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| 1 | Long-term prognostic impact of circulating tumour cells in gastric cancer patients显示文摘AIM To analyse the long-term prognostic impact of circulating tumour cells(CTCs) in gastric cancer patients who underwent surgery. METHODS A 7.5-m L peripheral vein blood sample was obtained from each patient with treatment-negative gastric adenocarcinoma before surgery. OBP-401, a telomerasespecific, replication-selective, oncolytic adenoviral agent carrying the green fluorescent protein gene, was used to label CTCs. Correlations between the number of CTCs and clinical end points were evaluated. RESULTS The median follow-up period of the surviving patients with gastric cancer was 60 mo. The CTC number tended to increase concomitantly with disease progression. The overall survival of patients with more than five CTCs in 7.5-m L of peripheral blood was lower than that of patients with five or less CTCs, although the difference was not significant(P = 0.183). A significant difference in relapse-free survival was found between patients with more than five and those with five or less CTCs(P = 0.034).CONCLUSION A lower number of CTCs was correlated with higher relapse-free survival rates in patients. Detection of CTCs using OBP-401 may be useful for predicting prognosis in gastric cancer. | Hiroaki Ito Jun Sato Yukio Tsujino Noriko Yamaguchi Satoshi Kimura Keigo Gohda Katsuhiro Murakami Manabu Onimaru Tohru Ohmori Fumihiro Ishikawa Haruhiro Inoue | 2016 | World Journal of Gastroenterology2016，22，46： | 8 |
| 2 | Submucosal tunnel endoscopy:Peroral endoscopicmyotomy and peroral endoscopic tumor resection显示文摘Peroral endoscopic myotomy(POEM) is an innovative,minimally invasive, endoscopic treatment for esophageal achalasia and other esophageal motility disorders, emerged from the natural orifice transluminal endoscopic surgery procedures, and since the first human case performed by Inoue in 2008, showed exciting results in international level, with more than 4000 cases globally up to now. POEM showed superior characteristics than the standard 100-year-old surgical or laparoscopic Heller myotomy(LHM), not only for all types of esophageal achalasia [classical(Ⅰ), vigorous(Ⅱ), spastic(Ⅲ), Chicago Classification], but also for advanced sigmoid type achalasia(S1 and S2), failed LHM, or other esophageal motility disorders(diffuse esophageal spasm, nutcracker esophagus or Jackhammer esophagus). POEM starts with a mucosal incision, followed by submucosal tunnel creation crossing the esophagogastric junction(EGJ) and myotomy. Finally the mucosal entry is closed with endoscopic clip placement. POEM permitted relatively free choice of myotomy length and localization. Although it is technically demanding procedure, POEM can be performed safely and achieves very good control of dysphagia and chest pain. Gastroesophageal reflux is the most common troublesome side effect, and is well controllable with proton pump inhibitors. Furthermore, POEM opened the era of submucosal tunnel endoscopy, with many other applications. Based on the same principles with POEM, in combination with new technological developments, such as endoscopic suturing, peroral endoscopic tumor resection(POET), is safely and effectively applied for challenging submucosal esophageal, EGJ and gastric cardia tumors(submucosal tumors), emerged from muscularis propria. POET showed up to know promising results, however, it is restricted to specialized centers. The present article reviews the recent data of POEM and POET and discussed controversial issues that need further study and future perspectives. | Nikolas Eleftheriadis Haruhiro Inoue Haruo Ikeda Manabu Onimaru Roberta Maselli Grace Santi | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 7 |
| 3 | Endoscopic Mucosal Resection, Endoscopic Submucosal Dissection, and Beyond: Full-Layer Resection for Gastric Cancer with Nonexposure Technique (CLEAN-NET)显示文摘 | Haruhiro Inoue Haruo Ikeda Toshihisa Hosoya Akira Yoshida Manabu Onimaru Michitaka Suzuki Shin-ei Kudo | 2012 | Surgical Oncology Clinics of North America2012，，1： | 2 |
