|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | On the Eve of Upgrading Antidepressants:(R)-Ketamine and Its Metabolites显示文摘Ketamine is a noncompetitive N-methyl-D-aspartate receptor(NMDAR)antagonist th has attracted widespread attention for its rapid-onset antidepressant effects,especially in individuals with treatment-resistant depression and suicidal ideation[1-3].Compared with the traditional antidepressants that take weeks,if not months,to benefit patients and are associated with a high rate of relapse,ketamine exerts its antidepressant effects | Kai Yuan Ying Han Kenji Hashimoto Lin Lu | 2016 | Neuroscience Bulletin2016，32，6： | 5 |
| 2 | Highly accurate colorectal cancer prediction model based on Raman spectroscopy using patient serum显示文摘BACKGROUND Colorectal cancer(CRC) is an important disease worldwide, accounting for the second highest number of cancer-related deaths and the third highest number of new cancer cases. The blood test is a simple and minimally invasive diagnostic test. However, there is currently no blood test that can accurately diagnose CRC.AIM To develop a comprehensive, spontaneous, minimally invasive, label-free, bloodbased CRC screening technique based on Raman spectroscopy.METHODS We used Raman spectra recorded using 184 serum samples obtained from patients undergoing colonoscopies. Patients with malignant tumor histories as well as those with cancers in organs other than the large intestine were excluded. Consequently, the specific diseases of 184 patients were CRC(12), rectal neuroendocrine tumor(2), colorectal adenoma(68), colorectal hyperplastic polyp(18), and others(84). We used the 1064-nm wavelength laser for excitation. The power of the laser was set to 200 mW.RESULTS Use of the recorded Raman spectra as training data allowed the construction of a boosted tree CRC prediction model based on machine learning. Therefore, the generalized R^2 values for CRC, adenomas, hyperplastic polyps, and neuroendocrine tumors were 0.9982, 0.9630, 0.9962, and 0.9986, respectively.CONCLUSION For machine learning using Raman spectral data, a highly accurate CRC prediction model with a high R^2 value was constructed. We are currently planning studies to demonstrate the accuracy of this model with a large amount of additional data. | Hiroaki Ito Naoyuki Uragami Tomokazu Miyazaki William Yang Kenji Issha Kai Matsuo Satoshi Kimura Yuji Arai Hiromasa Tokunaga Saiko Okada Machiko Kawamura Noboru Yokoyama Miki Kushima Haruhiro Inoue Takashi Fukagai Yumi Kamijo | 2020 | World Journal of Gastrointestinal Oncology2020，12，11： | 2 |
| 3 | Multiple Inflammatory Pseudotumor of the Liver, Mimicking Cholangiocarcinoma with Tumor Embolus in the Hepatic Vein: Report of a Case显示文摘 | Keita Kai Satoru Matsuyama Takao Ohtsuka Kenji Kitahara Daisuke Mori Kohji Miyazaki | 2007 | Surgery Today2007，，6： | 1 |
| 4 | Atmospheric mineral particles collected at Qira in the Taklamakan Desert, China 显示文摘 | Okada K Kai Kenji | 2004 | Atmospheric Environment2004，38，： | 1 |
| 5 | Dynamic changes of a typical linear dune in the Tengger Desert显示文摘The dynamical processes of a typical linear dune including morphological features, dune ridge swing range and crest height were investigated at different monitoring periods in the hinterland of Tengger Desert. The results indicated that the development of linear dune depends on not only the northwesterly prevailing wind, but also the winds from northeast and southwest. The dune ridge swayed along its fundamental strike and took on an eastward movement gradually. The original dune strike was NW70° on August 3, 1994, and then changed to NE15° on April 21, 2001. The dune crest increased by 1.8 m longitudinally, which manifested strong wind-blown sand activities in this region. Wind erosion frequently occured at the bottom of sand dune, while sand accumulation appeared on its mid-upper section. The mean wind erosion depth was 25 cm on the bottom of linear dune and the height difference of the control points on the dune's ridge was 1.13 m. Although the linear dune swayed laterally, the horizontal displacement of its ridge moved eastward 5.8 m averagely. The swing range of the dune crest line is very distinct, with a maximum value of 13.2 m. The highest site on the K-profile swayed on both sides of the dune ridge and the heights were 19.88 m at the control point K5, 19.61 m at K6 and 19.05 m at K7, respectively. The results indicated that the lateral swing of the linear dune was distinct under the northwesterly wind and it moved toward east gradually. | Zhang, KeCun Kai, KenJi Qu, JianJun Ling, YuQuan Niu, QingHe | 2010 | Journal of Arid Land2010，2，4： | 1 |
| 6 | Multiple Inflammatory Pseudotumor of the Liver, Mimicking Cholangiocarcinoma with Tumor Embolus in the Hepatic Vein: Report of a Case显示文摘 | Keita Kai Satoru Matsuyama Takao Ohtsuka Kenji Kitahara Daisuke Mori Kohji Miyazaki | 2007 | Surgery Today2007，，6： | 1 |
