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| 1 | Guidance for the clinical evaluation of traditional Chinese medicine-induced liver injury Issued by China Food and Drug Administration显示文摘1. Introduction Drug-induced liver injury (DILI), defined as liver injury caused by a drug and/or its metabolites, is a common clinical adverse drug reaction1–4. This type of injury can cause acute liver failure and even death in severe cases5. | Xiaohe Xiao Jianyuan Tang Yimin Mao Xiuhui Li Jiabo Wang Chenghai Liu Kewei Sun Yong’an Ye Zhengsheng Zou Cheng Peng Ling Yang Yuming Guo Zhaofang Bai Tingting He Jing Jing Fengyi Li Na An | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 22 |
| 2 | The current agonists and positive allosteric modulators ofα7 nAChR for CNS indications in clinical trials显示文摘The alpha-7 nicotinic acetylcholine receptor(α7 nAChR), consisting of homomeric α7 subunits, is a ligand-gated Ca^(2+)-permeable ion channel implicated in cognition and neuropsychiatric disorders. Enhancement of α7 nAChR function is considered to be a potential therapeutic strategy aiming at ameliorating cognitive deficits of neuropsychiatric disorders such as Alzheimer's disease(AD) and schizophrenia. Currently, a number of α7 nAChR modulators have been reported and several of them have advanced into clinical trials. In this brief review, we outline recent progress made in understanding the role of the α7 nAChR in multiple neuropsychiatric disorders and the pharmacological effects of α7 nAChR modulators used in clinical trials. | Taoyi Yang Ting Xiao Qi Sun Kewei Wang | 2017 | Acta Pharmaceutica Sinica B2017，7，6： | 10 |
| 3 | Preparation of TiC/Ni_3Al Composites by Upward Melt Infiltration显示文摘TiC/Ni3Al composites have been prepared using upward infiltration method. The densification was performed by both Ni3Al melt filling and TiC sintering during the infiltration. The dissolution of TiC in liquid Ni3Al has been evidenced by finding Ni3(Al,Ti)C after fast cooling in the TiC/Ni3Al composites. The dissolution may be responsible for the infiltration and sintering. Compared with downward infiltration, the upward infiltration brought about higher strength and fracture toughness and shorter infiltration time. TiC/20 vol. pct Ni3Al composite processed by upward infiltration had a flexural strength of 1476 MPa with a statistic Weibull modulus of 20.2 and a fracture toughness of 20.4 MPa . Better mechanical properties may be attributed to melt unidirectional movement in upward infiltration. | Yi PAN (Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China) Kewei SUN (National Engineering Research Center of Solid Waste Resources Recovery, Kunming University of Science and Technology,Kunming 650093, China) | 2000 | Journal of Materials Science & Technology2000，16，4： | 6 |
| 4 | Capsaicin enhances the antitumor activity of sorafenib in hepatocellular carcinoma cells and mouse xenograft tumors through increased ERK signaling显示文摘Sorafenib,酷氨酸蛋白质 kinases 的一个小禁止者,当前是为先进 hepatocellular 癌(HCC ) 的治疗的标准化疗药。尽管 sorafenib 改进 HCC 病人的幸存,它的功效不是最佳的并且要求进一步的改进。Capsaicin,从类辣椒的红辣椒辣椒的主要活跃部件,是 TRPV1 隧道,而且显示 antitumor 活动的不仅收缩筋并且提高癌症房间的敏感到细胞毒素的药。在这研究,我们在 vitro 和异种皮移植肿瘤在 HCC 房间上调查了联合 sorafenib 和 capsaicin 的 antitumor 效果。有 capsaicin 的治疗 dose-dependently 独自分别地与 137, 108 和 140.7 mol/L 的 IC 50 价值禁止了 HCC 房间线 PLC/PRF/7, HuH7 和 HepG2 的增长。TRPV1 隧道的明显的表示都没在 3 根 HCC 房间线被检测, TRPV1 隧道 blockers 没减轻 capsaicin 的 cytotoxicity。由对比,显著地联合 capsaicin 和 sorafenib 在房间增长上提高了抑制,完成高级 synergistic 效果(超过 50% 的抑制率) 并且支持 HCC 房间 apoptosis。在有 PLC/PRF/5 异种皮移植的裸体老鼠,联合了 capsaicin 的管理,没有明显的粗野毒性, sorafenib 显著地独自与任何一个代理人相比在肿瘤生长上提高了抑制。机械学地, capsaicin (10-200 mol/L ) dose-dependently 在 PLC/PRF/5 房间增加了 phosphorylated 英皇家空军之阶级最低之兵(津贴) 的层次,因此导致在肿瘤房间上提高了 sorafenib 敏感和 synergistic 抑制。一起拿,我们的结果建议英皇家空军之阶级最低之兵的增加 capsaicin 的 phosphorylation 贡献 sorafenib,和 capsaicin 的提高的 antitumor 活动可能在为 HCC 的处理改进 sorafenib 的功效有用。 | Su-shan ZHANG Yu-hao NI Chen-ru ZHAO Zhen QIAO Hong-xia YU Lu-yao WANG Jin-yan SUN Chen DU Jia-haoZHANG Li-ying DONG KeWei WANG Jian-jun GAO | 2018 | Acta Pharmacologica Sinica2018，39，3： | 4 |
