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| 1 | Crystallization mechanism and microstructure evolution of Li2O–Al2O3–SiO2 glass-ceramics with Ta2O5 as nucleating agent显示文摘 | Yaohui Li Kaiming Liang Bo Xu JianWei Cao | 2010 | Journal of Thermal Analysis and Calorimetry2010，，3： | 1 |
| 2 | Two-sided ultrasonic surface rolling process of aeroengine blades based on on-machine noncontact measurement显示文摘As crucial parts of an aeroengine,blades are vulnerable to damage from long-term operation in harsh environments.The ultrasonic surface rolling process(USRP)is a novel surface treatment technique that can highly improve the mechanical behavior of blades.During secondary machining,the nominal blade model cannot be used for secondary machining path generation due to the deviation between the actual and nominal blades.The clamping error of the blade also affects the precision of secondary machining.This study presents a two-sided USRP(TS-USRP)machining for aeroengine blades on the basis of on-machine noncontact measurement.First,a TS-USRP machining system for blade is developed.Second,a 3D scanning system is used to obtain the point cloud of the blade,and a series of point cloud processing steps is performed.A local point cloud automatic extraction algorithm is introduced to extract the point cloud of the strengthened region of the blade.Then,the tool path is designed on the basis of the extracted point cloud.Finally,an experiment is conducted on an actual blade,with results showing that the proposed method is effective and efficient. | Shulei YAO Xian CAO Shuang LIU Congyang GONG Kaiming ZHANG Chengcheng ZHANG Xiancheng ZHANG | 2020 | Frontiers of Mechanical Engineering2020，15，2： | 1 |
| 3 | TSA1 interacts with CSN1/CSN and may be functionally involved in Arabidopsis seedling development in darkness显示文摘COP9 signalosome (CSN ) 是参予多样的细胞、发展的过程的 multiprotein 建筑群。CSN1, CSN 的子单元之一,为经由一种总线标准的 multiprotein 建筑群的汇编是必要的(proteasome, COP9 signalosome 和开始因素 3 ) 在 CSN1 的 C 终端一半的领域。然而, CSN1 的 N 终端域(NTD ) 的角色,为 CSN 的函数批评,完全没被理解。用酵母二混血儿(Y2H ) 屏蔽,我们发现 CSN1 的 NTD 与联系 TSK 蛋白质 1 交往(TSA1 ) ,报导 Ca2+ 有约束力的蛋白质。在 CSN1 和 TSA1 之间的相互作用被 co-immunoprecipitation 在 Arabidopsis 证实。tsa1 异种在黑暗展出了短胚轴显型,但是类似于在白光下面的野类型的 Arabidopsis,它建议 TSA1 可能在黑暗中调整 Arabidopsis 胚轴开发。而且, TSA1 的表示在 csn1 0 异种(fus6 ) 是显著地更低的,当 CSN1 表示没随着弱 TSA1 表示在 tsa1 异种变化时。一起,这些调查结果在幼苗开发建议在 TSA1 和 CSN1 之间的一种功能的关系。 | Wenjun Li Baisheng Zang Citao Liu Lu Lu Ning Wei Kaiming Cao Xing Wang Deng Xiping Wang | 2011 | Journal of Genetics and Genomics2011，38，11： | 1 |
| 4 | Targeting papain-like protease for broad-spectrum coronavirus inhibition显示文摘The emergence of SARS-CoV-2 variants of concern and repeated outbreaks of coronavirus epidemics in the past two decades emphasize the need for next-generation pan-coronaviral therapeutics.Drugging the multi-functional papain-like protease(PLpro)domain of the viral nsp3 holds promise.However,none of the known coronavirus PLpro inhibitors has been shown to be in vivo active.Herein,we screened a structurally diverse library of 50,080 compounds for potential coronavirus PLpro inhibitors and identified a noncovalent lead inhibitor F0213 that has broad-spectrum anti-coronaviral activity,including against the Sarbecoviruses(SARSCoV-1 and SARS-CoV-2),Merbecovirus(MERS-CoV),as well as the Alphacoronavirus(hCoV-229E and hCoVOC43).Importantly,F0213 confers protection in both SARS-CoV-2-infected hamsters and MERS-CoV-infected human DPP4-knockin mice.F0213 possesses a dual therapeutic functionality that suppresses coronavirus replication via blocking viral polyprotein cleavage,as well as promoting antiviral immunity by antagonizing the PLpro deubiquitinase activity.Despite the significant difference of