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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Immunological response in alcoholic liver disease显示文摘The development of alcoholic liver disease (ALD) can be attributed to many factors that cause damage to the liver and alter its functions. Data collected over the last 30 years strongly suggests that an immune component may be involved in the onset of this disease. This is best evidenced by the detection of circulating autoantibodies, infiltration of immune cells in the liver, and the detection of hepatic aldehyde modified proteins in patients with ALD. Experimentally, there are numerous immune responses that occur when proteins are modified with the metabolites of ethanol. These products are formed in response to the high oxidative state of the liver during ethanol metabolism, causing the release of many inflammatory processes and potential of necrosis or apoptosis of liver cells. Should cellular proteins become modified with these reactive alcohol metabolites and be recognized by the immune system, then immune responses may be initiated. Therefore, it was the purpose of this article to shed some insight into how the immune system is involved in the development and/or progression of ALD. | Michael J Duryee Lynell W Klassen Geoffrey M Thiele | 2007 | World Journal of Gastroenterology2007，13，37： | 9 |
| 3 | Light-weight structures produced by laser beam joining for future applications in automobile and aerospace industry显示文摘 | E. Schubert M. Klassen I. Zerner C. Walz G. Sepold | 2001 | Journal of Materials Processing Tech2001，，1： | 3 |
| 4 | Hydrogen storage in magnesium-based hydrides and hydride composites显示文摘 | M. Dornheim S. Doppiu G. Barkhordarian U. Boesenberg T. Klassen O. Gutfleisch R. Bormann | 2007 | Scripta Materialia2007，，10： | 3 |
| 5 | 源于共同的机械、电气和自动化设计的薄板坯连铸连轧工艺开发显示文摘西马克德马格公司在冶金工业方面是一个领先的工业工厂解决方案提供商.统一设计的机械、电气和自动化方案使我们的用户无论是在产品质量、产量、生产的灵活性、工艺的稳定性以及易维护性方面,拥有了生产具有高性能的高级材料的技术.在薄板坯连铸连轧领域,这样的共同开发的例子如下:①CSP薄板坯连铸.结晶器液面控制,液压结晶器振动,用于楔形和速度优化的自动导航,带有LCR3(液芯压下)的液压扇形段调整,动态二冷水和结晶器监视系统;②CSP轧机.用于带材板形、连续凸度、平直度控制和自由轧制,采用了特定的磨辊以及相配套的串辊策略的CVC+技术;③用于实现厚度小于1mm带钢高效热轧的'薄规格技术包',包括采用'张力差活套'或'张力计活套'以及快速液压机构配合相应的自动化模块,如自动调平控制,以活套测量为基础的平直度控制,尾部监控或以楔形测量为基础的调平预设定.不仅是机械和电气的共同设计,还有共同的项目执行都将使工厂的运营者受益.例如,对于现代化改造项目和新安装的工厂,通过在交货之前在实验室内的联合测试,项目的投产时间得以优化.'工厂回路测试(PILT)'将仿真或甚至机械部件本身与真实的自动化系统(1级,2级和人机界面HMI)结合在一起.通过这样的共同解决方案,西马克德马格公司在电气和自动化领域已发展成'从电机轴一直到生产计划系统'的成套供货商和系统集成商,其目标就是致力于与其用户的长期伙伴关系,并与用户分享其所拥有的工艺经验. | Hans Esau Klassen Michael Reiner Jansen Hermann Wolters | 2004 | 钢铁2004，39，z1： | 3 |
| 6 | 气溶胶特性引起的感烟探测器灵敏性的数值预测(英文)显示文摘本研究结合时滞动力学灵敏度算法,描述了感烟探测器的反应时间,与时滞动力学灵敏度算法同时,大涡模拟火灾模型预测了与探测器相接近的烟浓度值,并描述了烟进入传感小室的输送情景。基于初始粒子的大小和分布,计算传感小室内的烟粒子浓度。由标准试验方法得出了实验数据。比较预测值和实验值,得出了合理一致的结果。 | 张伟 MICHAEL KLASSEN RICHARD ROBY | 2006 | 消防科学与技术2006，25，1： | 2 |
| 7 | Research-based practice: applying the standard nursing education显示文摘 | Klassen P G Karashmer J F Lile J L | 2002 | J Nurs Educ2002，41，3： | 1 |
| 8 | Pain and discomfort associated with mammography among urban low-income African-American women显示文摘 | Papas MA Klassen AC | 2005 | J Community Health2005，30，： | 1 |
| 9 | Mineral metabolism, mortal- ity, and morbidity in maintenance hemodialysis显示文摘 | Block GA Klassen PS Lazarus JM | 2004 | J Am Soc Nephrol2004，15，8： | 1 |
| 10 | Survival,migration and differentiation of retinal progenitor cellstransplanted on micro-machined poly (methyl methacrylate)scaffolds to the subretinal space显示文摘 | Tao S Young C Redenti S Zhang Y Klassen H Desai T | | 0，，06： | 1 |
| 11 | National profile of practice patterns for hemodialysis vascular access in the united states显示文摘 | Reddan D Klassen P Frankfield | 2002 | J Am Soc Nephrol2002，13，8： | 1 |
| 12 | Ball milling of systems with positive heat of mixing:effect of temperature in Ag-Cu显示文摘 | KLASSEN T HERR U AVERBACK R S | 1997 | Acta Mater1997，45，7： | 1 |
| 13 | At- mospheric Corrosivity Modeling-A Review显示文摘 | ROBERGE P R KLASSEN R D HABERECHT P W | 2002 | Materials & Design2002，23，3： | 1 |
| 14 | Atmospheric corrosivity modeling- a review显示文摘 | Roberge P R Klassen R D | 2002 | Materials and Design2002，23，： | 1 |
| 15 | Renal Disease in Obesity: The Need for Greater Attention显示文摘 | Przemyslaw Rutkowski André Klassen Katarina Sebekova Udo Bahner August Heidland | 2006 | Journal of Renal Nutrition2006，，3： | 1 |
| 16 | The quality of life in acne:a comparison with general medical conditions using generic questionnaires显示文摘 | Mallon E Newton JN Klassen A | 1999 | Br J Dermatol1999，140，4： | 1 |
| 17 | Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen显示文摘 | Shoman N Klassen S McFadden A | 2005 | Mod Pathol2005，18，2： | 1 |
| 18 | Formation of supersaturated solutions in the immiscible Ni-Ag system by mechanical alloying 显示文摘 | Xu J Klassen U H | 1996 | Journal of Applied Physics1996，79，8： | 1 |
| 19 | FRCPC Recent advances in the treatment of bronchiolitis and laryngitis显示文摘 | Terry P Klassen MD MSC | 1997 | Pediatric Clinics of North Am1997，44，1： | 1 |
| 20 | Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen 显示文摘 | Shoman N Klassen S McFadden A | 2005 | Mod Pathol2005，18，2： | 1 |
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