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| 1 | 雄激素补充疗法的诸多争议显示文摘雄激素已经成为目前在全世界各地被广泛使用的疗法之一。雄激素市场在过去十年中的迅猛增长归因于很多因素。比如,目前全球老龄化人群的增多。在美国,65岁以上人群的增加速度是65岁以下人群的2到3倍。再比如,整体不是很好的健康状况以及…些特殊的疾病(糖尿病、代谢综合症、心血管疾病和骨质疏松等)都与低血清睾酮水平有关。目前,关于雄激素治疗后前列腺癌的发展情况极少有报告,这就使得雄激素疗法成为一种具有吸引力的治疗方法。最后,不同形式的雄激素替代疗法的引入及其日益增多的市场宣传、促销和直接面对消费者的推广也促进了雄激素市场的增长。随着对雄激素替代疗法需求的增加,临床医生就越应该了解如何诊断和使用小剂量雄激素给予患者合适的治疗。 | Mohit Khera | 2015 | Asian Journal of Andrology2015，17，2： | 9 |
| 2 | SSR分子标记在花生杂种鉴定中的应用显示文摘以24份花生材料为亲本,配制22个杂交组合,并利用40对SSR引物对24份亲本材料进行多态性筛选,运用多态性引物鉴定92个F1代杂种的真伪.结果表明,不同组合亲本间多态性差异较大,差异最大的两亲本(GT-C20-D和Tamrun OL07)的多态性引物比例为65%.SSR标记法鉴定出49个单株为真杂种;而田间表型鉴定出62个单株为真杂种,与标记鉴定结果差异较大.本研究证实利用分子标记鉴定真假杂种非常必要,且准确可行.同时,本试验证明40对SSR引物具有较高的多态性,可直接用于花生遗传多样性、杂种鉴定以及遗传图谱构建等的研究. | 王辉 KHERA Pawan 李双铃 任艳 袁美 庄伟建 VARSHNEY Rajeev K 郭宝珠 谢联辉 | 2015 | 福建农林大学学报(自然科学版)2015，44，4： | 4 |
| 3 | Physiological normal levels of androgen inhibit proliferation of prostate cancer cells in vitro显示文摘为超过 70 年,浆液雄激素层次的严重减小引起了前列腺癌症(PCa ) 的回归并且增加的雄激素层次提高了 PCa 的生长,这被相信了。然而,众多的最近的研究询问了这个传统的信仰。在我们的学习, LNCaP 和 MDA PCa 2b PCa 房间与雄激素的各种各样的层次被对待 10 或 20 天,并且房间生长与水晶被测量紫 mitogenic 试金。结果显示 PCa 细胞的增长上的雄激素的效果发生在一个 biphasic 模式,与支持在为 LNCaP 细胞并且在为 MDA PCa 2b 细胞的 1 和 2 ng ml −1 之间的约 0.23 ng ml −1 的最佳的细胞生长的雄激素层次。两最佳的雄激素层次在成年的人的生理的低范围以内(< 2.4 ng ml −1) 。比最佳的雄激素在更低的集中铺平,增加支持的雄激素集中 PCa 房间的增长。在更高的集中,然而增加雄激素集中导致了剂量依赖者 proliferative 抑制。我们断定雄激素的生理地正常的层次在 vitro 禁止 PCa 房间的增长。然而,在很底层雄激素为 PCa 房间的起始的生长是必要的。 | Weitao Song Mohit Khera | 2014 | Asian Journal of Andrology2014，16，6： | 4 |
| 4 | Resistance to Aspergillus flavus in maize and peanut:Molecular biology, breeding, environmental stress,and future perspectives显示文摘The colonization of maize(Zea mays L.) and peanut(Arachis hypogaea L.) by the fungal pathogen Aspergillus flavus results in the contamination of kernels with carcinogenic mycotoxins known as aflatoxins leading to economic losses and potential health threats to humans. The regulation of aflatoxin biosynthesis in various Aspergillus spp. has been extensively studied, and has been shown to be related to oxidative stress responses. Given that environmental stresses such as drought and heat stress result in the accumulation of reactive oxygen species(ROS) within host plant tissues, host-derived ROS may play an important role in cross-kingdom communication between host plants and A. flavus. Recent technological advances in plant breeding have provided the tools necessary to study and apply knowledge derived from metabolomic, proteomic, and transcriptomic studies in the context of productive breeding populations. Here, we review the current understanding of the potential roles of environmental stress, ROS, and aflatoxin in the interaction between A.flavus and its host plants, and the current status in molecular breeding and marker discovery for resistance to A. flavus colonization and aflatoxin contamination in maize and peanut. We will also propose future directions and a working model for continuing research efforts linking environmental stress tolerance and aflatoxin contamination resistance in maize and peanut. | Jake C.Fountain Pawan Khera Liming Yang Spurthi N.Nayak Brian T.Scully Robert D.Lee Zhi-Yuan Chen Robert C.Kemerait Rajeev K.Varshney Baozhu Guo | 2015 | The Crop Journal2015，3，3： | 3 |
| 5 | The experience of three flipped classrooms in an urban university: an exploration of design principles显示文摘 | Min Kyu Kim So Mi Kim Otto Khera Joan Getman | 2014 | The Internet and Higher Education2014，，： | 3 |
| 6 | Analysis of genetic diversity and population structure of peanut cultivars and breeding lines from China,India and the US using simple sequence repeat markers显示文摘Cultivated peanut is grown worldwide as richsource of oil and protein. A broad genetic base is needed for cultivar improvement. The objectives of this study were to develop highly informative simple sequence repeat(SSR)markers and to assess the genetic diversity and population structure of peanut cultivars and breeding lines from different breeding programs in China, India and the US. A total of 111 SSR markers were selected for this study, resulting in a total of 472 alleles. The mean values of gene diversity and polymorphic information content(PIC) were 0.480 and 0.429, respectively.Country-wise analysis revealed that alleles per locus in three countries were similar. The mean gene diversity in the US,China and India was 0.363, 0.489 and 0.47 with an average PIC of 0.323, 0.43 and 0.412, respectively. Genetic analysis using the STRUCTURE divided these