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| 1 | Exogenous plant MIR168a specifically targets mammalian LDLRAPI: evidence of cross-kingdom regulation by microRNA显示文摘 | Lin Zhang Dongxia Hou Xi Chen Donghai Li Lingyun Zhu Yuj ing Zhang Jing Li Zhen Bian Xiangying Liang Xing Cai Yuan Yin Cheng Wang Tianfu Zhang Dihan Zhu Dianmu Zhang Jie Xu Qun Chen Yi Ba Jing Liu Qiang Wang Jianqun Chen Jin Wang Meng Wang Qipeng Zhang Junfeng Zhang Ke Zen Chen-Yu Zhang | 2012 | Cell Research2012，22，1： | 155 |
| 2 | 琥珀酸发酵生产工艺及其产品市场显示文摘发酵法生产的琥珀酸在食品、医药、表面活性剂、洗涤剂、绿色溶剂、生物可降解塑料和动植物生长刺激物等领域有广泛的应用前景,其衍生物的化学制品市场潜力每年超过2.7×l08kg。瘤胃微生物Actinobacillussuccinogenes以葡萄糖为底物发酵生产琥珀酸盐的产率可达110g/L。发酵生产工艺的改进,特别是产物提取技术的进步大大降低了生产的成本,使得发酵法生产琥珀酸在经济效益上极具吸引力。 | 詹晓北 朱一晖 Donghai Wang | 2003 | 食品科技2003，28，2： | 40 |
| 3 | A comparison of two kinds of eastward-moving mesoscale vortices during the mei-yu period of 2010显示文摘During the mei-yu period,the east edge of the Tibetan Plateau and the Dabie Mountain are two main sources of eastward-moving mesoscale vortices along the mei-yu front(MYF).In this study,an eastward-moving southwest vortex(SWV) and an eastward-moving Dabie vortex(DBV) during the mei-yu period of 2010 have been investigated to clarify the main similarities and differences between them.The synoptic analyses reveal that the SWV and DBV were both located at the lower troposphere;however,the SWV developed in a 'from top down' trend,whereas the DBV developed in an opposite way.There were obvious surface closed low centers corresponding to the DBV during its life span,whereas for the SWV,the closed low center only appeared at the mature stage.Cold and warm air intersected intensely after the formation of both the vortices,and the cold advection in the SWV case was stronger than that in the DBV case,whereas the warm advection in the DBV case was more intense than that in the SWV case.The Bay of Bengal and the South China Sea were main moisture sources for the SWV,whereas for the DBV,in addition to the above two moisture sources,the East China Sea was also an important moisture source.The vorticity budget indicates that the convergence was the most important common factor conducive to the formation,development,and maintenance of the SWV and DBV,whereas the conversion from the vertical vorticity to the horizontal one(tilting) was the most important common factor caused the dissipation of both of the vortices.The kinetic energy(KE) budget reveals that the KE generation by the rotational wind was the dominant factor for the enhancement of KE associated with the SWV,whereas for the DBV,the KE transport by the rotational wind was more important than the KE generation.The KE associated with the SWV and the DBV weakened with different mechanisms during the decaying stage.Furthermore,the characteristics of baroclinic and barotropic energy conversions during the life spans of both vortices indicate that the SWV and DBV both belong to the kind of subtropical mesoscale vortices. | FU ShenMing YU Fei WANG DongHai XIA RuDi | 2013 | Science China Earth Sciences2013，56，2： | 18 |
| 4 | Assessment of the GPM and TRMM Precipitation Products Using the Rain Gauge Network over the Tibetan Plateau显示文摘Using high-quality hourly observations from national-level ground-based stations, the satellite-based rainfall products from both the Global Precipitation Measurement(GPM) Integrated Multisatellit E Retrievals for GPM(IMERG) and its predecessor, the Tropical Rainfall Measuring Mission(TRMM) Multi-satellite Precipitation Analysis(TMPA), are statistically evaluated over the Tibetan Plateau(TP), with an emphasis on the diurnal variation.The results indicate that:(1) the half-hourly IMERG rainfall product can explicitly describe the diurnal variation over the TP, but with discrepancies in the timing of the greatest precipitation intensity and an overestimation of the maximum rainfall intensity over the whole TP. In addition, the performance of IMERG on the hourly timescale, in terms of the correlation coefficient and relative bias, is different for regions with sea level height