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| 1 | Preoperative serum carbohydrate antigen 19-9 levels predict early recurrence after the resection of early-stage pancreatic ductal adenocarcinoma显示文摘BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a serious disease with a poor prognosis.Only a minority of patients undergo surgery due to the advanced stage of the disease,and patients with early-stage disease,who are expected to have a better prognosis,often experience recurrence.Thus,it is important to identify the risk factors for early recurrence and to develop an adequate treatment plan.AIM To evaluate the predictive factors associated with the early recurrence of earlystage PDAC.METHODS This study enrolled 407 patients with stage I PDAC undergoing upfront surgical resection between January 2000 and April 2016.Early recurrence was defined as a diagnosis of recurrence within 6 mo of surgery.The optimal cutoff values were determined by receiver operating characteristic(ROC)analyses.Univariate and multivariate analyses were performed to identify the risk factors for early recurrence.RESULTS Of the 407 patients,98 patients(24.1%)experienced early disease recurrence:26(26.5%)local and 72(73.5%)distant sites.In total,253(62.2%)patients received adjuvant chemotherapy.On ROC curve analysis,the optimal cutoff values for early recurrence were 70 U/mL and 2.85 cm for carbohydrate antigen 19-9(CA 19-9)levels and tumor size,respectively.Of the 181 patients with CA 19-9 level>70 U/mL,59(32.6%)had early recurrence,compared to 39(17.4%)of 226 patients with CA 19-9 level≤70 U/mL(P<0.001).Multivariate analysis revealed that CA 19-9 level>70 U/mL(P=0.006),tumor size>2.85 cm(P=0.004),poor differentiation(P=0.008),and non-adjuvant chemotherapy(P=0.025)were significant risk factors for early recurrence in early-stage PDAC.CONCLUSION Elevated CA 19-9 level(cutoff value>70 U/mL)can be a reliable predictive factor for early recurrence in early-stage PDAC.As adjuvant chemotherapy can prevent early recurrence,it should be recommended for patients susceptible to early recurrence. | Sarang Hong Ki Byung Song Dae Wook Hwang Jae Hoon Lee Woohyung Lee Eunsung Jun Jaewoo Kwon Yejong Park Seo Young Park Naru Kim Dakyum Shin Hyeyeon Kim Minkyu Sung Yunbeom Ryu Song Cheol Kim | 2021 | World Journal of Gastrointestinal Surgery2021，13，11： | 2 |
| 2 | Prenatal exposure to valproic acid increases the neural progenitor cell pool and induces macrocephaly in rat brain via a mechanism involving the GSK-3β/β-catenin pathway显示文摘 | Hyo Sang Go Ki Chan Kim Chang Soon Choi Se Jin Jeon Kyung Ja Kwon Seol-Heui Han Jongmin Lee Jae Hoon Cheong Jong Hoon Ryu Chong-Hyun Kim Kwang Ho Ko Chan Young Shin | 2012 | Neuropharmacology2012，，6： | 1 |
| 3 | Can we apply the same indication of endoscopic submucosal dissection for primary gastric cancer to remnant gastric cancer?显示文摘 | Yoon Young Choi In Gyu Kwon Sang Kil Lee Hyun Ki Kim Ji Yeong An Hyoung Il Kim Jae Ho Cheong Richard Thomas Mliwa Sung Kwan Shin Yong Chan Lee Woo Jin Hyung Sung Hoon Noh | 2014 | Gastric Cancer2014，，2： | 1 |
| 4 | Reversine Induces Multipotency of Lineage-Committed Cells through Epigenetic Silencing of miR-133a显示文摘 | Munkyung Kim Sang Ah Yi Hyunwoo Lee So Young Bang Eun Kyung Park Min Gyu Lee Ki Hong Nam Ji Hee Yoo Dong Hoon Lee Hyun-Wook Ryu So Hee Kwon Jeung-Whan Han | 2014 | Biochemical and Biophysical Research Communications2014，，： | 1 |
| 5 | Hepatogenous Diabetes in Cirrhosis Is Related to Portal Pressure and Variceal Hemorrhage显示文摘 | Hyo Keun Jeon Moon Young Kim Soon Koo Baik Hong Jun Park Hoon Choi So Yeon Park Bo Ra Kim Jin Heon Hong Ki Won Jo Seung Yong Shin Jung Min Kim Jae Woo Kim Hyun Soo Kim Sang Ok Kwon Young Ju Kim Seung Hwan Cha Dong Joon Kim Ki Tae Suk Gab Jin Cheon Young D | 2013 | Digestive Diseases and Sciences2013，，11： | 1 |
| 6 | DDoS attack detection method using cluster analysis显示文摘 | Keunsoo Lee Juhyun Kim Ki Hoon Kwon Younggoo Han Sehun Kim | 2007 | Expert Systems With Applications2007，，3： | 1 |
| 7 | Endoscopic transcystic stent placement for an intrahepatic abscess due to gallbladder perforation显示文摘Perforation of the gallbladder with cholecystohepatic communication is a rare cause of liver abscess. Because it is a rare entity, the treatment modality has not been fully established. We report for the first time a patient with an intrahepatic abscess due to gallbladder perforation successfully treated by endoscopic stent placement into the gallbladder who had a poor response to continuous percutaneous drainage. | Myung Soo Kang Do Hyun Park Ki Du Kwon Jeong Hoon Park Suck-Ho Lee Hong-Soo Kim Sang-Heum Park Sun-Joo Kim | 2007 | World Journal of Gastroenterology2007，13，9： | 1 |
