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| 1 | Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers显示文摘 | Takuji Gotoda Akio Yanagisawa Mitsuru Sasako Hiroyuki Ono Yukihiro Nakanishi Tadakazu Shimoda Yo Kato | 2000 | Gastric Cancer2000，，4： | 8 |
| 2 | Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers显示文摘 | Takuji Gotoda Akio Yanagisawa Mitsuru Sasako Hiroyuki Ono Yukihiro Nakanishi Tadakazu Shimoda Yo Kato | 2000 | Gastric Cancer2000，，4： | 7 |
| 3 | Improving Ambient Wind Environments of a Cross-flow Wind Turbine near a Structure by using an Inlet Guide Structure and a Flow Deflector显示文摘A cross-flow wind turbine near a structure was tested for the performance. The results showed that the performance of a cross-flow wind turbine near a structure was up to 30% higher than the one without a structure. In addition, we tried to get higher performance of a cross-flow wind turbine by using an Inlet Guide Structure and a Flow Deflector. An Inlet Guide Structure was placed on the edge of a structure and a Flow Deflector was set near a cross-flow wind turbine and can improve ambient wind environments of the wind turbine, the maximum power coefficients were about 15 to 40% higher and the tip speed ratio range showing the high power coefficient was wide and the positive gradients were steep apparently. | Tadakazu TANINO Shinichiro NAKAO Genki UEBAYASHI | 2005 | Journal of Thermal Science2005，14，3： | 5 |
| 4 | Incidence of lymph node metastasis and the feasibility of endoscopic resection for undifferentiated-type early gastric cancer显示文摘 | Toshiaki Hirasawa Takuji Gotoda Satoshi Miyata You Kato Tadakazu Shimoda Hirokazu Taniguchi Junko Fujisaki Takeshi Sano Toshiharu Yamaguchi | 2009 | Gastric Cancer2009，，3： | 5 |
| 5 | Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations显示文摘BACKGROUND We recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with SLCO2 A1 gene(CEAS). Crohn's disease(CD) is a major differential diagnosis of CEAS, because these diseases share some clinical features. Therefore, there is a need to develop a convenient screening test to distinguish CEAS from CD.AIM To examine whether prostaglandin E major urinary metabolites(PGE-MUM) can serve as a biomarker to distinguish CEAS from CD.METHODS This was a transactional study of 20 patients with CEAS and 98 patients with CD.CEAS was diagnosed by the confirmation of homozygous or compound heterozygous mutation of SLCO2 A1. We measured the concentration of PGEMUM in spot urine by radioimmunoassay, and the concentration was compared between the two groups of patients. We also determined the optimal cut-off value of PGE-MUM to distinguish CEAS from CD by receiver operating characteristic(ROC) curve analysis.RESULTS Twenty Japanese patients with CEAS and 98 patients with CD were enrolled.PGE-MUM concentration in patients with CEAS was significantly higher than that in patients with CD(median 102.7 vs 27.9 μg/g × Cre, P < 0.0001). One log unit increase in PGE-MUM contributed to 7.3 increase in the likelihood for the diagnosis of CEAS [95% confidence interval(CI) 3.2-16.7]. A logistic regression analysis revealed that the association was significant even after adjusting confounding factors(adjusted odds ratio 29.6, 95%CI 4.7-185.7). ROC curve analysis revealed the optimal PGE-MUM cut-off value for the distinction of CEAS from CD to be 48.9 μg/g × Cre with 95.0% sensitivity and 79.6% specificity.CONCLUSION PGE-MUM measurement is a convenient, non-invasive and useful test for the distinction of CEAS from CD. | Yuichi Matsuno Junji Umeno Motohiro Esaki Yoichiro Hirakawa Yuta Fuyuno Yasuharu Okamoto Atsushi Hirano Shigeyoshi Yasukawa Fumihito Hirai Toshiyuki Matsui Shuhei Hosomi Kenji Watanabe Naoki Hosoe Haruhiko Ogata Tadakazu Hisamatsu Shunichi Yanai Shuji Kochi Koichi Kurahara Tsuneyoshi Yao Takehiro Torisu Takanari Kitazono Takayuki Matsumoto | 2019 | World Journal of Gastroenterology2019，25，14： | 5 |
