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| 1 | Primary structures of two hemagglutinins from the marine red alga, Hypnea japonica显示文摘 | Kanji Hori Ki minori Matsubara Keisuke Miyazawa | 2000 | Biochimica et Biophysica Acta2000，1474，： | 1 |
| 2 | Fabrication of TiB2 reinforced Al3Ti composite layer on Ti substrate by reactive-pulsed electric current sintering显示文摘 | Toshio Matsubara Tomohide Shibutani Keisuke Uenishi | 2002 | Materials Science and Engineering2002，，： | 1 |
| 3 | Wear and oxidation resistance of Al2O3 particle dispersed Al3Ti composite with a nanostructure prepared by pulsed electric current sintering of mechanically alloyed powders显示文摘 | Keisuke Uenishi Toshio Matsubara Tomohide Shibutani | 2002 | Intermetallies2002，10，： | 1 |
| 4 | Bezafibrate for the treatment of primary sclerosing cholangitis显示文摘 | Suguru Mizuno Kenji Hirano Minoru Tada Keisuke Yamamoto Yoko Yashima Hiroshi Yagioka Kazumichi Kawakubo Yukiko Ito Hirofumi Kogure Takashi Sasaki Toshihiko Arizumi Osamu Togawa Saburo Matsubara Yousuke Nakai Naoki Sasahira Takeshi Tsujino Hiroyuki Isayama | 2010 | Journal of Gastroenterology2010，，7： | 1 |
| 5 | Facile net cycloaddition approach to optically active 1,5-benzoth- iazepines显示文摘 | Yukihiro Fukata Keisuke Asano Seijiro Matsubara | 2015 | J Am Chem Soc2015，137，16： | 1 |
| 6 | Multicenter phase II study of S-1 monotherapy as second-line chemotherapy for advanced biliary tract cancer refractory to gemcitabine显示文摘 | Takashi Sasaki Hiroyuki Isayama Yousuke Nakai Suguru Mizuno Keisuke Yamamoto Hiroshi Yagioka Yoko Yashima Kazumichi Kawakubo Hirofumi Kogure Osamu Togawa Saburo Matsubara Yukiko Ito Naoki Sasahira Kenji Hirano Takeshi Tsujino Nobuo Toda Minoru Tada Masao | 2012 | Investigational New Drugs2012，，2： | 1 |
| 7 | Endoscopic evaluation of factors contributing to intrapancreatic biliary stricture in autoimmune pancreatitis显示文摘 | Kenji Hirano Minoru Tada Hiroyuki Isayama Keisuke Yamamoto Suguru Mizuno Hiroshi Yagioka Yoko Yashima Takashi Sasaki Hirofumi Kogure Osamu Togawa Toshihiko Arizumi Saburo Matsubara Yousuke Nakai Naoki Sasahira Takeshi Tsujino Takao Kawabe Masao Omata | 2010 | Gastrointestinal Endoscopy2010，，1： | 1 |
| 8 | A comparative clinical study of macrolide-sensitive and macrolide-resistant Mycoplasma pneumoniae infections in pediatric patients显示文摘 | Keita Matsubara Miyuki Morozumi Takafumi Okada Takahiro Matsushima Osamu Komiyama Michi Shoji Takashi Ebihara Kimiko Ubukata Yoshitake Sato Hironobu Akita Keisuke Sunakawa Satoshi Iwata | 2009 | Journal of Infection and Chemotherapy2009，，6： | 1 |
| 9 | Multicenter phase II study of S-1 monotherapy as second-line chemotherapy for advanced biliary tract cancer refractory to gemcitabine显示文摘 | Takashi Sasaki Hiroyuki Isayama Yousuke Nakai Suguru Mizuno Keisuke Yamamoto Hiroshi Yagioka Yoko Yashima Kazumichi Kawakubo Hirofumi Kogure Osamu Togawa Saburo Matsubara Yukiko Ito Naoki Sasahira Kenji Hirano Takeshi Tsujino Nobuo Toda Minoru Tada Masao | 2012 | Investigational New Drugs2012，，2： | 1 |
| 10 | Incremental Prognostic Significance of Peripheral Endothelial Dysfunction in Patients With Heart Failure With Normal Left Ventricular Ejection Fraction显示文摘 | Eiichi Akiyama Seigo Sugiyama Yasushi Matsuzawa Masaaki Konishi Hiroyuki Suzuki Toshimitsu Nozaki Keisuke Ohba Junichi Matsubara Hirofumi Maeda Yoko Horibata Kenji Sakamoto Koichi Sugamura Megumi Yamamuro Hitoshi Sumida Koichi Kaikita Satomi Iwashita Kuni | 2012 | Journal of the American College of Cardiology2012，，18： | 1 |
