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3篇 您的检索式:作者名="Kanya Honoki"
    题名 作者 年代 出处 被引量
1Lysophosphatidic acid receptor‐3 increases tumorigenicity and aggressiveness of rat hepatoma RH7777 cells显示文摘Kyoko Okabe Mai Hayashi Kohei Kato Mai Okumura Rie Fukui Kanya Honoki Nobuyuki Fukushima Toshifumi Tsujiuchi 2011Mol. Carcinog2011,,4:1
2Preventing aging with stem cell rejuvenation:Feasible or infeasible?显示文摘Characterized by dysfunction of tissues, organs, organ systems and the whole organism, aging results fromthe reduced function of effective stem cell populations. Recent advances in aging research have demonstrated that old tissue stem cells can be rejuvenated for the purpose of maintaining the old-organ function by youthful re-calibration of the environment where stem cells reside. Biochemical cues regulating tissue stem cell function include molecular signaling pathways that interact between stem cells themselves and their niches. Historically, plasma fractions have been shown to contain factors capable of controlling age phenotypes; subsequently, signaling pathways involved in the aging process have been identified. Consequently, modulation of signaling pathways such as Notch/Delta, Wnt, transforming growth factor-β, JAK/STAT, mammalian target of rapamycin and p38 mitogen-activated protein kinase has demonstrated potential to rejuvenate stem cell function leading to organismic rejuvenation. Several synthetic agents and natural sources, such as phytochemicals and flavonoids, have been proposed to rejuvenate old stem cells by targeting these pathways. However, several concerns still remain to achieve effective organismic rejuvenation in clinical settings, such as possible carcinogenic actions; thus, further research is still required.Kanya Honoki 2017World Journal of Stem Cells2017,9,1:1
3Sphere-forming stem-like cell populations with drug resistance in humansarcoma cell lines显示文摘Hiromasa Fujii Kanya Honoki Toshifumi Tsujiuchi Akira Kido Kazuhiro Yoshitani Yoshinori Takakura 2009International Journal of Oncology2009,,:1
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