below or above 3500 m;(2) the IMERG products, having higher correlation and lower root-mean-square error, perform better than the TMPA products on the daily and monthly timescales; and(3) the detection ability of IMERG is superior to that of TMPA, as corroborated by a higher Hanssen and Kuipers score, a higher probability of detection, a lower false alarm ratio, and a lower bias. Compared to TMPA, the IMERG products ameliorate the overestimation across the TP. In conclusion,GPM IMERG is superior to TRMM TMPA over the TP on multiple timescales. | Sijia ZHANG Donghai WANG Zhengkun QIN Yaoyao ZHENG Jianping GUO | 2018 | Journal of Meteorological Research2018，32，2： | 18 |
| 5 | Supercritical water oxidation of polyvinyl alcohol and desizing wastewater: Influence of NaOH on the organic decomposition显示文摘Polyvinyl alcohol is a refractory compound widely used in industry. Here we report supercritical water oxidation of polyvinyl alcohol solution and desizing wastewater with and without sodium hydroxide addition. However, it is difficult to implement complete degradation of organics even though polyvinyl alcohol can readily crack under supercritical water treatment. Sodium hydroxide had a significant catalytic effect during the supercritical water oxidation of polyvinyl alcohol. It appears that the OH ion participated in the C-C bond cleavage of polyvinyl alcohol molecules, the CO2-capture reaction and the neutralization of intermediate organic acids, promoting the overall reactions moving in the forward direction. Acetaldehyde was a typical intermediate product during reaction. For supercritical water oxidation of desizing wastewater, a high destruction rate (98.25%) based on total organic carbon was achieved. In addition, cases where initial wastewater was alkaline were favorable for supercritical water oxidation treatment, but salt precipitation and blockage issues arising during the process need to be taken into account seriously. | Jie Zhang Shuzhong Wang Yang Guo Donghai Xu Yanmeng Gong Xingying Tang | 2013 | Journal of Environmental Sciences2013，25，8： | 15 |
| 6 | H5N1 influenza virus-specific miRNA-like small RNA increases cytokine production and mouse mortality via targeting poly(rC)-binding protein 2显示文摘H5N1 流行性感冒病毒的感染在所有流行性感冒病毒之中引起最高的死亡。位于如此的高病毒的致病力下面的机制不完全地被理解。这里,我们报导 H5N1 流行性感冒病毒编码象 microRNA 一样小 RNA, miR-HA-3p,它从茎被处理由 Argonaute 2 的包含环的病毒的 RNA 先锋,和戏在在 H5N1 感染期间提高 cytokine 生产的一个角色。miR-HA-3p poly 指向的机械学的学习表演(rC ) 有约束力的蛋白质 2 (PCBP2 ) 并且压制它的表达式。与 PCBP2 being 一致 RIG-I/MAVS-mediated 抗病毒的天生的免疫的一个重要否定管理者,由 miR-HA-3p 的 PCBP2 表示的抑制在感染 H5N1 的人的巨噬细胞和老鼠支持 cytokine 生产病毒。我们断定 miR-HA-3p 是首先识别的流行性感冒编码病毒的象 microRNA 一样功能的 RNA 碎片和贡献导致 H5N1 的 cytokine 暴风雨和死亡的一个新奇毒力因素。 | Xihan Li Zheng Fu Hongwei Liang Yanbo Wang Xian Qi Meng Ding Xinlei Sun Zhen Zhou Ying Huang Hongwei Gu Limin Li Xi Chen Donghai Li Quan Zhao Fenyong Li Hua Wang Jin Wang Ke Zen Chen-Yu Zhang | 2018 | Cell Research2018，28，2： | 12 |
| 7 | Identification of aberrant cell cycle regulation in Epstein-Barr virus-associated nasopharyngeal carcinoma by cDNA microarray and gene set enrichment analysis显示文摘 | Wenling Zhang Zhaoyang Zeng Yanhong Zhou Wei Xiong Songqing Fan Lan Xiao Donghai Huang Zheng Li Dan Li Minghua Wu Xiaoling Li Shourong Shen Rong Wang Li Cao Ke Tang Guiyuan Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 11 |
| 8 | Land-surface processes and summer-cloud-precipitation characteristics in the Tibetan Plateau and their effects on downstream weather:a review and perspective显示文摘Correct understanding of the land-surface processes and cloud-precipitation processes in the Tibetan Plateau(TP)is an important prerequisite for the study and forecast of the downstream activities of weather systems and one of the key points for understanding the global atmospheric movement.In order to show the achievements that have been made,this paper reviews the progress on the observations for the atmospheric boundary layer,land-surface heat fluxes,cloud-precipitation distributions and vertical structures by using ground-and space-based multiplatform,multisensor instruments