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| 1 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 2 | Climate variability and change in the united states: potential impacts on vector and rodent borne disesses显示文摘 | Duane JG Paul R Kristie LE | 2001 | Environ Health Perspect2001，1092，： | 1 |
| 3 | Direct Intraoperative Measurement of Human Brain Temperature显示文摘 | Stone J Robert R Kristy Z | 1997 | Neuro Surgery1997，41，： | 1 |
| 4 | Are waist circumference and body mass index independently associated with cardiovascular disease risk in Chinese adults1,2,3显示文摘 | Rachel PW Gu DF Kristi R | 2005 | Am J Clin Nutr2005，81，： | 1 |
| 5 | Climate variability and change in the united states: potential impacts on vector and rodent borne diseases显示文摘 | Duane JG Paul R Kristie LE | 2001 | Environ Health Perspect2001，1092，： | 1 |
| 6 | Appropriate bodymass index and waist circumference cutoffs for categorizationof overweight and central adiposity among Chinese adults显示文摘 | Rachel PW Dongfeng G Kristi R | 2004 | Am J Clin Nutr2004，80，5： | 1 |
| 7 | Cigarette smoking and exposure to environmental tobacco smoke in China:the international collaborative study of cardiovascular disease in Asia显示文摘 | Dongfeng G Xigui W Kristi R | 2004 | American Journal of Public Health2004，94，： | 1 |
| 8 | The influence of photoperiod and temperature on the kinetics of stem elongation in Dendranthema grandiflorum显示文摘 | Tutty J R Hicklenton P R Kristie D N | 1994 | Journal of the American Society for Horticultural Science1994，119，2： | 1 |
| 9 | Prevalence of the metabolic syndrome and overweight among adults in China 显示文摘 | Gu DF Kristi R Wu XG | 2005 | Lancet2005，365，9468： | 1 |
| 10 | Brown adipose tissue regulates glucose homeostasis and insulin sensitivity显示文摘 | Stanford Kristin I Middelbeek Roeland J W Townsend Kristy L An Ding Nygaard Eva B Hitchcox Kristen M Markan Kathleen R Nakano Kazuhiro Hirshman Michael F Tseng Yu-Hua Goodyear Laurie J | 2013 | Journal of Clinical Investigation2013，，1： | 1 |
| 11 | Worldwide prevalence of hypertension:a systematic review显示文摘 | Patricia MK Megan W Kristi R | 2004 | J Hypertens2004，22，1： | 1 |
| 12 | Global burden of hyperten- sion : analysis of worldwide data 显示文摘 | Patricia MK Megan W Kristi R | 2005 | Lancet2005，365，9455： | 1 |
| 13 | Relationship between HbAlc level and peripheral arterial disease 显示文摘 | Paul M Rachel P Kristi R | 2005 | Diabetes Care2005，28，7： | 1 |
| 14 | Adolescents'Attention to Re- sponsibility Messages in Magazine Alcohol Advertisements: An Eye - Tracking Approach 显示文摘 | Steven R Thomsen Kristi Fulton | 2007 | Journal of Adolescent Health2007，41，1： | 1 |
| 15 | Global burden of hy- pertension : Analysis of worldwide data 显示文摘 | PATRICIA M K MEGAN W KRISTI R | 2005 | Lancet2005，365，9455： | 1 |
| 16 | Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface显示文摘 | Kristy R H Zhou Y Genbacev O | 2004 | J Clinical Invest2004，114，6： | 1 |
| 17 | Global burden of hyper tension:analysis of worldwide data显示文摘 | Patricia M K Megan W Kristi R | 2005 | The Lancet2005，365，9455： | 1 |
| 18 | Relationship between HbAlc level and Peripheral Arterial Disease显示文摘 | Paul M Rachel P Kristi R | 2005 | Diabetes Care2005，28，7： | 1 |
| 19 | Metabolic syndrome and risk of cardiovascular disease:a meta- analysis显示文摘 | Andrea G Kristi R Jiang He | 2006 | The American Journal of Medicine2006，119，： | 1 |
| 20 | Effect of surfactants on the interfacial tension and e- mulsion formation between water and carbon dioxide 显示文摘 | Sandro R P da Rocha Kristi L Harrison Keith P Johns- ton | 1999 | Langmuir1999，15，2： | 1 |
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