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| 1 | Pharmacokinetic Comparison of Sustained- and Immediate-Release Oral Formulations of Cilostazol in Healthy Korean Subjects: A Randomized, Open-Label, 3-Part, Sequential, 2-Period, Crossover, Single-Dose, Food-Effect, and Multiple-Dose Study显示文摘 | Donghwan Lee Lay Ahyoung Lim Seong Bok Jang Yoon Jung Lee Jae Yong Chung Jong Rak Choi Kiyoon Kim Jin Woo Park Hosang Yoon Jaeyong Lee Min Soo Park Kyungsoo Park | 2011 | Clinical Therapeutics2011，，12： | 1 |
| 2 | Expression of human peroxiredoxin isoforms in response to cervical carcinogenesis显示文摘 | Kiyoon Kim Miran Yu Seulhee Han Inkyung Oh Young-Jun Choi Sungsoo Kim Kyungsik Yoon Minhyung Jung Wonchae Choe | 2009 | Oncology Reports2009，，6： | 1 |
| 3 | Endosperm-specific expression of tyramine N-hydroxycinnamoyltransferase and tyrosine decarboxylase from a single self-processing polypeptide produces high levels of tyramine derivatives in rice seeds显示文摘 | Sangkyu Park Kiyoon Kang Young Soon Kim Kyoungwhan Back | 2009 | Biotechnology Letters2009，，6： | 1 |
| 4 | Release of overexpressed CypB activates ERK signaling through CD147 binding for hepatoma cell resistance to oxidative stress显示文摘 | Kiyoon Kim Hunsung Kim Kwon Jeong Min Jung Bum-Soo Hahn Kyung-Sik Yoon Byung Jin Geon-Ho Jahng Insug Kang Joohun Ha Wonchae Choe | 2012 | Apoptosis2012，，8： | 1 |
| 5 | Real-time porosity reduction during metal directed energy deposition using a pulse laser显示文摘Porosity is a challenging issue in additive manufacturing and is detrimental to the quality of the additively manufactured products.In this study,a real-time porosity reduction technique was developed by incorporating a pulse laser into a laser metal powder directed energy deposition(DED)system.The incorporated pulse laser can accelerate fluid flow within the melt pool and facilitate the escape of pores before complete solidification.It achieves this real-time porosity reduction by inducing accelerated and turbulent Marangoni flow,ultrasonic waves,and shock waves into the melt pool.The uniqueness and advantages of the proposed technique include the following:(1)For a laser metal powder DED process,this study proposed a noncontact,nondestructive,and real-time porosity reduction technique at the melt pool level.(2)It was experimentally and numerically validated that the developed technique did not alter the geometry and the grain structure of the manufactured Ti-6Al-4V samples.(3)Because the porosity reduction is accomplished at the melt pool level,its application is not limited by the size,shape,or complexity of the printing target.(4)The developed technique can be readily incorporated into the existing DED systems without any modification of the original tool-path design.The experimental results showed that the pore volume fraction decreased from 0.132%to 0.005%,no pores larger than 6×10^(4)μm^(3) were observed,and a 91%reduction in the total pore number was achieved when the pulse laser energy reached 11.5 mJ. | Hoon Sohn Peipei Liu Hansol Yoon Kiyoon Yi Liu Yang Sangjun Kim | 2022 | Journal of Materials Science & Technology2022，，21： | 0 |
| 6 | Reprogramming of cancer-associated fibroblasts by apoptotic cancer cells inhibits lung metastasis via Notch1-WISP-1 signaling显示文摘The interplay between apoptotic cancer cells and the tumor microenvironment modulates cancer progression and metastasis.Cancer-associated fibroblasts(CAFs)play a crucial role in promoting these events through paracrine communication.Here,we demonstrate that conditioned medium(CM)from lung CAFs exposed to apoptotic cancer cells suppresses TGF-β1-induced migration and invasion of cancer cells and CAFs.Direct exposure of CAFs to apoptotic 344SQ cells(ApoSQ)inhibited CAF migration and invasion and the expression of CAF activation markers.Enhanced secretion of Wnt‐induced signaling protein 1(WISP-1)by CAFs exposed to ApoSQ was required for these antimigratory and anti-invasive effects.Pharmacological inhibition of Notch1 activation or siRNA-mediated Notch1 silencing prevented WISP-1 production by CAFs and reversed the antimigratory and anti-invasive effects.Enhanced expression of the Notch ligand delta-like protein 1 on the surface of ultraviolet-irradiated apoptotic lung cancer cells triggered Notch1-WISP-1 signaling.Phosphatidylserine receptor brain-specific angiogenesis inhibitor 1(BAI1)-Rac1 signaling,which facilitated efferocytosis by CAFs,participated in crosstalk with Notch1 signaling for optimal production of WISP-1.In addition,a single injection of ApoSQ enhanced WISP-1 production,suppressed the expression of CAF activation markers in isolated Thy1^(+)CAFs,and inhibited lung metastasis in syngeneic immunocompetent mice via Notch1 signaling.Treatment with CM from CAFs exposed to ApoSQ suppressed tumor growth and lung metastasis,whereas treatment with WISP-1-immunodepleted CM from CAFs exposed to ApoSQ reversed the antitumorigenic and antimetastatic effects.Therefore,treatment with CM from CAFs exposed to apoptotic lung cancer cells could be therapeutically applied to suppress CAF activation,thereby preventing cancer progression and metastasis. | Hee Ja Kim Kyungwon Yang Kiyoon Kim Ye‐Ji Lee Sieun Lee Sung Yong Ahn Young‐Ho Ahn Jihee Lee Kang | 2022 | Cellular & Molecular Immunology2022，19，12： | 0 |
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