and the effect of the cloud system in the TP on the downstream weather.The results show that the form drag related to the topography,land-atmosphere momentum and scalar fluxes is an important part of the parameterization process.The sensible heat flux decreased especially in the central and northern TP caused by the decrease in wind speeds and the differences in the ground-air temperatures.Observations show that the cloud and precipitation over the TP have a strong diurnal variation.Studies also show the compressed-air column in the troposphere by the higher-altitude terrain of the TP makes particles inside clouds vary at a shorter distance in the vertical direction than those in the non-plateau area so that precipitation intensity over the TP is usually small with short duration,and the vertical structure of the convective precipitation over the TP is obviously different from that in other regions.In addition,the influence of the TP on severe weather downstream is preliminarily understood from the mechanism.It is necessary to use model simulations and observation techniques to reveal the difference between cloud precipitation in the TP and non-plateau areas in order to understand the cloud microphysical parameters over the TP and the processes of the land boundary layer affecting cloud,precipitation and weather in the downstream regions. | Yunfei Fu Yaoming Ma Lei Zhong Yuanjian Yang Xueliang Guo Chenghai Wang Xiaofeng Xu Kun Yang Xiangde Xu Liping Liu Guangzhou Fan Yueqing Li Donghai Wang | 2020 | National Science Review2020，7，3： | 10 |
| 9 | Structural basis of AMPK regulation by adenine nucleotides and glycogen显示文摘激活安培的蛋白质 kinase (AMPK ) 为糖尿病,肥胖,和癌症的治疗是一个中央细胞的精力传感器和精力动态平衡,和一个有希望的药目标的管理者。这里我们人的 α 的现在的低分辨率的水晶结构; 1 β 2 γ 1 holo-AMPK 建筑群跳了到它的 allosteric 调节的人安培和肝糖模仿 cyclodextrin,两个在 phosphorylated (4.05 Å) 并且 non-phosphorylated (4.60 Å) 状态。另外,我们解决了 2.95 Å人的 kinase 领域(KD ) 的结构跳了到邻近的 autoinhibitory 领域(帮助) 并且表现了广泛生物化学并且 mutational 研究。一起,这些研究由安培和肝糖说明 allosteric AMPK 调整的内在的机制,其绑定改变在交替的帮助(安培) 和糖类绑定模块(肝糖) 之间的 equilibria 相互作用。 | Xiaodan Li Lili Wang X Edward Zhou Jiyuan Ke Parker W de Waal Xin Gu M H Eileen Tan Dongye Wang Donghai Wu H Eric Xu Karsten Melcher | 2015 | Cell Research2015，25，1： | 8 |
| 10 | Flavonoid content and radical scavenging activity in fruits of Chinese dwarf cherry(Cerasus humilis) genotypes显示文摘The Chinese dwarf cherry(Cerasus humilis(Bge.) Sok.) is a small shrub with edible fruits. It is native to northern and western China. This species was included as a medicinal plant in the ‘‘Chinese Pharmacopeia'' and has emerged as an economically important crop for fresh fruit consumption, processing into juice and wine and nutraceutical products as well. To gain a better understanding of flavonoid biosynthesis and help develop value added products and better cultivars with greater health benefits, we analyzed total flavonoid content(TFC), composition, and radical scavenging activities in fruit extracts of 16 Chinese dwarf cherry genotypes. Fruit peel TFC ranged from 33.5 to72.8 mg/g REáFW(RE: rutin equivalent, FW: fresh weight)while fruit flesh TFC ranged from 4.3 to 16.9 mg/g REáFW.An HPLC analysis revealed that fruit extracts contained 14 flavonoids with considerable variation in their profiles across genotypes. The most abundant flavonoids in most genotypes were proanthocyanidin B1(PA-B1), proanthocyanidin B2(PA-B2), phloretin 20-O-glucoside(PG), and phloretin 20,40-O-diglucoside(PDG). Principal component analysis showed that PG, PA-B1, and PA-B2 had large,positive factor loading values in the first principal component for each genotype. Increased scavenging activity of2,2-diphenyl-1-picrylhydrazyl(DPPH) radicals was apparent in genotypes ‘Nongda 4', ‘Nongda 3', ‘Nongda 6',‘Wenfenli', and '10-32', suggesting promising applications in the production of nutraceutical products. In summary, our results will aid in breeding, fruit processing, and developing medicinal uses of the Chinese dwarf cherry. | Pengfei Wang Xiaopeng Mu Junjie Du Yu Gary Gao Donghai Bai Luting Jia Jiancheng Zhang Haiyan Ren Xiaofang Xue | 2018 | Journal of Forestry Research2018，29，1： | 8 |
