the use of pre-trained DNA vector and attention mechanism.The area under the receiver operating characteristic curve(AUROC)and the area under precision-recall curve(AUPR)were used to evaluate the predictive models.Results:The six specifc models achieved good performances for the corresponding virus groups(1 for AUROC and 1 for AUPR).The general model with pre-training vector and attention mechanism provided excellent predictions for all virus groups(1 for AUROC and 1 for AUPR)while those without pre-training vector or attention mechanism had obvi‑ously reduction of performance(about 5–25%).Re-training experiments showed that the general model has good capabilities of transfer learning(average for six groups:0.968 for AUROC and 0.942 for AUPR)and should give reason‑able prediction for potential pathogen of next pandemic.The artifcial negative data with the replacement of the coding region of the spike protein were also predicted correctly(100%accuracy).With the application of the Python programming language,an easy-to-use tool was created to implements our predictor.Conclusions:Robust deep learning model with pre-training vector and attention mechanism mastered the features from the whole genomes of animal-origin coronaviruses and could predict the risk of cross-species infection for early warning of next pandemic. | Zheng Kou Yi‑Fan Huang Ao Shen Saeed Kosari Xiang‑Rong Liu Xiao‑Li Qiang | 2021 | Infectious Diseases of Poverty2021，10，5： | 0 |
| 12 | Stress-induced phase transformation and phase boundary sliding in Ti: An atomically resolved in-situ analysis显示文摘In-situ tensile experiments on pure Ti were performed in a transmission electron microscope at room temperature.The dynamic process of stress-induced hexagonal closed-packed(hcp)to face-centered cu-bic(fcc)structural transformation ahead of a crack tip was captured at the atomic level.Intriguingly,a sliding behavior of the ensuing(0001)hcp/(1¯11)_(fcc) phase boundary was observed to further accommodate the plastic deformation until crack initiation.The sliding was accomplished via the successive conserva-tive glide of extended dislocations along the(0001)hcp/(1¯11)_(fcc) phase boundary.A molecular dynamics simulation was carried out to corroborate the experiments and the results confirm the new dislocation-mediated sliding mechanism. | Zongde Kou Xuteng Li Rong Huang Lixia Yang Yanqing Yang Tao Feng Si Lan Gerhard Wilde Qingquan Lai Song Tang | 2023 | Journal of Materials Science & Technology2023，，21： | 0 |
| 13 | Exploring Sulfur Chemistry in TMC-1 with NSRT显示文摘There have been several studies on sulfur depletion in dense cores like TMC-1(Taurus Molecular Cloud 1),employing updated reaction networks for sulfur species to explain the missing sulfur in the gas within dense clouds.Most of these studies used a C/O ratio of 0.7 or lower.We present NSRT(NanShan 26m Radio Telescope)observations of TMC-1 alongside results from time-dependent chemical simulations using an updated chemical network.Our findings highlight the impact of the C/O ratio on the gas-phase evolution of C2S and C3S.The simulation results show that the C/O ratio is an important parameter,playing a fundamental role in determining the gas-phase abundances of sulfur species in dense cores. | Wasim Iqbal Xiaohu Li Juan Tuo Ryszard Szczerba Yanan Feng Zhenzhen Miao Jiangchao Yang Jixing Ge Gleb Fedoseev Donghui Quan Qiang Chang Chuan-Lu Yang Tao Yang Gao-Lei Hou Yong Zhang Xuan Fang Xia Zhang Fangfang Li Rong Ma Xiaomin Song Zhiping Kou Yuxuan Sun | 2024 | Chinese Physics Letters2024，41，2： | 0 |
