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| 1 | Proposal of criteria to select candidates with colorectal liver metastases for hepatic resection:Comparison of our scoring system to the positive number of risk factors显示文摘AIM: To select accurately good candidates of hepatic resection for colorectal liver metastasis. METHODS: Thirteen clinicopathological features, which were recognized only before or during surgery, were selected retrospectively in 81 consecutive patients in one hospital (GroupⅠ). These features were entered into a multivariate analysis to determine independent and significant variables affecting long-term prognosis after hepatectomy. Using selected variables, we created a scoring formula to classify patients with colorectal liver metastases to select good candidates for hepatic resection. The usefulness of the new scoring system was examined in a series of 92 patients from another hospital (Group Ⅱ), comparing the number of selected variables. RESULTS: Among 81 patients of GroupⅠ, multivariate analysis, i.e. Cox regression analysis, showed that multiple tumors, the largest tumor greater than 5 cm in diameter, and resectable extrahepatic metastases were significant and independent prognostic factors for poor survival after hepatectomy (P < 0.05). In addition, these three factors: serosa invasion, local lymph node metastases of primary cancers, and post- operative disease free interval less than 1 year including synchronous hepatic metastasis, were not significant, however, they were selected by a stepwise method of Cox regression analysis (0.05 < P < 0.20). Using these six variables, we created a new scoring formula to classify patients with colorectal liver metastases. Finally, our new scoring system not only classified patients in GroupⅠvery well, but also that in Group Ⅱ, according to long-term outcomes after hepatic resection. The positive number of these six variables also classified them well.CONCLUSION: Both, our new scoring system and the positive number of significant prognostic factors are useful to classify patients with colorectal liver metastases in the preoperative selection of good candidates for hepatic resection. | Ikuo Nagashima Tadahiro Takada Miki Adachi Hirokazu Nagawa Tetsuichiro Muto Kota Okinaga | 2006 | World Journal of Gastroenterology2006，12，39： | 5 |
| 2 | Treatment of colorectal carcinoids:A new paradigm显示文摘It is often difficult to evaluate the grade of malignancy and choose an appropriate treatment for colorectal carcinoids in clinical settings. Although tumor size and depth of invasion are evidently not enough to stratify the risk of this rare tumor, the present guidelines or staging systems do not mention other clinicopathological variables. Recent studies, however, have shed light on the impact of lymphovascular invasion on the outcome of colorectal carcinoids. It has been revealed that the presence of lymphovascular invasion was among the strongest risk factors for metastasis along with tumor size and depth of invasion. Furthermore, tumors smaller than 1 cm, within submucosal invasion and without lymphovascular invasion, carry minimal risk for metastasis with 100% 5-year survival in the studies from Japan as well as from the USA. This would suggest that these tumors could be curatively treated by endoscopic resection or transanal local excision. On the other hand, colorectal carcinoids with either lymphovascular invasion or tumor size larger than 1 cm carry the risk for metastasis equivalent to adenocarcinomas. Therefore, it should be emphasized that histological examination of lymphovascular invasion is mandatory in the specimens obtained by endoscopic resection or transanal local excision, as this would provide useful information for determining the need for additional radical surgery with regional lymph node dissection. Although the present guidelines or TNM staging system do not mention the impact of lymphovascular invasion, this would be among the next promising targets in order to establish better guidelines and staging systems, particularly in early-stage colorectal carcinoids. | Tsuyoshi Konishi Toshiaki Watanabe Hirokazu Nagawa Masatoshi Oya Masashi Ueno Hiroya Kuroyanagi Yoshiya Fujimoto Takashi Akiyoshi Toshiharu Yamaguchi Tetsuichiro Muto | 2010 | World Journal of Gastrointestinal Surgery2010，2，5： | 5 |
