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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | 根治性切缘状态在接受完整结肠系膜切除术治疗的结肠癌患者中的预后价值显示文摘目的:与直肠癌的环周切缘(CRM)相比,根治性切缘(Ra?dial Margin)可能是结肠癌的潜在预后影响因素。目前尚无关于在完整结肠系膜切除术(CME)理念下探索根治性切缘对预后影响的研究。本研究旨在探索在CME治疗结肠癌前提下,根治性切缘状态对肿瘤结局的影响。方法:基于Severance医院的前瞻性结直肠癌登记系统数据,回顾性分析从2010年10月至2013年3月接受根治性切除的Ⅰ~Ⅲ期结肠癌患者资料。共834例接受CME的连续性结肠腺癌患者纳入本研究。根据根治性切缘距离将患者分为3组:A组,根治性切缘≥2 mm;B组,1 mm≤根治性切缘<2 mm;C组,根治性切缘<1 mm。比较各组的总生存期和无病生存期。 | 王枭杰 LEE J M CHUNG T KIM K M | 2020 | 结直肠肛门外科2020，26，2： | 3 |
| 3 | Hypervascular hepatocellular carcinoma: detection with double arterial phase multi-detector row helical CT显示文摘 | Murakami T Kim T Takamura M | 2001 | Radiology2001，218，3： | 2 |
| 4 | Successful orthotopic liver transplanation forl amivudine-associated YMDD mutant hepatitis B virus显示文摘 | SAAB S KIM M WRIGHT T L | 2000 | Gastroenterology2000，119，5： | 2 |
| 5 | Damage identification in beam-type structures: frequency-based method vs mode-shape-based method 显示文摘 | Kim J T Ryu Y S Cho H M | 2003 | Engineering Structures2003，25，1： | 2 |
| 6 | Strategies to tackle the challenges of external beam radiotherapy for liver tumors显示文摘Primary and metastatic liver cancer is an increasingly common and difficult to control disease entity.Radiation offers a non-invasive treatment alternative for these patients who often have few options and a poor prognosis.However,the anatomy and aggressiveness of liver cancer poses significant challenges such as accurate localization at simulation and treatment,management of motion and appropriate selection of dose regimen.This article aims to review the options available and provide information for the practical implementation and/or improvement of liver cancer radiation programs within the context of stereotactic body radiotherapy and image-guided radiotherapy guidelines.Specific patient inclusion and exclusion criteria are presented given the significant toxicity found in certain sub-populations treated with radiation.Indeed,certain sub-populations,such as those with tumor thrombosis or those with larger lesions treated with transarterial chemoembolization,have been shown to have significant improvements in outcome with the addition of radiation and merit special consideration.Implementing a liver radiation programrequires three primary challenges to be addressed:(1) immobilization and motion management;(2) localization;and(3) dose regimen and constraint selection.Strategies to deal with motion include simple internal target volume(ITV) expansions,non-gated ITV reduction strategies,breath hold methods,and surrogate marker methods to enable gating or tracking.Localization of the tumor and organs-at-risk are addressed using contrast infusion techniques to take advantage of different normal liver and cancer vascular anatomy,imaging modalities,and margin management.Finally,a dose response has been demonstrated and dose regimens appear to be converging.A more uniform approach to treatment in terms of technique,dose selection and patient selection will allow us to study liver radiation in larger and,hopefully,multicenter randomized studies. | Michael I Lock Jonathan Klein Hans T Chung Joseph M Herman Edward Y Kim William Small Nina A Mayr Simon S Lo | 2017 | World Journal of Hepatology2017，9，14： | 2 |
| 7 | Improved serpentine laminating micromixer with enhanced local advection显示文摘 | PARK J M KIM D S KANG T G | 2008 | Microfluidics and Nanofluidics2008，4，6： | 1 |
| 8 | Small hypervascular hepatocellular carcinoma revealed by double arterial phase CT per formed with single breath-hold scanning and automatic bolus tracking 显示文摘 | Kim T Murakami T Hori M etal | 2002 | AJR Am J Roentgenol2002，178，4： | 1 |
| 9 | Atmospheric wet deposition of trace elements to Chesapeake and Delaware Bays 显示文摘 | Kim G Scudlark J R Church T M | 2000 | Atmospheric Environment2000，34，： | 1 |
| 10 | On the Complete Convergence for Weighted Sums of Dependent Random Variables under Condition of Weighted Integrability 显示文摘 | Baek J I Ko M H Kim T S | 2008 | J Korean Math Soc2008，45，1： | 1 |
| 11 | Estimating Corn Leaf Chlorophyll Concentration from Leaf and Canopy Reflectance 显示文摘 | Daughtry C S T Wahhall C L Kim M S | 2000 | Remote Sensing of Environment2000，74，2： | 1 |
| 12 | Relationship be- tween psychological factors and quality of life in subtypes of gastroesophageal reflux disease显示文摘 | Oh J H Kim T S Choi M G | 2009 | Gut Liver2009，3，4： | 1 |
| 13 | Preparation and characterization of fouling-resistant TiO2 selfassembled nanocomposite membranes 显示文摘 | Bae T H Kim I C Tak T M | 2006 | Journal of Membrane Science2006，275，12： | 1 |
| 14 | Application of quasicrystalline particles as a strengthening phase in Mg-Zn-Y alloys 显示文摘 | Bae D H Lee M H Kim K T | 2002 | Journal of Alloys and Com- pouds2002，342，： | 1 |
| 15 | Estimating corn leaf chlorophyll concentration from leaf and canopy reflectanc显示文摘 | Daughtry C S T Walthall C L Kim M S | 2000 | Remote Sens Environ2000，74，： | 1 |
| 16 | A two-step structural damage limited instrumentation显示文摘 | Kim H M Bartkowiez T J | 1997 | Journal of Vibration and Acoustics- Transactions of the ASME1997，119，2： | 1 |
| 17 | Conductivity and Magnetoresistane of Polyacetylene Fiber Network显示文摘 | Kim G T Burghard M Suh D S | 1999 | Synth Met1999，105，： | 1 |
| 18 | Thermally driven thin film bulk acoustic resonator voltage controlled oscillators integrated with microheater elements 显示文摘 | Lee H M Kim H T Choi H K | 2004 | Jpn J Appl Phys Part2-Lett2004，43，1： | 1 |
| 19 | Solvent-assisted microcontact molding: A convenient method for fabricating three-dimensional structures of polymeric materials 显示文摘 | Kim E Xia T Zhao X H Whitesides G M | 1997 | Adv Mater1997，9，： | 1 |
| 20 | Trading costs and price discovery across stock index futures,and cash markets显示文摘 | Kim M Szakmary A C Schwarz T V | 1999 | The Journal of Futures Markets1999，19，： | 1 |
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