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| 1 | Novel mutations in the STK11 gene in Thai patients with Peutz-Jeghers syndrome显示文摘Peutz-Jeghers syndrome(PJS) ,a rare autosomal dominant inherited disorder,is characterized by hamartomatous gastrointestinal polyps and mucocutaneous pigmentation.Patients with this syndrome have a predisposition to a variety of cancers in multiple organs.Mutations in the serine/threonine kinase 11(STK11) gene have been identified as a major cause of PJS.Here we present the clinical and molecular findings of two unrelated Thai individuals with PJS.Mutation analysis by Polymerase Chain Reaction-sequencing of the entire coding region of STK11 revealed two potentially pathogenic mutations.One harbored a single nucleotide deletion(c.182delG) in exon 1 resulting in a frameshift leading to premature termination at codon 63(p.Gly61AlafsX63) .The other carried an in-frame 9-base-pair(bp) deletion in exon 7,c.907_915del9(p.Ile303_Gln305del) .Both deletions were de novo and have never been previously described.This study has expanded the genotypic spectrum of the STK11 gene. | Surasawadee Ausavarat Petcharat Leoyklang Paisarn Vejchapipat Voranush Chongsrisawat Kanya Suphapeetiporn Vorasuk Shotelersuk | 2009 | World Journal of Gastroenterology2009，15，42： | 8 |
| 2 | The trace amine receptor 4gene is not associated with schizophrenia in a sample linked to chromosome 6q23显示文摘 | Amann D Avidan N Kanyas K | 2006 | Mol Psychiatry2006，11，2： | 1 |
| 3 | Effect of detoxification on the functional and nutritional quality of proteins of karanja seed meal显示文摘 | VINAY B J SINDH U KANYA T | 2008 | Food Chemistry2008，106，1： | 1 |
| 4 | Preparation of phosphorylated bacterial cellulose as an adsorbent for metal ions显示文摘 | Tatsuya Oshima Kanya Kondo Keisuke Ohto | 2008 | React Funct Polym2008，68，： | 1 |
| 5 | Processing of carbon nanotube reinforced silicon nitfide composites by spark plasma sintering显示文摘 | Balazsi C Shen Z Kanya Z | 2005 | Composites Science and Technology2005，65，5： | 1 |
| 6 | Synthesis, characterisation and catalytic applications of sol - gel derived silica - phosphotungstic acid composites 显示文摘 | Kukovecz A Balogi Zs Kanya Z | 2002 | Catalysis A2002，228，： | 1 |
| 7 | Flexibility of the MCM-41 structure: pore expansion and wall-thickening in MCM-41 derivatives显示文摘 | Mahn D Kanya Z Halasz J | 2002 | Applied Catalysis A : General2002，232，： | 1 |
| 8 | Association study of cannabinoid receptor gene(CNR1)alleles and anorexia nervosa:differences between restricting and binging/purging subtypes显示文摘 | Siegfried Z Kanyas K Latzer Y | 2004 | Am J Med Genet B Neuropsychiatr Genet2004，125，： | 1 |
| 9 | Hypertension intracerebral hemorrlrage显示文摘 | Mizukami M Kongure K Kanya A | 1998 | New York1998，3，： | 1 |
| 10 | Reducing dimension-ality in principal component analysis-a method comparison显示文摘 | Kanya Z Forgacs E Cserhati T Illes Z | 2006 | Chromatographia2006，63，： | 1 |
| 11 | Toward a simple real-time control system for efficient management of furrow irrigation显示文摘 | Kanya L Khatri R J Smith | 2007 | Journal of Irrigation and Drainage Engineering2007，56，4： | 1 |
| 12 | Reduced expression of INK4a/ARF genes in stem-hke sphere cells from rat sarcomas显示文摘 | Fujii H Kanya H Toshifumi T | 2007 | Biochem Biophys Res Commun2007，362，3： | 1 |
| 13 | Preparation of phosphorylated bacterial cellulose as an adsorbent for metal ions显示文摘 | Tatsuya Oshima Kanya Kondo | 2008 | Reactive and Functional Polymers2008，68，： | 1 |
| 14 | Intravenous Immunogloblins in Rhesus Hemolytic Disease显示文摘 | Kanya M Srinivas M Anil N | 2003 | Indian Pediatr2003，70，9： | 1 |
| 15 | Lysophosphatidic acid receptor‐3 increases tumorigenicity and aggressiveness of rat hepatoma RH7777 cells显示文摘 | Kyoko Okabe Mai Hayashi Kohei Kato Mai Okumura Rie Fukui Kanya Honoki Nobuyuki Fukushima Toshifumi Tsujiuchi | 2011 | Mol. Carcinog2011，，4： | 1 |
| 16 | Effect of detoxification on the func- tional and nutritional quality of proteins of karanja seed meal 显示文摘 | VIANY B J KANYA T C S | 2007 | Food Chem2007，106，1： | 1 |
| 17 | Effect of minor components and heating rates on the fine textures of alite in portland cement clinker显示文摘 | Chikawa M I Kanya M | 1997 | Cem Concre Res1997，27，7： | 1 |
| 18 | Toward a simple real-time control system for efficient management of furrow irrigation显示文摘 | Kanya L Khatri Smith R J | 2007 | Journal of Irrigation and Drainage Engineering2007，56，4： | 1 |
| 19 | Preventing aging with stem cell rejuvenation:Feasible or infeasible?显示文摘Characterized by dysfunction of tissues, organs, organ systems and the whole organism, aging results fromthe reduced function of effective stem cell populations. Recent advances in aging research have demonstrated that old tissue stem cells can be rejuvenated for the purpose of maintaining the old-organ function by youthful re-calibration of the environment where stem cells reside. Biochemical cues regulating tissue stem cell function include molecular signaling pathways that interact between stem cells themselves and their niches. Historically, plasma fractions have been shown to contain factors capable of controlling age phenotypes; subsequently, signaling pathways involved in the aging process have been identified. Consequently, modulation of signaling pathways such as Notch/Delta, Wnt, transforming growth factor-β, JAK/STAT, mammalian target of rapamycin and p38 mitogen-activated protein kinase has demonstrated potential to rejuvenate stem cell function leading to organismic rejuvenation. Several synthetic agents and natural sources, such as phytochemicals and flavonoids, have been proposed to rejuvenate old stem cells by targeting these pathways. However, several concerns still remain to achieve effective organismic rejuvenation in clinical settings, such as possible carcinogenic actions; thus, further research is still required. | Kanya Honoki | 2017 | World Journal of Stem Cells2017，9，1： | 1 |
| 20 | Fine mapping of a schizophrenia susceptibility locus at chromosome 6q23: increased evidence for linkage and reduced linkage interval 显示文摘 | Levi A Kohn Y Kanyas K | 2005 | EurJ Hum Genet2005，13，6： | 1 |
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