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| 1 | Antioxidative phytoceuticals to ameliorate pancreatitis in animal models: An answer from nature显示文摘Despite enthusiastic efforts directed at elucidating critical underlying mechanisms towards the identification of novel therapeutic targets for severe acute pancreatitis(SAP), the disease remains without a specific therapy to be executed within the first hours to days after onset of symptoms. Although earlier management for SAP should aim to either treat organ failure or reduce infectious complications, the current standard of care for the general management of AP in the first hours to days after onset of symptoms include intravenous fluid replacement, nutritional changes, and the use of analgesics with a close monitoring of vital signs. Furthermore, repeated evaluation of severity is very important, as the condition is particularly unstable in the early stages. In cases where biliary pancreatitis is accompanied by acute cholangitis or in cases where biliary stasis is suspected,an early endoscopic retrograde cholangiopancreatography is recommended.However,practice guidelines regarding the treatment of pancreatitis are suboptimal.In chronic pancreatitis,conservative management strategies include lifestyle modifications and dietary changes followed by analgesics and pancreatic enzyme supplementation.Recently,attention has been focused on phytoceuticals or antioxidants as agents that could surpass the limitations associated with currently available therapies.Because oxidative stress has been shown to play an important role in the pathogenesis of pancreatitis,antioxidants alone or combined with conventional therapy may improve oxidativestress-induced organ damage.Interest in phytoceuticals stems from their potential use as simple,accurate tools for pancreatitis prognostication that could replace older and more tedious methods.Therefore,the use of antioxidative nutrition or phytoceuticals may represent a new direction for clinical research in pancreatitis.In this review article,recent advances in the understanding of the pathogenesis of pancreatitis are discussed and the paradigm shift underway to develop phytoceuticals and antioxidants to treat it is introduced.Despite the promise of studies evaluating the effects of antioxidants/phytoceuticals in pancreatitis,translation to the clinic has thus far been disappointing.However,it is expected that continued research will provide solid evidence to justify the use of antioxidative phytoceuticals in the treatment of pancreatitis. | Jong-Min Park Sooyeon Lee Mi Kyung Chung Sung-Hun Kwon Eun-Hee Kim Kwang Hyun Ko Chang Il Kwon Ki Baik Hahm | 2014 | World Journal of Gastroenterology2014，20，44： | 5 |
| 2 | Surface modification of silica nanoparticles by UV-induced graft polymerization of methyl methacrylate显示文摘 | Kim Sooyeon Kim Eunhye Kim Sungsoo | 2005 | Journal of Colloid and Interface Science2005，292，1： | 1 |
| 3 | The Diagnostic Validity of Citric Acid‐Free, High Dose 13 C ‐Urea Breath Test After H elicobacter pylori Eradication in K orea显示文摘 | Yong Hwan Kwon Nayoung Kim Ju Yup Lee Yoon Jin Choi Kichul Yoon Jae Jin Hwang Hyun Joo Lee AeRa Lee Yeon Sang Jeong Sooyeon Oh Hyuk Yoon Cheol Min Shin Young Soo Park Dong Ho Lee | 2015 | Helicobacter2015，，3： | 1 |
| 4 | Analysis of isothiocyanates in newly generated vegetables, Baemuchae (xBrassicoraphanus) as affected by growth显示文摘 | Lim Sooyeon Lee Joonhee Kim Jong Kee | 2009 | International Journal of Food Science and Technology2009，44，： | 1 |
| 5 | Face detec- tion based on skin color likelihood 显示文摘 | Yuseok Ban Sang-Ki Kim Sooyeon Kim | 2014 | Pattern Recognition2014，47，4： | 1 |
| 6 | Reactive oxygen species-induced activation of Yes-associated protein-1 through the c-Myc pathway is a therapeutic target in hepatocellular carcinoma显示文摘BACKGROUND The Hippo signaling pathway regulates organ size by regulating cell proliferation and apoptosis with terminal effectors including Yes-associated protein-1(YAP-1).Dysregulation in Hippo pathway has been proposed as one of the therapeutic targets in hepatocarcinogenesis.The levels of reactive oxygen species(ROS)increase during the progression from early to advanced hepatocellular carcinoma(HCC).AIM To study the activation of YAP-1 by ROS-induced damage in HCC and the involved signaling pathway.METHODS The expression of YAP-1 in HCC cells(Huh-7,HepG2,and SNU-761)was quantified using real-time polymerase chain reaction and immunoblotting.Human HCC cells were treated with