| 11 | Focusing in solids and application in acoustic imaging显示文摘Focusing in solids by surface transducer arrays(STA)and the acousticfield distribution on the focal axis are studied in this paper.The relation betweenthe source element width and the field strength at different order focuses is alsodiscussed.Numerical calculation is used to get the focal field distribution as theelement width is changed.Some practical problems such as the minimumdistinguishable frequency,the transversal and longitudinal resolution are investi-gated when this kind of focusing is used for NDT and acoustic imaging.Someexplorative experiments have been done to demonstrate the theory. | QIAO Donghai, WANG Chenghao ZHOU Yuying(Institute of Acoustics, Academia Sinica, Beijing 100080) | 1992 | Chinese Journal of Acoustics1992，11，4： | 5 |
| 12 | Investigating the spectral characteristic and humification degree of dissolved organic matter in saline-alkali soil using spectroscopic techniques显示文摘 | Qiang LI Xujing GUO Lu CHEN Yunzhen LI Donghai YUAN Benlin DAI Sisi WANG | 2017 | Frontiers of Earth Science2017，11，1： | 5 |
| 13 | “Three essential elements”of the primary health care system:A comparison between California in the US and Guangdong in China显示文摘The primary health care system(PHCS)is the portal and basis for the national health delivery system.There are a number of elements which comprise the PHCS,but the system cannot be established and developed without the support of“three essential elements,”including general practitioners(GPs),health insurance,and government health investment.Through comparative analysis of the“three essential elements”of the PHCS between California in the US and Guangdong in China,this article indicates that there are three important aspects in developing a PHCS in China,as follows:training qualified GPs;establishing a diversified health insurance system to strengthen the policy connections between health insurance and the PHCS thereby increasing government health investment;and broadening health financing channels. | Minfang Huang Donghai Wei Louis Rubino Lianshen Wang Dazhuang Li Bofeng Ding Gan Li | 2015 | Family Medicine and Community Health2015，3，1： | 5 |
| 14 | Resistivity response to the porosity and permeability of low rank coal显示文摘Laojunmiao coal samples from the eastern Junggar basin were studied to understand the relationship between coal resistivity and the physical parameters of coal reservoirs under high temperatures and pressures.Specifically,we analysed the relationship of coal resistivity to porosity and permeability via heating and pressurization experiments.The results indicated that coal resistivity decreases exponentially with increasing pressure.Increasing the temperature decreases the resistivity.The sensitivity of coal resistivity to the confining pressure is worse when the temperature is higher.The resistivity of dry coal samples was linearly related to φ~m.Increasing the temperature decreased the cementation exponent(m).Increasing the confining pressure exponentially decreases the porosity.Decreasing the pressure increases the resistivity and porosity for a constant temperature.Increasing the temperature yields a quadratic relationship between the resistivity and permeability for a constant confining pressure.Based on the Archie formula,we obtained the coupling relationship between coal resistivity and permeability for Laojunmiao coal samples at different temperatures and confining pressures. | Wang Gang Qin Yong Shen Jian Hu Yuanyuan Liu Donghai Zhao Long | 2016 | International Journal of Mining Science and Technology2016，26，2： | 4 |