| 6 | Size does not determine the grade of malignancy of early invasive colorectal cancer显示文摘AIM:To clarify the clinicopathological characteristics of small and large early invasive colorectal cancers(EI-CRCs),and to determine whether malignancy grade depends on size.METHODS:A total of 583 consecutive EI-CRCs treated by endoscopic mucosal resection or surgery at the National Cancer Center Hospital between 1980 and 2004 were enrolled in this study.Lesions were classified into two groups based on size:small(≤10mm) and large(>10mm).Clinicopathological features,incidence of lymph node metastasis(LNM) and risk factors for LNM,such as depth of invasion,lymphovascular invasion(LVI) and poorly differentiated adenocarcinoma(PDA) were analyzed in all resected specimens.RESULTS:There were 120(21%) small and 463(79%) large lesions.Histopathological analysis of the small lesion group revealed submucosal deep cancer(sm:≥1000 μm) in 90(75%) cases,LVI in 26(22%) cases,and PDA in 12(10%) cases.Similarly,the large lesion group exhibited submucosal deep cancer in 380(82%) cases,LVI in 125(27%) cases,and PDA in 79(17%) cases.The rate of LNM was 11.2% and 12.1% in the small and large lesion groups,respectively.CONCLUSION:Small EI-CRC demonstrated the same aggressiveness and malignant potential as large cancer. | Takahisa Matsuda Yutaka Saito Takahiro Fujii Toshio Uraoka Takeshi Nakajima Nozomu Kobayashi Fabian Emura Akiko Ono Tadakazu Shimoda Hiroaki Ikematsu Kuang-I Fu Yasushi Sano Takahiro Fujimori | 2009 | World Journal of Gastroenterology2009，15，22： | 4 |
| 7 | Immune aspects of the pathogenesis of inflammatory bowel disease显示文摘 | Tadakazu Hisamatsu Takanori Kanai Yohei Mikami Kazuaki Yoneno Katsuyoshi Matsuoka Toshifumi Hibi | 2012 | Pharmacology and Therapeutics2012，，： | 3 |
| 8 | Nonpolypoid neoplastic lesions of the colorectal mucosa显示文摘 | Shin ei Kudo René Lambert John I. Allen Hiroaki Fujii Takahiro Fujii Hiroshi Kashida Takahisa Matsuda Masaki Mori Hiroshi Saito Tadakazu Shimoda Shinji Tanaka Hidenobu Watanabe Joseph J. Sung Andrew D. Feld John M. Inadomi Michael J. O’Brien David A. Lieb | 2008 | Gastrointestinal Endoscopy2008，，4： | 3 |
| 9 | Incidence of lymph node metastasis and the feasibility of endoscopic resection for undifferentiated-type early gastric cancer显示文摘 | Toshiaki Hirasawa Takuji Gotoda Satoshi Miyata You Kato Tadakazu Shimoda Hirokazu Taniguchi Junko Fujisaki Takeshi Sano Toshiharu Yamaguchi | 2009 | Gastric Cancer2009，，3： | 3 |
| 10 | Applicability of second‐generation colon capsule endoscope to ulcerative colitis: A clinical feasibility study显示文摘 | Naoki Hosoe Katsuyoshi Matsuoka Makoto Naganuma Yosuke Ida Yuka Ishibashi Kayoko Kimura Kazuaki Yoneno Shingo Usui Kazuhiro Kashiwagi Tadakazu Hisamatsu Nagamu Inoue Takanori Kanai Hiroyuki Imaeda Haruhiko Ogata Toshifumi Hibi | 2013 | J Gastroenterol Hepatol2013，，7： | 3 |
| 11 | Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study显示文摘 | Kazuaki Kitajima Takahiro Fujimori Shigehiko Fujii Jun Takeda Yasuo Ohkura Hitoshi Kawamata Toshihide Kumamoto Shingo Ishiguro Yo Kato Tadakazu Shimoda Akinori Iwashita Yoichi Ajioka Hidenobu Watanabe Toshiaki Watanabe Tetsuichiro Muto Ko Nagasako | 2004 | Journal of Gastroenterology2004，，6： | 2 |
| 12 | Pathological response measured using virtual microscopic slides for gastric cancer patients who underwent neoadjuvant chemotherapy显示文摘BACKGROUND Although pathological response is a common endpoint used to assess the efficacy of neoadjuvant chemotherapy (NAC) for gastric cancer, the problem of a low rate of concordance from evaluations among pathologists remains unresolved. Moreover, there is no globally accepted consensus regarding the optimal evaluation. A previous study based on a clinical trial suggested that pathological response measured using digitally captured virtual microscopic slides predicted patients’ survival well. However, the pathological concordance rate of this approach and its usefulness in clinical practice were unknown. AIM To investigate the prognostic utility of pathological response measured using digital microscopic slides in clinical practice. METHODS We retrospectively