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| 1 | Expression of matrix metalloproteinases 2 and 9 in human gastric cancer and superficial gastritis显示文摘AIM:To assess expression of matrix metalloproteinases 2(MMP2)and MMP9 in gastric cancer,superficial gastritis and normal mucosa,and to measure metalloproteinase activity.METHODS:MMP2 and MMP9 mRNA expression was determined by quantitative real-time polymerase chain reaction.Normalization was carried out using three different factors.Proteins were analyzed by quantitative gelatin zymography(qGZ).RESULTS:18S ribosomal RNA(18SRNA)was very highly expressed,while hypoxanthine ribosyltransferase-1(HPRT-1)was moderately expressed.MMP2 was highly expressed,while MMP9 was not detected or lowly expressed in normal tissues,moderately or highly expressed in gastritis and highly expressed in cancer.Relative expression of 18SRNA and HPRT-1 showed no significant differences.Significant differences in MMP2 and MMP9 were found between cancer and normal tissue,but not between gastritis and normal tissue.Absolute quantification of MMP9 echoed this pattern,but differential expression of MMP2 proved conflictive.Analysis by qGZ indicated significant differences between cancer and normal tissue in MMP-2,total MMP-9,250 and 110 kDa bands.CONCLUSION:MMP9 expression is enhanced in gastric cancer compared to normal mucosa;interpretation of differential expression of MMP2 is difficult to establish. | Clara Luz Sampieri Sol de la Pea Mariana Ochoa-Lara Roberto Zenteno-Cuevas Kenneth León-Córdoba | 2010 | World Journal of Gastroenterology2010，16，12： | 46 |
| 2 | Endoscopic ultrasonography guided biliary drainage: Summary of consortium meeting, May 7^(th) , 2011, Chicago显示文摘Endoscopic retrograde cholangiopancreatography (ERCP) has become the preferred procedure for biliary or pancreatic drainage in various pancreatico-biliary disorders. With a success rate of more than 90%, ERCP may not achieve biliary or pancreatic drainage in cases with altered anatomy or with tumors obstructing access to the duodenum. In the past those failures were typically managed exclusively by percutaneous approaches by interventional radiologists or surgical intervention. The morbidity associated was significant especially in those patients with advanced malignancy, seeking minimally invasive interventions and improved quality of life. With the advent of biliary drainage via endoscopic ultrasound (EUS) guidance, EUS guided biliary drainage has been used more frequently within the last decade in different countries. As with any novel advanced endoscopic procedure that encompasses various approaches, advanced endoscopists all over the world have innovated and adopted diverse EUS guided biliary and pancreatic drainage techniques. This diversity has resulted in variations and improvements in EUS Guided biliary and pancreatic drainage; and over the years has led to an extensive nomenclature. The diversity of techniques, nomenclature and recent progress in our intrumentation has led to a dedicated meeting on May 7 th , 2011 during Digestive Disease Week 2011. More than 40 advanced endoscopists from United States, Brazil, Mexico, Venezuela, Colombia, Italy, France, Austria, Germany, Spain, Japan, China, South Korea and India attended this pivotal meeting. The meeting covered improved EUS guided biliary access and drainage procedures, terminology, nomenclature, training and credentialing; as well as emerging devices for EUS guided biliary drainage. This paper summarizes the meeting's agenda and the conclusions generated by the creation of this consortium group. | Michel Kahaleh Everson LA Artifon Manuel Perez-Miranda Kapil Gupta Takao Itoi Kenneth F Binmoeller California Pacific Medical Center San Francisco CA 94115 United States Marc Giovannini | 2013 | World Journal of Gastroenterology2013，19，9： | 15 |