| 4 | Endocytoscopic visualization of squamous cell islands within Barrett's epithelium显示文摘AIM: To study the endocytoscopic visualization of squamous cell islands within Barrett's epithelium. METHODS: Endocytoscopy (ECS) has been studied in the surveillance of Barrett's esophagus, with controversial results. In initial studies, however, a soft catheter type endocytoscope was used, while only methylene blue dye was used for the staining of Barrett's mucosa. Integrated type endocytoscopes (GIF-Q260 EC, Olympus Corp, Tokyo, Japan) have been recently developed, with the incorporation of a high-power magnifying endocytoscope into a standard endoscope together with narrow-band imaging (NBI). Moreover, double staining with a mixture of 0.05% crystal violet and 0.1% of methylene blue (CM) during ECS enables higher quality images comparable to conventional hematoxylin eosin histopathological images.RESULTS: In vivo endocytoscopic visualization of papillary squamous cell islands within glandular Barrett's epithelium in a patient with long-segment Barrett's esophagus is reported. Conventional white light endoscopy showed typical long-segment Barrett's esophagus, with small squamous cell islands within normal Barrett's mucosa, which were better visualized by NBI endoscopy. ECS after double CM staining showed regular Barrett's esophagus, while higher magnification (×480) revealed the orifices of glandular structures better. Furthermore, typical squamous cell papillary protrusion, classified as endocytoscopic atypia classification (ECA) 2 according to ECA, was identified within regular glandular Barrett's mucosa. Histological examination of biopsies taken from the same area showed squamous epithelium within glandular Barrett's mucosa, corresponding well to endocytoscopic findings. CONCLUSION: To our knowledge, this is the first report of in vivo visualization of esophageal papillary squamous cell islands surrounded by glandular Barrett's epithelium. | Nicholas Eleftheriadis Haruhiro Inoue Haruo Ikeda Manabu Onimaru Akira Yoshida Toshihisa Hosoya Roberta Maselli Shin-ei Kudo | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，4： | 2 |
| 5 | Per-oral Endoscopic Myotomy is a Viable Option for Failed Surgical Esophagocardiomyotomy Instead of Re-Do Surgical Heller Myotomy: A Single Center Prospective Study显示文摘 | Manabu Onimaru Haruhiro Inoue Haruo Ikeda Akira Yoshida Esperanza Grace Santi Hiroki Sato Hiroaki Ito Roberta Maselli Shin-ei Kudo | 2013 | Journal of the American College of Surgeons2013，，： | 2 |
| 6 | 54 Clinical Results in 300 Cases of POEM for Esophageal Achalasia a Single Institute Registered Prospective Study显示文摘 | Haruhiro Inoue Haruo Ikeda Manabu Onimaru Akira Yoshida Hiroki Sato Esperanza Grace R. Santi Roberta Maselli Nicholas Eleftheriadis Shin-Ei Kudo | 2013 | Gastrointestinal Endoscopy2013，，5： | 2 |
| 7 | Acetic acid spray enhances accuracy of narrow-band imaging magnifying endoscopy for endoscopic tissue characterization of early gastric cancer显示文摘 | Nikolas Eleftheriadis Haruhiro Inoue Haruo Ikeda Manabu Onimaru Akira Yoshida Roberta Maselli Grace Santi Shin-ei Kudo | 2013 | Gastrointestinal Endoscopy2013，，： | 2 |
| 8 | Predicting the chemosensitivity of pancreatic cancer cells by quantifyingthe expression levels of genes associated with the metabolism of gemcitabine and5-fluorouracil显示文摘 | Nobuaki Kurata Hayato Fujita Kenoki Ohuchida Kazuhiro Mizumoto Prawej Mahawithitwong Hiroshi Sakai Manabu Onimaru Tatsuya Manabe Takao Ohtsuka Masao Tanaka | 2011 | International Journal of Oncology2011，，2： | 2 |
| 9 | Magnification narrow-band imaging for the diagnosis of early gastric cancer: a review of the Japanese literature for the Western endoscopist显示文摘 | Bu’Hussain Hayee Haruhiro Inoue Hiroki Sato Esperanza Grace Santi Akira Yoshida Manabu Onimaru Haruo Ikeda Shin-ei Kudo | 2013 | Gastrointestinal Endoscopy2013，，： | 2 |
| 10 | Training in peroral endoscopic myotomy (POEM) for esophageal achalasia显示文摘 | Nicholas Eleftheriadis Haruhiro Inoue Shin-ei Kudo Roberta Maselli Toshihisa Hosoya Akira Yoshida Manabu Onimaru Haruo Ikeda | 2012 | Therapeutics and Clinical Risk Management (default)2012，，： | 1 |
| 11 | International multicenter experience with peroral endoscopic myotomy for the treatment of spastic esophageal disorders refractory to medical therapy (with video)显示文摘 | Mouen A. Khashab Ahmed A. Messallam Manabu Onimaru Ezra N. Teitelbaum Michael B. Ujiki Matthew E. Gitelis Rani J. Modayil Eric S. Hungness Stavros N. Stavropoulos Mohamad H. El Zein Hironari Shiwaku Rastislav Kunda Alessandro Repici Hitomi Minami Philip W | 2014 | Gastrointestinal Endoscopy2014，，： | 1 |
| 12 | Evaluation of the safety and efficacy of esophagojejunostomy after totally laparoscopic total gastrectomy using a trans-orally inserted anvil: a single-center comparative study显示文摘 | Hiroaki Ito Haruhiro Inoue Noriko Odaka Hitoshi Satodate Manabu Onimaru Haruo Ikeda Daisuke Takayanagi Kenta Nakahara Shin-ei Kudo | 2014 | Surgical Endoscopy2014，，6： | 1 |
| 13 | Per-Oral Endoscopic Myotomy: A Series of 500 Patients显示文摘 | Haruhiro Inoue Hiroki Sato Haruo Ikeda Manabu Onimaru Chiaki Sato Hitomi Minami Hiroshi Yokomichi Yasutoshi Kobayashi Kevin L. Grimes Shin-ei Kudo | 2015 | Journal of the American College of Surgeons2015，，2： | 1 |
