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| 1 | Quantitative assessment of the effect of ABCA1 R219K polymorphism on the risk of coronary heart disease显示文摘 | Yang Li Kefu Tang Kejun Zhou Zhiyun Wei Zhen Zeng Lin He Chunling Wan | 2012 | Molecular Biology Reports2012，，2： | 1 |
| 2 | Quantitative assessment of fibrosis-4 score and adverse clinical outcomes in patients with COVID-19显示文摘Dear editor,Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-Co V-2) is a global pandemic leading to a broad spectrum of clinical manifestations, from asymptomatic or mild-to-moderate symptoms, to severe illness, and even death. Accumulating evidence suggests that old age and underlying comorbidities。 | Kefu Tang Lu Wang Lu Shen Lin He Xi Wu | 2022 | Science China(Life Sciences)2022，65，12： | 0 |
| 3 | Highly Prevalent SARS-CoV-2 Antigenemia in COVID-19 Patients显示文摘Background:Many issues,such as severity assessment and antibody responses,remain to be answered eagerly for evaluation and understanding of COVID-19.Immune lesion is one of key pathogenesis of the disease.It would be helpful to understand the disease if an investigation on antigenemia and association was conducted in the patients with SARS-CoV-2 infection.Methods:A total of 156 patients admitted to the First People’s Hospital of Hefei or Anhui Provincial Hospital on January to February 2020 were involved in this study.SARS-CoV-2 nucleocapsid(NP)antigen,specific IgM/IgG antibodies,and RNA were detected in sequential sera from three COVID-19 patients,and additional 153 COVID-19 patients by means of NP-antigen capture enzyme-linked immunosorbent assay,colloidal gold quick diagnosis,and real-time RT-PCR,respectively.The clinical types of COVID-19 patients were classified into asymptomatic,mild,moderate,severe,and critical,following on the Chinese guideline of COVID-19 diagnosis and treatment.The demographic and clinical data of patients were obtained for comparable analysis.Results:NP antigen was detected in 5 of 20 sequential sera collected from three COVID-19 patients with typically clinical symptoms,and 60.13%(92/153)expanded samples collected within 17days after illness onset.No SARS-CoV-2 RNA segment was detected in these sera.The NP positive proportion reached a peak(84.85%,28/33)on 6 to 8days after illness onset.Both NP concentration and positive proportion were increased with the increase of clinical severity of COVID-19.Compared to NP negativepatients,NP positive patients had older age[years,medians(interquartileranges(IQR)),49(6)vs.31(11)],lowerpositive proportion of NP specific IgM[27.17%(25/92)vs.59.02%(36/61)],and IgG[21.74%(20/92)vs.59.02%(36/61)]antibodies,and longer duration[days,medians(IQR),24(10)vs.21(13)]from illness to recovery.Conclusions:SARS-CoV-2 NP antigenemia occurred in COVID-19,and presented highly prevalent at early stage of the disease.The antigenemia was related to clinical severity of the disease,and may beresponsible for the delay of detectable SARS-Cov-2IgM. | Wenyan Zhang Wei Liu Jiawang Lin Jing Jin Kefu Zhao Liwei Zhu Xiuzhen Wang Lijie Wang Renshu Tang Yindi Zhu Wei Zhou Enqing You Lei Zhang Xuxiang Liu Jinju Wu Lili Chen Wenjing Wang Qiang Zhang Rongbao Gao | 2022 | Infectious Diseases & Immunity2022，2，3： | 0 |
| 4 | Internalization and half-life of membrane-bound macrophage colony-stimulating factor显示文摘The binding of recombinant human macrophage colony-stimulating factor (M-CSF) soluble receptor (rh-M-CSF-sR) to membrane-bound macrophage colony stimulating factor (m-M-CSF) and the internalization and recycling of rh-M-CSF-sR/m-M-CSF complexes mediated by m-M-CSF were studied with a model of J6-1 cell line. The results indicated that m-M-CSF bound rh-M-CSF-sR with high affinity (Kd= 1.78×10 12 mol/L) and mediated a temperature- and energy-dependent internalization of rh-M-CSF-sR, and that internalized rh-M-CSF-sR could return to the cell surface in an m-M-CSF-bound state, suggesting that m-M-CSF may have a capability to mediate the internalization and recycling of rh-M-CSF-sR/m-M-CSF complexes. In addition, the half-lives of cell-associated M-CSF and its receptor of stimulated normal human cord blood mononuclear cells (CBMCs) and 4 leukemic cell lines were measured by indirect immunoflu-orescence and flow cytometry. The results showed that the half-lives of the various kinds of M-CSF isoforms and | TANG Shengsong LIU Hanzhi CHEN Guibin RAO Qing GENG Yiqi ZHENG Guoguang ZHENG Dexian WU Kefu | 2000 | Chinese Science Bulletin2000，45，18： | 0 |