evaluated pathological specimens of gastric cancer patients who underwent NAC followed by surgery and achieved R0 resection between March 2009 and May 2015. Residual tumor area and primary tumor beds were measured in one captured image slide, which contained the largest diameter of the resected specimens. We classified patients with < 10% residual tumor relative to the primary tumorous area as responders, and the rest as non-responders;we then compared overall survival (OS) and relapse-free survival (RFS) between these two groups. Next, we compared the prognostic utility of this method using conventional Japanese criteria. RESULTS Fifty-four patients were evaluated. The concordance rate between two evaluators was 96.2%. Median RFS of 25 responders and 29 non-responders was not reached (NR) vs 18.2 mo [hazard ratio (HR)= 0.35, P = 0.023], and median OS was NR vs 40.7 mo (HR = 0.3, P = 0.016), respectively. This prognostic value was statistically significant even after adjustment for age, eastern cooperative oncology group performance status, macroscopic type, reason for NAC, and T- and Nclassification (HR = 0.23, P = 0.018). This result was also observed even in subgroup analyses for different macroscopic types (Borrmann type 4/non-type 4) and histological types (differentiated/undifferentiated). Moreover, the adjusted HR for OS between responders and non-responders was lower in this method than that in the conventional histological evaluation of Japanese Classification of Gastric Carcinoma criteria (0.23 vs 0.39, respectively). CONCLUSION The measurement of pathological response using digitally captured virtual microscopic slides may be useful in clinical practice. | Sadayuki Kawai Tadakazu Shimoda Takashi Nakajima Masanori Terashima Katsuhiro Omae Nozomu Machida Hirofumi Yasui | 2019 | World Journal of Gastroenterology2019，25，35： | 2 |
| 13 | Homeostatic (IL-7) and effector (IL-17) cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease显示文摘 | Takanori Kanai Yasuhiro Nemoto Nobuhiko Kamada Teruji Totsuka Tadakazu Hisamatsu Mamoru Watanabe Toshifumi Hibi | 2009 | Current Opinion in Gastroenterology2009，，4： | 2 |
| 14 | Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study显示文摘 | Kazuaki Kitajima Takahiro Fujimori Shigehiko Fujii Jun Takeda Yasuo Ohkura Hitoshi Kawamata Toshihide Kumamoto Shingo Ishiguro Yo Kato Tadakazu Shimoda Akinori Iwashita Yoichi Ajioka Hidenobu Watanabe Toshiaki Watanabe Tetsuichiro Muto Ko Nagasako | 2004 | Journal of Gastroenterology2004，，6： | 2 |
| 15 | Multi-institutional study of risk factors of liver metastasis from colorectal cancer: correlation with CD10 expression显示文摘 | Shin Fujita Hirokazu Taniguchi Takashi Yao Tadakazu Shimoda Hideki Ueno Takashi Hirai Masayuki Ohue | 2010 | International Journal of Colorectal Disease2010，，6： | 1 |
| 16 | The chemicN properties and functional effects of polysaccharides dissolved in green tea infusion 显示文摘 | TADAKAZU T TOMOKI U HITOSHI K | 1998 | Nippon Shokuhin Kagaku Kaishi1998，45，4： | 1 |
| 17 | Alpha-Fetoprotein-Producing Carcinoma of the Colon显示文摘 | Shinichi Yachida M.D. Noriyoshi Fukushima M.D. Yukihiro Nakanishi M.D. Takayuki Akasu M.D. Hiroshi Kitamura M.D. Michiie Sakamoto M.D. Tadakazu Shimoda M.D | 2003 | Diseases of the Colon & Rectum2003，，6： | 1 |
| 18 | Improvement of fracture toughness in 7475 aluminum alloy by the RRA(Retrogression and Re-aging)process显示文摘 | Yoshiaki T | 1989 | Materials Transactions JIM1989，30，8： | 1 |
| 19 | Incidence of lymph node metastasis and the feasibility of endoscopic resection for undifferentiated-type early gastric cancer显示文摘 | Toshiaki Hirasawa Takuji Gotoda Satoshi Miyata You Kato Tadakazu Shimoda Hirokazu Taniguchi Junko Fujisaki Takeshi Sano Toshiharu Yamaguchi | 2009 | Gastric Cancer2009，，3： | 1 |
| 20 | Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers显示文摘 | Takuji Gotoda Akio Yanagisawa Mitsuru Sasako Hiroyuki Ono Yukihiro Nakanishi Tadakazu Shimoda Yo Kato | 2000 | Gastric Cancer2000，，4： | 1 |
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