| 14 | Activation of the 5-hydroxytryptamine 4 receptor ameliorates tight junction barrier dysfunction in the colon of type 1 diabetic mice显示文摘Hyperglycemia drives dysfunction of the intestinal barrier.5-Hydroxytryptaine 4 receptor(5-HT4R)agonists have been considered therapeutics for constipation in clnic.However,the roles of 5-HT4R activation in mucosa should be fully realized.Here,we investigate the effects of 5-HT4R activation on diabetes-induced disruption of the tight junction(TJ)barrier in the colon.Not surprisingly,the TJ barrier in diabetic mice with or without 5-HT4R is tremendously destroyed,as indicated by increased serum fluorescein isothiocyanate(FITC)-dextran and decreased transepithelial electrical resistance(TER).Simultaneously,decreased expressions of TJ proteins are shown in both wild-type(WT)and 5-HT4R knockout(KO)mice with diabetes.Notably,chronic treatment with intraperitoneal injection of a 5-HT4R agonist in WT mice with diabetes repairs the TJ barrier and promotes TJ protein expressions,including occludin,claudin-1 and ZO-1,in the colon,whereas a 5-HT4R agonist does not improve TJ barrier function or TJ protein expressions in 5-HT4R KO mice with diabetes.Furthermore,stimulation of 5-HT4R inhibits diabetesinduced upregulation of myosin light chain kinase(MLCK),Rho-associated coiled coil protein kinase 1(ROCK1),and phosphorylated myosin light chain(p-MLC),which are key molecules that regulate TJ integrity,in the colonic mucosa of WT mice.However,such action induced by a 5-HT4R agonist is not observed in 5-HT4R KO mice with diabetes.These findings indicate that 5-HT4R activation may restore TJ integrity by inhibiting the expressions of MLCK,ROCK1 and p-MLC,improving epithelial barrier function in diabetes. | Shasha Hu Yueting Kou Xiaochen Liu Weifang Rong Hongxiu Han Guohua Zhang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，12： | 0 |
| 15 | Traditional Chinese medicine nursing protocols for COVID-19显示文摘In order to facilitate nurses to understand the key points of COVID‑19’s common syndromes,master the key points of nursing with syndrome differentiation,use the advantages of traditional Chinese medicine(TCM)nursing characteristics,standardize TCM nursing behavior,and improve the TCM nursing effect,through the search of relevant information,combined with the clinical practice experience of more than 1 month of front‑line anti‑epidemic nursing staff,the TCM nursing protocols for COVID‑19(draft)were formed.After four rounds of expert consultation and discussion,and 15 times of collation and revision,the final version of TCM nursing protocols for COVID‑19 was formed.The TCM nursing protocols for COVID‑19 include the following five parts:key points of common syndromes,nursing for common symptoms/syndromes,TCM special nursing,healthy guidance,and difficulties in nursing;it is scientific and practical,and can provide clinical guidance for nursing of patients with COVID‑19. | Mei‑Zhen LIN Qiao‑Mei WU Yu LIU Zhong‑De ZHANG Gang‑Yi PENG Chang‑Xiu WAN Xiao‑Pan WANG Ying‑Rui MA Ping XIONG Hui‑Chao CHEN Qiu‑Ying DENG Li‑Li DENG Ding‑Rong QIU Lin WEI Jiu‑Hong YOU Yang‑Chen LIU Guang‑Qing ZHANG Li‑Xia KOU Ming‑Ming XU Yu‑Mei CHEN Yin‑Qin ZHONG Xiao‑Qin LU Han‑Jiao LIU Jin ZHOU Hong YE Xiao‑Zhen GONG Shi‑Miao LUO Xi‑Yan HU | 2020 | Journal of Integrative Nursing2020，2，2： | 0 |
| 16 | Fair E-Payment Protocol Based on Simple Partially Blind Signature Scheme显示文摘This paper presents a simple partially blind signature scheme with low computation. By converse using the partially blind signature scheme, we build a simple fair e-payment protocol. In the protocol, two participants achieve the goals of exchanging their digital signatures from each other in a simple way. An ad- vantage of this scheme is that this approach does not require the intervention of the third party in any case. The low-computation property makes our scheme very attractive for mobile client and smart-card implementation in many e-commerce applications. | LIU Jingwei SUN Rong KOU Weidong | 2007 | Wuhan University Journal of Natural Sciences2007，12，1： | 0 |
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