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| 1 | Accuracy of biometric formulae for intraocular lens power calculation in a teaching hospital显示文摘AIM: To evaluate the accuracy of three commonly used biometric formulae across different axial lengths(ALs) at one United States Veterans Affairs teaching hospital.METHODS: A retrospective chart review was conducted from November 2013 to May 2018. One eye of each patient who underwent cataract surgery with a monofocal intraocular lens(IOL) was included. The range of postoperative follow-up period was from 3 wk to 4 mo. The Holladay 2, Barrett Universal II, and Hill-Radial Basis Function(Hill-RBF) formulae were used to predict the postoperative refraction for all cataract surgeries. For each formula, we calculated the prediction errors [including mean absolute prediction error(MAE)] and the percentage of eyes within ±0.25 diopter(D) and ±0.5 D of predicted refraction. We performed subgroup analyses for short(AL<22.0 mm), medium(AL 22.0-25.0 mm), and long eyes(AL>25.0 mm).RESULTS: A total of 1131 patients were screened, and 909 met the inclusion criteria. Resident ophthalmologists were the primary surgeons in 710(78.1%) cases. We found no statistically significant difference in predictive accuracy among the three formulae over the entire AL range or in the short, medium, and long eye subgroups. Across the entire AL range, the Hill-RBF formula resulted in the lowest MAE(0.384 D) and the highest percentage of eyes with postoperative refraction within ±0.25 D(42.7%) and ±0.5 D(75.5%) of predicted. All three formulae had the highest MAEs(>0.5 D) and lowest percentage within ±0.5 D of predicted refraction(<55%) in short eyes.CONCLUSION: In cataract surgery patients at our teaching hospital, three commonly used biometric formulae demonstrate similar refractive accuracy across all ALs. Short eyes pose the greatest challenge to predicting postoperative refractive error. | Kevin S Tang Elaine M Tran Allison J Chen David R Rivera Jorge J Rivera Paul B Greenberg | 2020 | International Journal of Ophthalmology(English edition)2020，13，1： | 3 |
| 2 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 3 | Lake-Type Controls on Petroleum Source Rock Potential in Nonmarine Basins显示文摘 | Alan R Carroll Kevin M Bohacs | 2001 | AAPG Bulletin2001，85，2： | 1 |
| 4 | Synthesis, sintering, microstructure and mechanical properties of ceramics made by exothermic reactions 显示文摘 | CUTLER R A KEVIN M R | 1992 | J Am Ceram Soc1992，75，1： | 1 |
| 5 | The fate of nitro- gen applied to a mature Kentucky bluegrass turf显示文摘 | Kevin W F Kevin M O Crum J R | 2006 | Crop Science2006，46，： | 1 |
| 6 | Interaction of earthworm burrows and cracks in a clayey,subsurface-drained,soil显示文摘 | Shipitalo M J Visa Nuutinen Kevin R B | | 0，，： | 1 |
| 7 | Neural network models of Cryplosporidium parvum inactivation by chlorine dioxide and ozone显示文摘 | Kevin R Janes Petr M | 2007 | Environmental Engineering and Science2007，6，5： | 1 |
| 8 | Biology students' utilization of tutors'formative feedback: a qualitative interview study显示文摘 | PAUL O STEPHEN M KEVIN R | 2005 | Assessment & Evaluation in Higher Education2005，30，4： | 1 |
| 9 | The fate of nitrogen applied to a mature Kentucky bluegrass turf显示文摘 | Kevin W F Kevin M O Crum J R | 2006 | Crop Sci2006，46，： | 1 |
| 10 | Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study显示文摘 | Keith C Bible Vera J Suman Julian R Molina Robert C Smallridge William J Maples Michael E Menefee Joseph Rubin Kostandinos Sideras John C Morris Bryan McIver Jill K Burton Kevin P Webster Carolyn Bieber Anne M Traynor Patrick J Flynn Boon Cher Goh Hui Tan | 2010 | Lancet Oncology2010，，10： | 1 |