| 7 | Determination of esophageal squamous cell carcinoma and gastric adenocarcinoma on raw tissue using Raman spectroscopy显示文摘BACKGROUND Cancer detection is a global research focus,and novel,rapid,and label-free techniques are being developed for routine clinical practice.This has led to the development of new tools and techniques from the bench side to routine clinical practice.In this study,we present a method that uses Raman spectroscopy(RS)to detect cancer in unstained formalin-fixed,resected specimens of the esophagus and stomach.Our method can record a clear Raman-scattered light spectrum in these specimens,confirming that the Raman-scattered light spectrum changes because of the histological differences in the mucosal tissue.AIM To evaluate the use of Raman-scattered light spectrum for detecting endoscopically resected specimens of esophageal squamous cell carcinoma(SCC)and gastric adenocarcinoma(AC).METHODS We created a Raman device that is suitable for observing living tissues,and attempted to acquire Raman-scattered light spectra in endoscopically resected specimens of six esophageal tissues and 12 gastric tissues.We evaluated formalin-fixed tissues using this technique and captured shifts at multiple locations based on feasibility,ranging from six to 19 locations 200 microns apart in the vertical and horizontal directions.Furthermore,a correlation between the obtained Raman scattered light spectra and histopathological diagnosis was performed.RESULTS We successfully obtained Raman scattered light spectra from all six esophageal and 12 gastric specimens.After data capture,the tissue specimens were sent for histopathological analysis for further processing because RS is a label-free methodology that does not cause tissue destruction or alterations.Based on data analysis of molecular-level substrates,we established cut-off values for the diagnosis of esophageal SCC and gastric AC.By analyzing specific Raman shifts,we developed an algorithm to identify the range of esophageal SCC and gastric AC with an accuracy close to that of histopathological diagnoses.CONCLUSION Our technique provides qualitative information for real-time morphological diagnosis.However,further in vivo evaluations require an excitation light source with low human toxicity and large amounts of data for validation. | Hiroaki Ito Naoyuki Uragami Tomokazu Miyazaki Yuto Shimamura Haruo Ikeda Yohei Nishikawa Manabu Onimaru Kai Matsuo Masayuki Isozaki William Yang Kenji Issha Satoshi Kimura Machiko Kawamura Noboru Yokoyama Miki Kushima Haruhiro Inoue | 2023 | World Journal of Gastroenterology2023，29，20： | 0 |
| 8 | Direct synthesis of high-quality perovskite nanocrystals on a flexible substrate and deterministic transfer显示文摘Solid-state perovskite nanocrystals are promising coherent light sources, as there is optical feedback within the crystal structure. In order to utilize the high performance of perovskites for on-chip applications, or observe new physical phenomena, these crystals must be integrated with pre-fabricated electronic or photonic structures. However, the material's fragility has made the deterministic transfer a great challenge thus far. Here, we report the first deterministic transfer of perovskite nanocrystals with sub-micron accuracy. Cesium lead halide(CsPbI_3) nanocrystals were directly synthesized on flexible polydimethylsiloxane(PDMS) stamps via chemical vapor deposition(CVD) and subsequently transferred onto arbitrary substrates/structures. We demonstrated the transfer of a CsPbI_3 crystalline nanoplate(NP)onto an 8 mm fiber core and achieved single-mode whispering gallery mode lasing. Our method can be extended to a variety of other arbitrary substrates(e.g., electrodes, photonic structures, micromechanical systems), laying the foundations for previously unattainable opportunities in perovskites-based devices. | Yilun Wang Xing Cheng Kai Yuan Yi Wan Pan Li Yuhao Deng Haoran Yu Xiaolong Xu Yi Zeng Wanjin Xu Yanping Li Renmin Ma Kenji Watanabe Takashi Taniguchi Yu Ye Lun Dai | 2018 | Science Bulletin2018，63，23： | 0 |
| 9 | insulin-like growth factor-i enhances gut growth and improves mucosal barrier function in sepric rats显示文摘Sepsis causes gut mucosal metabolic derangem-ints and has been implicated in altered barrier func-tion.Insulin-like growth factor-I(IGF-I)has beenshown to accelerate somatic growth,as well as to in-duce growth of the gut.To investigate the effect ofIGF-I on gut mucosal metabolism and barrier functionin sepsis,32 male wistar rats underwent cecal ligationwere randomized to 2 groups:IGF-I(n=17)re-ceived parenteral nutrition(PN)plus IGF-I 4mg.kg.-1d-1and control group(n=15)received PNonly,or 3 days.On day 4,body weight(BW)gain, | Kai Chen M.D Toshitada Okuma M.D Kenji Okamura M.D Yoahimasa Miyauchi M.D | 1994 | 中华临床营养杂志1994，12，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员