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| 1 | Protein tyrosine phosphatase 1B inhibitory activities of ursane-type triterpenes from Chinese raspberry, fruits of Rubus chingii显示文摘Protein tyrosine phosphatase 1 B(PTP1 B) has led to an intense interest in developing its inhibitors as anti-diabetes, anti-obesity and anti-cancer agents. The fruits of Rubus chingii(Chinese raspberry) were used as a kind of dietary traditional Chinese medicine. The methanolic extract of R. chingii fruits exhibited significant PTP1 B inhibitory activity. Further bioactivity-guided fractionation resulted in the isolation of three PTP1 B inhibitory ursane-type triterpenes: ursolic acid(1), 2-oxopomolic acid(2), and 2α, 19α-dihydroxy-3-oxo-urs-12-en-28-oic acid(3). Kinetics analyses revealed that 1 was a non-competitive PTP1 B inhibitor, and 2 and 3 were mixed type PTP1 B inhibitors. Compounds 1-3 and structurally related triterpenes(4-8) were further analyzed the structure-activity relationship, and were evaluated the inhibitory selectivity against four homologous protein tyrosine phosphatases(TCPTP, VHR, SHP-1 and SHP-2). Molecular docking simulations were also carried out, and the result indicated that 1, 3-acetoxyurs-12-ene-28-oic acid(5), and pomolic acid-3β-acetate(6) bound at the allosteric site including α3, α6, and α7 helix of PTP1 B. | ZHANG Xiang-Yu LI Wei WANG Jian LI Ning CHENG Mao-Sheng KOIKE Kazuo | 2019 | Chinese Journal of Natural Medicines2019，17，1： | 5 |
| 2 | Decrease of CD56 + T Cells and Natural Killer Cells in Cirrhotic Livers With Hepatitis C May Be Involved in Their Susceptibility to Hepatocellular Carcinoma显示文摘 | Nobuaki Kawarabayashi Shuhji Seki Kazuo Hatsuse Takashi Ohkawa Yuji Koike Tsukasa Aihara Yoshiko Habu Ryusuke Nakagawa Katsunori Ami Hoshio Hiraide Hidetaka Mochizuki | 2000 | Hepatology2000，，5： | 2 |
| 3 | Biotransformation of paeonol by Panax ginseng root and cell cultures显示文摘 | Wei Li Kazuo Koike Yoshihisa Asada Takafumi Yoshikawa Tamotsu Nikaido | 2005 | Journal of Molecular Catalysis. B, Enzymatic2005，，4： | 1 |
| 4 | New Triterpenoid Saponins from Maesa tenera 显示文摘 | Kazuo Koike Zhonghuo Jia Tamotsu Nikaido | 2001 | Chem Pharm Bull2001，49，6： | 1 |
| 5 | Expert consensus for the treatment of disseminated intravascular coagulation in Japan显示文摘 | Hideo Wada Hidesaku Asakura Kohji Okamoto Toshiaki Iba Toshimasa Uchiyama Kazuo Kawasugi Shin Koga Toshihiko Mayumi Kaoru Koike Satoshi Gando Shigeki Kushimoto Yoshinobu Seki Seiji Madoiwa Ikuro Maruyama Akira Yoshioka | 2009 | Thrombosis Research2009，，1： | 1 |
| 6 | A New Prenylated Flavone from the Leaves of Glyeyrrhiza uralensis Cultivated in China 显示文摘 | Bai Hong Li Wei Koike Kazuo | 2004 | Heterocycles2004，63，9： | 1 |
| 7 | New biologically active triterpenoid saponins from scabiosa tschiliensis 显示文摘 | Quan zheng Kazuo Koike Li- kun Han | 2004 | J Nat Prod2004，67，： | 1 |
| 8 | Inhibitory effects of compounds isolated from fruit of Juglans mandshurica on pancreatic lipase显示文摘 | Likun Han Wei Li Sanae Narimatsu Lijuan Liu Hongwei Fu Hiromichi Okuda Kazuo Koike | 2007 | Journal of Natural Medicines2007，，2： | 1 |
| 9 | A Novel Biflavonoid from Roots of Glycyrrhiza uralensis Cultivated in China显示文摘 | Hong BAI Wei LI b Kazuo KOIKE | 2003 | Chemical and Pharmaceutical Bulletin2003，51，9： | 1 |
| 10 | Conyzasa- ponins I-Q, nine new triterpenoid saponins from Conyza blinii显示文摘 | Su YF Kazuo Koike Tamotsu Nikaido | 2003 | NatProd2003，66，12： | 1 |
| 11 | Triterpenoid saponins from Vaccaria segetalis 显示文摘 | Koike Kazuo Jia Zhong-hua Nikaido Tamotsu | 1998 | Phytochemistry1998，47，7： | 1 |
| 12 | Fiseheria A, a Novel Norditerpene Laetone from Euphorbia ischeriana 显示文摘 | Yuehu Pei Kazuo Koike Bing Han | 1999 | Tetrahedron Letters1999，，40： | 1 |
| 13 | Biotransformation of low - molecular weight alcohols by Coleus forskohlii hairy root cultures 显示文摘 | WEI Li Kazuo Koike Yoshihisa Asada | 2003 | Carbohydtate Research2003，338，： | 1 |
| 14 | Flavonoids from Glycyrrhiza pallidiflora hairy root cultures 显示文摘 | Wei Li Yoshihisa Asada Kazuo Koike | 2001 | Phytoehemistry2001，，58： | 1 |
| 15 | Preparation and properties of new tetrafunctional amphoteric surfactants bearing amino, carboxyl, and hydroxyl groups and an ether bond显示文摘 | Hisao Hidaka Takayoshi Koike Masami Kurihara Katsumi Hattori Nobuyo Iba Kazuo Hosoda Masafumi Moriya | 2003 | Journal of Surfactants and Detergents2003，，2： | 1 |
| 16 | Triterpenoid saponins from Ardisia crenata and their inhibitory activity on cAMP phosphodiesterase 显示文摘 | Kazuo Koike Tamotsu Nikaido | 1994 | Chem Pharm Bull1994，42，11： | 1 |
| 17 | Two novel triterpenoid pentasaccharides with an unusual glycosyl glycerol side chain from Aridsia crenata 显示文摘 | Kazuo Koike Tamotsu Nikaido | 1994 | Tetrahedron1994，50，11： | 1 |
| 18 | Minor Triterpenoid Saponins from Aridsia crenata 显示文摘 | Zhonghua Jia Saori Ohura | 1999 | Chem Pharm Bull1999，47，3： | 1 |
| 19 | New a-tetralonyl glucosides from the fruit of Juglans mandshurica 显示文摘 | Lijuan Liu Wei Li Koike Kazuo | 2004 | Chemical Pharmaceutical Bulletin2004，52，5： | 1 |
| 20 | Cytotoxic and Nitric Oxide Production‐Inhibitory Activities of Limonoids and Other Compounds from the Leaves and Bark of Melia azedarach显示文摘 | Xin Pan Masahiro Matsumoto Yuki Nishimoto Eri Ogihara Jie Zhang Motohiko Ukiya Harukuni Tokuda Kazuo Koike Momoko Akihisa Toshihiro Akihisa | 2014 | Chemistry & Biodiversity2014，，8： | 1 |
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