| 3 | Preoperative chemoradiation and extended pelvic lymphadenectomy for rectal cancer:Two distinct principles显示文摘Extended pelvic lymphadenectomy(EPL) with total mesorectal excision(TME) has been reported to provide oncological benefit in lower rectal cancer in Japan.In Western countries EPL is not widely accepted because of frequent morbidity but instead preoperative chemoradiation(CRT) followed by TME has been established as a standard treatment for decreasing local recurrence.Recently,several studies have focused on the comparison between these two distinct therapeutic approaches in Western countries and Japan.A study comparing Dutch trial data and Japanese data revealed that EPL and RT are almost equivalent in decreasing local recurrence in lower rectal cancer as compared with TME alone.Considering that almost 45 survival can be achieved by EPL even in the presence of metastatic lateral lymph nodes(LLNs),EPL performed by experienced surgeons definitely contributes to decrease local recurrence.On the other hand,a randomized controlled trial in Japan that compared EPL with conventional TME following preoperative RT revealed that EPL is associated with a higher frequency of sexual and urinary dysfunction without oncological benefits in the presence of preoperative RT.On this point,preoperative CRT followed by conventional TME without EPL would be a better therapeutic approach in patients without evident metastatic LLNs.For future treatment,it would be desirable to have a narrower indication for EPL using full advantage of recent improvement in image diagnosis.Although objective comparison of these two principles between Japan and the West is difficult due to differences in patient groups,further studies would lead to the next great step towards future improvement in treating lower rectal cancer. | Tsuyoshi Konishi Toshiaki Watanabe Hirokazu Nagawa Masatoshi Oya Masashi Ueno Hiroya Kuroyanagi Yoshiya Fujimoto Takashi Akiyoshi Toshiharu Yamaguchi Tetsuichiro Muto | 2010 | World Journal of Gastrointestinal Surgery2010，2，4： | 3 |
| 4 | Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study显示文摘 | Kazuaki Kitajima Takahiro Fujimori Shigehiko Fujii Jun Takeda Yasuo Ohkura Hitoshi Kawamata Toshihide Kumamoto Shingo Ishiguro Yo Kato Tadakazu Shimoda Akinori Iwashita Yoichi Ajioka Hidenobu Watanabe Toshiaki Watanabe Tetsuichiro Muto Ko Nagasako | 2004 | Journal of Gastroenterology2004，，6： | 2 |
| 5 | Significance of K-ras mutation and CEA level in pancreatic juice in the diagnosis of pancreatic cancer显示文摘 | Noriaki Futakawa Wataru Kimura Seiichi Yamagata Bin Zhao Han Ilsoo Tomomi Inoue Naohiro Sata Yoneei Kawaguchi Yoshiro Kubota Tetsuichiro Muto | 2000 | Journal of Hepato - Biliary - Pancreatic Surgery2000，，1： | 2 |
| 6 | Proliferative activity of intrahepatic colorectal metastases after preoperative hemihepatic portal vein embolization显示文摘 | Norihiro Kokudo Keiichiro Tada Makoto Seki Hirotoshi Ohta Kaoru Azekura Masashi Ueno Keiichiro Ohta Toshiharu Yamaguchi Toshiki Matsubara Takashi Takahashi Toshifusa Nakajima Tetsuichiro Muto Takaaki Ikari Akio Yanagisawa Yo Kato | 2001 | Hepatology2001，，2： | 2 |
| 7 | Treatment strategy for rectal carcinoids: A clinicopathological analysis of 229 cases at a single cancer institution显示文摘 | Akiyoshi Kasuga Akiko Chino Naoyuki Uragami Teruhito Kishihara Masahiro Igarashi Rikiya Fujita Noriko Yamamoto Masashi Ueno Masatoshi Oya Tetsuichiro Muto | 2012 | Journal of Gastroenterology and Hepatology2012，，12： | 2 |
| 8 | Minute gastric carcinoid tumor with regional lymph node metastasis显示文摘 | Toshihiko Shinohara Shigekazu Ohyama Hideki Nagano Nozomi Amaoka Keiichiro Ohta Toshiki Matsubara Toshiharu Yamaguchi Akio Yanagisawa Yo Kato Tetsuichiro Muto | 2003 | Gastric Cancer2003，，4： | 2 |
