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| 1 | Challenges to the early diagnosis and treatment of breast cancer in developing countries显示文摘This critical review of the literature assembles and compares available data on breast cancer clinical stage, time intervals to care, and access barriers in different countries. It provides evidence that while more than 70% of breast cancer patients in most high-income countries are diagnosed in stages Ⅰ and Ⅱ, only 20%-50% patients in the majority of low- and middleincome countries are diagnosed in these earlier stages. Most studies in the developed world show an association between an advanced clinical stage of breast cancer and delays greater than three months between symptom discovery and treatment start. The evidence assembled in this review shows that the median of this interval is 30-48 d in high-income countries but 3-8 mo in low- and middle-income countries. The longest delays occur between the first medical consultation and the beginning of treatment, known as the provider interval. The little available evidence suggests that access barriers and quality deficiencies in cancer care are determinants of provider delay in low- and middle-income countries. Research on specific access barriers and deficiencies in quality of care for the early diagnosis and treatment of breast cancer is practically non-existentin these countries, where it is the most needed for the design of cost-effective public policies that strengthen health systems to tackle this expensive and deadly disease. | Karla Unger-Salda?a | 2014 | World Journal of Clinical Oncology2014，5，3： | 12 |
| 2 | Association of Nutrition Parameters Including Bioelectrical Impedance and Systemic Inflammatory Response With Quality of Life and Prognosis in Patients With Advanced Non-Small-Cell Lung Cancer: A Prospective Study显示文摘 | Karla Sánchez-Lara JennyG Turcott Eva Juárez Patricia Guevara Carolina Nú?ez-Valencia LuisF. O?ate-Oca?a Diana Flores Oscar Arrieta | 2012 | Nutrition and Cancer2012，，4： | 3 |
| 3 | Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial显示文摘 | Ronald P DeMatteo Karla V Ballman Cristina R Antonescu Robert G Maki Peter WT Pisters George D Demetri Martin E Blackstein Charles D Blanke Margaret von Mehren Murray F Brennan Shreyaskumar Patel Martin D McCarter Jonathan A Polikoff Benjamin R Tan Kouros | 2009 | The Lancet2009，，9669： | 2 |
| 4 | Signal peptidases显示文摘 | Paetzel M Karla A Strynadka N C Dalbey R E | 2002 | Chem Rev2002，102，： | 1 |
| 5 | False Dichotomies and Leisure Research 显示文摘 | Henderson Karla A | 2006 | Leisure Studies2006，25，4： | 1 |
| 6 | Tau oligomers and aggregation in Alzheimer’s disease显示文摘 | Marco A.Meraz‐Ríos Karla I.Lira‐De León VictoriaCampos‐Pe?a Martha A.De Anda‐Hernández RaúlMena‐López | 2010 | Journal of Neurochemistry2010，，6： | 1 |
| 7 | False dichotomies, intellectual diversity, and the 'Either/Or' world : Leisure research in transition 显示文摘 | Henderson Karla A | 2000 | Journal of Leisure Research2000，32，1： | 1 |
| 8 | Struc-tural evolution of minibasins on the Utsira High,north-ern North Sea;implications for Jurassic sediment disper-sal and reservoir distribution显示文摘 | Christopher A L Jackson Karla E K | 2010 | Petroleum Geoscience2010，，： | 1 |
| 9 | Genome-wide RNAi screen identifies human host factors erucial for inlluenza vi- rus replication显示文摘 | Karlas A Maehuy N Shin Y el al | 2010 | Nature2010，463，7282： | 1 |
| 10 | Conceptual Organization at 6 and 8 Years of Age:Evidence from the SemanticPriming of Object Decisions显示文摘 | Hashimoto N Karla K Graham M A | 2007 | Journal of Speech Language and Hearing Research2007，50，： | 1 |
| 11 | Porcine endogenous retroviruses:no infection in patients treated with a bioreactor based on porcine liver cells显示文摘 | Irgang M Sauer IM Karlas A | 2003 | J Clin Virol2003，28，： | 1 |
