|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Position Estimation in Switched Reluctance Motor Drives Using the First Switching Har- monics Through Fourier Series 显示文摘 | Keunsoo Ha Rae-Young Kim Ramu R | 2011 | Industrial Electronics2011,58,12: | 1 |
| 2 | Theory and Operation of a Four-Quadrant Switched Reluctance Motor Drive with a Single Controllable Switch The Lowest Cost Four-Quadrant Brushless Motor Drive显示文摘 | Krishnan R Sung-Yeul Park Keunsoo Ha | 2005 | IEEE Trans Ind App2005,41,4: | 1 |
| 3 | Theory and operation of a four-quadrant switched reluctance motor drive with a single controllable switch-the lowest cost four-quadrant brushless motor drive显示文摘 | Krishnan R Sung-Yeul Park Keunsoo Ha | 2005 | Industry Applications IEEE Transactions2005,41,4: | 1 |
| 4 | Theory and operation of a four-quadrant switched re-luctance motor drive with a single controllable swiwh-the lowest cost four-quadrant brushless motor drive显示文摘 | Sung Y P Keunsoo H | 2005 | Industry Applications2005,41,4: | 1 |
| 5 | RANKL-responsive epigenetic mechanism reprograms macrophages into bone-resorbing osteoclasts显示文摘Monocyte/macrophage lineage cells are highly plastic and can differentiate into various cells under different environmental stimuli. Bone-resorbing osteoclasts are derived from the monocyte/macrophage lineage in response to receptor activator of NF-κB ligand (RANKL). However, the epigenetic signature contributing to the fate commitment of monocyte/macrophage lineage differentiation into human osteoclasts is largely unknown. In this study, we identified RANKL-responsive human osteoclast-specific superenhancers (SEs) and SE-associated enhancer RNAs (SE-eRNAs) by integrating data obtained from ChIP-seq, ATAC-seq, nuclear RNA-seq and PRO-seq analyses. RANKL induced the formation of 200 SEs, which are large clusters of enhancers, while suppressing 148 SEs in macrophages. RANKL-responsive SEs were strongly correlated with genes in the osteoclastogenic program and were selectively increased in human osteoclasts but marginally presented in osteoblasts, CD4+ T cells, and CD34+ cells. In addition to the major transcription factors identified in osteoclasts, we found that BATF binding motifs were highly enriched in RANKL-responsive SEs. The depletion of BATF1/3 inhibited RANKL-induced osteoclast differentiation. Furthermore, we found increased chromatin accessibility in SE regions, where RNA polymerase II was significantly recruited to induce the extragenic transcription of SE-eRNAs, in human osteoclasts. Knocking down SE-eRNAs in the vicinity of the NFATc1 gene diminished the expression of NFATc1, a major regulator of osteoclasts, and osteoclast differentiation. Inhibiting BET proteins suppressed the formation of some RANKL-responsive SEs and NFATc1-associated SEs, and the expression of SE-eRNA:NFATc1. Moreover, SE-eRNA:NFATc1 was highly expressed in the synovial macrophages of rheumatoid arthritis patients exhibiting high-osteoclastogenic potential. Our genome-wide analysis revealed RANKL-inducible SEs and SE-eRNAs as osteoclast-specific signatures, which may contribute to the development of osteoclast-specific therapeutic interventions. | Seyeon Bae Kibyeong Kim Keunsoo Kang Haemin Kim Minjoon Lee Brian Oh Kaichi Kaneko Sungkook Ma Jae Hoon Choi Hojoong Kwak Eun Young Lee Sung Ho Park Kyung-Hyun Park-Min | 2023 | Cellular & Molecular Immunology2023,20,1: | 1 |
| 6 | Position Estima- tion in Switched Reluctance Motor Drives Using the First Switching Harmonics Through Fourier Series显示文摘 | Keunsoo Ha Rae-Young Kim Ramu R | 2011 | In- dustrial Electronics2011,58,12: | 1 |
| 7 | Theory and operation of a four-quadrant switched reluctance motor drive with a single controllable switch-the lowest cost fourquadrantbrushless motor drive显示文摘 | KRISHNAN R SUNG Y P KEUNSOO H | 2005 | Industry Applications2005,41,4: | 1 |
| 8 | Theory and o-peration of a four-quadrant switched reluctance motor drive with a single controllable switch-the lowest cost four-quadrant brushless motor drive显示文摘 | Sung-Yeul Park Keunsoo Ha | 2005 | Industry Applications IEEE Transactions on2005,41,4: | 1 |
| 9 | DDoS attack detection method using cluster analysis显示文摘 | Keunsoo Lee Juhyun Kim Ki Hoon Kwon Younggoo Han Sehun Kim | 2007 | Expert Systems With Applications2007,,3: | 1 |
| 10 | DDoS attack detection method using cluster analysis 显示文摘 | Keunsoo Lee Juhyun Kim Ki Hoon Kwon Younggoo Han Sehun Kim | 2008 | Expert Systems with Applications2008,34,3: | 1 |
| 11 | Position Estimation in Switched Reluctance Motor Drives Using the First Switching Har- monies Through Fourier Series 显示文摘 | Keunsoo Ha Rae-Young Kim Ramu R | 2011 | Industrial Electronics2011,58,12: | 1 |
| 12 | DDoS Attack Detection Method Using Cluster Analysis显示文摘 | Keunsoo L Juhyun K Ki H K | 2008 | Expert Systems with Applications2008,34,3: | 1 |
| 13 | Single-controllable- switch-based switched reluctance motor driver for low cost, varia- ble-speed applications 显示文摘 | Jaehyuck Kim Keunsoo Ha Krishnan R | 2012 | IEEE Transactions on power Elec- tionics2012,27,1: | 1 |
| 14 | Position Estima- tion in Switched Reluctance Motor Drives Using the First Switching Harmonics Through Fourier Series 显示文摘 | Keunsoo Ha Rae-Young Kim R Krishnan | 2011 | IEEE Transactions on Industrial Electronics2011,58,12: | 1 |