| 5 | Inhibition of temperature-sensitive TRPV3 channel by two natural isochlorogenic acid isomers for alleviation of dermatitis and chronic pruritus显示文摘Genetic gain-of-function mutations of warm temperature-sensitive transient receptor potential vanilloid 3(TRPV3)channel cause Olmsted syndrome characterized by severe itching and keratoderma,indicating that pharmacological inhibition of TRPV3 may hold promise for therapy of chronic pruritus and skin diseases.However,currently available TRPV3 tool inhibitors are either nonselective or less potent,thus impeding the validation of TRPV3 as therapeutic target.Using whole-cell patch-clamp and single-channel recordings,we report the identification of two natural dicaffeoylquinic acid isomers isochlorogenic acid A(IAA)and isochlorogenic acid B(IAB)that selectively inhibit TRPV3 currents with IC50 values of 2.7±1.3 and 0.9±0.3μmol/L,respectively,and reduce the channel open probability to 3.7±1.2%and 3.2±1.1%from 26.9±5.5%,respectively.In vivo evaluation confirms that both IAA and IAB significantly reverse the ear swelling of dermatitis and chronic pruritus.Furthermore,the isomer IAB is able to rescue the keratinocyte death induced by TRPV3 agonist carvacrol.Molecular docking combined with site-directed mutations reveals two residues T636 and F666 critical for the binding of the two isomers.Taken together,our identification of isochlorogenic acids A and B that act as specific TRPV3 channel inhibitors and gating modifiers not only provides an essential pharmacological tool for further investigation of the channel pharmacology and pathology,but also holds developmental potential for treatment of dermatitis and chronic pruritus. | Hang Qi Yuntao Shi Han Wu Canyang Niu Xiaoying Sun KeWei Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 3 |
| 6 | Oncostatin M inhibits myoblast differentiation and regulates muscle regeneration显示文摘Oncostatin M (OSM ) 是 interleukin-6 家庭的 cytokine 并且在发炎期间起重要作用。然而,它在 myoblast 区别的角色和肌肉新生仍然保持未经勘探。我们这里证明 OSM potently 主要由激活 JAK1/STAT1/STAT3 小径禁止了 myoblast 区别。OSM downregulated myocyte 提高有约束力的因素 2A (MEF2A ) , upregulated Id1 和 Id2 的表示,并且禁止了 MyoD 和 MEF2 的 transcriptional 活动。另外, OSM 也提高了 STAT3 和 OSM 受体的表示,它组成了一个积极反馈环进一步放大导致 OSM 的发信号。而且,我们发现身体上与 MEF2 联系并且镇压的那 STAT1 它的 transcriptional 活动,它能说明 MEF2 的调停 OSM 的压抑。尽管在在 vivo 的正常肌肉无法发现, OSM 很快在肌肉损害上然后即时被导致就在 myoblasts 的多数前的 downregulated 区分。没有影响 myoblast 增长,在肌肉的 OSM 的延长表示损害了新生进程,建议 OSM 工作阻止增殖的 myoblasts 在肌肉新生的早阶段期间的早熟的区别。 | Fang Xiao Haixia Wang Xinrong Fu Yanfeng Li Kewei Ma Luguo Sun Xiang Gao Zhenguo Wu | 2011 | Cell Research2011，21，2： | 2 |
| 7 | An Aptamer-based Colorimetric Sensor for Streptomycin and Its Application in Food Inspection显示文摘 | LIU Zhongcheng ZHANG Yanfen XIE Yao SUN Ying BI Kewei CUI Zhe ZHAO Lijian FAN Wufang | 2017 | Chemical Research in Chinese Universities2017，33，5： | 2 |
| 8 | UV-enhanced bioactivity and cell response of micro-arc oxidized titania coatings显示文摘 | Yong Han Donghui Chen Jifeng Sun Yumei Zhang Kewei Xu | 2008 | Acta Biomaterialia2008，，5： | 2 |
| 9 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 10 | An Ef- fective Heuristic for the Integrated Scheduling Prob-lem of Automated Container Handling System Using Twin 40' Cranes 显示文摘 | Zheng Kewei Lu Zhiqiang Sun Xiaoming | 2010 | Computer Modeling and Simu lation2010，，2： | 1 |