| 15 | An investigation into the three-dimensional cloud structure over East Asia from the CALIPSO-GOCCP Data显示文摘The spatial distribution of clouds and their seasonal variations, and the three-dimensional(3D) cloud structures over East Asia have been analyzed with the CALIPSO-GOCCP data during the period from 2007 to 2012. The results show that there is a large cloud fraction greater than 0.7 over southern China, and the largest cloud fraction appears in southwest China. Besides, a large cloud fraction occurs over the southeast of the Tibetan Plateau. The total and high cloud fractions show notable variations with seasons, while the middle and low cloud fractions vary a little. As for cloud vertical structure, significant differences of the cloud vertical distributions are observed between over land and ocean. Cloud fractions and the height of the maximum cloud fractions decline gradually with the increasing latitude, except for the vertical-latitude profiles over the Tibetan Plateau regions. The longitude-vertical cross sections show similar patterns from the longitude 70° E to 140° E, except the profiles with large cloud fractions over the Tibetan Plateau. From the horizontal distribution patterns and vertical structures of the clouds over East Asia, it is concluded that the huge terrain of the Tibetan Plateau has significant impacts on the cloud formation over the Tibetan Plateau region and the areas to the east. At last, the clouds from the CALIPSO-GOCCP observations are compared to those from the ERA-Interim reanalysis data. The results indicate that the ERA-Interim reanalysis data provide reasonable spatial distribution patterns and the vertical structures in terms of the total cloud fraction over East Asia. However, the total cloud fraction was underestimated about 20% by the ERA-Interim reanalysis data over most parts of East Asia, especially over the neighboring areas east of the Tibetan Plateau. Additionally, the ERA-interim reanalysis data overestimate the cloud fractions at each level in the vertical direction. | YIN JinFang WANG DongHai XU HuanBin ZHAI GuoQing | 2015 | Science China Earth Sciences2015，58，12： | 4 |
| 16 | Design and immunogenicity assessment of HIV-1 virus-like particles as a candidate vaccine显示文摘The rapid growth of the global HIV/AIDS epidemic makes it a high priority to develop an effective vaccine.Since a live attenuated or inactivated HIV vaccine is not likely to be approved for clinical application due to safety concerns,HIV virus like particles(VLPs) offer an attractive alternative because they are considered safer since they lack viral genome.We got a stable eukaryotic cell line by G418 resistance selection,engineered to express the HIV-1 structure protein Gag and Env efficiently and stably.We confirmed the presence of Gag and Env proteins in the cell culture supernatant and that they could self-assemble into VLPs.These VLPs were found to be able to elicit specific humoral and cellular immune response after immunization without any adjuvant. | ZHANG XiZhen WANG XiaoDan ZHAO DongHai MENG XiangYu ZHAO XingHong YU XiangHui KONG Wei | 2011 | Science China(Life Sciences)2011，54，11： | 4 |
| 17 | Mesoscale Dynamics and Its Application in Torrential Rainfall Systems in China显示文摘Progress over the past decade in understanding moisture-driven dynamics and torrential rain storms in China is reviewed in this paper. First, advances in incorporating moisture effects more realistically into theory are described, including the development of a new parameter, generalized moist potential vorticity(GMPV) and an improved moist ageostrophic Q vector(Qum). Advances in vorticity dynamics are also described, including the adoption of a 'parcel dynamic' approach to investigate the development of the vertical vorticity of an air parcel; a novel theory of slantwise vorticity development, proposed because vorticity develops easily near steep isentropic surfaces; and the development of the convective vorticity vector(CVV)as an effective new tool. The significant progress in both frontal dynamics and wave dynamics is also summarized, including the geostrophic adjustment of initial unbalanced flow and the dual role of boundary layer friction in frontogenesis, as well as the interaction between topography and fronts, which indicate that topographic perturbations alter both frontogenesis and frontal structure. For atmospheric vortices, mixed wave/vortex dynamics has been extended to explain the propagation of spiral rainbands and the development of dynamical instability in tropical cyclones. Finally, we review wave and basic flow interaction in torrential rainfall, for which it was necessary to extend existing theory from large-scale flows to mesoscale fields, enriching our knowledge of mesoscale atmospheric dynamics. | GAO Shouting TAN Zhemin ZHAO Sixiong LUO Zhexian LU Hancheng WANG Donghai CUI Chunguang CUI Xiaopeng SUN Jianhua | 2015 | Advances in Atmospheric Sciences2015，32，2： | 4 |
