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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Testing for HCV Infection: An Update of Guidance for Clinicians and Laboratorians显示文摘 | Getchell Jane P Wroblewski Kelly E DeMaria Alfred Bean Christine L Parker Monica M Pandori Mark Dufour D Robert Busch Michael P Brecher Mark E Meyer William A Pesano Rick L Teo Chong-Gee Beckett Geoffrey A Araujo Aufra C Branson Bernard M D | 2013 | MMWR. Morbidity and Mortality Weekly Report2013，，18： | 3 |
| 3 | Characterization Study of Diamond and Diamond-like Carbon显示文摘 | Dowling D P Ahern M J Kelly T C | 1992 | Surface and Coating Technology1992，53，： | 2 |
| 4 | Unmetabolized folic acid in serum : acute studies in subjects consuming fortified food and supple- ments 显示文摘 | Kelly P McPartlin J Gogglns M | 1997 | Am J Clin Nun''1997，65，： | 1 |
| 5 | Surface alloying of AZ91D alloy by diffusion coating显示文摘 | Zhang M X Kelly P M | 2002 | J Mater Res2002，17，： | 1 |
| 6 | Influence of transglutaminase treatment on properties of micellar casein and products made therefrom 显示文摘 | Mounsey J S O ' Kennedy B T Kelly P M | 2005 | Lait2005，85，： | 1 |
| 7 | Crystallographic study of grain refinement in aluminum alloys using the edge- to-edge matching model显示文摘 | Zhang M X Kelly P M Easton M A | 2005 | Acta Mater2005，53，： | 1 |
| 8 | A low-glycemic index diet combined with exercise reduces insulin resistance,postprandial hyperinsulinemia,and glucose-dependent insulinotropic polypeptide responses in obese,prediabetichumans显示文摘 | Solomon T P Haus J M Kelly K R | 2010 | Am J Clin Nutr2010，92，6： | 1 |
| 9 | Robust analysis of the yeast proteome under 50 kDa by molecular-massbased fractionation and top-down mass spectrometry显示文摘 | Kellie J F Catherman A D Durbin K R Tran J C Tipton J D Norris J L Witkowski C E 2nd Thomas P M Kelleher N L | | 0，，01： | 1 |
| 10 | Hub networks and simulated schedule delay显示文摘 | Grove P G O'Kelly M E | 1986 | Papers in Regional Science1986，59，1： | 1 |
| 11 | Light-emitting fluorine photoreactive liquid crystals for organic electroluminescence显示文摘 | Aldred M P Eastwood A J Kelly S M | 2004 | Chem Mater2004，16，： | 1 |
| 12 | Late paleocene to eocene paleocenography of the equatorial pacific ocean: stable isotopes recorded at ocean drilling program site 865, allison guyot显示文摘 | Zachos J C Thomas E Parrow M Paul C K Kelly D C Silva I P Sliter W V Lohmann K C | 1995 | Paleoceanography1995，10，： | 1 |
| 13 | Effect of lactation on the de- cline of brush border lactase activity in neonatal pigs 显示文摘 | KELLY D KING T P MCFADYEN M | 1991 | Gut1991，32，： | 1 |
| 14 | The Characterization ofOxotremorine induced Hypothermic Response in the Rat 显示文摘 | Ryan P M Kelly J P Chambers P L | 1996 | Pharmacol Toxicol1996，79，5： | 1 |
| 15 | Re-evaluation of fibrogenic cytokines in lung fibrosis显示文摘 | Kelly M Kolb M Bonniaud P | | 0，，01： | 1 |
| 16 | Early experience with endoscopic carpal tunnel release 显示文摘 | Kelly C P Pulistetti D Jamieson A M | 1994 | J Hand surg Br1994，19，1： | 1 |
| 17 | The maximum entropy distribution of an asset inferred from option prices显示文摘 | Buchen P W Kelly M | 1996 | Journal of Financial and Quantitative Analysis1996，31，1： | 1 |
| 18 | Selective detection,enumeration and identification of potentially probiotic Lactobacillus and Bifidobacterium species in mixed bacterial populations显示文摘 | CHARTERIS W P KELLY P M MORELLI L | 1997 | International Journal of Food Microbiology1997，35，1： | 1 |
| 19 | Estrogen receptor status in BRCA1 and BRCA2-related breast cancer: the influence of age, grade, and histological type显示文摘 | William DF Kelly M Sun P | 2004 | Cancer Res2004，10，6： | 1 |
| 20 | Evidence of an energetic ion bombardment mechanism for bias-enhanced nucleation of diamond 显示文摘 | McGinnis S P Kelly M A Hagstorm S B | 1995 | Appl Plays Lett1995，66，： | 1 |
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