| 3 | Clinical simulation and foundation skills:an integrated multidisciplinary approach to teaching显示文摘 | Frederick G | 2004 | J Dent Educ2004，68，4： | 1 |
| 4 | Ultrasound-Guided Thrombin Injection for the Treatment of Postcatheterization Pseudoaneurysms显示文摘 | Lucy La Perna Jeffrey W. Olin Debbie Goines Mary Beth Childs Kenneth Ouriel | 2000 | Circulation: Journal of the American Heart Association2000，，19： | 1 |
| 5 | Seven Steps for Developing and Implementing a Preventive Training Program显示文摘 | Darin A. Padua Barnett Frank Alex Donaldson Sarah de la Motte Kenneth L. Cameron Anthony I. Beutler Lindsay J. DiStefano Stephen W. Marshall | 2014 | Clinics in Sports Medicine2014，，4： | 1 |
| 6 | Clinical simulation and foundation skills: an integrated multidiseiplinary approach to teaching 显示文摘 | Kenneth LA Frederick G | 2004 | J Dent Edue2004，68，4： | 1 |
| 7 | Overview of the American Heart Association 'Get With The Guidelines' Programs: Coronary Heart Disease,Stroke, and Heart Failure显示文摘 | Yuling H Kenneth LA | 2006 | Crit Path Cardiol2006，5，： | 1 |
| 8 | ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery 显示文摘 | Fleisher LA Beckman JA Kenneth A | 2007 | Circulation2007，116，41： | 1 |
| 9 | Clinical simulation and foundation skills: an integrated multidisciplinary approach to teaching 显示文摘 | Kenneth LA Frederick G | 2004 | J Dent Educ2004，68，4： | 1 |
| 10 | Results of multimodal treatment for desmoplastic small round cell tumors显示文摘 | Dave R. Lal Wendy T. Su Suzanne L. Wolden Kenneth C. Loh Shakeel Modak Michael P. La Quaglia | 2005 | Journal of Pediatric Surgery2005，，1： | 1 |
| 11 | Community Integration Island Tourism in Peru显示文摘 | la Arreola Daniel Madsen Kenneth | 2001 | Annals of Tourism Research2001，28，1： | 1 |
| 12 | Progress and limitations in the use of in vitro cell cultures to serve as a permeability screen for the blood- brain barrier显示文摘 | Mark G Kenneth LA | 2001 | J Pharm Sci2001，90，11： | 1 |
| 13 | Evaluation of the BBMEC model for screening the CNS Permeability of drugs 显示文摘 | Kenneth WO Michael LA Suzanne MBP | 2001 | J Pharmacol Toxicological Methods2001，45，： | 1 |
| 14 | Evaluation of the BMEC model for screening the CNS Permeability of drugs 显示文摘 | Kenneth WO Michael LA Suzanne MBP | 2001 | Pharmacol Toxicological Methods2001，45，： | 1 |
| 15 | Major histocompatibility complex I upregulation in clear cell renal cell carcinoma is associated with increased survival显示文摘Objective:To examine the prognostic value of tumor major histocompatibility complex I(MHCI)expression on survival and recurrence in patients with clear cell renal cell carcinoma(RCC).Methods:Fifty-three patients that underwent nephrectomy at our institution for clear cell RCC(T1eT3)with4 years of follow-up were queried from our nephrectomy database.Immunohistochemical staining for MHCI was performed on tumor specimens and MHCI expression was quantified with an automated image analysis technique.Patients were divided into high and low MHCI expression groups in order to study the relationship between MHCI expression and prognosis using the KaplaneMeier method and log-rank test.Results:Overall survival and recurrence free survival were increased in the high MHCI expression group compared to the low MHCI expression group(log-rank,p=0.036 and p=0.028,respectively).Patients alive at the end of the study had higher MHCI expression(mean positivity score 0.82)than those that died of disease(mean positivity score 0.76,t test,p=0.030).Patients that did not develop recurrence during the study period had higher MHCI expression(mean positivity score 0.83)than those that did develop recurrence(mean positivity score 0.78),but this difference was not significant(t test,p =0.079). | Rishi R.Sekar Claire M.De La Calle Dattatraya Patil Sarah A.Holzman Yoram Baum Umer Sheikh Jonathan H.Huang Adeboye O.Osunkoya Brian P.Pollack Haydn T.Kissick Kenneth Ogan Viraj A.Master | 2016 | Asian Journal of Urology2016，3，2： | 0 |
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