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| 1 | Endoscopic ultrasound-guided celiac plexus neurolysis using a reverse phase polymer显示文摘AIM:To assess the feasibility of endoscopic ultrasound(EUS)guided celiac plexus neurolysis(CPN) using a poloxamer. METHODS:In this prospective evaluation,six Yorkshire pigs underwent EUS-guided CPN.Three received an injection of 10 mL of 0.25%Lidocaine plus methylene blue(group 1) and three received an injection of 10 mL of 0.25%Lidocaine plus blue colored poloxamer(PS137-25)(group 2) .Necropsy was performed immediately after the animals were sacrificed.The abdominal and pelvic cavities were examined for the presence of methylene blue and the blue colored poloxamer.RESULTS:EUS-guided CPN was successfully performed in all 6 pigs without immediate complication.Methylene blue was identified throughout the peritoneal and retroperitoneal cavity in group 1.The blue colored poloxamer was found in the retroperitoneal cavity immediately adjacent to the aorta,in the exact location of the celiac plexus in group 2.CONCLUSION:EUS-guided CPN using a reverse phase polymer in a non-survival porcine model was technically feasible.The presence of a poloxamer gel at the site of the celiac plexus at necropsy indicates a precise delivery of the neurolytic agent. | Keith L Obstein Fernanda P Martins Gloria Fernández-Esparrach Christopher C Thompson | 2010 | World Journal of Gastroenterology2010，16，6： | 3 |
| 2 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 3 | Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS显示文摘 | Simon P Dunlop David Jenkins Keith R Neal Robin C Spiller | 2003 | Gastroenterology2003，，6： | 2 |
| 4 | The cloning of cattle interferon-A subtypes isolated from the gut epithelium of rotavirus infected calves显示文摘 | Paul J C Keith R P RobertA C | 1996 | Immunogenetics1996，44，： | 1 |
| 5 | Control of p70 S6 kinase by kinase activity of FRAP in vivo显示文摘 | Brown E J Beal P A Keith C T | 1995 | Nature1995，377，6548： | 1 |
| 6 | Large thoracic wall hema- toma following sternal reconstruction with transversal plate fixa- tion after deep sternal wound infection 显示文摘 | Schimmer C Keith P Neukam K | 2007 | Thorac Cardiovasc Surg2007，55，6： | 1 |
| 7 | Effect of salt and water balance on recovery of gastrointestinal function after elective colonic resection: a randomised controlled trial显示文摘 | Dileep N Lobo Kate A Bostock Keith R Neal Alan C Perkins Brain J Rowlands Simon P Allison | 2002 | The Lancet . 2002 (9320)2002，，9320： | 1 |
| 8 | The effect of liquid water on thunderstorm charging显示文摘 | W D Keith R P Mitzeva | 1991 | J Geophys Res1991，96，11： | 1 |
| 9 | Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study显示文摘 | Keith C Bible Vera J Suman Julian R Molina Robert C Smallridge William J Maples Michael E Menefee Joseph Rubin Kostandinos Sideras John C Morris Bryan McIver Jill K Burton Kevin P Webster Carolyn Bieber Anne M Traynor Patrick J Flynn Boon Cher Goh Hui Tan | 2010 | Lancet Oncology2010，，10： | 1 |
| 10 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 11 | Isotopic evidence of nitrate sources and denitrification in the Mississippi River,Illinois 显示文摘 | Samuel V P Keith C H Hackley W R | 2006 | Journal of Environmental Quality2006，35，： | 1 |
| 12 | Spatiotemporal patterning of reactive oxygen production and Ca^2+ wave propagation in Fucus Rhizoid cells 显示文摘 | Susana M C Alison R T Keith P R | 2002 | Plant Cell2002，14，： | 1 |
| 13 | The effect of liquid water on thunderstorm charging 显示文摘 | Saunders C P R Keith W D Mitzeva R P | 1991 | J Geophys Res1991，96，11： | 1 |
| 14 | The effect of liquid on thunderstorm charging显示文摘 | Saunders C P R Keith W D Mitzeva R P | 1991 | Journal of Geophysical Re- search1991，96，11： | 1 |
| 15 | State-space solutions to standard H2 and hinf control problems显示文摘 | John C Doyle Keith Clover Pramod P Khargonekar | 1989 | IEEE Transactions on Automatic Control1989，34，8： | 1 |
| 16 | Thermochemical and kinetic aspects of the sulfurization of Cu-Sb and Cu-Bi thin films显示文摘 | Diego C Laurence M P Keith D R | 2012 | Journal of Solid State Chemistry2012，186，： | 1 |
| 17 | Further laboratory studies of the charging of graupel during ice crystal interactions显示文摘 | Keith W D Saunders C P R | 1990 | Journal of the Atmospheric Sciences1990，25，： | 1 |
| 18 | Effect of increasing anode surface area on the performance of a single chamber microbial fuel cell 显示文摘 | Mirella D L Keith S Tom P C | 2010 | Chemical Enlineerin Journal2010，156，1： | 1 |
| 19 | The cloning of cattle interferon-A subtypes isolated from the gut epithelium of rotavirus-infected calves显示文摘 | Paul J C Keith R P Robert A C | 1996 | Immunogenetics1996，44，： | 1 |
| 20 | An improved simple morphological filter for the terrain classification of airborne LIDAR data显示文摘 | Thomas J P Keith C C William A M | 2013 | ISPRS Journal of Photogrammetry and Remote Sensing2013，77，： | 1 |
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