| 11 | A new Gibbs sampling DOA estimator based on Bayesian method 显示文摘 | Huang Jianguo Sun Yi Liu Kewei | 2003 | ICASSP2003，，： | 1 |
| 12 | Using an amylasepretreatment of pig manure to enhance biogas production 显示文摘 | Li Jianchang Sun Kewei He Juan | 2011 | Power and Energy Engineering Conference2011，，： | 1 |
| 13 | Enhanced Thermoelectric Transport Properties of La0.98Sr0.02CoO3-BiCuSeO Composite显示文摘 | Muhammad Umer Farooq Ziyuan Gao Sajid Butt Kewei Gao Xiaolu Pang Hidayat Ullah Shah Hasnain Mehdi Jafri Asif Mahmod Xigui Sun Nasir Mahmood | 2016 | Journal of Electrical Engineering2016，4，2： | 1 |
| 14 | Model-based system configuration approach for Internetware显示文摘Internetware,a new software paradigm,enables systems to be built and evolved for better service quality according to changes in the environment.However,at the same time Internetware greatly complicates system management tasks due to the autonomy,cooperation and evolution of its components.In fact,the configuration of large-scale Internet-based software in the real scenarios is likely to involve a large number of components and hundreds of associated configuration options with variables,whose values may be dynamically determined depending on the execution environment,or to cope with needs of customers.In this paper,we firstly analyze the configuration issues of Internetware,and then present a model-based engineering approach to managing the configuration for Internetware systematically.Based on the Architecture Based Composition model,an internetware configuration process model is proposed that abstracts the configuration in the lifecycle of Internetware.Focusing on the fundamental activities in configuration process,the methods and mechanisms of analyzing and performing the configuration in terms of its constraints,dependencies,heterogeneity and dynamics,with supporting tools to realize the configuration automation,are presented.The proposed methods and mechanisms have been implemented,validated and rolled out in IBM software products and Cloud center. | LI Ying SUN KeWei YANG Jie LIU TianCheng ZENG LiangZhao | 2013 | Science China(Information Sciences)2013，56，8： | 1 |
| 15 | Optimi- zation Design of the Mixed Flow Pump 显示文摘 | ZHANG Kewei SUN Jianping WANG Yiqun | 1995 | Proceedings of Second International Conference on Pumps and Fans1995，，： | 1 |
| 16 | Prognostic significance of the co?expression of nucleophosmin and trefoilfactor 3 in postoperative gastric cancer patients显示文摘 | Yong Li Zhenqing Sun Kewei Liu Wensheng Qiu Ruyong Yao Tongtong Feng Chao Xin Lu Yue | 2014 | Molecular and Clinical Oncology2014，，6： | 1 |
| 17 | 'Fish-Scale' Boy——Li Junwei in Beijing显示文摘AFTER a long struggle with the rare disease, ichthy-erythroderma, 12-year-old Li Junwei was eventually able to go to school. This has been his desire for years. Li was born in Gaoxiong City in Taiwan. Since infancy he has | FENG KEWEI SUN MAN | 1994 | Women of China1994，，4： | 0 |
| 18 | Analysis of the Influence of Geometrical Parameters on the Performance of a Proton Exchange Membrane Fuel Cell显示文摘A suitable channel structure can lead to efficient gas distribution and significantly improve the power density of fuel cells.In this study,the influence of two channel design parameters is investigated,namely,the ratio of the channel width to the bipolar plate ridge width(i.e.,the channel ridge ratio)and the channel depth.The impact of these parameters is evaluated with respect to the flow pattern,the gas composition distribution,the temperature field and the fuel cell output capability.The results show that a decrease in the channel ridge ratio and an increase in the channel depth can effectively make the distributions of velocity,temperature and concentration more uniform in each channel and improve the output capability of the fuel cell.An increase in the channel ridge ratio and depth obviously reduces the flow resistance and improves the flow characteristics. | Guodong Zhang Huifang Tao Da Li Kewei Chen Guoxiang Li Shuzhan Bai Ke Sun | 2024 | Fluid Dynamics & Materials Processing2024，20，1： | 0 |
