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| 1 | The resurgent landscape of xenotransplantation of pig organs in nonhuman primates显示文摘Organ shortage is a major bottleneck in allotransplantation and causes many wait-listed patients to die or become too sick for transplantation.Genetically engineered pigs have been discussed as a potential alternative to allogeneic donor organs.Although xenotransplantation of pig-derived organs in nonhuman primates(NHPs)has shown sequential advances in recent years,there are still underlying problems that need to be completely addressed before clinical applications,including(i)acute humoral xenograft rejection;(ii)acute cellular rejection;(iii)dysregulation of coagulation and inflammation;(iv)physiological incompatibility;and(v)cross-species infection.Moreover,various genetic modifications to the pig donor need to be fully characterized,with the aim of identifying the ideal transgene combination for upcoming clinical trials.In addition,suitable pretransplant screening methods need to be confirmed for optimal donor-recipient matching,ensuring a good outcome from xenotransplantation.Herein,we summarize the understanding of organ xenotransplantation in pigs-to-NHPs and highlight the current status and recent progress in extending the survival time of pig xenografts and recipients.We also discuss practical strategies for overcoming the obstacles to xenotransplantation mentioned above to further advance transplantation of pig organs in the clinic. | Xuan Zhang Quancheng Wang Jingjun Zhao Xiao Li Wei Peng Zhaoxu Yang Zhibin Lin Long Yang Rui Ding Kaishan Tao Kefeng Dou | 2021 | Science China(Life Sciences)2021，64，5： | 10 |
| 2 | Expert consensus on split-liver transplantation显示文摘With the dawn of organ donation after a citizen's death in China,the use of split-liver transplantation(SLT)can effectively increase the source of donor liver,reduce the waiting time for organ transplantation in patients,and particularly solve the problem of organ shortage in children.In recent years,many transplantation centers have been performing SLT to varying degrees and efficacy.At the current stage,the experiences of countries with advanced transplantation techniques should be used to establish an SLT consensus that is suitable for China to further increase the ratio and efficacy of SLT.In this paper,we combined expert experiences to generate an SLT expert consensus that included donor and donor liver evaluation,recipient selection criteria,donor and recipient matching,selection of splitting form and tools,blood vessels and bile ducts dissection and allocation,perioperative management of SLT,and organ allocation. | Operative Surgical Group,Branch of Surgery of Chinese Medical Association Transplantation Group,Branch of Surgery of Chinese Medical Association Guihua Chen Kefeng Dou Yang Yang Shuhong Yi Qing Yang | 2021 | Liver Research2021，5，1： | 2 |
| 3 | Prevalence of diabetes among men and women in China显示文摘 | Sunhu Yang Kefeng Dou Wenjie Song | 2010 | The New England Journal of Medicine2010，362，： | 1 |
| 4 | Complex intrahepatic biliary calculi comprehensive surgical treatment显示文摘 | Wang Desheng Dou Kefeng Gao Zhiqing | 2014 | Department of hepatobiliary surgery2014，10，14： | 1 |
| 5 | Prevalence of diabetes among men and women in China显示文摘 | Sunhu Yang Kefeng Dou Wenjie Song | 2010 | the New England Journal of Medicine2010，362，： | 1 |
| 6 | Complex intrahep- atic biliary calculi comprehensive surgical treatment显示文摘 | Wang Desheng Dou Kefeng Gao Zhiqing | 2014 | Departme- nt of Hepatobiliary Surgery2014，10，14： | 1 |
| 7 | Effect of wine and vinegar processing of Rhizoma Corydalis on the tissue distribution of tetrahydropalmatine, protopine and dehydrocorydaline in rats 显示文摘 | Zhiying Dou Kefeng Li | 2012 | Molecules2012，17，： | 1 |
| 8 | Overexpression of Bmi-1 contributes to the invasion and metastasis ofhepatocellular carcinoma by increasing the expression of matrix metalloproteinase(MMP)?2, MMP-9 and vascular endothelial growth factor via the PTEN/PI3K/Akt pathway显示文摘 | Xiaolei Li Zhaoxu Yang Wenjie Song Liang Zhou Qingjun Li Kaishan Tao Jingshi Zhou Xing Wang Zhigang Zheng Nan You Kefeng Dou Haimin Li | 2013 | International Journal of Oncology2013，，3： | 1 |
| 9 | Erratum: Tg737 inhibition results in malignant transformation in fetal liver stem/progenitor cells by promoting cell‐cycle progression and differentiation arrest显示文摘 | Nan You Weihui Liu Xiao Zhong Ru Ji Ming Zhang Houcheng You Kefeng Dou Kaishan Tao | 2011 | Mol Carcinog2011，，10： | 1 |
| 10 | Paclitaxel-loaded nanoparticles decorated with anti-CD133 antibody: a targeted therapy for liver cancer stem cells显示文摘 | Cheng Jin Zhaoxu Yang Jingyue Yang Haimin Li Yong He Jiaze An Ling Bai Kefeng Dou | 2014 | Journal of Nanoparticle Research2014，，1： | 1 |
| 11 | Preparation and characterization of targeted DOX–PLGA–PEG micelles decorated with bivalent fragment HAb18 F(ab′) 2 for treatment of hepatocellular carcinoma显示文摘 | Cheng Jin Wenqing Yang Ling Bai Junqing Wang Kefeng Dou | 2011 | Journal of Controlled Release2011，，： | 1 |
| 12 | Circular RNA: A new star of noncoding RNAs显示文摘 | Shibin Qu Xisheng Yang Xiaolei Li Jianlin Wang Yuan Gao Runze Shang Wei Sun Kefeng Dou Haimin Li | 2015 | Cancer Letters2015，，2： | 1 |
| 13 | Short-term tamoxifen administration improves hepatic steatosis and glucose intolerance through JNK/MAPK in mice显示文摘Nonalcoholic fatty liver disease (NAFLD) which is a leading cause of chronic liver diseases lacks effective treatment. Tamoxifen hasbeen proven to be the first-line chemotherapy for several solid tumors in clinics, however, its therapeutic role in NAFLD has neverbeen elucidated before. In vitro experiments, tamoxifen protected hepatocytes against sodium palmitate-induced lipotoxicity. Inmale and female mice fed with normal diets, continuous tamoxifen administration inhibited lipid accumulation in liver, andimproved glucose and insulin intolerance. Short-term tamoxifen administration largely improved hepatic steatosis and insulinresistance, however, the phenotypes manifesting inflammation and fibrosis remained unchanged in abovementioned models. Inaddition, mRNA expressions of genes related to lipogenesis, inflammation, and fibrosis were downregulated by tamoxifentreatment. Moreover, the therapeutic effect of tamoxifen on NAFLD was not gender or ER dependent, as male and female mice withmetabolic disorders shared no difference in response to tamoxifen and ER antagonist (fulvestrant) did not abolish its therapeuticeffect as well. Mechanistically, RNA sequence of hepatocytes isolated from fatty liver revealed that JNK/MAPK signaling pathwaywas inactivated by tamoxifen. Pharmacological JNK activator (anisomycin) partially deprived the therapeutic role of tamoxifen intreating hepatic steatosis, proving tamoxifen improved NAFLD in a JNK/MAPK signaling-dependent manner. | Zhiqiang Fang Hao Xu Juanli Duan Bai Ruan Jingjing Liu Ping Song Jian Ding Chen Xu Zhiwen Li Kefeng Dou Lin Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 0 |
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