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| 1 | Association between tear film break up time and blink interval in visual display terminal users显示文摘AIM:To investigate the association between tear film break up time(TBUT)and blinking interval in visual display terminal(VDT)users.METHODS:Nine hundred and thirty VDT users underwent dry eye testing,and functional visual acuity(FVA)test.The blinking interval during FVA was compared with TBUT.Subjects with longer blinking interval than TBUT were considered as unstable tear film.Logistic regression analysis revealed the risk factors for unstable tear group.RESULTS:Among 930 workers,858 subjects(92.3%)participated in this study.Almost 80% of the subjects were categorized into the unstable tear group.Unstable tear group has significantly lower Schirmer values and TBUT(17.5±11.6 vs 21.1±11.5 mm,3.7±2.6 vs 5.7±2.7s,both P<0.001).There were no significant differences in epithelial staining or severity of symptoms.Logistic regression showed that over 40y was a risk for being unstable tear group[odds ratio(OR)=1.53;95%confidence interval(CI)=1.06-2.20].Contact lens use was protective factor for being in the unstable tear group(OR=0.37;95%CI=0.26-0.53).CONCLUSION:Subjects with shorter TBUT than blinking interval are prevalent among VDT users.Subjects over the age of 40 shows an increased risk for unstable tear film. | Miki Uchino Motoko Kawashima Yuichi Uchino Kazuo Tsubota Norihiko Yokoi | 2018 | International Journal of Ophthalmology(English edition)2018，11，10： | 5 |
| 2 | Gender differences in adolescent dry eye disease:a health problem in girls显示文摘AIM: To evaluate the signs and symptoms of dry eye disease(DED) in adolescents. METHODS: This was a cross-sectional, case-control study and outpatients aged 10 to 19y were recruited from six eye clinics of various practices and locations in Japan, and 253 non-DED subjects and 70 DED patients were enrolled. Participants were examined for DED-related signs. Patients were also interviewed to ascertain the presence or absence of six common DED-related symptoms: dryness, irritation, pain, eye fatigue, blurring, and photophobia. Main outcome measures were differences in signs and symptoms of dry eye disease between boys and girls.RESULTS: Of the 323 adolescents recruited, 70(21.7%) were diagnosed with DED. Significant differences between the non-DED and DED groups were found for short tear break-up time(BUT; ≤5s; P=0.000) and superficial punctate keratopathy(SPK; staining score ≥3; P=0.000). Late adolescent girls reported fewer symptoms than late adolescent boys, although their DED-related signs were worse compared to other groups. The prevalence and severity of DED were similar in the Tokyo area compared with suburban and local areas but myopic errors were worse. CONCLUSION: We find that adolescents reported symptoms of DED similar to those found in adults, and the majority have short BUT-type DED. The prevalence and severity of DED in late adolescent girls is comparable with adults. Adolescents with DED are underserved and we believe that DED is a hidden but potentially serious health problem for this age group. | Masahiko Ayaki Motoko Kawashima Miki Uchino Kazuo Tsubota Kazuno Negishi | 2018 | International Journal of Ophthalmology(English edition)2018，11，2： | 5 |
| 3 | Monitoring the expression pattern of around 7,000 Arabidopsis genes under ABA treatments using a full-length cDNA microarray显示文摘 | Motoaki Seki Junko Ishida Mari Narusaka Miki Fujita Tokihiko Nanjo Taishi Umezawa Asako Kamiya Maiko Nakajima Akiko Enju Tetsuya Sakurai Masakazu Satou Kenji Akiyama Kazuko Yamaguchi-Shinozaki Piero Carninci Jun Kawai Yoshihide Hayashizaki Kazuo Shinozaki | 2002 | Functional & Integrative Genomics2002，，6： | 1 |
