|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Arabidopsis CBL-Interacting Protein Kinases Regulate Carbon/Nitrogen-Nutrient Response by Phosphorylating Ubiquitin Liqase ATL31显示文摘响应可得到的碳(C) 和氮(N) 营养素的比率,植物调整他们的新陈代谢,生长,和发展,一个过程叫了 C/N-nutrient 反应。然而, C/N-nutrient 发信号的分子的基础仍然保持大部分不清楚。在这研究,我们识别了交往的三 CALCINEURIN 象 B 一样(CBL ) 蛋白质 KINASES (CIPK ) , CIPK7, CIPK12,和 CIPK14,在 Arabidopsis 在萌芽以后的生长期间给 C/N-nutrient 反应的管理者调音。CIPK7, CIPK12,和 CIPK14 的单个大美人的异种显示出超敏性到高 C/low N 条件,它在他们的三倍大美人的异种被提高,显示他们起一个否定作用并且部分至少在 C/N-nutrient 反应冗余地工作。而且,这些 CIPK 被发现调整 ATL31,经由 phosphorylation 依赖的 ubiquitination 涉及 C/N-nutrient 反应的 ubiquitin ligase 和 14-3-3 蛋白质的 proteasomal 降级的功能。CIPK7, CIPK12,和 CIPK14 身体上与 ATL31,和 CIPK14 交往了,与 CBL8 行动,直接以一种 Ca 2+-dependent 方式的 phosphorylated ATL31。进一步的分析证明这些 CIPK 为 ATL31 phosphorylation 和稳定被要求,它调停响应 C/N-nutrient 的 14-3-3 蛋白质的降级调节。这些调查结果提供新卓见进 C/N-nutrient 发信号由蛋白质 phosphorylation 调停了。 | Shigetaka Yasuda Shoki Aoyama Yoko Hasegawa Takeo Sato Junji Yamaguchi | 2017 | Molecular Plant2017，10，4： | 5 |
| 2 | Proposed criteria to differentiate heterogeneous eosinophilic gastrointestinal disorders of the esophagus, including eosinophilic esophageal myositis显示文摘AIM To define clinical criteria to differentiate eosinophilic gastrointestinal disorder(Eo GD) in the esophagus. METHODS Our criteria were defined based on the analyses of the clinical presentation of eosinophilic esophagitis(Eo E), subepithelial eosinophilic esophagitis(s Eo E) and eosinophilic esophageal myositis(Eo EM), identified by endoscopy, manometry and serum immunoglobulin E levels(s-Ig E), in combination with histological and polymerase chain reaction analyses on esophageal tissue samples.RESULTS In five patients with Eo E, endoscopy revealed longitudinal furrows and white plaques in all, and fixed rings in two. In one patient with s Eo E and four with Eo EM, endoscopy showed luminal compression only. Using manometry, failed peristalsis was observed in patients with Eo E and s Eo E with some variation, while Eo EM was associated with hypercontractile or hypertensive peristalsis, with elevated s-Ig E. Histology revealed the following eosinophils per high-power field values. Eo E = 41.4 ± 7.9 in the epithelium and 2.3 ± 1.5 in the subepithelium; s Eo E = 3 in the epithelium and 35 in the subepithelium(conventional biopsy); Eo EM = none in the epithelium, 10.7 ± 11.7 in the subepithelium(conventional biopsy or endoscopic mucosal resection) and 46.8 ± 16.5 in the muscularis propria(peroral esophageal muscle biopsy). Presence of dilated epithelial intercellular space and downward papillae elongation were specific to Eo E. Eotaxin-3, IL-5 and IL-13 were overexpressed in Eo E.CONCLUSION Based on clinical and histological data, we identified criteria, which differentiated between Eo E, s Eo E and Eo EM, and reflected a different pathogenesis between these esophageal Eo GDs. | Hiroki Sato Nao Nakajima Kazuya Takahashi Go Hasegawa Ken-ichi Mizuno Satoru Hashimoto Satoshi Ikarashi Kazunao Hayashi Yutaka Honda Junji Yokoyama Yuichi Sato Shuji Terai | 2017 | World Journal of Gastroenterology2017，23，13： | 2 |
| 3 | Transient Stability Assessment of Synchronous Generator in Power System with High-Penetration Photovoltaics显示文摘 | Masaki Yagami Takahiko Hasegawa Junji Tamura | 2012 | Journal of Mechanics Engineering and Automation2012，2，12： | 2 |