H2O2,which is a major component of ROS in living organisms,and with either YAP-1 small interfering RNA(siRNA)or control siRNA.To investigate the role of YAP-1 in HCC cells under oxidative stress,MTS assays were performed.Immunoblotting was performed to evaluate the signaling pathway responsible for the activation of YAP-1.Eighty-eight surgically resected frozen HCC tissue samples and 88 nontumor liver tissue samples were used for gene expression analyses.RESULTS H2O2 treatment increased the mRNA and protein expression of YAP-1 in HCC cells(Huh-7,HepG2,and SNU-761).Suppression of YAP-1 using siRNA transfection resulted in a significant decrease in tumor proliferation during H2O2 treatment both in vitro and in vivo(both P<0.05).The oncogenic action of YAP-1 occurred via the activation of the c-Myc pathway,leading to the upregulation of components of the unfolded protein response(UPR),including 78-kDa glucoseregulated protein and activating transcription factor-6(ATF-6).The YAP-1 mRNA levels in human HCC tissues were upregulated by 2.6-fold compared with those in nontumor tissues(P<0.05)and were positively correlated with the ATF-6 Levels(Pearson’s coefficient=0.299;P<0.05).CONCLUSION This study shows a novel connection between YAP-1 and the UPR through the c-Myc pathway during oxidative stress in HCC.The ROS-induced activation of YAP-1 via the c-Myc pathway,which leads to the activation of the UPR pathway,might be a therapeutic target in HCC. | Yuri Cho Min Ji Park Koeun Kim Sun Woong Kim Wonjin Kim Sooyeon Oh Joo Ho Lee | 2020 | World Journal of Gastroenterology2020，26，42： | 1 |
| 7 | Surface modification of silica nanoparticles by UV-induced graft polymerization of methyl methacrylate显示文摘 | Sooyeon Kim Eunhye Kim Sungsoo Kim | 2005 | Journal of Colloid and Interface Science2005，292，1： | 1 |
| 8 | Success Rate Queue-Based Relocation Algorithm of Sensory Network to Overcome Non-Uniformly Distributed Obstacles显示文摘With the recent development of big data technology that collects and analyzes various data,the technology that continuously collects and analyzes the observed data is also drawing attention.Moreover,its importance is growing in data collection in areas where people cannot access.In general,it is not easy to properly deploy IoT wireless devices for data collection in these areas,and it is also inappropriate to use general wheel-based mobile devices for relocation.Recently,researches have been actively carried out on hopping moving models in place of wheel-based movement for the inaccessible regions.The majority of studies,however,so far have unrealistic assumptions that all IoT devices know the overall state of the network and the current state of each device.Moreover,various physical terrain environments,such as coarse gravel and sand,can change from time to time,and it is impossible for all devices to recognize these changes in real-time.In this paper,with the migration success rate of IoT hopping devices being relocated,the method of estimating the varying environment is proposed.This method can actively reflect the changing environment in real-time and is a realistic distributed environment-based relocation protocol on behalf of non-realistic,theory-based relocation protocols.Also,one of the significant contributions of this paper is to evaluate its performance using the OMNeT++simulation tool for the first time in the world to reflect actual physical environmental conditions.Compared to previous studies,the proposed protocol was able to actively reflect the state of the surrounding environment,which resulted in improved migration success rates and higher energy efficiency. | Sooyeon Park Moonseong Kim Woochan Lee | 2020 | Computers, Materials & Continua2020，，11： | 0 |
| 9 | Gut microbiota as a potential key to modulating humoral immunogenicity of new platform COVID-19 vaccines显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)is a novel respiratory infectious disease,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which led to a global pandemic.Although vaccination is the best measure to overcome a pandemic,the immunogenicity of vaccines can be influenced by diverse factors,including intrinsic(age,sex,genetics,and comorbidities),extrinsic(diet,nutrition,and behavior),and vaccine-associated characteristics. | Hye Seong Bo Kyu Choi Young-Hee Han Jun Hyoung Kim Jeong-An Gim Sooyeon Lim Ji Yun Noh Hee Jin Cheong Woo Joo Kim Joon Young Song | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
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