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| 1 | A kind of double-sided porous anodic alumina membrane fabricated with the three-step anodic oxidation method显示文摘The porous anodic alumina membranes(PAAMs)have been successfully used as templates for the fabrication of functional nano-materials due to their outstanding regularity and physicochemical properties.In this paper,a transparent double-sided anodic alumina membrane with ultra-thin aluminum substrate was fabricated with the three-step anodic oxidation method in the oxalic acid electrolyte.The characters such as the top-surface morphology,membrane thickness,and depth of nanopores of this three-layer(Al2O3-Al-Al2O3)sandwiched nano-structure were controllable through regulating the main anodic oxidation conditions,e.g.,anodic oxidation time of various steps,coating remove process.The experiments data revealed that the aluminum substrate is exponential declined with the oxidation time when it was approximately reduced by a few micrometers.This new double-sided anodic alumina membrane can be used as the high-quality functional field emission materials and templates. | ZHANG Chen WANG KaiGe GAO ZeYang WU JunJun REN JunYing ZHANG LiangLiang GU ChangZhi BAI JinTao | 2014 | Science China(Technological Sciences)2014，57，2： | 2 |
| 2 | Toxoplasma gondii infection induces cell apoptosis via multiple pathways revealed by transcriptome analysis显示文摘Toxoplasma gondii is a worldwide parasite that can infect almost all kinds of mammals and cause fatal toxoplasmosis in immunocompromised patients.Apoptosis is one of the principal strategies of host cells to clear pathogens and maintain organismal homeostasis,but the mechanism of cell apoptosis induced by T.gondii remains obscure.To explore the apoptosis influenced by T.gondii,Vero cells infected or uninfected with the parasite were subjected to apoptosis detection and subsequent dual RNA sequencing(RNA-seq).Using high-throughput Illumina sequencing and bioinformatics analysis,we found that pro-apoptosis genes such as DNA damage-inducible transcript 3(DDIT3),growth arrest and DNA damage-inducibleα(GADD45 A),caspase-3(CASP3),and high-temperature requirement protease A2(Htr A2)were upregulated,and anti-apoptosis genes such as poly(adenosine diphosphate(ADP)-ribose)polymerase family member 3(PARP3),B-cell lymphoma 2(Bcl-2),and baculoviral inhibitor of apoptosis protein(IAP)repeat containing 5(BIRC5)were downregulated.Besides,tumor necrosis factor(TNF)receptor-associated factor 1(TRAF1),TRAF2,TNF receptor superfamily member 10 b(TNFRSF10 b),disabled homolog2(DAB2)-interacting protein(DAB2 IP),and inositol 1,4,5-trisphosphate receptor type 3(ITPR3)were enriched in the upstream of TNF,TNF-related apoptosis-inducing ligand(TRAIL),and endoplasmic reticulum(ER)stress pathways,and TRAIL-receptor2(TRAIL-R2)was regarded as an important membrane receptor influenced by T.gondii that had not been previously considered.In conclusion,the T.gondii RH strain could promote and mediate apoptosis through multiple pathways mentioned above in Vero cells.Our findings improve the understanding of the T.gondii infection process through providing new insights into the related cellular apoptosis mechanisms. | Kaige DU Fei LU Chengzuo XIE Haojie DING Yu SHEN Yafan GAO Shaohong LU Xunhui ZHUO | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，4： | 1 |