| 19 | Cold weather and Kashin-Beck disease显示文摘Kashin-Beck disease(KBD)is an endemic osteoarthropathy.Its distribution region covers a long and narrow belt on the Pacific side and belongs to continental climate with short summer,long frost period,and large temperature differences between day and night.In particular,KBD patients are typically scattered in the rural areas with seasonal features such as cold winters and rainy autumns.Etiological studies have demonstrated that the carrier of pathogenic factors is the grains produced in endemic areas.Risk factors for KBD include fungal contamination of grains due to poor storage conditions associated with cold weather.The epidemiological characteristics of KBD include agricultural area,early age of onset,gender equality,family aggregation,regional differences,and annual fluctuations.A series of preventive measures have been successfully taken in the past decades.National surveillance data indicate that the annual incidence of KBD is gradually declining. | Kewei Wang Jun Yu Dianjun Sun | 2023 | Frigid Zone Medicine2023，3，1： | 0 |
| 20 | Pharmacological characterization of JWX-A0108 as a novel type Ⅰ positive allosteric modulator of a7 nAChR that can reverse acoustic gating deficits in a mouse prepulse inhibition model显示文摘The a7 nicotinic acetylcholine receptor (a7 nAChR) is a ligand-gated Ca^2+-permeable homopentameric ion channel implicated in cognition and neuropsychiatric disorders. Pharmacological enhancement of a7 nAChR function has been suggested for improvement of cognitive deficits. In the present study, we characterized a thiazolyl heterocyclic derivative, 6-(2-chloro-6- methylphenyl)-2-((3-fluoro-4-methylphenyl)amino)thiazolo[4,5-cflpyrimiclin-7(6H)-one (JWX-A0108), as a novel type I a7 nAChR positive allosteric modulator (PAM), and evaluated its ability to reverse auditory gating and spatial working memory deficits in mice. In Xenopus oocytes expressing human nAChR channels, application of JWX-A0108 seleaively enhanced a7 nAChR-mediated inward current in the presence of the agonist ACh (EC50 value = 4.35 ±0.12 pM). In hippocampal slices, co-application of ACh and JWXA0108 (10 pM for each) markedly increased both the frequency and amplitude of spontaneous inhibitory postsynaptic currents (sIPSCs) recorded in pyramidal neurons, but JWX-A0108 did not affect GABA-induced current in oocytes expressing human GABAa receptor aip3y2 and a5(33Y2 subtypes. In mice with MK-801-induced deficits in auditory gating, administration of JWX-A0108 (1, 3, and 10 mg/kg, i.p.) dose-dependently attenuates MK-801-induced auditory gating deficits in five prepulse intensities (72, 76, 80,84, and 88 dB). Furthermore, administration of JWX-A0108 (0.03, 0.1, or 0.3 mg/kg, i.p.) significantly reversed MK-801-induced impaired spatial working memory in mice. Our results demonstrate that JWX-A0108 is a novel type Ⅰ PAM of a7 nAChR, which may be beneficial for improvement of cognitive deficits commonly found in neuropsychiatric disorders such as schizophrenia and Alzheimer's disease. | Li-lan Sun Tao-yi Yang Ning-ning Wei Wei Lu Wen-xuan Jiao Qi-qi Zhou Yong-zhen Miao Qin Gao Xin-tong Wang Qi Sun KeWei Wang | 2019 | Acta Pharmacologica Sinica2019，40，6： | 0 |
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