| 8 | Extrapulmonary small-cell carcinoma of the liver显示文摘 | Young Hoon Kim Ryuk Kwon Ghap Joong Jung Myung Hwan Roh Sang Young Han Hyuk Chan Kwon Jin Sook Jeong Tae Beom Shin Jong Young Oh Ki Nam Lee | 2004 | Journal of Hepato-Biliary-Pancreatic Surgery2004，，5： | 1 |
| 9 | DDoS attack detection method using cluster analysis 显示文摘 | Keunsoo Lee Juhyun Kim Ki Hoon Kwon Younggoo Han Sehun Kim | 2008 | Expert Systems with Applications2008，34，3： | 1 |
| 10 | Multistage Decision-Directed Channel Estimation Scheme for DS-CDMA System with M-ary Orthogonal Signaling 显示文摘 | Byeong Hoon Park Ki Jun Kim Soon-Yil Kwon Keum Chan Whang | 2000 | IEEE Transactions on Communications2000，49，1： | 1 |
| 11 | Randomized controlled trial to evaluate the efficacy and safety of fexuprazan compared with esomeprazole in erosive esophagitis显示文摘BACKGROUND Fexuprazan,a novel potassium-competitive acid blocker,reversibly suppresses the K+/H+-ATPase enzyme in proton pumps within gastric parietal cells.Fexuprazan’s suppression of gastric acid was maintained in healthy individuals for 24 h in a dose-dependent manner.AIM To compare fexuprazan to esomeprazole and establish its efficacy and safety in patients with erosive esophagitis(EE).METHODS Korean adult patients with endoscopically confirmed EE were randomized 1:1 to receive fexuprazan 40 mg or esomeprazole 40 mg once daily for eight weeks.The primary endpoint was the proportion of patients with healed EE confirmed by endoscopy at week 8.The secondary endpoints included the healing rate of EE at week 4,symptom response,and quality of life assessment.Safety profiles and serum gastrin levels were compared between the groups.RESULTS Of the 263 randomized,218 completed the study per protocol(fexuprazan 40 mg,n=107;esomeprazole 40 mg,n=111).Fexuprazan was non-inferior to esomeprazole regarding the healing rate at week 8[99.1%(106/107)vs 99.1%(110/111)].There were no between-group differences in the EE healing rate at week 4[90.3%(93/103)vs 88.5%(92/104)],symptom responses,and quality of life assessments.Additionally,serum gastrin levels at weeks 4 and 8 and drug-related side effects did not significantly differ between the groups.CONCLUSION Fexuprazan 40 mg is non-inferior to esomeprazole 40 mg in EE healing at week 8.We suggest that fexuprazan is an alternative promising treatment option to PPIs for patients with EE. | Kang Nyeong Lee Oh Young Lee Hoon Jai Chun Jin Il Kim Sung Kook Kim Sang Woo Lee Kyung Sik Park Kook Lae Lee Suck Chei Choi Jae-Young Jang Gwang Ha Kim In-kyung Sung Moo In Park Joong Goo Kwon Nayoung Kim Jae Jun Kim Soo Teik Lee Hyun Soo Kim Ki Bae Kim Yong Chan Lee Myung-Gyu Choi Joon Seong Lee Hwoon-Yong Jung Kwang Jae Lee Jie-Hyun Kim Hyunsoo Chung | 2022 | World Journal of Gastroenterology2022，28，44： | 0 |
| 12 | Robotic versus laparoscopic distal pancreatectomy for pancreatic ductal adenocarcinoma: A propensity score-matched analysis显示文摘Background: Minimally invasive surgery is becoming increasingly popular in the field of pancreatic surgery. However, there are few studies of robotic distal pancreatectomy(RDP) for pancreatic ductal adenocarcinoma(PDAC). This study aimed to investigate the efficacy and feasibility of RDP for PDAC. Methods: Patients who underwent RDP or laparoscopic distal pancreatectomy(LDP) for PDAC between January 2015 and September 2020 were reviewed. Propensity score matching analyses were performed. Results: Of the 335 patients included in the study, 24 underwent RDP and 311 underwent LDP. A total of 21 RDP patients were matched 1:1 with LDP patients. RDP was associated with longer operative time(209.7 vs. 163.2 min;P = 0.003), lower open conversion rate(0% vs. 4.8%;P < 0.001), higher cost(15 722 vs. 12 699 dollars;P = 0.003), and a higher rate of achievement of an R0 resection margin(90.5% vs. 61.9%;P = 0.042). However, postoperative pancreatic fistula grade B or C showed no significant intergroup difference(9.5% vs. 9.5%). The median disease-free survival(34.5 vs. 17.3 months;P = 0.588) and overall survival(37.7 vs. 21.9 months;P = 0.171) were comparable between the groups. Conclusions: RDP is associated with longer operative time, a higher cost of surgery, and a higher likelihood of achieving R0 margins than LDP. | Dakyum Shin Jaewoo Kwon Jae Hoon Lee Seo Young Park Yejong Park Woohyung Lee Ki Byung Song Dae Wook Hwang Song Cheol Kim | 2023 | Hepatobiliary & Pancreatic Diseases International2023，22，2： | 0 |
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