|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | Unique microRNA molecular profiles in lung cancer diagnosis and prognosis显示文摘 | Nozomu Yanaihara Natasha Caplen Elise Bowman Masahiro Seike Kensuke Kumamoto Ming Yi Robert M. Stephens Aikou Okamoto Jun Yokota Tadao Tanaka George Adrian Calin Chang-Gong Liu Carlo M. Croce Curtis C. Harris | 2006 | Cancer Cell2006，，3： | 4 |
| 3 | Dual-color deep-tissue three-photon microscopy with a multiband infrared laser显示文摘Multiphoton microscopy combined with genetically encoded fluorescent indicators is a central tool in biology.Threephoton(3P)microscopy with excitation in the short-wavelength infrared(SWIR)water transparency bands at 1.3 and 1.7μm opens up new opportunities for deep-tissue imaging.However,novel strategies are needed to enable in-depth multicolor fluorescence imaging and fully develop such an imaging approach.Here,we report on a novel multiband SWIR source that simultaneously emits ultrashort pulses at 1.3 and 1.7μm that has characteristics optimized for 3P microscopy:sub-70 fs duration,1.25 MHz repetition rate,and μJ-range pulse energy.In turn,we achieve simultaneous 3P excitation of green fluorescent protein(GFP)and red fluorescent proteins(mRFP,mCherry,tdTomato)along with third-harmonic generation.We demonstrate in-depth dual-color 3P imaging in a fixed mouse brain,chick embryo spinal cord,and live adult zebrafish brain,with an improved signal-to-background ratio compared to multicolor twophoton imaging.This development opens the way towards multiparametric imaging deep within scattering tissues. | Khmaies Guesmi Lamiae Abdeladim Samuel Tozer Pierre Mahou Takuma Kumamoto Karolis Jurkus Philippe Rigaud Karine Loulier Nicolas Dray Patrick Georges Marc Hanna Jean Livet Willy Supatto Emmanuel Beaurepaire Frédéric Druon | 2018 | Light(Science & Applications)2018，7，1： | 3 |
| 4 | Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study显示文摘 | Kazuaki Kitajima Takahiro Fujimori Shigehiko Fujii Jun Takeda Yasuo Ohkura Hitoshi Kawamata Toshihide Kumamoto Shingo Ishiguro Yo Kato Tadakazu Shimoda Akinori Iwashita Yoichi Ajioka Hidenobu Watanabe Toshiaki Watanabe Tetsuichiro Muto Ko Nagasako | 2004 | Journal of Gastroenterology2004，，6： | 2 |
| 5 | Outcome in disappearing colorectal cancer liver metastases during oxaliplatin-basedchemotherapy显示文摘 | Tomojiro Ono Hideyuki Ishida Kensuke Kumamoto Norimichi Okada Keiichiro Ishibashi | 2012 | Oncology Letters2012，，5： | 2 |