| 11 | The Brigham,sling……A reliable,endoscopic,autologous,treatment for female SUI显示文摘 | BY Kevin R Loughlin M D | 1998 | Contemporary Urology1998，10，11： | 1 |
| 12 | High-grade pancreatic intraepithelial lesions: prevalence and implications in pancreatic neoplasia显示文摘BACKGROUND: High-grade pancreatic intraepithelial neoplasia(Pan IN-3), a precursor of pancreatic ductal adenocarcinoma(PDAC), is not universally detected in resected pancreatic neoplasms. We sought to determine the prevalence and prognostic relevance of Pan IN-3 lesions in primary surgical resections of PDACs and intraductal papillary mucinous neoplasms(IPMNs).METHODS: A retrospective review of a tertiary care center pathology database(1/2000-6/2014) was performed. Demographics, imaging, pathology, disease-recurrence, and survival data were reviewed.RESULTS: A total of 458 patients who underwent primary pancreatic resection were included. 'Pan IN-3' lesions were found in 74(16.2%) patients who either had PDAC(n=67) or main duct(MD)-IPMN(n=7). Among IPMN-MDs, Pan IN-3 lesions were exclusively found in those with pathological evidence of chronic pancreatitis. For PDACs, the median overall survival(OS) for pancreata with Pan IN-3 lesions was significantly better than those without(OS 1.12 years, interquartile range [IQR] 0.72, 2.05 years vs OS 0.86 years, IQR 0.64,1.60 years respectively; P=0.04). Multivariate Cox regression analysis demonstrated that the presence of Pan IN-3 lesions was associated with a reduced risk of death(HR=0.43; 95% CI: 0.23-0.82; P=0.01).CONCLUSIONS: Following primary resection of pancreatic adenocarcinoma, the lower survival observed in patients without Pan IN-3 lesions might suggest a state of complete or accelerated transformation. Further investigations are necessary to validate these findings that might impact disease prognosis and management. | Jean R Park Feng Li Veeral M Oza Brett C Sklaw Kevin M Cronley Michael Wellner Benjamin Swanson Somashekar G Krishna | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，2： | 1 |
| 13 | A sequence variation scan of the coagulation factor VIII(FVIII) structural gene and associations with plasma FVIII activity level显示文摘 | Kevin R Deepa K Diane M | 2007 | Blood2007，109，9： | 1 |
| 14 | Speaker recognition using neural networks and conventional classifiers 显示文摘 | Kevin R F Richard J M Khaled T A | 1994 | IEEE Trans on Speech and Audion processing1994，2，1： | 1 |
| 15 | Time series analysis of CO concentrations from an Eastern Kentucky coal fire显示文摘 | James C Hower Jennifer M K O’keefe Kevin R Henke | 2011 | International Journal of Coal Geology2011，88，： | 1 |
| 16 | CO2,CO,and Hg emissions from Truman Shepherd and Ruth Mullins coal fires,eastern Kentucky,USA显示文摘 | Jennifer M K O’keefe Kevin R Henke James C Hower | 2010 | Science of the Total Environment2010，408，： | 1 |
| 17 | Simultaneous single event charge sharing and parasitic bipolar conduction in a highly-scaled sram design 显示文摘 | BRIAN D O DENNIS R B KEVIN M W | 2005 | IEEE Trans on Nucl Sci2005，52，6： | 1 |
| 18 | Speaker recognition using neural networks and conventional classifiers 显示文摘 | Kevin R F Richard J M Khaled T A | 1994 | IEEE Trans on Speech and Audio processing1994，2，1： | 1 |
| 19 | Stratigraphic classification of ancient lakes : balancing tectonic and climatic controls 显示文摘 | Alan R C Kevin M B | 1999 | Geology February1999，27，： | 1 |
| 20 | A comparison of various seaweed-based diets and formulated feed on growth rate of abalone in a land-based aquaculture system显示文摘 | Krishni N Gavin M Kevin R | 2006 | Journal of Applied Phycology2006，18，： | 1 |
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