| 4 | Results of a multicenter study of 1,057 cases of rectal cancer treated by laparoscopic surgery显示文摘 | Nobuyoshi Miyajima Masaki Fukunaga Hirotoshi Hasegawa Jun-ichi Tanaka Junji Okuda Masahiko Watanabe | 2009 | Surgical Endoscopy2009，，1： | 1 |
| 5 | Liver Resection for Multiple Colorectal Liver Metastases with Surgery Up-front Approach: Bi-institutional Analysis of 736 Consecutive Cases显示文摘 | Akio Saiura Junji Yamamoto Kiyoshi Hasegawa Rintaro Koga Yoshihiro Sakamoto Shojiro Hata Masatoshi Makuuchi Norihiro Kokudo | 2012 | World Journal of Surgery2012，，9： | 1 |
| 6 | Mouse CD20 expression and function显示文摘 | Junji Uchidal Youngkyun Lee Minoru Hasegawa | 2004 | International Immunology2004，16，1： | 1 |
| 7 | Fundamental Study of Side Impact Analysis Using the Finite Element Model of the Human Thorax 显示文摘 | Katsuya Furusu Isao Watanabe Chiharu Kato Kazuo Miki Junji Hasegawa | 2001 | Japan Society of Automotive Engineers Review2001，22，： | 1 |
| 8 | A Study of Knee Joint Ki- nematics and Mechanics Using a Human FE Model显示文摘 | Kitagawa Y Hasegawa Junji Yasuki T | 2005 | Stapp Car Crash Journal2005，，49： | 1 |
| 9 | MouseCD20expression and function显示文摘 | Junji Uchidal Youngkyun Lee Minoru Hasegawa | 2004 | International Immunology2004，16，1： | 1 |
| 10 | Results of a multicenter study of 1,057 cases of rectal cancer treated by laparoscopic surgery显示文摘 | Nobuyoshi Miyajima Masaki Fukunaga Hirotoshi Hasegawa Jun-ichi Tanaka Junji Okuda Masahiko Watanabe | 2009 | Surgical Endoscopy2009，，1： | 1 |
| 11 | Rapid on‐site evaluation by endosonographer during endoscopic ultrasound‐guided fine needle aspiration for pancreatic solid masses显示文摘 | Tsuyoshi Hayashi Hirotoshi Ishiwatari Makoto Yoshida Michihiro Ono Tsutomu Sato Koji Miyanishi Yasushi Sato Masayoshi Kobune Rishu Takimoto Tomoko Mitsuhashi Hiroko Asanuma Jiro Ogino Tadashi Hasegawa Tomoko Sonoda Junji Kato | 2013 | J Gastroenterol Hepatol2013，，4： | 1 |
| 12 | Results of a multicenter study of 1,057 cases of rectal cancer treated by laparoscopic surgery显示文摘 | Nobuyoshi Miyajima Masaki Fukunaga Hirotoshi Hasegawa Jun-ichi Tanaka Junji Okuda Masahiko Watanabe | 2009 | Surgical Endoscopy2009，，： | 1 |
| 13 | Pancreas-sparing duodenectomy for gastrointestinal stromal tumor显示文摘 | Suguru Yamashita Yoshihiro Sakamoto Akio Saiura Junji Yamamoto Tomoo Kosuge Taku Aoki Yasuhiko Sugawara Kiyoshi Hasegawa Norihiro Kokudo | 2014 | The American Journal of Surgery2014，，4： | 1 |
| 14 | Large edge magnetism in oxidized few-layer black phosphorus nanomeshes显示文摘房间温度的形成和控制磁性的顺序在二维(2D ) 材料是为创新磁性底、基于 spintronic 的技术的来临的挑战性的探索。迄今为止,在 2D 材料的边磁力试验性地在终止的氢(H) 被观察了 graphene nanoribbons (GNR ) 和 graphene nanomeshes (GNM ) ,而是测量磁化仍然保持太小允许想象实际应用。此处,我们报导从氧(O) 获得的大房间温度边强磁性(FM ) 的试验性的证据终止了很少层黑人磷(P) nanomeshes (BPNM ) 的之字形毛孔边。磁化价值比那些为终止 H 的 GNM 报导的每统一区域是大 100 倍的 ~ ,当磁力为终止 H 的 BPNM 是不在的时。磁化大小和第一原则的模拟建议如此的一份磁性的订单的起源能源自与 O 原子在边 P 之间联合的铁磁性的纺纱,导致在边原子价乐队的强壮的旋转本地化,并且从完整的毛孔的一致氧化,在一个大区域和夹层上的边旋转相互作用。我们的调查结果为认识到高效率的 2D 铺平道路灵活磁性并且没有稀罕磁性的元素的使用的 spintronic 设备。 | Yudai Nakanishi Ayumi Ishi Chika Ohata David Soriano Ryo Iwaki Kyoko Nomura~ Miki Hasegawa Taketomo Nakamura Shingo Katsumoto Stephan Roche Junji Haruyama | 2017 | Nano Research2017，10，2： | 0 |
| 15 | Arsenic pollution of groundwater and its release mechanism in the central part of the Hetao Plain, Inner Mongolia, China显示文摘 | Hanjin LUO Hiroki Hagiwara Kouichi Terasaki Fumio Kanai Takahisa Yoshimura Junji Akai Takeo Ta kano Tadashi Hasegawa Yoh'ichi Sakai | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