| 11 | A Dipeptidyl Peptidase-4 Inhibitor, Des-Fluoro-Sitagliptin, Improves Endothelial Function and Reduces Atherosclerotic Lesion Formation in Apolipoprotein E–Deficient Mice显示文摘 | Junichi Matsubara Seigo Sugiyama Koichi Sugamura Taishi Nakamura Yukio Fujiwara Eiichi Akiyama Hirofumi Kurokawa Toshimitsu Nozaki Keisuke Ohba Masaaki Konishi Hirofumi Maeda Yasuhiro Izumiya Koichi Kaikita Hitoshi Sumida Hideaki Jinnouchi Kunihiko Matsui | 2012 | Journal of the American College of Cardiology2012，，3： | 1 |
| 12 | Pancreatic Cancer in Patients With Pancreatic Cystic Lesions: A Prospective Study in 197 Patients显示文摘 | Minoru Tada Takao Kawabe Masatoshi Arizumi Osamu Togawa Saburo Matsubara Natsuyo Yamamoto Yosuke Nakai Naoki Sasahira Kenji Hirano Takeshi Tsujino Keisuke Tateishi Hiroyuki Isayama Nobuo Toda Haruhiko Yoshida Masao Omata | 2006 | Clinical Gastroenterology and Hepatology2006，，10： | 1 |
| 13 | Body Characteristics of Professional Japanese Keirin Cyclists: Flexibility, Pelvic Tilt, and Muscle Strength显示文摘 | Yuto Tashiro Satoshi Hasegawa Shu Nishiguchi Naoto Fukutani Daiki Adachi Takayuki Hotta Saori Morino Hidehiko Shirooka Yuma Nozaki Hinako Hirata Moe Yamaguchi Seishiro Tasaka Tomohumi Matsushita Keisuke Matsubara Tomoki Aoyama | 2016 | Journal of Sports Science2016，4，6： | 0 |
| 14 | Why is endosonography insufficient for residual diagnosis after neoadjuvant therapy for esophageal cancer?Solutions using muscle layer evaluation显示文摘BACKGROUND The diagnosis of residual tumors using endoscopic ultrasound(EUS)after neoadjuvant therapy for esophageal cancer is considered challenging.However,the reasons for this difficulty are not well understood.AIM To investigate the ultrasound imaging features of residual tumors and identify the limitations and potential of EUS.METHODS This exploratory prospective observational study enrolled 23 esophageal squamous cell carcinoma patients receiving esophagectomy after neoadjuvant therapy[15 patients after neoadjuvant chemotherapy(NAC)and 8 patients after chemoradiotherapy(CRT)]at the Department of Surgery,Chiba University Hospital,between May 2020 and October 2021.We diagnosed the T stage for specimens using ultrasound just after surgery and compared ultrasound images with the cut surface of the fixed specimens of the same level of residual tumor.The ratio of esophageal muscle layer defect measured by ultrasound was compared with clinicopathological factors.Furthermore,the rate of reduction for the muscle layer defect was evaluated using EUS images obtained before and after neoadjuvant therapy.RESULTS The accuracy of T stage rate was 61%(n=14/23),which worsened after CRT(38%,n=3/8)than after NAC(73%,n=11/15)because of overstaging.Moreover,pT0 could not be diagnosed in all cases.The detection rate of residual tumor for specimens using ultrasound retrospectively was 75%(n=15/20).There was no correlation between after-NAC(79%,n=11/14)and after-CRT(67%,n=4/6)detection rate.The detection of superficial and submucosal types was poor.The pathologic tumor size and pathological response were correlated.Tumor borders were irregular and echogenicity was mixed type after CRT.There was a correlation between the pT stage(pT0/1 vs pT2/3)and the length of muscle layer circumference(P=0.025),the length of muscle layer defect(P<0.001),and the ratio of muscle layer defect(P<0.001).There was also a correlation between the pT stage and the rate of muscle layer defect reduction measured by EUS(P=0.001).CONCLUSION Compared to pathological images,some tumors are undetectable by ultrasound.Focusing on the esophageal muscle layer might help diagnose the depth of the residual tumor. | Shohei Yonemoto Masaya Uesato Akira Nakano Kentaro Murakami Takeshi Toyozumi Tetsuro Maruyama Hiroshi Suito Tomohide Tamachi Manami Kato Shunsuke Kainuma Keisuke Matsusaka Hisahiro Matsubara | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，5： | 0 |
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