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| 1 | Using the Prostate Imaging Reporting and Data System version 2 (PI-RIDS v2) to detect prostate cancer can prevent unnecessary biopsies and invasive treatment显示文摘 | Chang Liu Shi-Liang Liu Zhi-Xian Wang Kai Yu Chun-Xiang Feng Zan Ke Liang Wang Xiao-Yong Zeng | 2018 | Asian Journal of Andrology2018，20，5： | 13 |
| 2 | Identification of ferroptosis as a novel mechanism for antitumor activity of natural product derivative a2 in gastric cancer显示文摘Ferroptosis is a type of cell death accompanied by iron-dependent lipid peroxidation,thus stimulating ferroptosis may be a potential strategy for treating gastric cancer,therapeutic agents against which are urgently required.Jiyuan oridonin A(JDA) is a natural compound isolated from Jiyuan Rabdosia rubescens with anti-tumor activity,unclear anti-tumor mechanisms and limited water solubility hamper its clinical application.Here,we showed a2,a new JDA derivative,inhibited the growth of gastric cancer cells.Subsequently,we discovered for the first time that a2 induced ferroptosis.Importantly,compound a2 decreased GPX4 expression and overexpressing GPX4 antagonized the anti-proliferative activity of a2.Furthermore,we demonstrated that a2 caused ferrous iron accumulation through the autophagy pathway,prevention of which rescued a2 induced ferrous iron elevation and cell growth inhibition.Moreover,a2 exhibited more potent anti-cancer activity than 5-fluorouracil in gastric canc er cell line-derived xenograft mice models.Patient-derived tumor xenograft models from different patients displayed varied sensitivity to a2,and GPX4 downregulation indicated the sensitivity of tumors to a2.Finally,a2 exhibited well pharmacokinetic characteristic s.Overall,our data suggest that inducing ferroptosis is the major mechanism mediating anti-tumor activity of a2,and a2 will hopefully serve as a promising compound for gastric cancer treatment. | Ying Liu Zan Song Yajie Liu Xubin Ma Wang Wang Yu Ke Yichao Xu Dequan Yu Hongmin Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 10 |
| 3 | Three new eudesmane sesquiterpenes from Artemisia vestita显示文摘Three eudesmane sesquiterpene lactones,namely artemivestinolides A–C(1–3),along with three known 11-epimeric lactones(4–6),were isolated from the aerial parts of Artemisia vestita.Their structures were elucidated on the basis of extensive spectroscopic analyses(IR,HR-ESIMS,1D NMR and 2D NMR),and the absolute confgurations were determined by single-crystal X-ray diffraction(with copper radiation).Furthermore,in an in vitro assay,the three new compounds exhibited a moderate inhibition of the lipopolysaccharide(LPS)-induced nitric oxide(NO)production in BV-2 microglial cells. | Shuai-Hua Tian Xing-Yun Chai Ke Zan Ke-Wu Zeng Peng-Fei Tu | 2013 | Chinese Chemical Letters2013，24，9： | 3 |
| 4 | MRI feature analysis of uncommon prostatic malignant tumors显示文摘 | Zhao-Yan Feng Xiang-De Min Liang Wang Ba-Sen Li Zan Ke Pei-Pei Zhang Zhen Kang | 2018 | Asian Journal of Andrology2018，20，3： | 2 |
| 5 | Chemical ingredients isolated from the aerial paret of Artemisia anomala 显示文摘 | ZAN Ke CHEN Xiao-qing FU Qiang | 2010 | Journal of Chinese Pharmaceutical Scientes2010，19，2： | 1 |
| 6 | Diagnostic Performance and Interobserver Consistency of the Prostate Imaging Reporting and Data System Version 2: A Study on Six Prostate Radiologists with Different Experiences from Half a Year to 17 Years显示文摘 | Zan Ke Liang Wang Xiang-De Min Zhao-Yan Feng Zhen Kang Pei-Pei Zhang Ba-Sen Li Hui-Juan You Sheng-Chao Hou | 2018 | Chinese Medical Journal2018，，14： | 1 |
| 7 | Ex- perimental research of critical condensate saturation and flow characteristics of gas condensate reservoir显示文摘 | Li Qian Li Xiangfang Zan Ke Shi Juntai Song Zhaojie | 2013 | Petroleum Sci- ence and Technology2013，31，13： | 1 |
| 8 | Quantitative analysis of triterpenoids in different parts of Ilex hainanensis, Ilex stewardii and llex pubescens using HPLC - ELSD and HPLC - MS and antibacterial activity 显示文摘 | CHEN XIAOQING ZAN KE YANG JIE | 2011 | Food Chemistry2011，126，3： | 1 |
| 9 | 查看详情显示文摘 | Peng T Ke D Wu C Ping C Ma L Zan L | | 0，，： | 1 |
| 10 | Qualitative and quantitative evaluation of Flos Puerariae by using chemical fingerprint in combination with chemometrics method显示文摘In order to better control the quality of Flos Puerariae(FP),qualitative and quantitative analyses were initially performed by using chemical fingerprint and chemometrics methods in this study.First,the fingerprint of FP was developed by HPLC and the chemical markers were screened out by similarity analysis(SA),hierarchical clustering analysis(HCA),principal components analysis(PCA),and orthogonal partial least squares discriminant analysis(OPLS-DA).Next,the chemical constituents in FP were profiled and identified by HPLC coupled to Fourier transform ion cyclotron resonance mass spectrometry(HPLCFT-ICR MS).Then,the characteristic constituents in FP were quantitatively analyzed by HPLC.As a result,31 common peaks were assigned in the fingerprint and 6 of them were considered as qualitative markers.A total of 35 chemical constituents were detected by HPLC-FT-ICR MS and 16 of them were unambiguously identified by comparing retention time,UV absorption wavelength,accurate mass,and MS/MS data with those of reference standards.Subsequently,the contents of glycitin,genistin,tectoridin,glycitein,genistein,and tectorigenin in 13 batches of FP were detected,ranging from 0.4438 to 11.06 mg/g,0.955 to 1.726 mg/g,9.81 to 57.22 mg/g,3.349 to 41.60 mg/g,0.3576 to 0.989 mg/g,and 2.126 to 9.99 mg/g,respectively.In conclusion,fingerprint analysis in combination with chemometrics methods could discover chemical markers for improving the quality control standard of FP.It is expected that the strategy applied in this study will be valuable for further quality control of other traditional Chinese medicines. | Jing Han Ke Xu Quanxiang Yan Wenwen Sui Haotian Zhang Sijie Wang Zan Zhang Ziyun Wei Fei Han | 2022 | Journal of Pharmaceutical Analysis2022，12，3： | 0 |
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