| 16 | Case series of three patients with hereditary diffuse gastric cancer in a single family:Three case reports and review of literature显示文摘BACKGROUND Hereditary diffuse gastric cancer(HDGC)is a familial cancer syndrome often associated with germline mutations in the CDH1 gene.However,the frequency of CDH1 mutations is low in patients with HDGC in East Asian countries.Herein,we report three cases of HDGC harboring a missense CDH1 variant,c.1679C>G,from a single Japanese family.CASE SUMMARY A 26-year-old female(Case 1)and a 51-year-old male(father of Case 1),who had a strong family history of gastric cancer,were diagnosed with advanced diffuse gastric cancer.After genetic counselling,a 25-year-old younger brother of Case 1 underwent surveillance esophagogastroduodenoscopy that detected small signet ring cell carcinoma foci as multiple pale lesions in the gastric mucosa.Genetic analysis revealed a CDH1 c.1679C>G variant in all three patients.CONCLUSION It is important for individuals suspected of having HDGC to be actively offered genetics evaluation.This report will contribute to an increased awareness of HDGC. | Masahiro Hirakawa Kohichi Takada Masanori Sato Chisa Fujita Naotaka Hayasaka Takayuki Nobuoka Shintaro Sugita Aki Ishikawa Miyako Mizukami Hiroyuki Ohnuma Kazuyuki Murase Koji Miyanishi Masayoshi Kobune Ichiro Takemasa Tadashi Hasegawa Akihiro Sakurai Junji Kato | 2020 | World Journal of Gastroenterology2020，26，42： | 0 |
| 17 | Methotrexate-related lymphoproliferative disorders in the liver: Case presentation and mini-review显示文摘BACKGROUND Immunosuppression is effective in treating a number of diseases,but adverse effects such as bone marrow suppression,infection,and oncogenesis are of concern.Methotrexate is a key immunosuppressant used to treat rheumatoid arthritis.Although it is effective for many patients,various side effects have been reported,one of the most serious being methotrexate-related lymphoproliferative disorder.While this may occur in various organs,liver involvement is rare.Information on these liver lesions,including clinical characteristics,course,and imaging studies,has not been summarized to date.CASE SUMMARY We present a case of 70-year-old woman presented with a 2-wk history of fever and abdominal pain.She had had rheumatoid arthritis for 5 years and was being treated with medication including methotrexate.Contrast-enhanced computed tomography revealed multiple low density tumors in the liver and the histological analyses showed significant proliferation of lymphocytes in masses that were positive on immunohistochemical staining for CD3,CD4,CD8,and CD79a but negative for CD20 and CD56.Staining for Epstein-Barr virus-encoded RNA was negative.And based on these findings,the liver tumors were diagnosed as Methotrexate-related lymphoproliferative disorders.A timedependent disappearance of the liver tumors after stopping methotrexate supported the diagnoses.CONCLUSION The information obtained from our case and a review of 9 additional cases reported thus far assist physicians who may face the challenge of diagnosing and managing this disorder. | Takeshi Mizusawa Kenya Kamimura Hiroki Sato Takeshi Suda Hiroyuki Fukunari Go Hasegawa Osamu Shibata Shinichi Morita Akira Sakamaki Junji Yokoyama Yu Saito Yoshihisa Hori Yuduru Maruyama Fumitoshi Yoshimine Takahiro Hoshi Shinichi Morita Tsutomu Kanefuji Masaaki Kobayashi Shuji Terai | 2019 | World Journal of Clinical Cases2019，7，21： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员