peanut lines into two populations(P_1, P_2), which was consistent with the dendrogram based on genetic distance(G_1, G_2) and the clustering of principal component analysis. The groupings were related to peanut market types and the geographic origin with a few admixtures. The results could be used by breeding programs to assess the genetic diversity of breeding materials to broaden the genetic base and for molecular genetics studies. | Hui Wang Pawan Khera Bingyan.Huang Mei Yuan Ramesh Katam Weijian Zhuang Karen Harris-Shultz Kim M.Moore Albert K.Culbreath Xinyou Zhang Rajeev K.Varshney Lianhui Xie Baozhu Guo | 2016 | Journal of Integrative Plant Biology2016，58，5： | 2 |
| 7 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 8 | Botulinum toxin A inhibits ATP release from bladder urothelium after chronic spinal cord injury显示文摘 | KHERA M SOMOGYI G T KISS S | 2004 | Neurochem Int2004，45，7： | 1 |
| 9 | Screening the population for left ventricular hypertrophy and left ventric- ular systolic dysfunction using natriuretic peptides:resuhs from the Dallas Heart Study 显示文摘 | de Lemos JA MeGnire DK Khera A | 2009 | Am Heart J2009，157，： | 1 |
| 10 | Cholesterol efl'lox capacity, high-density lipoprotein function, and atheroscle- rosis显示文摘 | Khera AV Cuehel M de la Llera-Moya LM | 2011 | N Engl J Med2011，364，2： | 1 |
| 11 | Glucose enhances mesangial cell apoptosis显示文摘 | Khera T Martin J Riley S | 2006 | Lab Invest2006，86，6： | 1 |
| 12 | Adenylate cyclase activator forskolin alleviates intracerebroventricular propionic acid-induced mitochondrial dysfunction of autistic rats显示文摘Neuronal mitochondrial dysfunction increases inflammatory mediators and leads to free radical generation and anti-oxidant enzymatic alterations,which are major neuropathological hallmarks responsible for autism.Mitochondrial dysfunction in autism is associated with decreased ATP levels due to reduced levels of cyclic adenosine monophosphate.Rat models of autism were established by intracerebroventricular injection of propionic acid.These rat models had memory dysfunction,decreased muscle coordination and gait imbalance.Biochemical estimation of propionic acid-treated rats showed changes in enzyme activity in neuronal mitochondrial electron transport chain complexes and increases in pro-inflammatory cytokines,oxidative stress and lipid biomarkers.Oral administration of 10,20 and 30 mg/kg adenylate cyclase activator forskolin for 15 days reversed these changes in a dose-dependent manner.These findings suggest that forskolin can alleviate neuronal mitochondrial dysfunction and improve neurological symptoms of rats with autism.This study was approved by the RITS/IAEC,SIRSA,HARYANA on March 3,2014(approval No.RITS/IAEC/2014/03/03). | Sidharth Mehan Saloni Rahi Aarti Tiwari Tarun Kapoor Kajal Rajdev Ramit Sharma Himanshi Khera Sourabh Kosey Umesh Kukkar Rajesh Dudi | 2020 | Neural Regeneration Research2020，15，6： | 1 |
| 13 | HIV seroprevalence among tuberculosis patients in India,2006-2007显示文摘 | RAIZADA N CHAUHAN L S KHERA A | 2008 | PLoS One2008，3，8： | 1 |
| 14 | Denitrification,N2O and CO2 fluxes in rice-wheat cropping system as affected by crop residues,fertilizer N and legume green manure显示文摘 | Aulakh M S Khera T S Doran J W | 2001 | Biology and Fertility of Soils2001，34，： | 1 |
| 15 | Red cell life span hetero- geneity in hematologically normal people is sufficient to alter HbAlc显示文摘 | Cohen RM Franco RS Khera PK | 2008 | Blood2008，112，10： | 1 |
| 16 | An advanced approach for computer modeling and prototyping of the human tooth显示文摘 | Chang KH Magdum S Khera SC | 2003 | Ann Biomed Eng2003，31，5： | 1 |
| 17 | Interleukin-18, the metabolic syndrome, and subclinical atherosclerosis:results from the Dallas Heart Study 显示文摘 | Zirlik A AbduUah SM Gerdes N MacFarlane L Schonbeck U Khera A | 2007 | Arterioscler Thromb Vasc Biol2007，27，： | 1 |
| 18 | On-statin cholesteryl ester transfer protein mass and risk of recurrent coronary events (from the pravastatin or atorvastatin evaluation and infection therapy thrombolysis in myocardial infarction 22 study)显示文摘 | Khera AV Wolfe ML Cannon CP | 2010 | Am J Cardiol2010，106，4： | 1 |
| 19 | Complement receptor 1:disease associations and therapeutic Implications显示文摘 | Khera R Das N | 2009 | Mol Immunol2009，46，： | 1 |
| 20 | Effect of prolonged treatment with levamisole on vitiligo with limited and low-spreading disease显示文摘 | Pasricha JS Khera V | 1994 | Int J Dermatol1994，33，8： | 1 |
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