| 5 | Coral records of Mid-Holocene sea-level highstands and climate responses in the northern South China Sea显示文摘High-resolution sea-level data and high-precision dating of corals in the northern South China Sea(SCS)during the Holocene provide a reference and historical background for current and future sea-level changes and a basis for scientific assessment of the evolutionary trend of coral reefs in the SCS.Although sporadic studies have been performed around Hainan Island in the northern SCS,the reconstructed sea level presents different values or is controversial because the indicative meaning of the sea-level indicators were neither quantified nor uniform criteria.Here,we determined the quantitative relationship between modern living coral and sea level by measuring the top surfaces of 27 live Porites corals from the inner reef flat along the east coast of Hainan Island and assessed the accuracy of results obtained using coral as sea-level indicators.Additionally,three in situ fossil Porites corals were analyzed based on elevation measurements,digital X-ray radiography,and U-Th dating.The survey results showed that the indicative meanings for the modern live Porites corals is(146.09±8.35)cm below the mean tide level(MTL).It suggested that their upward growth limit is constrained by the sea level,and the lowest low water is the highest level of survival for the modern live Porites corals.Based on the newly defined indicative meanings,6 new sea-level index points(SLIPs)were obtained and 19 published SLIPs were recalculated.Those SLIPs indicated a relative sea level fluctuation between(227.7±9.8)cm to(154.88±9.8)cm MTL between(5393±25)cal a BP and(3390±12)cal a BP,providing evidences of the Mid-Holocene sea-level highstand in the northern SCS.Besides that,our analysis demonstrated that different sea-level histories may be produced based on different indicative meanings or criteria.The dataset of 276 coral U-Th ages indicates that coral reef development in the northern SCS comprised the initial development,boom growth,decline,and flourishing development again.A comparison with regional records indicated that synergistic effects of climatic and environmental factors were involved in the development of coral reefs in the northern SCS.Thus,the cessation of coral reef development during the Holocene in the northern SCS was probably associated with the dry and cold climate in South China,as reflected in the synchronous weakening of the ENSO and East Asian summer monsoon induced by the reduction of the 65°N summer insolation,which forced the migration of the Intertropical Convergence Zone. | Yuanfu Yue Lichao Tang Kefu Yu Rongyong Huang | 2024 | Acta Oceanologica Sinica2024，43，2： | 0 |
| 6 | IN-SITU OBSERVATION OF CRACK TIP DEFORMATION IN A DUPLEX STAINLESS STEEL显示文摘The development of dislocation structures in the plastic zone ahead of a crack tip has been in-vestigated in a duplex stainless steel during in-situ deformation experiments in a scanningtransmission electron microscope.It was found that the dislocation distribution wassignificantly different in the ferrite and in the austenite.In the ferrite grains,the dislocationsemitted by the crack tip may cross-slip out of the original slip planes and form a broad plasticzone.However,in the austenite,the dislocation free zone is small and the dislocations emittedby the crack pile up in its slip plane.The selection of slip systems at the crack tip depends onthe crack tip Schmid factors in both phases.But after large deformation,the selection of thesecond slip systems at the craek tip in austenite does not depend on the Schmid factors. | YAO Kefu TANG Naiyong CHEN Nanping Tsinghua University,Beijing,China | 1989 | Acta Metallurgica Sinica(English Letters)1989，2，6： | 0 |
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