| 18 | Catalyzing polysulfide conversion by g-C3N4 in a graphene network for long-life lithium-sulfur batteries显示文摘 | Meng Wang Qinghua Liang Junwei Han Ying Tao Donghai Liu Chen Zhang Wei Lv Quan-Hong Yang | 2018 | Nano Research2018，11，6： | 4 |
| 19 | Genome-wide dissection of segregation distortion using multiple inter-subspecific crosses in rice显示文摘Mendelian inheritance can ensure equal segregation of alleles from parents to offspring, which provides fundamental basis for genetics and molecular biology. Segregation distortion(SD) leads to preferential transmission of certain alleles from generation to generation. Such violation of Mendelian genetic principle is often accompanied by reproductive isolation and eventually speciation. Although SD is observed in a wide range of species from plants to animals, genome-wide dissection of such biased transmission of gametes is rare. Using nine inter-subspecific rice crosses, a genome-wide screen for SD loci is performed, which reveals 61 single-locus quantitative trait loci and 194 digenic interactions showing distorted transmission ratio, among which 24 new SD loci are identified. Biased transmission of alleles is observed in all nine crosses, suggesting that SD exists extensively in rice populations. 72.13% distorted regions are repeatedly detected in multiple populations, and the most prevalent SD hotspot that observed in eight populations is mapped to chromosome 3. Xian alleles are transmitted at higher frequencies than geng alleles in inter-subspecific crosses, which change the genetic composition of the rice populations. Epistatic interaction contributes significantly to the deviation of Mendelian segregation at the whole-genome level in rice, which is distinct from that in animals. These results provide an extensive archive for investigating the genetic basis of SD in rice, which have significant implications in understanding the reproductive isolation and formation of inter-subspecific barriers during the evolution. | Guangwei Li Jiye Jin Yan Zhou Xufeng Bai Donghai Mao Cong Tan Gongwei Wang Yidan Ouyang | 2019 | Science China(Life Sciences)2019，62，4： | 4 |
| 20 | Ensemble prediction experiments using conditional nonlinear optimal perturbation显示文摘Two methods for initialization of ensemble forecasts are compared, namely, singular vector (SV) and conditional nonlinear optimal perturbation (CNOP). The comparison is done for forecast lengths of up to 10 days with a three-level quasi-geostrophic (QG) atmospheric model in a perfect model scenario. Ten cases are randomly selected from 1982/1983 winter to 1993/1994 winter (from December to the following February). Anomaly correlation coefficient (ACC) is adopted as a tool to measure the quality of the predicted ensembles on the Northern Hemisphere 500 hPa geopotential height. The results show that the forecast quality of ensemble samples in which the first SV is replaced by CNOP is higher than that of samples composed of only SVs in the medium range, based on the occurrence of weather re-gime transitions in Northern Hemisphere after about four days. Besides, the reliability of ensemble forecasts is evaluated by the Rank Histograms. The above conclusions confirm and extend those reached earlier by the authors, which stated that the introduction of CNOP improves the forecast skill under the condition that the analysis error belongs to a kind of fast-growing error by using a barotropic QG model. | JIANG ZhiNa MU Mu WANG DongHai | 2009 | Science China Earth Sciences2009，52，4： | 4 |
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