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| 1 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 2 | Superior Survival in Treatment of Primary Nonmetastatic Pediatric Osteosarcoma of the Extremity显示文摘 | Ross M. Wilkins MD John W. Cullen MD Lorrie Odom MD Brandt A. Jamroz MD Patsy McGuire Cullen MS CPNP Kyle Fink MD Sanford D. Peck MD Sydney L. Stevens MD Cynthia M. Kelly MD Anne B. Camozzi BA | 2003 | Annals of Surgical Oncology2003，，5： | 1 |
| 3 | Lower Mortality in Magnet Hospitals显示文摘 | Mchugh MD Kelly LA Smith HL | 2013 | Medical Care2013，51，5： | 1 |
| 4 | Angiography and embolisation for solid abdominal organ injury in adults: a current perspective 显示文摘 | Wallis A Kelly MD Jones L | 2010 | World J Emerg Surg2010，5，： | 1 |
| 5 | A correlation between a proteomic evaluation and conventional measurements in the assessment of renal proximal tubular toxicity 显示文摘 | Kelly MD Lock EA | 2003 | Toxicol Sci2003，73，1： | 1 |
| 6 | Results of laparoscopic bile duct exploration viacholedochotomy显示文摘 | Kelly MD | 2010 | ANZ J Surg2010，80，10： | 1 |
| 7 | Laparoscopic anatomy of the cystic artery显示文摘 | Hugh TB Kelly MD Li B | 1992 | Am J Surg1992，163，： | 1 |
| 8 | Safety education in a Pediatric Primary Care Setting显示文摘 | Barbara Kelly MD Carmen Sein MSW | 1987 | PEDIATRICS1987，79，5： | 1 |
| 9 | Large cell neuroendocrine carcinoma of the cervix:prognostic factors and survival advantage with platinum chemotherapy显示文摘 | Embry JR Kelly MG Post MD | 2011 | Gynecol Oncol2011，120，3： | 1 |
| 10 | CRM197-conjugated serogroup C meningococcal capsular polysaccharide, but not the native polysaccharide, induces persistent antigen-specific memory B cells 显示文摘 | Kelly DF Snape MD Clutterbuck EA | 2006 | Blood2006，108，8： | 1 |
| 11 | Laparoscopic anatomy of the cystic artery显示文摘 | Hugh TB Kelly MD Li B | 1992 | A m J S u r g1992，163，： | 1 |
| 12 | Laparoscopic anatomy of the cystic ar-tery显示文摘 | Hugh TB Kelly MD Li B | 1992 | Am J Surg1992，163，6： | 1 |
| 13 | Mirizzi syndrome显示文摘 | Kelly MD | 2005 | ANZ J Surg2005，75，6： | 1 |
| 14 | Large cell neuroendocrine carcinoma of the cervix: prognostic factors and survival advantage with platinum chemotherapy 显示文摘 | Embry JR Kelly MG Post MD | 2011 | Gynecol Oncol2011，120，3： | 1 |
| 15 | Lack of serum bactericidal activity in preschool children two years after a single dose of serogroup C meningococcal polysaccharide-protein conjugate vaccine显示文摘 | Snape MD Kelly DF Green B | 2005 | Pediatr Infect Dis J2005，24，2： | 1 |
| 16 | Laparoscopic anatomy of the cystic artery显示文摘 | Hugh TB Kelly MD Li B | 1992 | Am J Sury1992，163，1： | 1 |
| 17 | Self - management of chronic disease and hospital read- mission A care transition strategy显示文摘 | Kelly MD | 2011 | J Nurs Heahhc Chronic I11n2011，3，1： | 1 |
| 18 | Successful treatment of a patient with stage Ⅳ rhabdoid tumor of the kidney:case report and review 显示文摘 | Waldron PE Rodgers BM Kelly MD | 1999 | J Pediatr Hematol Oncol1999，21，1： | 1 |
| 19 | Lack of serum bactericidal activity in preschool children two years after a single dose of serogroup C meningococcal polysaccharideprotein conjugate vaccine显示文摘 | Snape MD Kelly DF Green B | 2005 | Pediatr Infect Dis J2005，24，2： | 1 |
| 20 | Hepati- tis B awareness and education: A failing grade显示文摘 | Kelly W Burak MD FRCPC MSc(Epid) | 2011 | Can J Gastroenterol2011，25，3： | 1 |
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