substrate recognition,mode of inhibition studies suggest that F0213 is a competitive inhibitor against SARS2-PLpro via binding with the 157K amino acid residue,whereas an allosteric inhibitor of MERSPLpro interacting with its 271E position.Our proof-ofconcept findings demonstrated that PLpro is a valid target for the development of broad-spectrum anticoronavirus agents.The orally administered F0213 may serve as a promising lead compound for combating the ongoing COVID-19 pandemic and future coronavirus outbreaks. | Shuofeng Yuan Xiaopan Gao Kaiming Tang Jian-Piao Cai Menglong Hu Peng Luo Lei Wen Zi-Wei Ye Cuiting Luo Jessica Oi-Ling Tsang Chris Chun-Yiu Chan Yaoqiang Huang Jianli Cao Ronghui Liang Zhenzhi Qin Bo Qin Feifei Yin Hin Chu Dong-Yan Jin Ren Sun Jasper Fuk-Woo Chan Sheng Cui Kwok-Yung Yuen | 2022 | Protein & Cell2022，13，12： | 0 |
| 5 | An unusual anterior mitral leaflet perforation in a patient with no infective endocarditis:a case report显示文摘Background:Mitral valve perforation refers to the occurrence of cracks or openings in the structure of the mitral valve,allowing blood to escape through these gaps.Typically,this is caused by infective endocarditis and the most common site is the anterior leaflet.However,it is crucial to explore other potential causes of valve damage,particularly when conventional risk factors are not apparent.Case presentation:We present a case of a middle-aged male patient who developed mitral valve perforation because of aortic valve regurgitation in the absence of infective endocarditis.Conclusion:Exploring such rare cases contributes to a deeper understanding of valvular diseases and enhances clinical decision making for effective management. | Kaiming Wei Yu Yao Chuanzhen Liu Yuan Cao | 2024 | Emergency and Critical Care Medicine2024，4，1： | 0 |
| 6 | Approximate Optimal Filter Design for Vehicle System through Actor‑Critic Reinforcement Learning显示文摘Precise state and parameter estimations are essential for identification,analysis and control of vehicle engineering problems,especially under significant model and measurement uncertainties.The widely used filtering/estimation algorithms,such as Kalman series like Kalman filter,extended Kalman filter,unscented Kalman filter,and particle filter,generally aim to approach the true state/parameter distribution via iteratively updating the filter gain at each time step.However,the optimal-ity of these filters would be deteriorated by unrealistic initial condition or significant model error.Alternatively,this paper proposes to approximate the optimal filter gain by considering the effect factors within infinite time horizon,on the basis of estimation-control duality.The proposed approximate optimal filter(AOF)problem is designed and subsequently solved by actor-critic reinforcement learning(RL)method.The AOF design transforms the traditional optimal filtering problem with the minimum expected mean square error into an optimal control problem with the minimum accumulated estimation error,in which the estimation error is used as the surrogate system state and the infinite-horizon filter gain is the control input.The estimation-control duality is proved to hold when certain conditions about initial vehicle state distributions and policy structure are maintained.In order to evaluate of the effectiveness of AOF,a vehicle state estimation problem is then demonstrated and compared with the steady-state Kalman filter.The results showed that the obtained filter policy via RL with different discount factors can converge to theoretical optimal gain with an error within 5%,and the average estimation errors of vehicle slip angle and yaw rate are less than 1.5×10–4. | Yuming Yin Shengbo Eben Li Kaiming Tang Wenhan Cao Wei Wu Hongbo Li | 2022 | Automotive Innovation2022，5，4： | 0 |