| 14 | Control of severe strictures after circumferential endoscopic submucosal dissection for esophageal carcinoma: oral steroid therapy with balloon dilation or balloon dilation alone显示文摘 | Hiroki Sato Haruhiro Inoue Yasutoshi Kobayashi Roberta Maselli Esperanza Grace R. Santi Bu’Hussain Hayee Kenta Igarashi Akira Yoshida Haruo Ikeda Manabu Onimaru Yutaka Aoyagi Shin-ei Kudo | 2013 | Gastrointestinal Endoscopy2013，，2： | 1 |
| 15 | 728 Clinical Results of 500 POEM Cases for Esophageal Achalasia and Related Diseases in a Single Institute显示文摘 | Haruhiro Inoue Manabu Onimaru Haruo Ikeda Chiaki Sato Hiroki Sato Shin-Ei Kudo | 2014 | Gastrointestinal Endoscopy2014，，5： | 1 |
| 16 | Microvasculature of the esophagus and gastroesophageal junction: Lesson learned from submucosal endoscopy显示文摘Advanced therapeutic endoscopy,in particular endoscopic mucosal resection,endoscopic submucosal dissection,per-oral endoscopic myotomy,submucosal endoscopic tumor resection opened a new era where direct esophageal visualization is possible.Combining these information with advanced diagnostic endoscopy,the esophagus is organized,from the luminal side to outside,into five layers(epithelium,lamina propria with lamina muscularis mucosa,submucosa,muscle layer,adventitia).A specific vascular system belonging to each layer is thus visible: Mucosa with the intra papillary capillary loop in the epithelium and the sub-epithelial capillary network in the lamina propria and,at the lower esophageal sphincter(LES) level with the palisade vessels; submucosa with the drainage vessels and the spindle veins at LES level; muscle layer with the perforating vessels; periesophageal veins in adventitia.These structures are particularly important to define endoscopic landmark for the gastro-esophageal junction,helpful in performing submucosal therapeutic endoscopy. | Roberta Maselli Haruhiro Inoue Haruo Ikeda Manabu Onimaru Akira Yoshida Esperanza Grace Santi Hiroki Sato Bu'Hussain Hayee Shin-Ei Kudo | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，19： | 0 |
| 17 | Determination of esophageal squamous cell carcinoma and gastric adenocarcinoma on raw tissue using Raman spectroscopy显示文摘BACKGROUND Cancer detection is a global research focus,and novel,rapid,and label-free techniques are being developed for routine clinical practice.This has led to the development of new tools and techniques from the bench side to routine clinical practice.In this study,we present a method that uses Raman spectroscopy(RS)to detect cancer in unstained formalin-fixed,resected specimens of the esophagus and stomach.Our method can record a clear Raman-scattered light spectrum in these specimens,confirming that the Raman-scattered light spectrum changes because of the histological differences in the mucosal tissue.AIM To evaluate the use of Raman-scattered light spectrum for detecting endoscopically resected specimens of esophageal squamous cell carcinoma(SCC)and gastric adenocarcinoma(AC).METHODS We created a Raman device that is suitable for observing living tissues,and attempted to acquire Raman-scattered light spectra in endoscopically resected specimens of six esophageal tissues and 12 gastric tissues.We evaluated formalin-fixed tissues using this technique and captured shifts at multiple locations based on feasibility,ranging from six to 19 locations 200 microns apart in the vertical and horizontal directions.Furthermore,a correlation between the obtained Raman scattered light spectra and histopathological diagnosis was performed.RESULTS We successfully obtained Raman scattered light spectra from all six esophageal and 12 gastric specimens.After data capture,the tissue specimens were sent for histopathological analysis for further processing because RS is a label-free methodology that does not cause tissue destruction or alterations.Based on data analysis of molecular-level substrates,we established cut-off values for the diagnosis of esophageal SCC and gastric AC.By analyzing specific Raman shifts,we developed an algorithm to identify the range of esophageal SCC and gastric AC with an accuracy close to that of histopathological diagnoses.CONCLUSION Our technique provides qualitative information for real-time morphological diagnosis.However,further in vivo evaluations require an excitation light source with low human toxicity and large amounts of data for validation. | Hiroaki Ito Naoyuki Uragami Tomokazu Miyazaki Yuto Shimamura Haruo Ikeda Yohei Nishikawa Manabu Onimaru Kai Matsuo Masayuki Isozaki William Yang Kenji Issha Satoshi Kimura Machiko Kawamura Noboru Yokoyama Miki Kushima Haruhiro Inoue | 2023 | World Journal of Gastroenterology2023，29，20： | 0 |
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