| 4 | Ocular surface changes and discomfort in patients with meibomian gland dysfunction 显示文摘 | Jun Shimazaki Miki Sakata Kazuo Tsubota | 1995 | Arch Ophthalmol1995，113，： | 1 |
| 5 | A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations显示文摘 | Minako Imamura Shiro Maeda Toshimasa Yamauchi Kazuo Hara Kazuki Yasuda Takashi Morizono Atsushi Takahashi Momoko Horikoshi Masahiro Nakamura Hayato Fujita Tatsuhiko Tsunoda Michiaki Kubo Hirotaka Watada Hiroshi Maegawa Miki Okada-Iwabu Masato Iwabu Nobuhi | 2012 | Human Molecular Genetics2012，，13： | 1 |
| 6 | A comparison of magnifying and nonmagnifying colonoscopy for diagnosis of colorectal polyps: A prospective study显示文摘 | Kazuo Konishi Kazuhiro Kaneko Toshinori Kurahashi Taikan Yamamoto Miki Kushima Akira Kanda Hisao Tajiri Keiji Mitamura | 2003 | Gastrointestinal Endoscopy2003，，1： | 1 |
| 7 | Monitoring the expression profiles of 7 000 Arabidopsis genes under drought,cold and high-salinity stresses using a full-lenghth cDNA microarray显示文摘 | Motoaki S Mari N Junko I Tokihiko N,Miki F,Youko O,Asako K,Maiko N,Akiko E,Tetsuya S,Masakazu S,Kenji A,Teruaki T,Kazuko Y S,Piero C,Jun K,Yoshihide H,Kazuo S | | 0，，： | 1 |
| 8 | Noninvasive Interference Tear Meniscometry in Dry Eye Patients With Sj?gren Syndrome显示文摘 | Atsuro Uchida Miki Uchino Eiki Goto Eri Hosaka Yuko Kasuya Kazumi Fukagawa Murat Dogru Yoko Ogawa Kazuo Tsubota | 2007 | American Journal of Ophthalmology2007，，2： | 1 |
| 9 | Fundamental Study of Side Impact Analysis Using the Finite Element Model of the Human Thorax 显示文摘 | Katsuya Furusu Isao Watanabe Chiharu Kato Kazuo Miki Junji Hasegawa | 2001 | Japan Society of Automotive Engineers Review2001，22，： | 1 |
| 10 | Identification of stress-tolerance-related transcription-factor genes via mini-scale Full-length cDNA Over-eXpressor (FOX) gene hunting system显示文摘 | Miki Fujita Saho Mizukado Yasunari Fujita Takanari Ichikawa Miki Nakazawa Motoaki Seki Minami Matsui Kazuko Yamaguchi-Shinozaki Kazuo Shinozaki | 2007 | Biochemical and Biophysical Research Communications2007，，2： | 1 |
| 11 | Monitoring the expression pattern of around 7,000 Arabidopsis genes under ABA treatments using a full-length cDNA microarray显示文摘 | Motoaki Seki Junko Ishida Mari Narusaka Miki Fujita Tokihiko Nanjo Taishi Umezawa Asako Kamiya Maiko Nakajima Akiko Enju Tetsuya Sakurai Masakazu Satou Kenji Akiyama Kazuko Yamaguchi-Shinozaki Piero Carninci Jun Kawai Yoshihide Hayashizaki Kazuo Shinozaki | 2002 | Functional & Integrative Genomics2002，，6： | 1 |
| 12 | Monitoring expression profiles of Arabidopsis genes during cold acclimation and deacclimation using DNA microarrays显示文摘 | Youko Oono Motoaki Seki Masakazu Satou Kei Iida Kenji Akiyama Tetsuya Sakurai Miki Fujita Kazuko Yamaguchi-Shinozaki Kazuo Shinozaki | 2006 | Functional & Integrative Genomics2006，，3： | 1 |
| 13 | Dry Eye Disease and Work Productivity Loss in Visual Display Users: The Osaka Study显示文摘 | Miki Uchino Yuichi Uchino Murat Dogru Motoko Kawashima Norihiko Yokoi Aoi Komuro Yukiko Sonomura Hiroaki Kato Shigeru Kinoshita Debra A. Schaumberg Kazuo Tsubota | 2013 | American Journal of Ophthalmology2013，，： | 1 |
| 14 | Surgical Management of Adult Sigmoid Colon Intussusception Caused by a Malignant Tumor: Report of a Case显示文摘 | Keiji Matsuda Kazufumi Suda Kazuo Tamura Tomoaki Deguchi Eriko Yamazaki Hiroshi Yago Tsuyoshi Inaba Toshio Takeshima Miki Adachi Kota Okinaga | 2003 | Surgery Today2003，，10： | 1 |
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