| 3 | Highly Dispersed Pd Nanoparticles Supported on Zr-Doped MgAl Mixed Metal Oxides for 2-Ethylanthraquinone Hydrogenation显示文摘In this study,Pd-Mg(Al)-LDH/γ-Al2O3 and Pd-Mg(Al)Zr-LDH/γ-Al2O3 precursors were synthesized by impregnating Na2PdCl4 on Mg(Al)-LDH/γ-Al2O3 and Mg(Al)Zr-LDH/γ-Al2O3,and then the precursors were calcinated and reduced to obtain Pd-Mg(Al)-MMO/γ-Al2O3 and Pd-Mg(Al)Zr-MMO/γ-Al2O3 catalysts.Compared with Pd/γ-Al2O3 catalyst,the hydrogenation efficiency of Pd-Mg(Al)-MMO/γ-Al2O3 and Pd-Mg(Al)Zr-MMO/γ-Al2O3 increased by 15.7%and 24.0%,respectively.Moreover,the stability of Pd-Mg(Al)Zr-MMO/γ-Al2O3 catalyst was also higher than that of Pd/γ-Al2O3.After four runs,the hydrogenation efficiency of Pd/γ-Al2O3 decreased from 12.1 to 10.0 g/L,while that of Pd-Mg(Al)Zr-MMO/γ-Al2O3 decreased from 15.0 to 14.3 g/L.The active aquinones selectivities of all catalysts were almost 99%.The structures of the catalysts were characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),N2 adsorption–desorption,inductively coupled plasma-atomic emission spectrometry(ICP-AES),CO chemisorption analysis,transmission electron microscopy(TEM),temperature-programmed reduction with hydrogen(H2-TPR),and X-ray photoelectron spectroscopy(XPS).The results indicate that the improved catalytic performance is attributed to the stronger interaction between Pd and Mg(Al)Zr-MMO/γ-Al2O3,smaller Pd particle size and higher Pd dispersion.This work develops an effective method to synthesize highly dispersed Pd nanoparticles based on the layered double hydroxides(LDHs)precursor. | Yunhao Wang Kaige Gao Chenliang Ye Ang Li Cuili Guo Jinli Zhang | 2019 | Transactions of Tianjin University2019，25，6： | 1 |
| 4 | Structural dynamics of the yeast Shwachman- Diamond syndrome protein (Sdol) on the ribosome and its implication in the 60S subunit maturation显示文摘 | Chengying Ma Kaige Yan Dan Tan Ningning Li Yixiao Zhang Yi Yuan Zhifei Li Meng-Qiu Dong Jianlin Lei Ning Gao | 2016 | Protein & Cell2016，7，3： | 0 |
| 5 | Structural insights into the assembly of the 30S ribosomal subunit in vivo: functional role of S5 and location of the 17S rRNA precursor sequence显示文摘在里面 ribosomal 子单元的 vivo 汇编是高度复杂的进程与在蛋白质汇编和 rRNA 成熟事件之间的紧密的协作,例如选择的库的 rRNA 先锋,以及修正合拢并且处理。在房间,很多因素被要求保证子单元生产的效率和忠实。这里,我们描绘子单元在因素 0 Escherichia coli 紧张(rsgArbfA ) 积累了的不成熟的 30S。与在缓冲区系统改变盐集中孤立的不成熟的 30S 子单元在蛋白质作文和结构上显示出有趣的差别。明确地,中介在二个形成对照的盐条件下面发源(高、低) 多半反映二个特殊集会阶段, 3 领域集会的相对早、迟了的阶段分别地。详细结构的分析表明在 17S rRNA 的 5 结束和 30S 头域的汇编的成熟之间的机械学的联合,并且在协调这二个事件归因 S5 的一个唯一的角色。而且,我们的结构的结果多半揭示 17S rRNA 的 unprocessed 终端序列的地点,并且建议 17S rRNA 的成熟事件能在子单元生产和蛋白质翻译上作为质量控制机制被采用。 | Zhixiu Yang Qiang Guo Simon Goto Yuling Chen Ningning Li Kaige Yan Yixiao Zhang Akira Muto Haiteng Deng Hyouta Himeno Jianlin Lei Ning Gao | 2014 | Protein & Cell2014，5，5： | 0 |
| 6 | 环形RNA结构与降解调控PKR激活和天然免疫反应显示文摘文章简介环形RNA(circ RNA)来自RNA聚合酶II的转录本并以共价键形成闭环结构。虽然在哺乳动物细胞中普遍表达,但是绝大部分环形RNA的功能仍不清楚。外显子反向剪接成环发生效率很低,但产生的环形RNA非常稳定。该研究证明环形RNA分子倾向于形成长度为16-26bp双链RNA茎环结构,可以结合并抑制天然免疫因子PKR的活性。 | 刘楚霄 李响 南芳 Shan Jiang Xiang Gao Si-Kun Guo Wei Xue Yange Cui Kaige Dong Huihua Ding Bo Qu Zhaocai Zhou 沈南 杨力 陈玲玲 | 2020 | 科学新闻2020，，2： | 0 |
| 7 | Studying the current properties of buffer solution through micro-fluidic channels driven with the pulse bias显示文摘In the research of bio-molecular chips and sensors,extra electric biases are most often employed to control and manipulate the DNA and protein molecules moving through micro/nano-fluidic channels.In order to accurately and flexibly control the bio-molecules as they move within the channels,a clear understanding of how the current changes within the buffer solution caused by an applied bias is fundamental.In this report,the current changed value of different buffer solutions,e.g.,KCl,TE,and TBE was systematically studied with real-time monitoring and quantitative analysis in the situation of the buffers moving through a fluidic channel with a 5 m inner diameter,driven by biases of 50 or 100 mV.The results revealed that the relationship between the current changed value and the pause interval of the applied electric field is highly consistent with the Hill Equation,which is helpful for accurately detecting and manipulating single biomolecules in microfluidic sensors and biochips. | GAO ZeYang WANG KaiGe ZHANG Chen MA HongWei WANG GuiRen BAI JinTao | 2014 | Science China(Technological Sciences)2014，57，2： | 0 |
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