| 9 | Proposal of a new and simple staging system of colorectal liver metastasis显示文摘AIM: To create a new, simple and useful staging system for colorectal liver metastasis analogous to the Tumor Node Metastasis classification system of International Union Against Cancer. METHODS: A retrospective review was undertaken of 81 consecutive patients who underwent partial hepatec- tomy for colorectal liver metastases (group 1). Clinical and pathological features of both primary and metastatic liver cancers were entered into a multivariate analysis to determine independent variables helpful in accurately predicting long-term prognosis after hepatectomy. Using selected variables, we created a new staging system like TNM classification. The usefulness of the new staging system was examined in a series of 92 patients from an- other hospital (group 2). RESULTS: Multivariate analysis showed that 81 patients in group 1 had significant multiple hepatic tumors with the largest tumor being more than 5 cm in diameter, resectable extrahepatic distant metastases, and inde- pendent prognostic factors for poor survival after hepa- tectomy. Using these three variables, we created a new staging system to classify patients with colorectal liver metastases. Finally, our new staging system classified the patients both in group 1 and in group 2. CONCLUSION: Our new staging system of colorectal liver metastasis is simple and useful for staging patients. | Ikuo Nagashima Tadahiro Takada Hirokazu Nagawa Tetsuichiro Muto Kota Okinaga | 2006 | World Journal of Gastroenterology2006，12，43： | 2 |
| 10 | Indication and Benefit of Pelvic Sidewall Dissection for Rectal Cancer显示文摘 | Kenichi Sugihara M.D. Hirotoshi Kobayashi M.D. Tomoyuki Kato M.D. Takeo Mori M.D. Hidetaka Mochizuki M.D. Shingo Kameoka M.D. Kazuo Shirouzu M.D. Tetsuichiro Muto M.D | 2006 | Diseases of the Colon & Rectum2006，，11： | 2 |
| 11 | Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study显示文摘 | Kazuaki Kitajima Takahiro Fujimori Shigehiko Fujii Jun Takeda Yasuo Ohkura Hitoshi Kawamata Toshihide Kumamoto Shingo Ishiguro Yo Kato Tadakazu Shimoda Akinori Iwashita Yoichi Ajioka Hidenobu Watanabe Toshiaki Watanabe Tetsuichiro Muto Ko Nagasako | 2004 | Journal of Gastroenterology2004，，6： | 2 |
| 12 | Bloodless liver resection using the Monopolar Floating Ball plus Ligasure diathermy: Preliminary results of 16 liver resections显示文摘 | Yoshihiro Sakamoto Junji Yamamoto Norihiro Kokudo Makoto Seki Tomoo Kosuge Toshiharu Yamaguchi Tetsuichiro Muto Masatoshi Makuuchi | 2004 | World Journal of Surgery2004，，2： | 1 |
| 13 | Preoperative Radiation Response Evaluated by 18-Fluorodeoxyglucose Positron Emission Tomography Predicts Survival in Locally Advanced Rectal Cancer显示文摘 | Keiichi Nakagawa M.D. Hideomi Yamashita M.D. Naoki Nakamura M.D. Hiroshi Igaki M.D. Masao Tago M.D. Yoshio Hosoi M.D. Toshimitsu Momose M.D. Kuni Ohtomo M.D. Tetsuichiro Muto M.D. Hirokazu Nagawa M.D | 2008 | Diseases of the Colon & Rectum2008，，7： | 1 |
| 14 | Inhibition of Vascular Endothelial Growth Factor (VEGF) Signaling in Cancer Causes Loss of Endothelial Fenestrations, Regression of Tumor Vessels, and Appearance of Basement Membrane Ghosts显示文摘 | Tetsuichiro Inai Michael Mancuso Hiroya Hashizume Fabienne Baffert Amy Haskell Peter Baluk Dana D. Hu-Lowe David R. Shalinsky Gavin Thurston George D. Yancopoulos Donald M. McDonald | 2004 | The American Journal of Pathology2004，，1： | 1 |
| 15 | Self-limited spontaneous dissection of the main trunk of the superior mesenteric artery显示文摘 | Hiroshi Yasuhara Hiroshi Shigematsu Tetsuichiro Muto | 1998 | Journal of Vascular Surgery1998，，： | 1 |
| 16 | Flat adenoma as of colorectal carcinoma in hereditary nonpolyposis colorectal carcinoma 显示文摘 | TOSHIAKI W TETSUICHIRO M TOSHIO S | 1996 | Cancer1996，77，4： | 1 |
| 17 | Correlation of the therapeutic effect of activated tumor-draining lymph node cells with specific interferon-γ production in vitro显示文摘 | Shinichi Sameshima Keisuke Sakai Hirokazu Nagawa Nelson Tsuno Joji Kitayama Tetsuichiro Muto | 1999 | Surgery Today1999，，1： | 1 |
| 18 | Significance of K-ras mutation and CEA level in pancreatic juice in the diagnosis of pancreatic cancer显示文摘 | Noriaki Futakawa Wataru Kimura Seiichi Yamagata Bin Zhao Han Ilsoo Tomomi Inoue Naohiro Sata Yoneei Kawaguchi Yoshiro Kubota Tetsuichiro Muto | 2000 | Journal of Hepato - Biliary - Pancreatic Surgery2000，，1： | 1 |
| 19 | Endorectal Ultrasonography and Treatment of Early Stage RectalCancer显示文摘 | Takayuki Akasu Hitoshi Kondo Yoshihiro Moriya Kenichi Sugihara Takuji Gotoda Shin Fujita Tetsuichiro Muto Tadao Kakizoe | 2000 | World Journal of Surgery2000，，9： | 1 |
| 20 | Results of the double stapling procedure in colorectal surgery显示文摘 | Chuan Gang Fu Tetsuichiro Muto Tadahiko Masaki | 1997 | Surg Today1997，6，27： | 1 |
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