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| 1 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 2 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 3 | Projection of the Zhujiang(Pearl) River Delta's potential submerged area due to sea level rise during the 21st century based on CMIP5 simulations显示文摘Projections of potential submerged area due to sea level rise are helpful for improving understanding of the influence of ongoing global warming on coastal areas. The Ensemble Empirical Mode Decomposition method is used to adaptively decompose the sea level time series in order to extract the secular trend component. Then the linear relationship between the global mean sea level(GMSL) change and the Zhujiang(Pearl) River Delta(PRD)sea level change is calculated: an increase of 1.0 m in the GMSL corresponds to a 1.3 m(uncertainty interval from1.25 to 1.46 m) increase in the PRD. Based on this relationship and the GMSL rise projected by the Coupled Model Intercomparison Project Phase 5 under three greenhouse gas emission scenarios(representative concentration pathways, or RCPs, from low to high emission scenarios RCP2.6, RCP4.5, and RCP8.5), the PRD sea level is calculated and projected for the period 2006–2100. By around the year 2050, the PRD sea level will rise 0.29(0.21 to 0.40) m under RCP2.6, 0.31(0.22 to 0.42) m under RCP4.5, and 0.34(0.25 to 0.46) m under RCP8.5, respectively.By 2100, it will rise 0.59(0.36 to 0.88) m, 0.71(0.47 to 1.02) m, and 1.0(0.68 to 1.41) m, respectively. In addition,considering the extreme value of relative sea level due to land subsidence(i.e., 0.20 m) and that obtained from intermonthly variability(i.e., 0.33 m), the PRD sea level will rise 1.94 m by the year 2100 under the RCP8.5scenario with the upper uncertainty level(i.e., 1.41 m). Accordingly, the potential submerged area is 8.57×103 km2 for the PRD, about 1.3 times its present area. | XIA Jiangjiang YAN Zhongwei ZHOU Wen FONG Soi Kun LEONG Ka Cheng TANG Iu Man CHANG S W LEONG W K JIN Shaofei | 2015 | Acta Oceanologica Sinica2015，34，9： | 3 |
| 4 | Emergency re opera- tion for postoperative hemorrhage following partial esophagec- tomy for carcinoma of the e~phagus and cardia of the stomach 显示文摘 | Kun L YunJie W QingShu C | 2001 | Dis Esophagus2001，14，34： | 1 |
| 5 | Eigenstructure Method for Robust Array Processing显示文摘 | Youn W S Kun C | 1990 | Electronics Letters1990，26，10： | 1 |
| 6 | The Infl uences of Reaction Conditions on Phenanthrene Hydrogenation over Ni W/Al2O3Catalyst显示文摘 | Kun W Jun G Demin H | 2012 | Adv Mater Res2012，，： | 1 |
| 7 | Enhanced mechanical properties and degradability of poly(butylene succinate)and poly(lactic acid)blends显示文摘 | Jian Z Xiao W W Kun H | 2013 | Iran Polym J2013，22，： | 1 |
| 8 | Research on the WeChat Information Transmission Topology Based on Social Network Analysis 显示文摘 | W Kun S Duoyong | 2015 | OpenCybernetics & Systemics Journal2015，，： | 1 |
| 9 | Increase of xylitol productivity by cell-recycle fermentation of Candida tropicalis using submerged membrane bioreactor 显示文摘 | KWON S G PARK S W OH D KUN | 2006 | J Biosei Bioeng2006，101，1： | 1 |
| 10 | Emergency re-operation for postoperative hemorrhage following partial esophagectomy for carcinoma of the esophagus and cardia of the stomach显示文摘 | Kun L Yun-Jie W Qing-Shu C | 2001 | Dis Esophagus2001，14，34： | 1 |
| 11 | Specific Associanon of Human Telomerase Activity with Immortal Cells and Cancer显示文摘 | KUN N W PRATYSZEK M A PROWSE K R | 1994 | Science1994，266，5193： | 1 |
| 12 | Numerical prediction experiment on Typhoon Maggie (9903) 显示文摘 | Kun F S Chisheng W Pan H I | 2001 | Acta Oceanologica Sinica/Haiyang Xuebao2001，20，2： | 1 |
| 13 | Remediation of petroleum-contaminated loess soil by surfactant-en- hanced flushing technique 显示文摘 | Zhu Kun Hart W Yang Jiantao | 2005 | J Environ Sci Health2005，40，10： | 1 |
| 14 | Rho A/ROK pathway related to the mechanism of higher susceptibility to spasm in RA than in IMA显示文摘 | Kun X Lefeng W Rongjing D | 2009 | J Card Surg2009，24，6： | 1 |
| 15 | Berberine inhibits the migration and invasion of T24 bladder cancer cells via reducing the expression of heparanase显示文摘 | Yan L Yan K Kun W | 2013 | Tumour Biol2013，34，1： | 1 |
| 16 | Re-examination of characteristic FT-IR spectrum of secondary layer in bi- layer oleic acid-coated Fe304 nanoparticles显示文摘 | Kun Y Huabei P Yuhua W | 2010 | Applied Surface Science2010，25，10： | 1 |
| 17 | Purification and Biochemical Characterization of Thermostable Phytase from Newly Isolated Bacillus Subtilis CF92显示文摘 | Sung W H !I H C Kun S C | 2011 | Journal of the Korean Society for Applied Biological Chemistry2011，54，1： | 1 |
| 18 | Molecular cloning and expression analysis of CmMlol in melon显示文摘 | Cheng H Kun W Liu D | 2012 | Molecular Biology Reports2012，39，2： | 1 |
| 19 | Control of variable speed gaits for a biped robot显示文摘 | Kun A L Miller W T III | 1999 | IEEE Robotics and Automation Magazine1999，6，3： | 1 |
| 20 | Prevalence of post-traumatic stress disorder in Sichuan Province,China after the 2008 Wenchuan earthquake显示文摘 | Kun P Chen X Han S Gong X Chen M Zhang W | | 0，，11： | 1 |
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