| 6 | Evaluation of mercury methylation in fresh and pre dried sediments using ^(203)Hg radioisotope显示文摘Mercury methylation rates in fresh and pre dried river sediments were determined in sediment water systems spiked with 203 HgCl 2 at a level of 0.75—0.95 ppm as Hg. At the end of the incubation period (21—38 days), methylmercury production in the fresh sediments was in the order of 3.0% to 13.75%, whereas in the pre dried sediments the methylation was much lower, at 0.6% to 3.9%. The highest methylation levels were generally recorded in the uppermost, 1 cm layer of the sediment column. Total mercury concentration in water in equilibrium with the 203 Hg spiked fresh sediments was in the range of 44.7 to 634 ng/L, whereas in equilibrium with the pre dried sediments the concentration was in the range of 19.5 to 34.5 ng/L. The proportion of methylmercury to total mercury in the water varied from 9.4% to 66.6% over the fresh sediments, and from 7.1% to 10.8% over the pre dried sediments. In the system consisting of water, sediment and sediment inverterbrates the concentrations of methylmercury were 8.61 to 15.69 ng/g in the sediment, 0.011 ng/ml in the water, and 9.22 to 40.69 ng/g in the inverterbrates. Methylmercury bioaccumualtion factors (BAFs) were in the order of 274 to 8087 relative to the water, and 0.25 to 7.31 relative to the sediment. These results provide further evidence for the tendency of methylmercury to accumulate in high concentrations in aquatic organisms, even at very low total mercury concentration in water. | J.R.Ikingura 1, H.Akagi 2, J.R.D.Guimaraes 3 (1. University of Dar es Salaam, P.O.Box 35052, Dar es Salaam, Tanzania 2. Nat. Inst. for Minamata Disease, 4058 Hama, Minamata, 867 Kumamoto, Japan 3. Lab. de Radioisotopos, Universidade Federal Do Rio | 2000 | Journal of Environmental Sciences2000，12，S1： | 2 |
| 7 | Unique microRNA molecular profiles in lung cancer diagnosis and prognosis显示文摘 | Nozomu Yanaihara Natasha Caplen Elise Bowman Masahiro Seike Kensuke Kumamoto Ming Yi Robert M. Stephens Aikou Okamoto Jun Yokota Tadao Tanaka George Adrian Calin Chang-Gong Liu Carlo M. Croce Curtis C. Harris | 2006 | Cancer Cell2006，，3： | 2 |
| 8 | Effect of an extract of Ganoderma lucidum in men with lower urinary tract symptoms: a double-blind, placebo-controlled randomized and dose-ranging study显示文摘瞄准:进行一个双窗帘,控制安慰剂使随机化并且评估 Ganoderma 的摘录的安全和功效的变化剂量的学习易懂嗯(G。易懂嗯) 在有更低的泌尿道症状(LUTS ) 的人。方法:我们注册了男志愿者(≥ 50 年) 与一个国际前列腺症状分数(IPSS;问题 1-7 ) ≥ 5 并且前列腺特定的抗原(PSA ) 价值 <
4 ng/mL。志愿者被使随机化进一些安慰剂(n = 12 ) , G。易懂 0.6 mg 的 um (n = 12 ) , 6 mg (n = 12 ) 或 60 mg (n = 14 ) ,管理从前每日。功效在 IPSS 和山峰尿流动率(Q_( 最大)) 从基线作为一个变化被测量。前列腺体积和残余尿被 ultrasonography 估计,并且包括 PSA 层次,验血在基线并且在处理的结束被测量。结果:全面管理很好被容忍,没有主要不利效果。在在试验性的组之间的变化的大小的统计意义在星期被观察 4 和 8。没有变化被观察关于 Q_( 最大) ,残余尿,前列腺体积或 PSA 铺平。结论:G 的摘录。易懂嗯很好被容忍,在 IPSS 的改进被观察。G 的摘录的推荐剂量。易懂嗯是在有 LUTS 的人的 6 mg。 | Masanori Noguchi Tatsuyuki Kakuma Katsuro Tomiyasu Yoshiko Kurita Hiroko Kukihara Fumiko Konishi Shoichiro Kumamoto Kuniyoshi Shimizu Ryuichiro Kondo Kei Matsuoka | 2008 | Asian Journal of Andrology2008，10，4： | 2 |