| 7 | Proteomic identification of potential target proteins regulated by an ASK1-mediated proteolysis pathway显示文摘ASK1 (ARABIDOPSIS 象 SKP1 一样) 蛋白质是招募的 ubiquitin ligase 建筑群指向的 SCF (Skp1-Cullin-F 盒子蛋白质) 的一个批评部件为由 26S proteosome 的降级的蛋白质。为了调查蛋白质,那被调停 ASK1 的解朊作用小径在 Arabidopsis 花影响,我们用二维的电气泳动(2-DE ) 比较了 Arabidopsis 野类型和 ask1 异种花芽的 proteomes。有在与野类型花相比的 ask1 异种花的更高或更低的丰富的十个蛋白质点被切除并且使分析遭到了到进一步集体的 spectrometry (MS ) 。结果证明他们是涉及相片形态发生,生理节奏的摆动,翻译以后的过程,压力反应和房间扩大或延伸的蛋白质,建议那些过程在 ask1 异种被影响。基因也是的这些的抄本层次基于 Affymetrix 基因芯片比较了微数组数据。没有重要差别为大多数基因被观察,建议有在 ask1 异种的累积的提高的层次的蛋白质能是一条调停 ASK1 的解朊作用小径调整的候选人目标。阐明的这些结果帮助在 Arabidopsis 发展过程并且也的 ASK1 的多种的功能表明关于基因功能学习蛋白质层次的重要性和必要性。 | Xiaofeng Wang Weimin Ni Xiaochun Ge Jiejin Zhang Hong Ma Kaiming Cao | 2006 | Cell Research2006，16，5： | 0 |
| 8 | Metal–Oleate Complex?Derived Bimetallic Oxides Nanoparticles Encapsulated in 3D Graphene Networks as Anodes for Efficient Lithium Storage with Pseudocapacitance显示文摘In this manuscript, we have demonstrated the delicate design and synthesis of bimetallic oxides nanoparticles derived from metal–oleate complex embedded in 3D graphene networks(MnO/CoMn_2O_4 GN), as an anode material for lithium ion batteries. The novel synthesis of the MnO/CoMn_2O_4 GN consists of thermal decomposition of metal–oleate complex containing cobalt and manganese metals and oleate ligand, forming bimetallic oxides nanoparticles, followed by a selfassembly route with reduced graphene oxides. The MnO/CoMn_2O_4 GN composite, with a unique architecture of bimetallic oxides nanoparticles encapsulated in 3D graphene networks, rationally integrates several benefits including shortening the di usion path of Li^+ ions, improving electrical conductivity and mitigating volume variation during cycling. Studies show that the electrochemical reaction processes of MnO/Co Mn_2O_4 GN electrodes are dominated by the pseudocapacitive behavior, leading to fast Li^+ charge/discharge reactions. As a result, the MnO/CoMn_2O_4 GN manifests high initial specific capacity, stable cycling performance, and excellent rate capability. | Yingying Cao Kaiming Geng Hongbo Geng Huixiang Ang Jie Pei Yayuan Liu Xueqin Cao Junwei Zheng Hongwei Gu | 2019 | Nano-Micro Letters2019，11，1： | 0 |
| 9 | Numerical investigation on temperature–humidity field under mechanical ventilation in the construction period of hot-humid tunnel along the Sichuan–Tibet Railway显示文摘High temperature–humidity environment is one of the severe challenges in constructing Sichuan–Tibet railway tunnels.For enhancing construction efficiency and guaranteeing tunnel worker safety,addressing the high temperature–humidity environment has irreplaceable significance.This study innovatively investigated the distribution law and evolution process of the thermal–humidity coupling field dur-ing tunnel construction.Besides,the corresponding ventilation measures were proposed based on the evaluation heat index(HI).If the initial temperature of the surrounding rock is constant,the distance between the ventilation duct outlet and the tunnel working face should not be greater than 30 m.Otherwise,the cooling performance of ventilation will be significantly weakened;If this temperature ranges in 65–85℃,the recommended ventilation velocity is 10–25 m/s,and the ventilation distance should not exceed 20 m.The con-clusions in this study are beneficial to better understand the high temperature–humidity environment in tunnel construction and can be a guideline for practical engineering application. | Kaiming Zhao Yanping Yuan Fujian Jiang Xiaoling Cao | 2023 | Underground Space2023，，1： | 0 |
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