| 12 | Porcine endogenous retroviruses:no infection in patients treated with a bioreactor based on porcine liver cells显示文摘 | Irgang M Sauer IM Karlas A | 2003 | J Clin Virol2003，28，2： | 1 |
| 13 | Inhibition of porcine endogenous retroviruses by RNA interference: increasing the safety of xenotransplantation 显示文摘 | Karlas A Kurth R Denner J | 2004 | Virology2004，325，1： | 1 |
| 14 | Healthcare staff as promoters of parental presence at anesthetic induction:Net Promoter Score survey显示文摘BACKGROUND Surgical intervention is usually a traumatic event that causes stress and anxiety in the pediatric patient and the family environment.To reduce the harmful effects of presurgical anxiety,parental presence during induction of anesthesia(PPIA)is one of the more notable interventions used in medical centers.However,data on this measure are difficult to evaluate and often face resistance from healthcare staff.AIM To analyze the perception of the healthcare workers after the implementation of a PPIA program.METHODS A survey was developed and sent by email to all the healthcare staff working in the children’s area of a tertiary hospital.It consisted of 14 items divided into positive aspects of PPIA and negative aspects of PPIA evaluated with the use of a Likert scale(1 to 5).The demographics of the respondents were included in the data collected.The answers to the questions were interpreted through the Net Promoter Score(NPS).The statistical analysis compared the differences in the responses to each question of the survey made by the different groups of health personnel included.RESULTS A total of 141 surveys were sent out,with a response rate of 69%.Of the total number of responses,68%were from women and 32%from men.The average age of the participants was 42.3±10.6 years.As for the positive questions about the PPIA,83%had an NPS>50,and only one had a score between 0 and 50,which means that the quality of the service was rated as excellent or good by 100%of the respondents.On the other hand,100%of the negative questions about the PPIA had a negative NPS.Responses to the question“PPIA increases patient safety”were significantly different(P=0.037),with a lower percentage of pediatric surgeons(70%)thinking that PPIA increased patient safety,compared with anesthesiologists(90%),nursing(92%),and other medical personnel(96%).CONCLUSION The personnel who participated in the PPIA program at our center were in favor of implementation.There were no validated arguments to support worker resistance to the development of the PPIA. | María Velayos Karla Estefanía María Alvarez María C Sarmiento Lucas Moratilla Pascual Sanabria Francisco Hernández Manuel V López Santamaría | 2021 | World Journal of Clinical Pediatrics2021，10，6： | 1 |
| 15 | Electrochemical impedance spectroscopy study during acceler- ated life test of conductive oxides: Yi (Ru+Yi+Ce)0:-system 显示文摘 | Leonardo M Da Silva Karla C Femandes Luiz A De Faria et a l | 2004 | Electrochemica Acta2004，49，27： | 1 |
| 16 | Genome-wide RNAi screen identifies human host factors crucial for influenza virus replicatin显示文摘 | Karlas A Machuy N Shin Y | 2010 | Nature2010，463，7282： | 1 |
| 17 | Normal fault growth and fault-related folding in a salt-influenced rift basin:south viking graben,offshore norway显示文摘 | Karla E K Jackson Christopher A L Larsen E | 2010 | Journal of Structural Geology2010，32，4： | 1 |
| 18 | Construction and evaluation of an expression vector allowing the stable expression of foreign antigens in a Salmonella typhimurium vaccine strain 显示文摘 | Tijhaar E J Zheng-Xin Y Karlas J A | 1994 | Vaccine1994，12，11： | 1 |
| 19 | Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication显示文摘 | Karlas A Machuy N Shin Y | 2010 | Nature2010，463，： | 1 |
| 20 | Molecular characterization and antimicrobial susceptibility patterns of clostridium difficile strains isolated from hospitals in south-east Soctland显示文摘 | Mutlu E Wroe A J Karla S H | 2007 | J Med Microbiol2007，56，： | 1 |
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