| 9 | Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study显示文摘 | Kazuaki Kitajima Takahiro Fujimori Shigehiko Fujii Jun Takeda Yasuo Ohkura Hitoshi Kawamata Toshihide Kumamoto Shingo Ishiguro Yo Kato Tadakazu Shimoda Akinori Iwashita Yoichi Ajioka Hidenobu Watanabe Toshiaki Watanabe Tetsuichiro Muto Ko Nagasako | 2004 | Journal of Gastroenterology2004，，6： | 2 |
| 10 | Randomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms显示文摘瞄准:评估 Ganoderma 的一篇摘录的安全和功效易懂嗯那出现最强壮 5 α-reductase 在由一个双窗帘的 19 朵可食、药用的蘑菇的摘录之中的禁止的活动,控制安慰剂,使随机化并且在有更低的尿道症状(LUTS ) 的人的变化剂量的学习。方法:在这试用,我们随机分配了与 G 有 slight-to-moderate LUTS 到 12 星期处理的超过 49 年岁的 88 个人。易懂嗯摘录(6 mg 一次一天) 或安慰剂。主要结果措施是在国际前列腺症状分数(IPSS ) 和 uroflowmetry 的变量的变化。第二等的结果措施在前列腺尺寸包括了变化,剩余在 voiding,实验室价值和报导不利效果以后的尿体积。结果: G。易懂嗯对为改进全部的 IPSS, 2.1 个点在处理的目的减少的安慰剂有效、显著地优异(吝啬的差别, −1.18 点;95% 信心间隔, −1.74 到 −0.62;P <
0.0001 ) 。没有变化关于生活分数的质量被观察,山峰尿流动,吝啬的尿流动,剩余尿,前列腺体积,浆液前列腺特定的抗原或睾丸激素层次。全面处理很好没有严重不利效果被容忍。结论:G 的摘录。易懂嗯很好被容忍并且改进了 IPSS 分数。这些结果用 G 的摘录为长持续时间鼓励了植物治疗法的进一步的、大规模评估。易懂嗯在有 LUTS 的人上。 | Masanori Noguchi Tatsuyuki Kakuma Katsuro Tomiyasu Akira Yamada Kyogo Itoh Fumiko Konishi Shoichiro Kumamoto Kuniyoshi Shimizu Ryuichiro Kondo Kei Matsuoka | 2008 | Asian Journal of Andrology2008，10，5： | 2 |
| 11 | Candida biofilms显示文摘 | Kumamoto C A | 2002 | Curr Opin Microbiol2002，5，6： | 1 |
| 12 | Expression of inducible nitric oxide synthase and heat shock proteins in periapical inflammatory lesions显示文摘 | Suzuki T Kumamoto H Ooya K | 2002 | J Oral Pathol Med2002，31，： | 1 |
| 13 | The role of TGF-beta in digestive organ disease显示文摘 | Takenoshita S Fukushima T Kumamoto K | 2002 | J Gastroenterol2002，12，： | 1 |
| 14 | In vivo patch-clamp analysis of IPSCs evoked in rat substantia gelatinosa neurons by cutaneous mechanical stimulation显示文摘 | Furue H Kumamoto E | 2000 | J Neurophysiol2000，84，4： | 1 |
| 15 | Lunar radar sounder ob- servations of subsurface layers under the nearside maria of the Moon 显示文摘 | Ono T Kumamoto A Nakagawa H | 2009 | Science2009，323，： | 1 |
| 16 | Benign cementoblastoma involving multiple maxillary teeth:Report of a case with a review of the literature显示文摘 | Ohki K Kumamoto H Nitta Y | 2004 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2004，97，1： | 1 |
| 17 | A contact -activated kinase signals candida albicans invasive growth and biofilm development 显示文摘 | KUMAMOTO CA | 2005 | Proc NatlAcad Sci U S A2005，102，15： | 1 |
| 18 | Ring-opening reaction of unactivated 3-arylaziridine-2-carboxylates with nitrile reagents显示文摘 | Hayashi Y Kumamoto T Kawahata M | 2010 | Tetrahedron2010，66，： | 1 |
| 19 | Genetic analysis in fungi using restriction enzyme mediated integration显示文摘 | Riggle P J Kumamoto C A | 1998 | Current Opinion in Microbiology1998，1，： | 1 |
| 20 | Candida albicans biofilms produce antifungal-tolerant persister cel s显示文摘 | LaFleur MD Kumamoto CA Lewis K | | 0，，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员