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| 1 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | Chromosomal evolution in Balsaminaceae with cytological observations on 45 species from Southeast Asia 显示文摘 | Song Y Yuan YM Kupfer P 2003 | 2003 | Caryolog2003，56，： | 1 |
| 3 | Seedcoat micromorphology of Impatiens (Balsaminaceae) from China 显示文摘 | Song Y Yuan YM Kupfer P 2005 | 2005 | Bot J Linn Soc2005，149，： | 1 |
| 4 | Thin Solid Films显示文摘 | Richter F Kupfer H Schlott P Gessner T Kaufmann C | 2001 | 389( 1-2 ):2782001，389，12： | 1 |
| 5 | Infrageneric phylogeny of the genus Gentiana (Gentianaceae) inferred from nucleotide sequences of internal transcribed spacers (ITS) of nuclear ribosomal DNA显示文摘 | Yuan Y M Kupfer P Doyle J J | 1996 | American Journal of Botany1996，83，： | 1 |
| 6 | Fifteen years of env C2V3C3evolution in six individuals infected clonally with human immunodeficiency virus type 1显示文摘 | Kupfer B Sing T Schuffler P | 2007 | Journal of medical virology2007，79，11： | 1 |
| 7 | Detection of bocavirus DNA in nasopharyngeal aspirates of a child with bronchiolitis显示文摘 | Simon A Groneck P Kupfer B | 2007 | J In {ect2007，54，3： | 1 |
| 8 | Coming to terms with the terms of risks显示文摘 | Kraemer H C Kazdin A E Offord D R Kessler R C Jensen P S Kupfer D J | 1997 | Archives of General Psychiatry1997，54，： | 1 |
| 9 | Infrageneric phylogeny of the genus Gentiana (Gentianaceae) inferred from nucleotide spacer(ITS) of nuclear ribosomal DNA 显示文摘 | YUAN Y-M KUPFER P DOYLE J J | 1996 | American Journal of Botany1996，83，： | 1 |
| 10 | Detection of bocavirus DNA in nasopharyngeal asp irates of a child with bronchiolitis 显示文摘 | SIMON A GRONECK P KUPFER B | 2007 | Jlnfee2007，54，3： | 1 |
| 11 | Infragenefic phylogeny of the genus Gentiana (Gentianaceae) inferred from nucleotide sequences of the internal transcribed spacers (ITS) of unclear ribosomal DNA显示文摘 | Yuan YM Kupfer P Doyle JJ | 1996 | Amer J Bot1996，83，： | 1 |
| 12 | Optical properties and mechanical stress in SiO2/Nb2O5 multilayers 显示文摘 | Richter F Kupfer H Schlott P | 2001 | Thin Solid Films2001，389，12： | 1 |
| 13 | Infrageneric phylogeny of the genus Gentiana (Genti-anaceae) inferred from nucleotide sequences of internal transcribed spacers(ITS) of nuclear ribosomal DNA 显示文摘 | Yuan Y M Kupfer P Doyle J J | 1996 | Amer J Bot1996，83，3： | 1 |
| 14 | Structure and composition of riparian forest edge显示文摘 | Kupfer J A Malanson G P | 1993 | Physical Geogrphy1993，14，3： | 1 |
| 15 | Infrageneric phylogeny of the genusGentianainferrred from nucleotide sequences of the internal transcribed spacers of the nuclear ribosomal DNA显示文摘 | Yuan Y M Kupfer P Doyle J J | 1996 | American Journal of Botany1996，83，： | 1 |
| 16 | The genome of the versatile nitrogen fixer Azorhizobium caulinodans ORS571 显示文摘 | Lee K B Backer P D Aono T Liu C T Suzuki S Suzuki T Kaneko T Yamada M Tabata S Kupfer D | 2008 | BMC Genomics2008，9，： | 1 |
| 17 | Fifteen years of env C2V3C3 evolution in six individuals infected clonally with human immunodeficiency virus type 1 显示文摘 | Kupfer B Sing T Schuffler P | 2007 | Journal of medical virology2007，79，16： | 1 |
| 18 | Detection of bocavirus DNA in nasopharyngeal aspirates of a child with bronchiolitis 显示文摘 | Simon A Groneck P Kupfer B | 2007 | J Infec2007，54，3： | 1 |
| 19 | Infrageneric phylogeny of thegenus Gentiana (Gentianaceae) inferred from nucleotide se-quences of the internal transcribed spacers (ITS) of nuclear ribo-somal DNA显示文摘 | YuanY M Kupfer P Doyle J J | 1996 | American Journal of Botany1996，83，5： | 1 |
| 20 | Genetic relationships of Aeromonas strains inferred from 16S rRNA,gyrB,and rpoB gene sequences 显示文摘 | Kupfer M Kuhnert P Koeczak B M | 2006 | Int J Syst Evol Micmbiol2006，，5： | 1 |
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